Abstract:
The described invention provides histone deacetylase (HDAC) inhibitor compounds with substituted benzimidazole, benzimidazolone and benzotriazole heterocycles showing selective inhibition of histone deacetylase isoform HDAC6. The described invention further provides methods of making such compounds and methods of inhibiting HDAC, treating HDAC- associated diseases, including cell proliferative disorders, such as cancer, autoimmune or inflammatory diseases and neurodegenerative diseases.
Abstract:
A device (1) and method for delivering a plurality of securing elements or clips (10) to a target region in a body. Further, the method and device (1) deliver and place a plurality of clips (10) to secure an implant to a target region. The device (1) allows an operator to remotely control the delivery and placement of shape memory clips (10) to effectively and precisely fasten the clips (10) directly to th target region, or alternatively, to use the clips (10) to secure the implant to the target region. Advantageously, the device (10) allows for the application of the plurality of clips (10) from within a lumen of a vessel.
Abstract:
A method and apparatus for stabilizing glow plasma discharges by suppressing the transition from glow-to-arc includes a perforated dielectric plate having an upper surface and a lower surface and a plurality of holes extending therethrough. The perforated dielectric plate is positioned over the cathode. Each of the holes acts as a separate active current limiting micro-channel that prevents the overall current density from increasing above the threshold for the glow-to-arc transition. This allows for a stable glow discharge to be maintained for a wide range of operating pressures (up to atmospheric pressures) and in a wide range of electric fields include DC and RF fields of varying strength.
Abstract:
The present invention relates to surface-patterned microgels to which molecular beacon probes are immobilized. The immobilized molecular beacon probes exhibit both low non-specific background and high specific fluorescence. Also disclosed are related arrays, related detection methods, and preparation methods.
Abstract:
Hydrogen peroxide is produced by a direct combination of hydrogen and oxygen, the process includes: a. reacting a combination of hydrogen-containing gas stream and oxygen-containing gas stream on a catalyst in the presence of a solvent; b. maintaining (a) under low pressure; and c. conducting (a)-(b) in a microreactor system. The catalyst of the process for the production of hydrogen peroxide by a direct combination of hydrogen and oxygen is a sol-gel catalyst with a platinium group metal on an acidified support.
Abstract:
A sterilization and decontamination system in which a non-thermal plasma discharge device is disposed upstream of a suspension media (e.g., a filter, electrostatic precipitator, carbon bed). The plasma discharge device generates a plasma that is emitted through apertures (e.g., capillaries or slits) in the primary dielectric. Plasma generated active sterilizing species when exposed to contaminants or undesirable particulate matter is able to deactivate or reduce such matter in contaminated fluid stream and/or on objects. Thus, the undesirable contaminants in the fluid to be treated are first reduced during their exposure to the plasma generated active sterilizing species in the plasma region of the discharge device. Furthermore, the plasma generated active sterilizing species are carried downstream to suspension media and upon contact therewith deactivate the contaminants collected on the suspension media itself. Advantageously, the suspension media may be cleansed in situ. To increase the sterilization efficicency an additive, free or carrier gas (e.g., alcohol, water, dry air) may be injected into the apertures defined in the primary dielectric. These additives increase the concentration of plasma generated active sterilizing agents while reducing the byproduct of generated undesirable ozone pollutants. Downstream of the filter the fluid stream may be further treated by being exposed to a catalyst media or additional suspension media to further reduce the amount of undesirable particulate matter.
Abstract:
A large aperture, high spatial resolution vibration and acoustic sensing device is provided. The sensor is capable of directional resolution of acoustic sources in gaseous, liquid, and solid media, and can be employed as a directional microphone or a directional hydrophone. The sensor can also be used as a high-resolution vibration displacement sensor. The device is formed of thin films comprising two electret layers (25, 35) and a compliant intermediate layer (30) disposed therebetween. Conductive coatings (20, 37) disposed on the electret layers can be patterned and etched to provide a plurality of discrete sensing elements (40), forming a directional array. The sensor can be transparent, thereby allowing usage as a large area microphone disposed on top of a computer screen, video monitor, windows, or walls.
Abstract:
A device (10) which employs an acoustic signal having one or more frequencies for penetrating into ground, water, or sediments and vibrating a compliant buried object (8) is provided. When these acoustic signals encounter an acoustically compliant object (8) such as a mine, the acoustic signals vibrate the compliant object (8), leading to a vibration of the compliant object (8) against the boundaries of the surrounding medium such as ground sediment, creating a nonlinear distortion of the probing signal including the generation of harmonics and acoustic waves with combination frequencies (nonlinear signals). These nonlinear vibrating signals are received from the surface by a sensor (20). The amplitude of the measured nonlinear signals indicates the presence of an acoustically compliant object (8) such as a mine. The present invention also relates to a method and apparatus which emits an electromagnetic RF probing signal and acoustic or vibration signal (modulating signal), detects the reflected electromagnetic signal from the buried object (8), and processes the received signal, identifying the modulation caused by vibration.