公开(公告)号：WO2010124285A1

公开(公告)日：2010-10-28

申请号：PCT/US2010/032425

申请日：2010-04-26

Applicant: MEDTRONIC INC. ,  SKARDA, Jim ,  STEWART, Mark ,  KEOGH, James ,  FRANCISCHELLI, David ,  GARDESKI, Ken ,  POSS, Tom ,  NEIDERT, Michael

Inventor： SKARDA, Jim ,  STEWART, Mark ,  KEOGH, James ,  FRANCISCHELLI, David ,  GARDESKI, Ken ,  POSS, Tom ,  NEIDERT, Michael

IPC: A61B19/00 ,  A61N1/05 ,  A61B17/00

CPC classification number: A61B1/00154 ,  A61B1/00135 ,  A61B34/20 ,  A61B90/361 ,  A61B2017/00243 ,  A61B2017/00336 ,  A61B2034/2051 ,  A61N1/056

Abstract: The present invention provides devices, instruments, systems, and methods to navigate medical instruments within the thoracic cavity. More specifically, the present invention provides a navigation system comprising medical instruments having electromagnetic tracking functionality and the integration of previously acquired imaging into a user interface of the navigation system.

Abstract translation: 本发明提供了用于在胸腔内导航医疗器械的装置，仪器，系统和方法。 更具体地，本发明提供了一种导航系统，其包括具有电磁跟踪功能的医疗仪器和将先前获取的成像集成到导航系统的用户界面中。

公开(公告)号：WO2008040979A1

公开(公告)日：2008-04-10

申请号：PCT/GB2007/003766

申请日：2007-10-04

Applicant: ARK THERAPEUTICS LTD. ,  JIA, Haiyan ,  ZACHARY, Ian ,  TICKNER, Michelle ,  CHENG, Lili ,  CHAPMAN, Chris ,  ELLARD, Katie ,  HARTZOULAKIS, Basil ,  JARVIS, Ashley ,  LYNCH, Rosemary ,  NALLY, Jamie ,  SELWOOD, David ,  STEWART, Mark

Inventor： JIA, Haiyan ,  ZACHARY, Ian ,  TICKNER, Michelle ,  CHENG, Lili ,  CHAPMAN, Chris ,  ELLARD, Katie ,  HARTZOULAKIS, Basil ,  JARVIS, Ashley ,  LYNCH, Rosemary ,  NALLY, Jamie ,  SELWOOD, David ,  STEWART, Mark

IPC: C07D277/56 ,  C07D307/68 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07K5/06 ,  C07K5/08 ,  A61P3/00 ,  A61P25/00 ,  A61P35/00 ,  C07C279/04

CPC classification number: C07D333/38 ,  C07C279/12 ,  C07D277/56 ,  C07D307/68 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The present invention is a compound of formula (I) or formula (II) which are suitable as NP-1 antagonists.

Abstract translation: 本发明是适合作为NP-1拮抗剂的式（I）或式（II）的化合物。

公开(公告)号：WO2007140331A3

公开(公告)日：2008-01-17

申请号：PCT/US2007069789

申请日：2007-05-25

Applicant: MEDTRONIC INC ,  STEWART MARK T ,  FRANCISCHELLI DAVID E ,  KEOGH JAMES R ,  HISSONG JAMES B ,  SKARDA JAMES R ,  LEE HOTAIK ,  SMITH NADINE B

Inventor： STEWART MARK T ,  FRANCISCHELLI DAVID E ,  KEOGH JAMES R ,  HISSONG JAMES B ,  SKARDA JAMES R ,  LEE HOTAIK ,  SMITH NADINE B

IPC: A61N7/02

CPC classification number: A61B17/320068 ,  A61B8/4281 ,  A61B34/20 ,  A61B2017/320076 ,  A61B2017/320078 ,  A61B2018/00291 ,  A61B2034/2051 ,  A61B2090/378 ,  A61B2090/3782 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

Abstract: A device and method for ablating tissue is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding an ablating member within the patient while tracking the position of the ablating member in the patient, positioning the ablating member in a desired position to ablate tissue, emitting ablating energy from the ablating member to form an ablated tissue area and removing the ablating member from the patient.

Abstract translation: 公开了一种用于消融组织的装置和方法，包括以下步骤：获取患者的解剖图像，将图像与患者相关联，在跟踪患者内的消融部件的位置的同时引导患者内的消融部件，定位消融 成员在消融组织的期望位置，从烧蚀构件发出消融能量以形成消融的组织区域，并从患者身上移除消融部件。

公开(公告)号：WO2007127664A1

公开(公告)日：2007-11-08

申请号：PCT/US2007/066952

申请日：2007-04-19

Applicant: MEDTRONIC, INC. ,  PLOTT, Christopher J. ,  OLSON, Andrew L. ,  CLOUTIER, Patrick J. ,  SMITH, Christopher W. ,  STEWART, Mark T. ,  FRANCISCHELLI, David E. ,  BRISCOE, Roderick E. ,  HAEG, Daniel C. ,  KIM, David J.S. ,  HOBDAY, Michael J. ,  KANAYINKAL, Tessy ,  GUBBIN, Douglas H. ,  ROTHSTEIN, Paul T. ,  CARDINAL, Joseph E. ,  FOLEY, Jessica L. ,  LEUER, Leonard H. ,  DAIGLE, Thomas P.

Inventor： PLOTT, Christopher J. ,  OLSON, Andrew L. ,  CLOUTIER, Patrick J. ,  SMITH, Christopher W. ,  STEWART, Mark T. ,  FRANCISCHELLI, David E. ,  BRISCOE, Roderick E. ,  HAEG, Daniel C. ,  KIM, David J.S. ,  HOBDAY, Michael J. ,  KANAYINKAL, Tessy ,  GUBBIN, Douglas H. ,  ROTHSTEIN, Paul T. ,  CARDINAL, Joseph E. ,  FOLEY, Jessica L. ,  LEUER, Leonard H. ,  DAIGLE, Thomas P.

IPC: A61B17/12 ,  A61B17/128 ,  A61B17/00

CPC classification number: A61B17/12009 ,  A61B17/12013 ,  A61B17/1285 ,  A61B2017/00243 ,  A61B2017/00296 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00632 ,  A61B2017/12018

Abstract: Some embodiments of the invention provide a system for occluding a left atrial appendage of a patient. Some embodiments of the system can include a ring occluder that can be positioned around the left atrial appendage and a ring applicator to position the ring occluder with respect to the left atrial appendage. One embodiment discloses a method of accessing endocardial surfaces of the heart through the atrial appendage. Additional embodiments of the invention provide a clip occluder that can be positioned around the left atrial appendage. A clip applicator can position the clip occluder with respect to the left atrial appendage.

Abstract translation: 本发明的一些实施例提供一种用于闭塞患者的左心耳的系统。 该系统的一些实施例可以包括可以围绕左心耳定位的环形阻塞器和环形施放器，以相对于左心耳定位环形闭塞器。 一个实施例公开了通过心房附近获得心脏心内膜表面的方法。 本发明的另外的实施例提供了可围绕左心耳定位的夹子封堵器。 夹子施放器可以相对于左心耳定位夹子封堵器。

公开(公告)号：WO2007089676A1

公开(公告)日：2007-08-09

申请号：PCT/US2007/002333

申请日：2007-01-26

Applicant: MEDTRONIC, INC. ,  THOMPSON, Mark ,  DICKERSON, Darrin ,  BOWMAN, Brett, S. ,  KELLY, Christopher, F. ,  MALECKI, William, W. ,  FRANCISCHELLI, David ,  STEWART, Mark ,  DAIGLE, Thomas ,  GUBBIN, Douglas ,  KIM, David ,  ROTHSTEIN, Paul ,  PODBELSKI, Adam ,  PLOTT, Christopher ,  YAFFE, Benjamin, K.

Inventor： THOMPSON, Mark ,  DICKERSON, Darrin ,  BOWMAN, Brett, S. ,  KELLY, Christopher, F. ,  MALECKI, William, W. ,  FRANCISCHELLI, David ,  STEWART, Mark ,  DAIGLE, Thomas ,  GUBBIN, Douglas ,  KIM, David ,  ROTHSTEIN, Paul ,  PODBELSKI, Adam ,  PLOTT, Christopher ,  YAFFE, Benjamin, K.

IPC: A61B17/00 ,  A61B1/00 ,  A61B17/02 ,  A61B19/00 ,  A61B17/32

CPC classification number: A61B17/00234 ,  A61B1/0055 ,  A61B17/0218 ,  A61B18/1482 ,  A61B90/30 ,  A61B2017/003 ,  A61B2017/00367 ,  A61B2017/320044 ,  A61B2090/0811

Abstract: A device for dissecting tissue and/or guidance of a second device to a desired physiological location, the device comprising: an elongate shaft comprising a proximal portion and a distal portion, wherein the distal portion comprises a plurality of segments that articulate with respect to one another; and a handle attached to the proximal portion of the shaft, wherein the handle comprises controls for articulating the plurality of segments of the distal portion of the shaft with respect to one another. A system for dissecting tissue and or guiding a medical device to a desired physiological location.

Abstract translation: 一种用于将第二装置的组织和/或引导解剖到期望的生理位置的装置，所述装置包括：细长轴，其包括近端部分和远侧部分，其中所述远端部分包括多个相对于一个 另一个; 以及附接到所述轴的近侧部分的手柄，其中所述手柄包括用于相对于彼此铰接所述轴的远侧部分的所述多个段的控制。 一种用于将组织切割和/或将医疗装置引导至所需生理位置的系统。

公开(公告)号：WO2007067945A2

公开(公告)日：2007-06-14

申请号：PCT/US2006/061722

申请日：2006-12-07

Applicant: MEDTRONIC, INC ,  FRANCISCHELLI, David, E ,  HISSONG, James, B. ,  KEOGH, James, R. ,  SKARDA, James, R. ,  STEWART, Mark, T.

Inventor： FRANCISCHELLI, David, E ,  HISSONG, James, B. ,  KEOGH, James, R. ,  SKARDA, James, R. ,  STEWART, Mark, T.

CPC classification number: A61N7/02 ,  A61B8/4272 ,  A61B18/1442 ,  A61B34/20 ,  A61B2017/00243 ,  A61B2018/00291 ,  A61B2034/2051 ,  A61B2034/2053 ,  A61B2034/2063 ,  A61B2090/378 ,  A61B2090/397 ,  A61N7/022 ,  A61N2007/0078

公开(公告)号：WO2006063032A3

公开(公告)日：2006-11-30

申请号：PCT/US2005044230

申请日：2005-12-05

Applicant: CONSTAR INT INC ,  EASTMAN CHEM CO ,  STEWART MARK EDWARD ,  ESTEP ROBERT NOAH ,  GAMBLE BENJAMIN ,  CLIFFTON MICHAEL DUANE ,  QUILLEN DONNA RICE ,  BUEHRIG LAVONNA SUZANNE ,  GOVINDARAJAN VENKAT ,  DAUZVARDIS MATTHEW J

Inventor： STEWART MARK EDWARD ,  ESTEP ROBERT NOAH ,  GAMBLE BENJAMIN ,  CLIFFTON MICHAEL DUANE ,  QUILLEN DONNA RICE ,  BUEHRIG LAVONNA SUZANNE ,  GOVINDARAJAN VENKAT ,  DAUZVARDIS MATTHEW J

IPC: C09K3/00 ,  B29D22/00 ,  C08G69/26 ,  C08K3/08

CPC classification number: C08K3/08 ,  B29B2911/1402 ,  B29B2911/14026 ,  B29B2911/14033 ,  B29B2911/1404 ,  B29B2911/14106 ,  B29B2911/14113 ,  B29B2911/1412 ,  B29B2911/14126 ,  B29B2911/14133 ,  B29B2911/1414 ,  B29B2911/14146 ,  B29B2911/14153 ,  B29B2911/1416 ,  B29B2911/14166 ,  B29B2911/14173 ,  B29B2911/1418 ,  C08K2003/0843 ,  C08K2003/0893 ,  C08L67/00

Abstract: The present invention concerns a method for forming an article by combining a polyester polymer and an oxygen scavenging composition comprising a polyamide in the presence of zinc and a cobalt in a melt processing zone to form a melt; and forming an article such as a sheet or preform from the melt. Also provided are molten formulated polyester polymer compositions containing a blend of a polyethylene terephthalate polymer and a polyamide polymer along with zinc and cobalt. Articles made from the composition are resistant to the transmission of oxygen, possess short induction periods, and have high capacity for sustaining lengthy periods of low oxygen transmission through the wall of the article.

Abstract translation: 本发明涉及通过在熔融加工区中在锌和钴的存在下将聚酯聚合物和包含聚酰胺的除氧组合物结合以形成熔体来形成制品的方法; 并且从熔体形成诸如片材或预成型件的制品。 还提供了熔融配制的聚酯聚合物组合物，其含有聚对苯二甲酸乙二醇酯聚合物和聚酰胺聚合物以及锌和钴的共混物。 由该组合物制成的制品对氧的传输具有抵抗力，具有短的诱导期，并具有用于维持穿过制品壁的长时间的低氧气透过的高容量。

公开(公告)号：WO2004100813A2

公开(公告)日：2004-11-25

申请号：PCT/US2004/014224

申请日：2004-05-07

Applicant: MEDTRONIC, INC. ,  STEWART, Mark, T. ,  FIEDLER, Gary, R. ,  SANDSTONE, Jeffrey, D.

Inventor： STEWART, Mark, T. ,  FIEDLER, Gary, R. ,  SANDSTONE, Jeffrey, D.

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B10/0233 ,  A61B2018/00011 ,  A61B2018/1407 ,  A61B2018/1435 ,  A61B2218/002

Abstract: According to the present invention, a catheter having at least one multi-purpose lumen formed through the catheter terminates proximal a relatively complex-shaped distal portion thereof. In one form of this embodiment, the relatively complex-shaped distal portion comprises a looped portion having diagnostic- and/or ablation-type electrodes coupled thereto and an elongated diameter-adjusting member coupled proximal the distal end of the looped portion. The multi-purpose lumen may be used to alternately accommodate a variety of dedicated materials; such as, (i) a guide wire for initial deployment or later repositioning of the catheter, (ii) a volume or flow of a contrast media and the like, (iii) a deployable hollow needle or tube and the like used to biopsy adjacent tissue or dispense a therapeutic agent into a volume of tissue, and (iv) a cooling fluid, such as saline solution and the like dispensed at least during therapeutic tissue ablation procedures.

Abstract translation: 根据本发明，具有通过导管形成的至少一个多用途腔的导管终止于其相对复杂形状的远端部分的近端。 在该实施例的一种形式中，相对复杂形状的远侧部分包括具有耦合到其上的诊断和/或消融型电极的环形部分和在环形部分的远端附近耦合的细长直径调节构件。 多用途腔可用于交替容纳各种专用材料; 例如，（i）用于初始部署或稍后重新定位导管的导丝，（ii）造影剂等的体积或流动，（iii）用于活检相邻的可展开的空心针或管等 组织或将治疗剂分配到一定体积的组织中，和（iv）至少在治疗性组织消融过程期间分配的冷却液，例如盐水溶液等。

公开(公告)号：WO2013019378A1

公开(公告)日：2013-02-07

申请号：PCT/US2012/046479

申请日：2012-07-12

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  STEWART, Mark T. ,  HONECK, Jordon D.

Inventor： STEWART, Mark T. ,  HONECK, Jordon D.

IPC: A61B18/02 ,  A61B18/14

CPC classification number: A61B18/1492 ,  A61B18/02 ,  A61B2018/0022 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00994 ,  A61B2018/0212 ,  A61B2018/0237 ,  A61B2018/0262 ,  A61B2018/1437

Abstract: A medical system, including a catheter body, an elongate body disposed in the catheter body; an expandable element having a proximal portion coupled to the catheter body and a distal portion coupled to the elongate body, the distal portion of the expandable element defining the distal-most portion of the medical device; a mesh or array of longitudinal splines substantially surrounding the expandable element, at least a portion of the mesh or splines being electrically conductive; and a coolant source in fluid communication with the expandable element.

Abstract translation: 医疗系统，包括导管主体，设置在导管主体中的细长主体; 可扩张元件，其具有联接到导管主体的近端部分和联接到细长主体的远端部分，可扩张元件的远端部分限定医疗装置的最远部分; 基本上围绕所述可膨胀元件的纵向花键的网状物或阵列，所述网状物或花键的至少一部分是导电的; 以及与可膨胀元件流体连通的冷却剂源。

公开(公告)号：WO2012142197A1

公开(公告)日：2012-10-18

申请号：PCT/US2012/033171

申请日：2012-04-12

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  STEWART, Mark T. ,  DAVIE, Scott W. ,  DESROCHERS, Giles

Inventor： STEWART, Mark T. ,  DAVIE, Scott W. ,  DESROCHERS, Giles

IPC: A61B5/0408 ,  A61B5/042 ,  A61B5/00

CPC classification number: A61B5/743 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/0402 ,  A61B5/0422 ,  A61B5/055 ,  A61B5/14542 ,  A61B5/6852 ,  A61B6/12 ,  A61B6/503 ,  A61B8/0841 ,  A61B8/0883

Abstract: A method of mapping electrophysiological information, including receiving imaging information for a tissue region; receiving a monophasic action potential signal from the tissue region; assigning a value corresponding to a depolarization segment of the monophasic action potential signal; receiving location information associated with the monophasic action potential signal; and generating an image based on the imaging information, the assigned value, and the location information.

Abstract translation: 一种映射电生理信息的方法，包括接收组织区域的成像信息; 从所述组织区域接收单相动作电位信号; 分配与单相动作电位信号的去极化部分对应的值; 接收与单相动作电位信号相关联的位置信息; 以及基于成像信息，分配值和位置信息生成图像。