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公开(公告)号：USRE45170E1
公开(公告)日：2014-09-30
申请号：US14015881
申请日：2013-08-30
Applicant: Stichting Dienst Landbouwkundig Onderzoek
Inventor： Hilda Elizabeth Smith
CPC classification number: C12R1/46 , A61K39/00 , A61K39/092 , A61K2039/522 , C07K14/315 , C12N9/1048
Abstract: The invention relates to Streptococcus suis infection in pigs, vaccines directed against those infections and tests for diagnosing Streptococcus suis infections. The invention provides an isolated or recombinant nucleic acid encoding a capsular gene cluster of Streptococcus suis or a gene or gene fragment derivated thereof. The invention further provides a nucleic acid probe or primer allowing species or serotype-specific detection of Streptococcus suis. The invention also provides a Streptococcus suis antigen and vaccine derived thereof.
Abstract translation: 本发明涉及猪链球菌感染，针对这些感染的疫苗和用于诊断猪链球菌感染的试验。 本发明提供了编码链球菌荚膜基因簇的分离或重组核酸或其衍生的基因或基因片段。 本发明还提供了允许种类或血清型特异性检测猪链球菌的核酸探针或引物。 本发明还提供了猪链球菌抗原及其衍生的疫苗。
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22.发明授权公开(公告)号：US10433572B2
公开(公告)日：2019-10-08
申请号：US14386785
申请日：2013-03-19
Applicant: Stichting Dienst Landbouwkundig Onderzoek
Inventor： Rian Adriana Hendrika Timmermans , Ricardo Ermirio De Moraes , Hendrikus Cornelis Mastwijk , Ariette Margaretha Matser
Abstract: The invention relates to an apparatus for fast and homogeneously heating a liquid product to a heating temperature by means of resistive heating, the apparatus comprising at least two vertically mounted, longitudinal, heating chambers that are arranged in series. The invention further relates to a process for fast and homogeneously heating a liquid product to a heating temperature by means of resistive heating in such apparatus comprising (a) continuously supplying the liquid product to the first heating chamber in series and flowing the liquid product continuously through the at least two heating chambers; (b) continuously generating an electrical current through the liquid product flowing through the heating chambers by continuously applying an electrical potential over each heating chamber, wherein the direction of the current is continuously alternated with a frequency of at least 500 Hz, to obtain heated liquid product; and (c) continuously discharging heated liquid product from the last heating chamber in series, wherein the liquid product has an electrical conductivity of at least 0.03 S/m.
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公开(公告)号：US20160002608A1
公开(公告)日：2016-01-07
申请号：US14796345
申请日：2015-07-10
Applicant: Stichting Dienst Landbouwkundig Onderzoek
CPC classification number: C12N7/00 , A61K39/12 , C07K14/005 , C12N2510/02 , C12N2760/12022 , C12N2760/12034 , C12N2760/12043 , C12N2760/12051 , C12N2760/12221 , C12N2760/12233 , C12N2760/12234 , Y02A50/397
Abstract: The invention relates to methods of producing infectious bunyavirus replicon particles. These bunyavirus replicon particles are safe and can be used outside a biosafety containment. The invention further relates to recombinant bunyavirus replicon particles and uses of these recombinant bunyavirus replicon particles.
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公开(公告)号：US20150296779A1
公开(公告)日：2015-10-22
申请号：US14647667
申请日：2012-11-28
Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK
Inventor： Martijn FIERS , Kimberly BOUTILIER
IPC: A01N43/42 , A01N43/40 , C07D401/04 , A01N43/38
CPC classification number: A01N43/42 , A01H4/001 , A01N43/38 , A01N43/40 , C07D215/54 , C07D401/04
Abstract: Cyclopentyl 2,7,7-trimethyl-5-oxo-4-(4-pyridinyl)-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate and similar compounds are potentiators of auxin-induced somatic embryogenesis in plants. In particular, the inventors have discovered certain of these compounds induce somatic embryogenesis in Arabidopsis in the presence of 2,4-D. Also tested is BAY K 8644. Methods of inducing somatic embryogenesis comprise exposing selected plant tissues, e.g. seed embryos, to auxins, e.g. 2.4-D and the compounds.
Abstract translation: 环戊基2,7,7-三甲基-5-氧代-4-（4-吡啶基）-1,4,5,6,7,8-六氢-3-喹啉羧酸酯和类似化合物是生长素诱导的体细胞胚发生的增强剂 植物。 特别地，本发明人发现这些化合物中某些化合物在2,4-D存在下诱导拟南芥中的体细胞胚发生。 还测试了BAY K 8644.诱导体细胞胚发生的方法包括将所选择的植物组织，例如， 种子胚，到生长素，例如 2.4-D和化合物。
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25.发明申请MAMMALIAN-TYPE GLYCOSYLATION IN PLANTS BY EXPRESSION OF NON-MAMMALIAN GLYCOSYLTRANSFERASES 有权通过表达非马氏甘露糖衍生物的植物中的MAMMALIAN-TYPE GLYCOSYLATION公开(公告)号：US20150176020A1
公开(公告)日：2015-06-25
申请号：US14341296
申请日：2014-07-25
Applicant: Stichting Dienst Landbouwkundig Onderzoek
CPC classification number: C12N15/8257 , C07K2319/00 , C12N9/1051 , C12N15/8245 , C12N15/8246 , C12P21/005
Abstract: The present invention relates to non-mammalian β-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian β-1,4-galactosyltransferases and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian β-1,4-galactosyltransferases.
Abstract translation: 本发明涉及可以以其野生型或修饰形式使用的非哺乳动物和β-蔗糖-1,4-半乳糖基转移酶。 本发明进一步涉及表达非哺乳动物和-1,4'-半乳糖基转移酶的转化植物和植物细胞以及产生具有改变且优选哺乳动物型糖基化的糖蛋白的方法。 本发明另外提供了非哺乳动物和-1,4'-半乳糖基转移酶的核酸分子和表达载体。
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Patent Agency Ranking
公开(公告)号：US20150065749A1
公开(公告)日：2015-03-05
申请号：US14390211
申请日：2013-03-28
Applicant: Stichting Dienst Landbouwkundig Onderzoek
Inventor： Daniël Stephan Van Es , Jacobus van Haveren , Henricus Wilhelmus Carolina Raaijmakers , Frits van der Klis , Gerardus Petrus Franciscus Maria van Engelen , Augustinus Emmanuël Frissen
IPC: C07C51/235
CPC classification number: C07C51/235 , B01J21/04 , B01J21/063 , B01J23/52 , B01J23/66 , C07C59/285 , C07H1/00 , C07H7/033
Abstract: Disclosed is the oxidation of uronic acids, such as galacturonic acid, to the corresponding aldaric acids (characterized by the formula HOOC—(CHOH)n-COOH, with n being an integer of from 1 to 5) such as galactaric acids. The starting material comprising the uronic acid is subjected to oxygen under the influence of a supported gold catalyst and in the presence of a base. The oxidation occurs in good selectivity and yield, under unexpectedly mild conditions. A source of galacturonic acids is pectin, such as that derived from sugar beet pulp.
Abstract translation: 公开了将糖醛酸如半乳糖醛酸氧化成相应的阿拉德酸（其特征在于式HOOC-（CHOH）n-COOH，n为1至5的整数），如乳糖酸。 包含糖醛酸的起始材料在负载的金催化剂的影响下和在碱的存在下进行氧化。 在意想不到的温和条件下，氧化以良好的选择性和产率出现。 半乳糖醛酸的来源是果胶，例如衍生自甜菜糖浆的果胶。
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27.发明申请PROCESS FOR FAST AND HOMOGENEOUSLY HEATING A LIQUID PRODUCT AND APPARATUS FOR SUCH PROCESS 审中-公开快速均匀加热液体产品和方法的方法公开(公告)号：US20150050400A1
公开(公告)日：2015-02-19
申请号：US14386785
申请日：2013-03-19
Applicant: Stichting Dienst Landbouwkundig Onderzoek
Inventor： Rian Adriana Hendrika Timmermans , Ricardo Ermirio De Moraes , Hendrikus Cornelis Matswijk , Ariette Margaretha Matser
CPC classification number: A23L2/48 , A23B5/01 , A23C3/02 , A23L3/005 , A23L3/01 , A23V2002/00 , H05B3/60
Abstract: The invention relates to an apparatus for fast and homogeneously heating a liquid product to a heating temperature by means of resistive heating, the apparatus comprising at least two vertically mounted, longitudinal, heating chambers that are arranged in series. The invention further relates to a process for fast and homogeneously heating a liquid product to a heating temperature by means of resistive heating in such apparatus comprising (a) continuously supplying the liquid product to the first heating chamber in series and flowing the liquid product continuously through the at least two heating chambers; (b) continuously generating an electrical current through the liquid product flowing through the heating chambers by continuously applying an electrical potential over each heating chamber, wherein the direction of the current is continuously alternated with a frequency of at least 500 Hz, to obtain heated liquid product; and (c) continuously discharging heated liquid product from the last heating chamber in series, wherein the liquid product has an electrical conductivity of at least 0.03 S/m.
Abstract translation: 本发明涉及一种用于通过电阻加热将液体产品快速均匀地加热到加热温度的装置，该装置包括串联布置的至少两个垂直安装的纵向加热室。 本发明还涉及通过这种设备中的电阻加热将液体产物快速均匀地加热至加热温度的方法，包括：（a）将液体产物串联连续供应到第一加热室，并将液体产物连续地流过 所述至少两个加热室; （b）通过在每个加热室上连续施加电位，连续地通过流过加热室的液体产物产生电流，其中电流的方向以至少500Hz的频率连续地交替，以获得加热的液体 产品; 和（c）连续地从最后一个加热室排出加热的液体产物，其中液体产物具有至少0.03S / m的电导率。
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公开(公告)号：US20140371472A1
公开(公告)日：2014-12-18
申请号：US14375230
申请日：2013-02-19
Applicant: Stichting Dienst Landbouwkundig Onderzoek
Inventor： Erik Hagberg , Kevin Martin , Jerome Le Notre , Daniel Stephan van Es , Jacobus van Haveren , Jan van EE
IPC: C07D493/04 , B01J23/755 , B01J23/42 , B01J23/52 , B01J23/46 , B01J23/44
CPC classification number: C07D493/04 , B01J23/42 , B01J23/44 , B01J23/462 , B01J23/464 , B01J23/52 , B01J23/755
Abstract: Disclosed is a process for the preparation of isoidide from isosorbide. An aqueous solution of isosorbide is subjected to epimerization in the presence of hydrogen under the influence of a catalyst comprising ruthenium on a support, preferably a carbon support. The process of the invention can be conducted using a relatively low hydrogen pressure, and leads to a desired distribution of epimers, favoring isoidide over isomannide and isosorbide.
Abstract translation: 公开了从异山梨醇制备异氰酸酯的方法。 在氢气存在下，在包含钌的催化剂在载体，优选碳载体上的影响下，使异山梨醇的水溶液进行差向异构化。 本发明的方法可以使用相对较低的氢气压力进行，并导致差向异构体的期望分布，有利于异麦芽酮糖苷和异山梨醇上的异氰酸酯。
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公开(公告)号：USPP28397P3
公开(公告)日：2017-09-19
申请号：US14998739
申请日：2016-02-09
Inventor： Rene Smulders
IPC: A01H5/08
Abstract: A new and distinct cultivar of Apple tree named ‘WUR37’, characterized by its upright plant habit; vigorous growth habit; numerous fruit produced per plant; fruits with red-colored skin spotted with lenticels; resistance to Apple Scab; and suitability for organic farming practices.
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公开(公告)号：US09636653B2
公开(公告)日：2017-05-02
申请号：US14431524
申请日：2013-09-24
Inventor： Erhan Bat , Pascal Jonkheijm , Aart Van Amerongen , Jurriaan Hüskens
CPC classification number: B01J19/0046 , B01J2219/00382 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00619 , B01J2219/00659 , B05D1/18 , C40B60/14
Abstract: A stamp for making a microarray of biomolecules, wherein the stamp has a stamp body having a stamping surface for stamping the biomolecules onto a substrate, a plurality of reservoirs for liquids having the biomolecules, wherein each of the reservoirs has a bottom wall and a plurality of channels extending between each of the bottom wall and the stamping surface, wherein each of the reservoirs and the channels has a macroporous hydrogel and wherein the stamping surface is provided with a hydrophobic coating.
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