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    Meniscus prosthesis
    21.
    发明专利
    Meniscus prosthesis 未知

    公开(公告)号：AU2015228989A1

    公开(公告)日：2016-09-22

    申请号：AU2015228989

    申请日：2015-03-10

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT MORE PARTICULARLY RADBOUD UNIVERSITEIT NIJMEGEN ,  DSM IP ASSETS BV

    Inventor： KOENEN JACOB ,  DAAMEN EDWIN ,  VAN TIENEN TONY ,  BUMA PIETER

    IPC: A61F2/38 ,  A61F2/30

    Abstract: The invention is directed to a meniscus prosthesis comprising an arc-shaped meniscus prosthesis body having a main portion (1) comprising a reinforcing part (2) and two end portions (1A, 1B) comprising fixation parts (2A, 2B), wherein the main portion (1) comprises a part made of a first biocompatible, non- resorbable material extending between the two end portions (1A, 1B), wherein the reinforcing part (2) and the fixation parts (2A, 2B) are made of a second biocompatible, non-resorbable material and wherein the reinforcing part (2) extends between the fixation parts (2A, 2B) and wherein the fixation parts (2A, 2B) have a through hole (3A, 3B), the first biocompatible, non-resorbable material has a tensile modulus of at most 100 MPa as determined by ISO 527-1 and the second biocompatible, non-resorbable material has a tensile modulus of at least 01 MPa as determined by ISO 527-1.

    mRNA ratios in urinary sediments and/or urine as a prognostic and/or theranostic marker for prostate cancer
    22.
    发明专利
    mRNA ratios in urinary sediments and/or urine as a prognostic and/or theranostic marker for prostate cancer 未知

    公开(公告)号：AU2005318369B2

    公开(公告)日：2012-02-09

    申请号：AU2005318369

    申请日：2005-12-23

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

    Inventor： VERHAEGH GERALD ,  WITJES ALFRED J ,  SCHALKEN JACK A ,  HESSELS DAPHNE

    IPC: C12Q1/68

    Abstract: Described herein are methods and kits for prognosis of prostate cancer in a subject. The methods comprises: (a) determining the ratio of PCA3 and PSA expression in a urine sample and (b) correlating the value of the PCA3/PSA ratio with the aggressiveness and mortality risk of prostate cancer in the subject. Kits for prognosing prostate cancer are also described. More particularly, the present invention features a method for prognosing prostate cancer in a biological sample of a patient comprising: assessing the amount of a prostate cancer specific PCA3 mRNA and the amount of PSA in the biological sample; determining a ratio value of this amount of prostate cancer specific PCA3 mRNA over the amount of PSA; comparing the ratio value to at least one predetermined cut-off value, wherein a ratio value above the predetermined cut-off value is indicative of a higher risk of mortality of prostate cancer as compared to a ratio value below the predetermined cut-off value.

    Specific method of prostate cancer detection based on PCA3 gene, and kits therefor
    23.
    发明专利
    Specific method of prostate cancer detection based on PCA3 gene, and kits therefor 未知

    公开(公告)号：AU2004254043A1

    公开(公告)日：2005-01-13

    申请号：AU2004254043

    申请日：2004-06-30

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT UNIVERSITY MEDICAL CENTRE NIJMEGEN

    Inventor： VERHAEGH GERALD ,  SMIT FRANK ,  SCHALKEN JACK A ,  HESSELS DAPHNE

    IPC: C12Q1/68

    Abstract: The invention relates to a method to diagnose prostate cancer by detecting a PCA3 sequence. In one embodiment the method and kit enables amplification of PCA3 RNA through an exon-exon junction of a spliced PCA3 mRNA, and methods and kits to detect an amplified PCA3 RNA, using a probe which spans the amplified exon-exon junction. The methods and kits can detect a PCA3 RNA lacking one intron or more. Also provided are methods of detecting PCA3 RNA expressed in non-prostate tissue or cells of the urinary tract, which comprises PCA3 intron 3. In addition, methods are provided to determine whether a sample from a subject contains or lacks prostate cells, by performing a hybridization and/or amplification reaction on RNA from the sample to detect the presence or level of PCA3 RNA that lacks at least one intron and distinguishing a prostate cell from a non-prostate cell.

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