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    OPTICAL-BASED SENSING DEVICES
    22.
    发明专利
    OPTICAL-BASED SENSING DEVICES 未知

    公开(公告)号：CA2768913C

    公开(公告)日：2016-08-02

    申请号：CA2768913

    申请日：1999-08-26

    Applicant: SENSORS FOR MEDICINE AND SCIENCE INC

    Inventor： COLVIN ARTHUR E ,  DALE GREGORY A ,  ZERWEKH PAUL SAMUEL ,  LESHO JEFFREY C ,  LYNN ROBERT W

    IPC: G01N21/64 ,  A61B5/00 ,  A61B5/1459 ,  G01N21/17 ,  G01N21/27 ,  G01N21/41 ,  G01N21/77 ,  G01N33/543

    Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body (12) with a source of radiation embedded therein (18). Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.

    Electro-optical sensing device with reference channel
    28.
    发明专利
    Electro-optical sensing device with reference channel 未知

    公开(公告)号：AU2002256413B2

    公开(公告)日：2007-06-07

    申请号：AU2002256413

    申请日：2002-05-03

    Applicant: SENSORS FOR MEDICINE AND SCIENCE INC

    Inventor： COLVIN JR ARTHUR E ,  LYNN ROBERT W

    IPC: G01N21/77 ,  G01N21/64 ,  G01N21/78

    Abstract: An electro-optical sensing device for detecting the presence and concentration of an analyte in a liquid or gaseous medium includes a pair of indicator elements positioned to receive radiation from a radiation source and transmit radiation to a pair of photosensitive elements. The indicator elements each contain indicator molecules having an optical characteristic responsive to the presence of an analyte; however, one of the indicator elements is covered by an analyte-impermeable chamber that renders the indicator element insensitive to the presence of the analyte in the medium outside the chamber so that it can be used as a reference to cancel environmental and systemic variables that affect both indicator elements. The chamber preferably holds an analyte-containing fluid in contact with the reference indicator element so that the indicator elements operate under nominally identical conditions. The indicator element used to measure the analyte in the external medium is preferably also covered, but in a manner that provides direct contact between the analyte and the indicator element.

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