公开(公告)号：CA2768913C

公开(公告)日：2016-08-02

申请号：CA2768913

申请日：1999-08-26

Applicant: SENSORS FOR MEDICINE AND SCIENCE INC

Inventor： COLVIN ARTHUR E ,  DALE GREGORY A ,  ZERWEKH PAUL SAMUEL ,  LESHO JEFFREY C ,  LYNN ROBERT W

IPC: G01N21/64 ,  A61B5/00 ,  A61B5/1459 ,  G01N21/17 ,  G01N21/27 ,  G01N21/41 ,  G01N21/77 ,  G01N33/543

Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body (12) with a source of radiation embedded therein (18). Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.

公开(公告)号：AU2009293042A1

公开(公告)日：2010-03-25

申请号：AU2009293042

申请日：2009-09-21

Applicant: SENSORS FOR MEDICINE AND SCIENCE INC

Inventor： COLVIN ARTHUR E ,  O'CONNOR CASEY J ,  FERRARO DANIEL C

IPC: A61B5/1455

Abstract: The present invention provides systems and methods for measuring an analyte in a medium without exposing the medium to contamination. The systems and methods employ a novel combination of a small sensor device embedded in a Luer cap and capable of wirelessly transmitting data to a reading device.

公开(公告)号：CA2670457C

公开(公告)日：2016-08-09

申请号：CA2670457

申请日：2007-11-30

Applicant: SENSORS FOR MEDICINE AND SCIENCE INC

Inventor： COLVIN ARTHUR E ,  MORTELLARO MARK ALAN ,  MODZELEWSKA ANETA

IPC: C07F5/02 ,  G01N33/66

Abstract: Compounds having enhanced oxidation stability are disclosed. The compounds have an aryl boronic acid residue having one or more electron withdrawing groups on the aromatic moiety which contains the boronic acid residue, such that the molecule has enhanced oxidation resistance as compared to a corresponding molecule without the one or more electron withdrawing groups. The compounds are preferably anthracene-based indicator compounds used m the determination of the presence or concentration of glucose.

公开(公告)号：AU2013204149A1

公开(公告)日：2013-05-02

申请号：AU2013204149

申请日：2013-04-12

Applicant: SENSORS FOR MEDICINE AND SCIENCE INC

Inventor： COLVIN JASON D ,  COLVIN ARTHUR E ,  DEHENNIS ANDREW ,  KRSMANOVIC JODY L

IPC: A61B5/00 ,  G01N21/64 ,  H01L25/16 ,  H01L33/44 ,  H01L33/52 ,  H01L33/54 ,  H01L33/62

Abstract: 'uilu-ll Illu u tu l5 10p 4I utIn V SPCCIllClhIO1.d-I l/104//U3 A semiconductor device for harsh environments, comprising: a printed circuit board having a top surface with a plurality of gold bonding pads; a light emitting diode, including: a substantially transparent substrate, a semiconductor layer deposited on a bottom surface of the substrate, a plurality of gold bonding pads, coupled to the semiconductor layer, formed on the bottom surface of the substrate, and a plurality of gold micro posts, formed on the bonding pads, bonded to the gold bonding pads of the printed circuit board; an underfill layer, including a polymer and a filler, disposed between the bottom surface of the substrate and the top surface of the printed circuit board, to reduce water infiltration under the light emitting diode substrate; and a substantially transparent, hemispherical diffuser, mounted to a top surface of the substrate, to diffuse the light emitted through the top surface of the substrate. PRINTED CIRCUIT 20

公开(公告)号：AU2007325650B2

公开(公告)日：2012-07-12

申请号：AU2007325650

申请日：2007-11-30

Applicant: SENSORS FOR MEDICINE AND SCIENCE INC

Inventor： MODZELEWSKA ANETA ,  MORTELLARO MARK ALAN ,  COLVIN ARTHUR E

IPC: C07F5/02 ,  G01N33/66

Abstract: Compounds having enhanced oxidation stability are disclosed. The compounds have an aryl boronic acid residue having one or more electron withdrawing groups on the aromatic moiety which contains the boronic acid residue, such that the molecule has enhanced oxidation resistance as compared to a corresponding molecule without the one or more electron withdrawing groups. The compounds are preferably anthracene-based indicator compounds used m the determination of the presence or concentration of glucose.