公开(公告)号：US10011706B2

公开(公告)日：2018-07-03

申请号：US15274990

申请日：2016-09-23

Applicant: The Board of Regents for Oklahoma State University

Inventor： Muthu Subramanian Mohan ,  Kunal Mishra ,  Ranji K. Vaidyanathan

IPC: C08K5/16 ,  C09C1/44 ,  C08K3/04 ,  C08K9/06

CPC classification number: C08K9/06 ,  C08K3/04 ,  C08K3/042 ,  C08K2201/011 ,  C09C1/44

Abstract: According to an embodiment, a method for grafting POSS (polyhedral silsesquioxane) nanomaterial to graphene oxide is described for use in preparation of high performance composite materials. In another embodiment, amine functionalized graphene oxide may be particularly suitable. In this embodiment, POSS molecules grafted to amine functionalized graphene oxide are synthesized by reacting graphene oxide with different POSS molecules. The amine functionalized graphene oxide may be dissolved in a solvent and the reaction may include the presence of a catalyst. The resultant POSS grafted graphene oxide/POSS grafted amine functionalized graphene oxide may be mixed with a resin (epoxy) in a masterbatch. The masterbatch may then be packaged and sold. The masterbatch material may then be introduced into the interlaminar area of graphite/epoxy composites. Biodegradability and interlaminar fracture toughness testing results from the use of epoxy based nanocomposites containing POSS modified graphene oxide polymer are expected to improve.

公开(公告)号：US20180125139A1

公开(公告)日：2018-05-10

申请号：US15790480

申请日：2017-10-23

Applicant: The Board of Regents for Oklahoma State University

Inventor： MARY SUSAN RUPPERT-STROESCU ,  ELIZABETH SCHRANTZ ,  CARISSA ELIZABETH GABILHERI ,  LYNAE JONICE DOWDELL

IPC: A41H3/06 ,  A41D31/00 ,  A41H43/04 ,  D05B5/00 ,  D04H1/4274

CPC classification number: A41H3/06 ,  A41D31/0005 ,  A41H27/00 ,  A41H42/00 ,  A41H43/04 ,  D04H1/4274 ,  D05B5/00 ,  D05D2305/30 ,  D10B2403/01 ,  D10B2403/03

Abstract: This disclosure addresses a problem in relation to the environmental destruction that excessive apparel production can produce. In various embodiments, existing textile products are deconstructed into pieces of fabric and then reassembled into apparel in a manner that creates minimal or zero waste. In some embodiments, the fabric pieces will be positioned inside of one or more pattern pieces so as to completely cover each one without overlapping its border. The positioned pieces will be treated with an adhesive and then have a paper layer adhered to it to hold the positioned fabric pieces in place while they are stitched together. Then, the resulting sandwich will be soaked to remove the paper and dissolve the adhesive. The resulting unified fabric component will then be available to be stitched together with other similarly formed fabric components to form a garment.

公开(公告)号：US20170096535A1

公开(公告)日：2017-04-06

申请号：US15127966

申请日：2015-03-23

Applicant: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY

Inventor： KRISHNA PRASAD BASTOLA ,  RANJI K. VAIDYANATHAN

IPC: C08G77/42 ,  C08J5/04 ,  C08J7/04 ,  C08J5/24 ,  C09D139/06 ,  C09D183/10

CPC classification number: C08G77/42 ,  C08J5/005 ,  C08J5/042 ,  C08J5/24 ,  C08J7/047 ,  C08J2351/00 ,  C08J2363/00 ,  C08J2439/06 ,  C08J2483/10 ,  C09D139/06 ,  C09D183/10

Abstract: According to an embodiment, natural polymers will be used to enhance the biodegradability of nanocomposites, increase potential use of sustainable polymer matrices, improve the interlaminar fracture toughness of graphite/epoxy composites and attain complete nanoparticle dispersion through covalent bonding of nanoparticles and natural polymers. The starch derivatives containing POSS (polyhedral silsesquioxane) were synthesized by reacting natural polymer with different POSS molecules in a solvent in presence of a catalyst. Interlaminar fracture toughness testing results from the epoxy based nanocomposites containing 3, 5, 7, and 10 wt % POSS modified natural polymer in the interlaminar area are presented. The biodegradability of the composites is expected to improve through the incorporation of the natural polymer derivatives.

公开(公告)号：US20160332382A1

公开(公告)日：2016-11-17

申请号：US15111444

申请日：2015-01-13

Applicant: KING'S COLLEGE LONDON ,  THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY ,  TECHNOVENT LIMITED

Inventor： Trevor Coward ,  Swati Jindal ,  Mark Waters ,  James Smay

IPC: B29C67/00 ,  B33Y10/00 ,  B33Y30/00

CPC classification number: B29C67/0088 ,  B29B7/38 ,  B29C64/106 ,  B29C64/124 ,  B29C64/20 ,  B29C64/209 ,  B29C64/277 ,  B29C64/386 ,  B29C64/393 ,  B29K2083/00 ,  B29K2083/005 ,  B29L2031/7532 ,  B33Y10/00 ,  B33Y30/00 ,  C08L83/04

Abstract: Firstly, a custom designed 3D printer with x-y-z gantry robot with an accuracy of 0.1 μm was adapted with a custom designed printing head (51b). Secondly, a two component silicone elastomer suitable for RP was developed that incorporates the desired characteristics and properties similar to those commercially available for the provision of facial and body prostheses. The silicone elastomer is composed of polydimethylsiloxane (PDMS) chains, filler, catalyst and crosslinker. By varying the amount of these components the mechanical properties of the silicone elastomer can be altered, for example, tensile strength, tear strength, hardness and wettability. To achieve these desired properties consideration must also be given to the set time and viscosity of the silicone elastomer and additionally the speed at which the material is printed.

Abstract translation: 首先，使用定制设计的打印头（51b），使用具有0.1μm精度的x-y-z龙门机器人的定制设计的3D打印机。 其次，开发了适用于RP的双组分硅氧烷弹性体，其具有与市售可用于提供面部和身体假体相似的所需特性和性质。 硅氧烷弹性体由聚二甲基硅氧烷（PDMS），填料，催化剂和交联剂组成。 通过改变这些组分的量，可以改变硅氧烷弹性体的机械性能，例如拉伸强度，撕裂强度，硬度和润湿性。 为了达到这些期望的性质，还必须考虑硅氧烷弹性体的凝固时间和粘度以及材料印刷速度。

公开(公告)号：US09492523B2

公开(公告)日：2016-11-15

申请号：US13709689

申请日：2012-12-10

Applicant: The Board of Regents for Oklahoma State University

Inventor： Wendy L. Picking ,  William D. Picking

IPC: A61K39/395 ,  A61K39/112 ,  C07K14/25 ,  A61K39/00

CPC classification number: A61K39/0283 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/55544 ,  A61K2039/58 ,  C07K14/25 ,  Y02A50/476

Abstract: Broad-based, cross-protective, O-serotype independent vaccines against Shigella and related pathogenic organisms are provided. The vaccines comprise one or more of the type III secretion (TTS) apparatus needle proteins IpaD and IpaB, and/or the IpaB cognate chaperone protein IpgC. Chimeric proteins of IpaD and IpaB, and/or IpgC are also encompassed.

Abstract translation: 提供了针对志贺氏菌和相关致病生物体的基于广泛的交叉保护性O-血清型独立疫苗。 疫苗包含一种或多种III型分泌物（TTS）装置针蛋白IpaD和IpaB，和/或IpaB同源分子伴侣蛋白IpgC。 还包括IpaD和IpaB的嵌合蛋白和/或IpgC。

公开(公告)号：US20160220655A1

公开(公告)日：2016-08-04

申请号：US15013454

申请日：2016-02-02

Applicant: The Board of Regents for Oklahoma State University ,  University of Kansas

Inventor： Wendy L. Picking ,  William D. Picking

IPC: A61K39/112 ,  C07K14/255

CPC classification number: A61K39/0275 ,  A61K2039/64 ,  C07K14/255 ,  C07K2319/40 ,  Y02A50/482 ,  Y02A50/484

Abstract: Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.

Abstract translation: 本文所述的抗原分子和组合物可防止伤寒和非伤寒沙门氏菌血清型的感染。 免疫方法包括使用抗原分子。

公开(公告)号：US20160215303A1

公开(公告)日：2016-07-28

申请号：US14909578

申请日：2014-08-04

Applicant: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY ,  BRIGHAM YOUNG UNIVERSITY

Inventor： Hasan K. Atiyeh ,  Randy S. Lewis ,  John Randall Phillips ,  Raymond L. Huhnke

IPC: C12P7/06

CPC classification number: C12P7/065 ,  C12N1/20 ,  C12N1/38 ,  Y02E50/17

Abstract: Providing a microbial catalyst in a reaction broth, providing an adsorptive solid into the reaction broth, providing a producer gas into the reaction broth, and obtaining a fermentation product from the reaction broth resulting from activity of the microbial catalyst in the presence of the adsorptive solid.

Abstract translation: 在反应肉汤中提供微生物催化剂，向反应液中提供吸附固体，向反应液中提供生产气体，并在吸附固体存在下获得由微生物催化剂活性产生的反应液中的发酵产物 。

公开(公告)号：US20160166621A1

公开(公告)日：2016-06-16

申请号：US15047906

申请日：2016-02-19

Applicant: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

Inventor： Melanie J. Boileau ,  Kenneth D. Clinkenbeard ,  Rinosh Joshua Mani ,  John J. Iandolo ,  Huda Mussa

IPC: A61K35/74 ,  A61K9/00 ,  A61K9/19 ,  C12N1/20

CPC classification number: A61K35/74 ,  A61K9/0048 ,  A61K9/0073 ,  A61K9/19 ,  A61K47/36 ,  A61K47/38 ,  A61K2035/11 ,  C12N1/20

Abstract: Compositions and methods for treating and/or preventing bacterial infections in animals such as bovines are provided. The compositions and methods utilize the predatory bacterium Bdellovibrio bacteriovorus to treat and/or prevent infections such as infectious bovine keratoconjunctivitis (IBK) and bovine respiratory disease (BRD). Use of the bacterium obviates the need for chemotherapeutic measures.

Abstract translation: 提供了用于治疗和/或预防动物如牛中的细菌感染的组合物和方法。 组合物和方法利用掠食性细菌Bdellovibrio bacteriovorus来治疗和/或预防感染如感染性牛角膜结膜炎（IBK）和牛呼吸道疾病（BRD）。 细菌的使用不需要化学治疗措施。

公开(公告)号：US20160122207A1

公开(公告)日：2016-05-05

申请号：US14842453

申请日：2015-09-01

Applicant: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY

Inventor： CHAD J. PENN

IPC: C02F1/28 ,  B01J20/32

CPC classification number: C02F1/288 ,  B01J20/08 ,  B01J20/3204 ,  B01J20/3236 ,  B01J2220/4893 ,  C02F1/281 ,  C02F2101/105 ,  C02F2103/001 ,  C02F2103/007

Abstract: A method of preparing a contaminant phosphorous adsorber comprises providing a slag material, sieving the slag material to remove particles smaller than about 0.5 millimeters in diameter and precipitating amorphous Al hydroxide minerals on the surface of the sieved slag prior to exposing the slag to phosphorous.

Abstract translation: 制备污染物磷吸附剂的方法包括提供炉渣材料，筛选炉渣材料以除去直径小于约0.5毫米的颗粒，并且在将炉渣暴露于磷之前，在筛选的炉渣的表面上沉淀无定形的Al氢氧化物矿物质。

公开(公告)号：US20160051697A1

公开(公告)日：2016-02-25

申请号：US14680862

申请日：2015-04-07

Applicant: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY

Inventor： CAREY N. POPE ,  ASHISH RANJAN ,  JING LIU POPE ,  STEVE HARTSON ,  JOSHUA RAMSEY

IPC: A61K47/48 ,  A61K38/46

CPC classification number: C12Y301/01008 ,  A61K9/5146 ,  A61K38/465 ,  A61K38/50 ,  A61K38/54 ,  A61K47/6849 ,  A61K47/6935 ,  C12Y305/01001 ,  Y02A50/411

Abstract: According to one embodiment, a person's own RBCs can be recruited as secondary bioscavenger carriers in vivo using a nanopolymer-BChE complex, with an affinity ligand (antibody or peptide) for selective targeting to the RBCs and a cell-penetrating peptide for uptake into the RBCs. A general approach according to an embodiment involves parenteral administration of the nanodevice to gain access to the systemic circulation, which then seeks out and attaches to the person's RBCs, followed by transport into the RBCs (to minimize clearance from the circulation), leading to long-term circulation of the bioscavenger enzymes and thus protection against intoxication.

Abstract translation: 根据一个实施方案，可以使用纳米聚合物-BChE复合物体内使用亲和配体（抗体或肽）来选择性靶向RBCs和用于吸收到细胞的细胞穿透肽中的个体自身的RBCs作为第二生物识别载体 红细胞 根据一个实施方案的一般方法涉及肠道外施用纳米器官以获得进入系统循环，然后该系统循环寻求并附着于该人的RBC，随后运送到RBC（以使流通中的间隙最小化），导致长时间 - 生物活性酶的循环，从而防止中毒。