公开(公告)号：US20160051697A1

公开(公告)日：2016-02-25

申请号：US14680862

申请日：2015-04-07

Applicant: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY

Inventor： CAREY N. POPE ,  ASHISH RANJAN ,  JING LIU POPE ,  STEVE HARTSON ,  JOSHUA RAMSEY

IPC: A61K47/48 ,  A61K38/46

CPC classification number: C12Y301/01008 ,  A61K9/5146 ,  A61K38/465 ,  A61K38/50 ,  A61K38/54 ,  A61K47/6849 ,  A61K47/6935 ,  C12Y305/01001 ,  Y02A50/411

Abstract: According to one embodiment, a person's own RBCs can be recruited as secondary bioscavenger carriers in vivo using a nanopolymer-BChE complex, with an affinity ligand (antibody or peptide) for selective targeting to the RBCs and a cell-penetrating peptide for uptake into the RBCs. A general approach according to an embodiment involves parenteral administration of the nanodevice to gain access to the systemic circulation, which then seeks out and attaches to the person's RBCs, followed by transport into the RBCs (to minimize clearance from the circulation), leading to long-term circulation of the bioscavenger enzymes and thus protection against intoxication.

Abstract translation: 根据一个实施方案，可以使用纳米聚合物-BChE复合物体内使用亲和配体（抗体或肽）来选择性靶向RBCs和用于吸收到细胞的细胞穿透肽中的个体自身的RBCs作为第二生物识别载体 红细胞 根据一个实施方案的一般方法涉及肠道外施用纳米器官以获得进入系统循环，然后该系统循环寻求并附着于该人的RBC，随后运送到RBC（以使流通中的间隙最小化），导致长时间 - 生物活性酶的循环，从而防止中毒。