公开(公告)号：WO2019010361A1

公开(公告)日：2019-01-10

申请号：PCT/US2018/041003

申请日：2018-07-06

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： LITVINOV, Dmitri ,  CHANG, Long ,  WILLSON, Richard

IPC: G01N27/74 ,  G01N27/327 ,  G01N33/543

Abstract: A biosensor may provide a magnetoresistive (MR) film comprising a nonmagnetic layer may be sandwiched between the two ferromagnetic layers. The MR film may be positioned on a substrate, where the edges of the MR film are in contact with leads. Additionally, the leads may be in contact with pads. The sensors may provide quasi-digital readout that enable greatly enhanced sensitivity. In some embodiments, biosensors may be arranged as array of sensors. The array of sensors may be arranged as a symmetric or asymmetric N 1 x N 2 array, where N 1 and N 2 are integers, N 1 represents the number of sensors linked together in series, and N 2 represents the number of sensor sets in parallel, where each sensor set may comprise one or more sensors. Further, the array of sensors may be coupled to a voltmeter, which may be a single voltmeter in some cases that allows the sensors to all be probed simultaneously.

公开(公告)号：WO2018204913A1

公开(公告)日：2018-11-08

申请号：PCT/US2018/031370

申请日：2018-05-07

Applicant: TRACT PHARMACEUTICALS, INC. ,  BOARD OF REGENTS OF THE UNIVERSITY OF HOUSTON SYSTEM

Inventor： XIAN, Wa ,  MCKEON, Frank ,  VINCENT, Matthew P.

IPC: A61K35/38 ,  C12N5/07 ,  A61K38/18 ,  A61P1/00

Abstract: The present invention addresses IBD from the standpoint of mucosal stem cells cloned from defined regions of the gastrointestinal tract. In the case of pediatric Crohn's disease, for example, isolation of those stem cells according to the methods of the present invention reveals a pattern of inflammatory gene expression in stem cells from the terminal ileum and colon that is epigenetically maintained despite months of continuous cultivation in the absence of immune or stromal cells, or of intestinal microbes. Superimposed on this distributed inflammatory phenotype is a differentiation defect that profoundly and specifically alters the mucosal barrier properties of the terminal ileum. The co-existence of diseased and normal stem cells within the same endoscopic biopsies of Crohn's disease patients implicates an epigenetically enforced heterogeneity among mucosal stem cells in the dynamics of this condition.

公开(公告)号：WO2018183633A1

公开(公告)日：2018-10-04

申请号：PCT/US2018/025077

申请日：2018-03-29

Applicant: UNIVERSITY OF HOUSTON SYSTEM ,  TRUSTEES OF TUFTS COLLEGE

Inventor： CUNY, Gregory ,  SUEBSUWONG, Chalada ,  DEGTEREV, Alexei

IPC: A61K31/44 ,  A61P19/00

Abstract: Identified compounds demonstrate protein kinase inhibitory activity and inhibition of dependent cell signaling pathways, such as NOD2 cell signaling. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin- like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.

公开(公告)号：WO2018160629A1

公开(公告)日：2018-09-07

申请号：PCT/US2018/020114

申请日：2018-02-28

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： MAYERICH, David ,  ERIKSEN, Jason

IPC: A61B5/00

Abstract: Imaging systems and methods, referred to herein as surface ablation lathe tomography (SALT), may be capable of providing whole organ tomography to provide 3D imaging. The system may provide a UV source that excites a sample, and a camera may capture imaging of fluorescent emission cause by the excitation. The tissue sample may be treated or stained with an imaging agent, such as fluorescent markers with fluorescently-tagged antibodies. The sample may also be infused with and/or embedded in paraffin wax. The tissue sample embedded in paraffin may be placed on a rotating mechanism that rotates, while the UV source excites a desired region and the camera captures imaging of a thin surface layer or shell of the sample. The system may also provide an ablation mechanism, such as a microtome blade or lathe, to ablate surface of the sample during rotation to allow imaging of subsequent layers of the sample. Once the sample has been fully imaged, a 3D map of the tissue sample, which may be an entire organ, can be provided.

公开(公告)号：WO2018132397A1

公开(公告)日：2018-07-19

申请号：PCT/US2018/013049

申请日：2018-01-10

Applicant: CHEN, Jiefu ,  LIU, Xinyu ,  JACKSON, David R. ,  UNIVERSITY OF HOUSTON SYSTEM

Inventor： CHEN, Jiefu ,  LIU, Xinyu ,  JACKSON, David R.

IPC: G01N22/00

Abstract: An oil-based mud wellbore imaging apparatus for measuring formation permittivity and resistivity includes a reflectometry-type microwave scanning system. The system contains at least one high-Q microstrip resonator with one or more slots on the top surface. The microstrip resonator is excited by one port, which is fed with electromagnetic signals by a coaxial cable. From the phase detection of signal at the port, the formation resistivity and permittivity can be determined and corresponding borehole images can be generated.

公开(公告)号：WO2018022883A1

公开(公告)日：2018-02-01

申请号：PCT/US2017/044173

申请日：2017-07-27

Applicant: UNIVERSITY OF HOUSTON SYSTEM ,  TECNOLÓGICO DE MONTERREY

Inventor： WILLSON, Richard C. ,  KIM, Jinsu ,  VU, Binh V. ,  VÁZQUEZ VILLEGAS, Olga Patricia ,  RUIZ RUIZ, Federico Augusto ,  RITO PALOMARES, Marco Antonio

IPC: C12M1/34 ,  C12Q1/68 ,  G01N21/64 ,  G01N21/76 ,  G01N33/50 ,  G01N33/53

CPC classification number: G01N21/76 ,  C12Q1/26 ,  G01N33/62 ,  G01N33/66 ,  G01N33/70 ,  G01N2021/755 ,  G01N2800/042

Abstract: Methods, devices and kit for analyzing a sample comprising 1,5-anhydroglucitol and a first analyte via one or more chemiluminescent reactions. Certain embodiments include measuring a first light response resulting from a first chemiluminescent reaction and measuring a second light response resulting from a second chemiluminescent reaction. Certain embodiments also include comparing the first light response to the second light response to determine a ratio of 1,5-anhydroglucitol and the first analyte.

Abstract translation: 用于通过一个或多个化学发光反应分析包含1,5-脱水葡萄糖醇和第一分析物的样品的方法，装置和试剂盒。 某些实施方案包括测量由第一化学发光反应产生的第一光响应并测量由第二化学发光反应产生的第二光响应。 某些实施方案还包括将第一光响应与第二光响应进行比较以确定1,5-脱水葡萄糖醇与第一分析物的比率。

公开(公告)号：WO2018005530A1

公开(公告)日：2018-01-04

申请号：PCT/US2017/039549

申请日：2017-06-27

Applicant: UNIVERSITY OF HOUSTON SYSTEM ,  BOSE, Anima B. ,  LI, Wei

Inventor： BOSE, Anima B. ,  LI, Wei

IPC: C01B25/42 ,  C01G19/00 ,  H01M8/1016

Abstract: A method of restoring the proton conductivity of a sintered pyrophosphate membrane of intermediate temperature fuel cells (IT-FCs) by introducing phosphoric acid into the sintered SnP 2 O 7 membrane to react with the degraded SnP 2 O 7 species and thus restore the membrane pyrophosphate and proton conductivity. Such cells operate with low external humidification, and the active area of the cells may be fabricated up to 100 cm 2 in size.

Abstract translation: 通过向烧结的SnP 2 O 3中引入磷酸来恢复中温燃料电池（IT-FC）的烧结焦磷酸盐膜的质子传导性的方法， 7膜与降解的SnP 2 O 7物质反应并因此恢复膜焦磷酸盐和质子传导性。 这样的电池在外部加湿很低的情况下工作，电池的有效面积可以制成高达100cm2的尺寸。

公开(公告)号：WO2017172409A1

公开(公告)日：2017-10-05

申请号：PCT/US2017/023338

申请日：2017-03-21

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： GHASEMI, Hadi ,  IRAJIZAD, Peyman ,  HASNAIN, Munib

IPC: H01F1/44 ,  H01F41/24

Abstract: Modified surfaces of the present disclosure include a surface or substrate material, a magnetic field, which may be generated through the use of a magnet placed at a distance beneath the surface or substrate, or placed above the surface or substrate, or through the use of a magnetic surface or substrate, and a magnetic fluid, such as ferrofluid or ferrogel, deposited in a layer on the top of the surface or substrate. The modified surfaces may be icephobic. In addition, a droplet of liquid placed on the modified surface can be manipulated through placement of a local heat source in proximity to the droplet, without contacting the droplet.

Abstract translation: 本公开的修改表面包括表面或衬底材料，磁场，其可以通过使用放置在表面或衬底之下的距离处的磁体而产生，或者放置在表面之上 或基底上，或者通过使用磁性表面或基底，以及沉积在表面或基底顶部的层中的磁性流体（例如铁磁流体或铁硅胶）。 修改过的表面可能是憎氧的。 另外，可以通过在液滴附近放置局部热源而不接触液滴来操纵置于改性表面上的液滴。

公开(公告)号：WO2017160929A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022437

申请日：2017-03-15

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： SELVAMANICKAM, Venkat

IPC: C30B11/00 ,  B32B9/04 ,  B32B19/00

CPC classification number: H01L31/03926 ,  B32B9/04 ,  B32B19/00 ,  C30B23/025 ,  C30B25/18 ,  C30B25/183 ,  C30B29/06 ,  C30B29/08 ,  C30B29/42 ,  H01L31/02168 ,  H01L31/022425 ,  H01L31/028 ,  H01L31/0304 ,  H01L31/0392 ,  H01L31/03921 ,  H01L31/1804 ,  H01L31/184 ,  Y02E10/50

Abstract: A semiconductor device and method for fabricating same is disclosed. Embodiments are directed to a semiconductor device and fabrication of same which include a polycrystalline or amorphous substrate. An electrically conductive Ion Beam-Assisted Deposition (IBAD) template layer is positioned above the substrate. At least one electrically conductive hetero-epitaxial buffer layer is positioned above the IBAD template layer. The at least one buffer layer has a resistivity of less than ΙΟΟμΩαη. The semiconductor device and method foster the use of bottom electrodes thereby avoiding complex and expensive lithography processes.

Abstract translation: 公开了一种半导体器件及其制造方法。 实施例涉及包括多晶或非晶衬底的半导体器件及其制造。 导电离子束辅助沉积（IBAD）模板层位于基板上方。 至少一个导电异质外延缓冲层位于IBAD模板层上方。 该至少一个缓冲层具有小于100μΩ的电阻率。 该半导体器件和方法促进了底部电极的使用，从而避免了复杂和昂贵的光刻工艺。

公开(公告)号：WO2017059227A1

公开(公告)日：2017-04-06

申请号：PCT/US2016/054737

申请日：2016-09-30

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： VARADARAJAN, Navin

IPC: B01L3/00

CPC classification number: B01L3/5085 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0896 ,  B81C3/001

Abstract: A multi-use combined micro and nanowell plate may provide nanowell arrays within the individual microwells of the plate. One or more microwells of the plate may provide an array of nanowells disposed at the bottom of the microwell. The combined micro and nanowell plate may be formed from a top frame with voids defining the microwells, and a bottom plate with voids defining the array of nanowells. When the top frame and the bottom plate are joined, the nanowell arrays may be aligned with the microwells to provide a combined micro/nanowell.

Abstract translation: 多用组合的微型和纳米级板可以在板的各个微孔内提供纳米线阵列。 板的一个或多个微孔可以提供设置在微孔底部的纳米孔阵列。 组合的微型和纳米级板可以由具有限定微孔的空隙的顶部框架和具有限定纳米孔阵列的空隙的底板形成。 当顶部框架和底板连接时，纳米线阵列可以与微孔对准以提供组合的微/纳米线。