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1.发明申请
公开(公告)号：WO2018160629A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/020114
申请日：2018-02-28
Applicant: UNIVERSITY OF HOUSTON SYSTEM
Inventor： MAYERICH, David , ERIKSEN, Jason
IPC: A61B5/00
Abstract: Imaging systems and methods, referred to herein as surface ablation lathe tomography (SALT), may be capable of providing whole organ tomography to provide 3D imaging. The system may provide a UV source that excites a sample, and a camera may capture imaging of fluorescent emission cause by the excitation. The tissue sample may be treated or stained with an imaging agent, such as fluorescent markers with fluorescently-tagged antibodies. The sample may also be infused with and/or embedded in paraffin wax. The tissue sample embedded in paraffin may be placed on a rotating mechanism that rotates, while the UV source excites a desired region and the camera captures imaging of a thin surface layer or shell of the sample. The system may also provide an ablation mechanism, such as a microtome blade or lathe, to ablate surface of the sample during rotation to allow imaging of subsequent layers of the sample. Once the sample has been fully imaged, a 3D map of the tissue sample, which may be an entire organ, can be provided.
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公开(公告)号：WO2020102698A1
公开(公告)日：2020-05-22
申请号：PCT/US2019/061765
申请日：2019-11-15
Applicant: UNIVERSITY OF HOUSTON SYSTEM
Inventor： MAYERICH, David , ERIKSEN, Jason
Abstract: Milling with ultraviolet excitation (MUVE) realizes high-throughput multiplex imaging of large three-dimensional samples. The instrumentation may comprise a UV- source attachment, precision stage attachment, and/or a blade assembly, and the instrumentation may overcome several constraints inherent to current state-of-the-art three-dimensional microscopy. MUVE offers throughput that is orders of magnitude faster than other technology by collecting a two-dimensional array of pixels simultaneously. The proposed instrumentation also utilizes serial ablation and provides the opportunity for true whole-organ imaging at microscopic resolution.
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公开(公告)号：EP3881056A1
公开(公告)日：2021-09-22
申请号：EP19884320.3
申请日：2019-11-15
Applicant: University of Houston System
Inventor： MAYERICH, David , ERIKSEN, Jason
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