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    BINDING AGENTS FOR CD44 GLYCOPROTEINS AND METHODS OF USE
    22.
    发明申请
    BINDING AGENTS FOR CD44 GLYCOPROTEINS AND METHODS OF USE 审中-公开
    作为CD44 GLYCOPROTEIN的结合剂的GALECTIN-8AND功能衍生物及其使用方法

    公开(公告)号：WO2003072606A2

    公开(公告)日：2003-09-04

    申请号：PCT/IL2003/000153

    申请日：2003-02-27

    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM ,  MELNIK, Lora ,  GOLAN, Itshak ,  NAOR, David ,  ZICK, Yehiel

    Inventor： MELNIK, Lora ,  GOLAN, Itshak ,  NAOR, David ,  ZICK, Yehiel

    IPC: C07K14/705

    CPC classification number: A61K38/1709

    Abstract: The present invention is based on the finding that Gal-8 binds to carbohydrates of cell surface CD44std and CD44v and activates a chain of biological events within the cells. A specific effect exhibited was the induction of apoptosis in the CD44std and CD44v expressing cells. Thus, the present invention concerns the use of an active agent for achieving a therapeutic effect on a target cell, the therapeutic effect comprises binding of said active agent to a standard CD44 (CD44std) glycoprotein or to a CD44 variant (CD44v) expressed by said target cell, the active agent being galectin-8 (Gal-8) or a functional derivative thereof. The active ingredient may be used for the preparation of a pharmaceutical composition, for the treatment of a disease or a disorder or for diagnostic purposes.

    Abstract translation: 本发明基于Gal-8与细胞表面CD44std和CD44v的碳水化合物结合并激活细胞内生物学事件链的发现。 具体表现为CD44std和CD44v表达细胞凋亡诱导。 因此，本发明涉及活性剂用于实现对靶细胞的治疗作用的用途，治疗效果包括将所述活性剂与标准CD44（CD44std）糖蛋白或由所述的CD44（CD44std）糖蛋白表达的CD44变体（CD44v）的结合 靶细胞，活性剂是半乳凝素-8（Gal-8）或其功能性衍生物。 活性成分可用于制备药物组合物，用于治疗疾病或病症或用于诊断目的。

    ION TRAPPING
    23.
    发明申请
    ION TRAPPING 审中-公开
    离子捕捉

    公开(公告)号：WO2002103747A1

    公开(公告)日：2002-12-27

    申请号：PCT/IL2002/000468

    申请日：2002-06-17

    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD. ,  ZAJFMAN, Daniel ,  HEBER, Oded ,  PEDERSEN, Henrik, B. ,  RUDICH, Yinon ,  SAGI, Irit ,  RAPPAPORT, Michael

    Inventor： ZAJFMAN, Daniel ,  HEBER, Oded ,  PEDERSEN, Henrik, B. ,  RUDICH, Yinon ,  SAGI, Irit ,  RAPPAPORT, Michael

    IPC: H01J49/40

    CPC classification number: H01J3/40 ,  H01J49/027 ,  H01J49/406 ,  H01J49/4245

    Abstract: A method for trapping of a plurality of charged particles in a charged particle trap. The trap includes first and second electrode mirrors (2, 3) having a common optical axis (4), the mirrors being arranged in alignment at two extremities thereof. The mirrors are capable, when voltage is applied thereto, of creating respective electric fields defined by key field parameters. The electric fields are configured to reflect charged particles causing their oscillation between the mirrors. The method includes introducing into the trap, along the optical axis, the plurality of charged particles as a beam (10) having pre-determined key beam parameters. The method further includes choosing the key field parameters for at least one of the mirrors such as to induce bunching among charged particles in the beam.

    Abstract translation: 一种用于在带电粒子阱中捕获多个带电粒子的方法。 该陷阱包括具有公共光轴（4）的第一和第二电极镜（2,3），该反射镜在其两端配置成对准。 当施加电压时，反射镜能够产生由关键场参数定义的各个电场。 电场被配置为反射带电粒子，导致它们在反射镜之间振荡。 该方法包括沿着光轴将多个带电粒子作为具有预定的键束参数的光束（10）引入陷阱。 该方法还包括为至少一个反射镜选择关键场参数，以便在光束中的带电粒子之间引起聚束。

    CONJUGATES OF POORLY IMMUNOGENIC ANTIGENS AND SYNTHETIC PEPTIDE CARRIERS AND VACCINES COMPRISING THEM
    24.
    发明申请
    CONJUGATES OF POORLY IMMUNOGENIC ANTIGENS AND SYNTHETIC PEPTIDE CARRIERS AND VACCINES COMPRISING THEM 审中-公开
    不良免疫原抗体和合成肽载体与包含它们的疫苗的结合

    公开(公告)号：WO1994003208A1

    公开(公告)日：1994-02-17

    申请号：PCT/US1993007096

    申请日：1993-07-28

    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD. ,  COHEN, Irun, R. ,  FRIDKIN, Matityahu ,  KONEN-WAISMAN, Stephanie

    Inventor： YEDA RESEARCH AND DEVELOPMENT COMPANY LTD.

    IPC: A61K39/385

    CPC classification number: C07K14/47 ,  A61K39/0275 ,  A61K2039/6043 ,  A61K2039/627 ,  Y02A50/412 ,  Y02A50/482 ,  Y02A50/484

    Abstract: The invention relates to conjugates of poorly immunogenic antigens, e.g. peptides, proteins and polysaccharides, with a synthetic peptide carrier constituting a T cell epitope derived from the sequence of human heat shock protein hsp65, or an analog thereof, said peptide or analog being capable of increasing substantially the immunogenicity of the poorly immunogenic antigen. Suitable peptides according to the invention are Pep278h, which corresponds to positions 458-474 of human hsp65, and Pep II, which corresponds to positions 437-448 of human hsp65, but in which two cysteine residues at positions 442 and 447 are replaced serine residues.

    Abstract translation: 本发明涉及低免疫原性抗原的缀合物，例如 肽，蛋白质和多糖，其中构成衍生自人热休克蛋白hsp65序列的T细胞表位的合成肽载体或其类似物，所述肽或类似物能够显着增加低免疫原性抗原的免疫原性。 根据本发明的合适的肽是Pep278h，其对应于人hsp65的位置458-474和对应于人hsp65的437-448位的Pep II，但其中442和447位的两个半胱氨酸残基被置换为丝氨酸残基 。

    VIRUS INACTIVATION
    25.
    发明申请
    VIRUS INACTIVATION 审中-公开
    病毒灭活

    公开(公告)号：WO1987001592A1

    公开(公告)日：1987-03-26

    申请号：PCT/US1986001928

    申请日：1986-09-17

    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. ,  LIPPA, Arnold, S. ,  SCHEER, David, I.

    Inventor： YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

    IPC: A61K31/685

    CPC classification number: A61K31/685 ,  Y10S514/885 ,  Y10S514/934

    Abstract: A virus having a lipid-containing capsid, such as AIDS virus, is inactivated by contacting the virus with an inactivating amount of phosphatidyl choline. Such a virus can be inactivated in fluids such as virus-contaminated body fluids or derivatives, e.g., blood or blood derivatives. The phosphatidyl choline can be present in an Active Lipid (AL) composition further comprising neutral lipids and phosphatidyl ethanolamine. Phosphatidyl choline, and an AL composition containing same, is useful for the treatment or prophylaxis of Acquired Immune Deficiency Syndrome (AIDS) in mammals.

    SOLAR COMBINED CYCLE POWER SYSTEMS
    28.
    发明申请
    SOLAR COMBINED CYCLE POWER SYSTEMS 审中-公开
    太阳能组合循环电力系统

    公开(公告)号：WO2010082206A1

    公开(公告)日：2010-07-22

    申请号：PCT/IL2010/000048

    申请日：2010-01-19

    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD ,  HELIOFOCUS LTD. ,  ZOHAR, Yotam ,  MANDELBERG, Eli ,  KARNI, Jacob

    Inventor： ZOHAR, Yotam ,  MANDELBERG, Eli ,  KARNI, Jacob

    IPC: H01L31/042

    CPC classification number: F03G6/06 ,  F01K3/00 ,  F01K7/16 ,  F03G6/067 ,  F28D21/001 ,  H02K7/1807 ,  Y02E10/46 ,  Y02E20/16

    Abstract: A combined cycle power system is provided comprising at least one solar power plant including a concentrating dish configured to concentrate solar radiation; a solar receiver disposed and configured to utilize concentrated solar radiation for heating a first working fluid, and a first turbine configured for generating electricity by expansion therein of the heated first working fluid, and at least one recovery power plant including a heat recovery unit configured for utilizing exhaust heat of the first turbine to heat a second working fluid, and a second turbine configured for generating electricity by expansion therein of the heated second working fluid.

    Abstract translation: 提供了一种联合循环动力系统，其包括至少一个太阳能发电厂，其包括被配置为集中太阳辐射的浓缩盘; 太阳能接收器，其设置和配置为利用集中的太阳辐射来加热第一工作流体;以及第一涡轮机，其被配置为通过在其中扩张加热的第一工作流体而发电;以及至少一个回收发电厂，其包括热回收单元， 利用第一涡轮机的排热来加热第二工作流体，以及第二涡轮机，其被配置用于通过在其中膨胀加热的第二工作流体来发电。

    SOLAR RECEIVERS AND SYSTEMS THEREOF
    30.
    发明申请
    SOLAR RECEIVERS AND SYSTEMS THEREOF 审中-公开
    太阳能接收器及其系统

    公开(公告)号：WO2009027986A2

    公开(公告)日：2009-03-05

    申请号：PCT/IL2008/001180

    申请日：2008-08-31

    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD ,  KARNI, Jacob

    Inventor： KARNI, Jacob

    CPC classification number: F03G6/06 ,  F24S20/20 ,  Y02E10/41 ,  Y02E10/46

    Abstract: A solar receiver comprises a housing having a front, radiation-facing, end and a rear end, the front end being formed with a cavity therein; a window mounted at the front end of the housing and projecting inside the cavity; a receiver chamber defined within the cavity between the housing and the window, the receiver chamber having a working fluid inlet for ingress of working fluid to be heated therewithin, and a working fluid outlet for egress therethrough of the heated fluid; and a solar absorber within the receiver chamber for absorbing the solar radiation and heating the working fluid. The solar absorber comprises at least one tubular member configured for maintaining fluid isolation between contents thereof and contents of the receiver chamber. The solar absorber is configured for heating working fluid within the receiver chamber exterior to the tubular member, and working fluid within the tubular member

    Abstract translation: 太阳能接收器包括具有前面，面向辐射的端部和后端的壳体，前端在其中形成有空腔; 窗口，其安装在壳体的前端并在腔体内突出; 接收器室限定在壳体和窗口之间的空腔内，接收器室具有工作流体入口，用于进入待加热的工作流体;以及工作流体出口，用于通过其加热的流体流出; 以及在接收器室内的用于吸收太阳辐射并加热工作流体的太阳能吸收器。 太阳能吸收器包括至少一个管状构件，其被配置用于保持其内容物与容纳室的内容物之间的流体隔离。 太阳能吸收器被配置用于加热管状构件外部的接收器室内的工作流体和管状构件内的工作流体

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