公开(公告)号：WO2015019347A1

公开(公告)日：2015-02-12

申请号：PCT/IL2014/050701

申请日：2014-08-04

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD.

Inventor： REUVENY, Eitan ,  GARTY, Erez S. ,  BEN-NUN, Avraham ,  KAMINITZ, Ayelet

IPC: A61K39/395 ,  A61P37/02 ,  G01N33/564 ,  G01N33/53

CPC classification number: G01N33/5052

Abstract: The present invention is directed to methods for treating immune disorders, inter alia, multiple sclerosis, comprising administering a therapeutically effective amount of at least one G protein gated Inward Rectifying K+ channel (GIRK) inhibitor to a subject in need thereof. The present invention further provides GIRKs as markers of B cell subtypes.

Abstract translation: 本发明涉及用于治疗免疫疾病，尤其是多发性硬化症的方法，包括向有需要的受试者施用治疗有效量的至少一种G蛋白门控内向整流K +通道（GIRK）抑制剂。 本发明还提供作为B细胞亚型标记的GIRK。