Tumor necrosis factor inhibitory protein and its purification
    5.
    发明申请
    Tumor necrosis factor inhibitory protein and its purification 审中-公开
    肿瘤坏死因子抑制蛋白及其纯化

    公开(公告)号:US20020165354A1

    公开(公告)日:2002-11-07

    申请号:US10036452

    申请日:2002-01-07

    CPC classification number: C07K14/7151 A61K38/00 C07K16/2866

    Abstract: Recombinant DNA encoding Tumor Necrosis Factor (TNF) Inhibitory Protein, or an active fragment thereof, is obtained. The TNF Inhibitory Protein has the ability to inhibit: (a) the binding of TNF to its receptors, and (b) the cytotoxic effect of TNF. TNF Inhibitory Protein and salts, functional derivatives and active fractions thereof can be used to antagonize the deleterious effects of TNF by eliminating TNF from the body, and to reduce the cytotoxic activity of TNF by binding to TNF and thereby to inhibit the binding of TNF to its receptors. The DNA may be in an expression vector. Host cells transfected with such an expression vector may be used to produce the TNF Inhibitory Protein.

    Abstract translation: 获得编码肿瘤坏死因子(TNF)抑制蛋白或其活性片段的重组DNA。 TNF抑制蛋白具有抑制(a)TNF与其受体的结合的能力,和(b)TNF的细胞毒性作用。 TNF抑制蛋白及其盐,功能衍生物及其活性成分可用于通过从体内消除TNF来拮抗TNF的有害作用,并通过与TNF结合而降低TNF的细胞毒活性,从而抑制TNF与TNF结合 其受体。 DNA可以是表达载体。 用这种表达载体转染的宿主细胞可用于产生TNF抑制蛋白。

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