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公开(公告)号：KR1020140130378A
公开(公告)日：2014-11-10
申请号：KR1020140124108
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844 , C12Q1/6813
Abstract: 민감성 피부에 대해서 특이적으로 유전자 발현량이 증가 또는 억제되는 바이오 마커가 개시된다. 상기 민감성 피부에 특이적인 바이오 마커를 이용하여 민감성 피부 진단 키트 및 자극감 완화제의 스크리닝 방법 등에 활용할 수 있다.
Abstract translation: 公开了具有基因表达的生物标志物，其对于敏感性皮肤特异性地增加或减少。 敏感皮肤特异性的生物标志物用于敏感皮肤的这种诊断试剂盒和刺激释放剂的筛选方法。 所述诊断试剂盒包含：一种或多种作为NFκB1转录因子多核苷酸的多核苷酸或其片段，其中所述片段包含十个或更多个连续核苷酸，或与片段互补的多核苷酸和多核苷酸; 和具有多核苷酸结合表面的固体支持物。
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公开(公告)号：KR1020140123032A
公开(公告)日：2014-10-21
申请号：KR1020140124111
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844 , C12Q1/6813
Abstract: Disclosed is a biomarker having the amount of gene expression be specifically increased or reduced for sensitive skin. The biomarker specific to sensitive skin is used in such a diagnostic kit for sensitive skin and a screening method of an abirritant. The biomarker for diagnosis of sensitive skin according to the present invention one or more gene selected from a group composed of HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A, FKBP5, PI3, PSPH, HORMAD1, SPRR2G, and ACTR2 or a group composed of KBTBD10, TTN, ACTA1, MYBPC1, MB, MYOZ1, TPM1, CA3, CASQ1, ENO3, RBP4, GYG2, PPP1R1A, PYGM, G0S2, NEB, H19, LIPE, PLIN, H19, GPAM, FABP4, CIDEC, LPL, PCK1, ADIPOQ, PDE3B, ACVR1C, LPL, FABP4, DKFZP761N09121, TNMD, ATP6V1B1, C8orf22, and CRISP3.
Abstract translation: 公开了对敏感性皮肤具有特异性增加或减少的基因表达量的生物标志物。 敏感性皮肤特异性生物标志物用于这种用于敏感性皮肤的诊断试剂盒和中枢刺激剂的筛选方法。 根据本发明的用于诊断敏感性皮肤的生物标志物选自由HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A， FKBP5，PI3，PSPH，HORMAD1，SPRR2G和ACTR2或由KBTBD10，TTN，ACTA1，MYBPC1，MB，MYOZ1，TPM1，CA3，CASQ1，ENO3，RBP4，GYG2，PPP1R1A，PYGM，G0S2，NEB，H19 ，LIPE，PLIN，H19，GPAM，FABP4，CIDEC，LPL，PCK1，ADIPOQ，PDE3B，ACVR1C，LPL，FABP4，DKFZP761N09121，TNMD，ATP6V1B1，C8orf22和CRISP3。
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公开(公告)号：KR1020140118972A
公开(公告)日：2014-10-08
申请号：KR1020140124107
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844 , C12Q1/6813
Abstract: Disclosed is a biomarker by which the amount of gene expression is increased or the gene expression is inhibited specifically with respect to sensitive skin. The biomarker can be used for a kit for testing sensitive skin and a method for screening an agent for alleviating irritation. The test kit includes: a polynucleotide of a TNFRSF19 gene, one or more polynucleotides which are fragments of the polynucleotide of the TNFRSF19 gene and include 10 or more serial nucleotides, or a polynucleotide complementary to the polynucleotide stated earlier and fragments thereof; and a solid scaffold having the surface on which the polynucleotides are bound.
Abstract translation: 公开了一种基因表达量增加或相对于敏感皮肤特异性抑制基因表达的生物标志物。 生物标志物可用于测试敏感性皮肤的试剂盒和用于筛选试剂以减轻刺激性的方法。 测试试剂盒包括：TNFRSF19基因的多核苷酸，一种或多种多核苷酸，其是TNFRSF19基因的多核苷酸的片段，并且包括10个或更多个序列核苷酸，或与前述多核苷酸互补的多核苷酸及其片段; 和具有结合多核苷酸的表面的固体支架。
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公开(公告)号：KR1020140101707A
公开(公告)日：2014-08-20
申请号：KR1020140092564
申请日：2014-07-22
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/97 , A61Q19/08 , Y10S514/847
Abstract: The present invention relates to a composition for promoting differentiation of a human mesenchymal stem cell into an adipocyte and, more specifically, to a composition which contains at least one kind among Mucunae caulis, Galangal, Korean aralia root, and Melia azedarach L. extracts as an active component to promote the differentiation of a human mesenchymal stem cell into an adipocyte to produce a lipid droplet to increase the volume and elasticity of the skin and reduce wrinkles.
Abstract translation: 本发明涉及一种用于促进人间充质干细胞分化为脂肪细胞的组合物，更具体地，涉及在瓜瓜，高甘兰，韩国檀香和Melia azedarach L.提取物中至少含有一种的组合物 促进人间充质干细胞分化为脂肪细胞以产生脂滴以增加皮肤的体积和弹性并减少皱纹的活性成分。
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公开(公告)号：KR1020140089505A
公开(公告)日：2014-07-15
申请号：KR1020140081131
申请日：2014-06-30
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
Abstract: The present invention discloses a biomarker of which a gene expression level increases or decreases specifically with respect to sensitive skin. The biomarker specific to sensitive skin can be applied to a kit for identifying sensitive skin and a screening method of an irritation reliever. The biomarker for identifying sensitive skin includes one or more genes selected from a group constituted by HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A,FKBP5, PI3, PSPH, HORMAD1, SPRR2G and ACTR2.
Abstract translation: 本发明公开了相对于敏感性皮肤特异性地基因表达水平升高或降低的生物标志物。 敏感皮肤特异性的生物标志物可用于鉴定敏感皮肤的试剂盒和刺激缓解剂的筛选方法。 识别敏感皮肤的生物标志物包括选自HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A，FKBP5，PI3，PSPH组成的组中的一种或多种基因 ，HORMAD1，SPRR2G和ACTR2。
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Patent Agency Ranking
公开(公告)号：KR1020140062660A
公开(公告)日：2014-05-26
申请号：KR1020120128937
申请日：2012-11-14
Applicant: (주)아모레퍼시픽
Abstract: The present invention relates to a composition for promoting differentiation of human mesenchymal stem cells to adipocytes and, more specifically, to a composition comprising a Torilidis fructus extract as an active ingredient for promoting differentiation of human mesenchymal stem cells to adipocytes to generate lipid droplets, thereby increasing the volume and elasticity of skin and alleviating wrinkles.
Abstract translation: 本发明涉及用于促进人间充质干细胞分化为脂肪细胞的组合物，更具体地，涉及包含Torilidis fructus提取物作为活性成分的组合物，用于促进人间充质干细胞分化为脂肪细胞从而产生脂滴 增加皮肤的体积和弹性，减轻皱纹。
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公开(公告)号：KR1020120140450A
公开(公告)日：2012-12-31
申请号：KR1020110060194
申请日：2011-06-21
Applicant: (주)아모레퍼시픽
IPC: A61K36/62 , C12N5/0775 , A61P17/00
CPC classification number: A61K36/62 , A61Q90/00 , C12N5/0662 , C12N5/0669
Abstract: PURPOSE: A composition with Nelumbinis Semen extracts as an active ingredient for promoting the differentiation of adipocyte in human mesenchymal stem cell is provided to promote differentiating the adipocyte from a human mesenchymal stem cell to produce lipid droplet, enhance the electricity and the volume of skin and reduce wrinkles. CONSTITUTION: A composition for skin external application for promoting the differentiation of adipocyte contains Nelumbinis Semen extracts as an active ingredient. The composition promotes differentiating adipocyte from a mesenchymal stem cell. The mesenchymal stem cell is a human mesenchymal cell. The composition increases adipocyte tissue. For the total weight of the composition, a Nelumbinis Semen extract weighs ranging from 0.001 to 30%. The composition enhances the volume of skin and the elasticity of skin, and reduces skin wrinkles. A pharmaceutical composition for promoting the differentiation of a adipocyte cell contains Nelumbinis Semen as an active ingredient. A Nelumbinis Semen extract is administered from 0.001mg /kg /day-2000mg /kg /day. [Reference numerals] (AA) Relative revelation amount; (BB) Negative control group; (CC) Ligustri Fructus; (DD) Veratri Rhizoma Et Radix; (EE) Forsythiae Fructus; (FF) Nelumbo semen
Abstract translation: 目的：提供具有Nelumbinis Semen提取物作为促进人间充质干细胞中脂肪细胞分化的活性成分的组合物，以促进脂肪细胞与人间充质干细胞的分化，产生脂滴，增强皮肤的电力和体积， 减少皱纹。 构成：用于促进脂肪细胞分化的皮肤外用应用组合物含有Nelumbinis Semen提取物作为活性成分。 该组合物促进脂肪细胞与间充质干细胞分化。 间充质干细胞是人类间充质细胞。 组合物增加脂肪细胞组织。 对于组合物的总重量，Nelumbinis Semen提取物的重量范围为0.001至30％。 该组合物增强皮肤的体积和皮肤的弹性，并减少皮肤皱纹。 用于促进脂肪细胞分化的药物组合物含有Nelumbinis Semen作为活性成分。 Nelumbinis精液提取物以0.001mg / kg /天-2000mg / kg /天施用。 （附图标记）（AA）相对启示量; （BB）阴性对照组; （CC）Ligustri Fructus; （DD）Veratri Rhizoma Et Radix; （EE）连翘; （FF）Nelumbo精液
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公开(公告)号：KR1020120088896A
公开(公告)日：2012-08-09
申请号：KR1020100115854
申请日：2010-11-19
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , C12N5/071 , A61K31/7105 , C12Q1/68
CPC classification number: C12N15/113 , A61K31/7105 , C12N5/0625 , C12Q1/68 , C12Q2600/158 , C12Q2600/178
Abstract: PURPOSE: A composition containing miRNA molecule or mimic of DUOX2 for controlling skin cell differentiation is provided to regulate DUOX2, filagrin, loricrin, keratin 1, and keratin 10 genes. CONSTITUTION: A composition for controlling skin cell differentiation contains miRNA molecule or mimic of DUOX2 having 7-25 bases with a base sequence of sequence number 1. The miRNA molecule or mimic targets 1358th to 1364th nucleic acids of DUOX2 mRNA 3'-UTR. The composition promotes skin cell differentiation. A miRNA inhibitor of DUOX2 targets 1358th to 1364th nucleic acids of DUOX2 mRNA 3'-UTR. The composition suppresses skin cell differentiation. The skin cell is keratinocytes.
Abstract translation: 目的：提供含有miRNA分子或模拟DUOX2用于控制皮肤细胞分化的组合物，用于调节DUOX2，丝胶蛋白，氯氰菊酯，角蛋白1和角蛋白10基因。 构成：用于控制皮肤细胞分化的组合物包含miRNA分子或具有7-25个碱基的DUOX2的模拟物，其碱基序列为序列号1. miRNA分子或模拟物靶向DUOX2 mRNA 3'-UTR的第1358至第1364位核酸。 该组合物促进皮肤细胞分化。 DUOX2的miRNA抑制剂靶向DUOX2 mRNA 3'-UTR的1358至1364位核酸。 该组合物抑制皮肤细胞分化。 皮肤细胞是角质细胞。
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公开(公告)号：KR1020120058866A
公开(公告)日：2012-06-08
申请号：KR1020100120373
申请日：2010-11-30
Applicant: (주)아모레퍼시픽
IPC: A61K38/06 , A61K31/728 , A61K35/12 , A61K8/64 , A61Q19/08
CPC classification number: A61K38/06 , A61K8/64 , A61K31/728 , A61K35/12 , A61Q19/08
Abstract: PURPOSE: A composition containing tripeptides, low molecular hyaluronic acid, mineral, and vitamin is provided to enhance stemness of adipose-derived stem cells. CONSTITUTION: A composition for enhancing stemness of adipose-derived stem cells contains 0.001-3 wt% of tripeptide of glycine-proline-hydroxyproline(Gly-Pro-Hyp), 0.01-50 wt% of low molecular hyaluronic acid, 0.001-3 wt% of mineral, and 0.001-3 wt% of vitamin as active ingredients. The composition is designed from ECM(extracellular matrix). The stem cell is human adipose derived stem cells(hADSCs).
Abstract translation: 目的：提供含有三肽，低分子透明质酸，矿物质和维生素的组合物，以增强脂肪来源的干细胞的干性。 构成：用于增强脂肪来源的干细胞的干性的组合物含有0.001-3重量％的甘氨酸 - 脯氨酸 - 羟脯氨酸（Gly-Pro-Hyp）的三肽，0.01-50重量％的低分子透明质酸，0.001-3重量％ ％的矿物质和0.001-3重量％的维生素作为活性成分。 该组合物由ECM（细胞外基质）设计。 干细胞是人类脂肪干细胞（hADSCs）。
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公开(公告)号：KR1020110018067A
公开(公告)日：2011-02-23
申请号：KR1020090075678
申请日：2009-08-17
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A composition containing ortho-dihydroxyisoflavone derivative for improving skin regeneration or skin elasticity is provided to induce proliferation of epidermal keratinocyte stem cells. CONSTITUTION: A composition for improving skin regeneration or skin elasticity contains 0.001-30 weight% of ortho-dihydroxyisoflavoen derivative of 4',7,8-trihydroxyisoflavone, 4',6,7-trihydroxyisoflavone, or 3',4',7-trihydroxyisoflavone as an active ingredient. An external use skin composition, pharmaceutical composition, or cosmetic composition contains the composition.
Abstract translation: 目的：提供含有用于改善皮肤再生或皮肤弹性的邻位二羟基异黄酮衍生物的组合物，以诱导表皮角化细胞干细胞的增殖。 构成：用于改善皮肤再生或皮肤弹性的组合物含有0.001-30重量％的4'，7,8-三羟基异黄酮，4'，6,7-三羟基异黄酮或3'，4'，7'-三羟基异黄酮的邻二羟基异佛尔酮衍生物， 三羟基异黄酮作为活性成分。 外用皮肤组合物，药物组合物或化妆品组合物含有该组合物。
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