Abstract:
본 발명은 바닐로이드 수용체(바닐로이드 수용체 1; VR1; TRPV1) 길항제로서의 신규 화합물, 그의 이성질체 또는 약제학적으로 허용가능한 그의 염; 및 이를 함유하는 약제학적 조성물에 관한 것이다. 본 발명은 통증, 편두통, 관절통, 신경통, 신경 장해, 신경 손상, 피부 질환, 방광 과민증, 과민성 대장 증후군, 대변절박증, 호흡 질환, 피부자극, 눈 또는 점막의 염증, 위-십이지장 궤양, 염증성 질환, 귀 질환, 심장 질환 등과 같은 질병의 예방 또는 치료를 위한 약제학적 조성물을 제공한다.
Abstract:
PURPOSE: A benzoic acid amide compound is provided to have excellent a skin-whitening effect without side effects by suppressing melanin generation and decreasing tyrosinase activity. CONSTITUTION: A benzoic acid amide compound, an isomer thereof, pharmaceutically-acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof is represented by chemical formula 1. In the chemical formula 1: each of R1, R3, and R4 is independently selected from hydrogen, hydroxy, C1-C5 alkoxy, C3-C6 cycloalkoxy, aryloxy, and C1-C15 haloalkoxy; R2 is selected from hydrogen, C1-C5 alkyl, C3-C6 cycloalkyl, aryl, and C1-C5 haloalkyl; and n is an integer from 1-5.
Abstract:
PURPOSE: A method for evaluating skin moisturizing ability is provided to quickly and accurately distinguish CER(NS) in a horny substance and to screen a product for enhancing moisturizing ability. CONSTITUTION: A method for evaluating skin moisturizing ability comprises: a step of preparing a sample from a test person; a step of measuring TEWL(transepidermal water loss) of the sample; a step of measuring each content of 8 kinds of ceramides(C16Cer, C18Cer, C18:1Cer, C20Cer, C24Cer, C24:1Cer, C16SM and C18SM) by chromatography; a step of drawing correlation function of TEWL and each ceramide content; and a step of digitizing the skin moisturizing ability of the test person. The ceramide content is measured by UPLC-MS/MS-ESI.
Abstract:
PURPOSE: An antithrombotic composition containing colored bean extract and fraction thereof is provided to contain adenosine and to treat cardiovascular and cerebralvascular diseases and hypertension. CONSTITUTION: An antithrombotic composition contains colored bean extract isolated using water, C1-C5 alcohol, or mixture thereof and organic acid. The organic acid includes citric acid, acetic acid, butyric acid, palmitic acid, oxalic acid, tartaric acid, carboxylic acid, or sulfonic acid. The C1-C5 alcohol is methane, ethanol, isopropylalcohol, n-propyl alcohol, n-butanol, or isobutanol. A fraction of the extract is prepared by fractioning the alcohol extract of colored beans using a synthetic adsorption column containing polystylene and benzene polymers.
Abstract:
PURPOSE: A compound is provided to treat heart diseases, pain, and hair growth-associated diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating pharmacological stimulation and/or abnormal expression of vaniloid receptor 1(VR1) contains a compound of chemical formula I, II, III, or IV, isomer thereof, or pharmaceutically acceptable salt and pharmaceutically acceptable carrier. The pharmaceutical composition is applied to rat, mouse, livestock, and human. The pharmaceutical composition is used by rectal, intravenous, intramuscular, or subcutaneous administration.
Abstract:
PURPOSE: A slimming cosmetic composition containing 2-cyclopentene-1-one oxime derivative is provided to promote lipid lysis in adipocytes(3T3-L1) and to reduce body fat. CONSTITUTION: A slimming cosmetic composition contains 2-cyclopentene-1-one oxime derivatives compound of chemical formula 1 or pharmaceutically acceptable salt as an active ingredient. The cosmetic composition induces decrease of neutral fat by promoting lipid lysis. The cosmetic composition is used in the form of emulsion, lotion, cream, gel, oil, spray, ointment, powder, compact, pack cleanser, shampoo, rinse, patch, or pad.
Abstract:
본 발명은 바닐로이드 수용체 (Vanilloid Receptor 1 ; VR1 ; TRPV1)의 길항제로서 신규한 화합물 또는 약제학적으로 허용가능한 그의 염; 및 이를 함유하는 약제학적 조성물에 관한 것이다. 본 발명의 화합물 또는 조성물은 통증, 편두통, 관절통, 신경통, 신경병증, 신경손상, 피부질환, 과민성방광, 과민성대장증후군, 변실금, 호흡기질환, 피부, 눈 또는 점막의 자극, 위십이지장궤양, 염증성질환, 이(耳)질환, 및 심장질환 등의 예방 및 치료에 유용하다. 바닐로이드 수용체 길항제, N-페닐벤즈아마이드 유도체