신규 벤조산아미드 화합물
    23.
    发明公开
    신규 벤조산아미드 화합물 有权
    新颖的苯甲酸化合物

    公开(公告)号:KR1020130015954A

    公开(公告)日:2013-02-14

    申请号:KR1020110078309

    申请日:2011-08-05

    Abstract: PURPOSE: A benzoic acid amide compound is provided to have excellent a skin-whitening effect without side effects by suppressing melanin generation and decreasing tyrosinase activity. CONSTITUTION: A benzoic acid amide compound, an isomer thereof, pharmaceutically-acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof is represented by chemical formula 1. In the chemical formula 1: each of R1, R3, and R4 is independently selected from hydrogen, hydroxy, C1-C5 alkoxy, C3-C6 cycloalkoxy, aryloxy, and C1-C15 haloalkoxy; R2 is selected from hydrogen, C1-C5 alkyl, C3-C6 cycloalkyl, aryl, and C1-C5 haloalkyl; and n is an integer from 1-5.

    Abstract translation: 目的:提供苯甲酸酰胺化合物以通过抑制黑色素产生和降低酪氨酸酶活性而具有优异的美白效果而没有副作用。 构成:化学式1表示苯甲酸酰胺化合物,其异构体,药学上可接受的盐,其前药,其水合物或其溶剂合物。在化学式1中,R1,R3和 R 4独立地选自氢,羟基,C 1 -C 5烷氧基,C 3 -C 6环烷氧基,芳氧基和C 1 -C 15卤代烷氧基; R2选自氢,C1-C5烷基,C3-C6环烷基,芳基和C1-C5卤代烷基; n为1-5的整数。

    각질내 세라마이드류의 구성비율과 보습능과의 관계 연구를 통한 피부 보습력 평가법
    24.
    发明公开
    각질내 세라마이드류의 구성비율과 보습능과의 관계 연구를 통한 피부 보습력 평가법 无效
    通过确定角质层中神经酰胺的组分比例来评估皮肤保湿能力的方法

    公开(公告)号:KR1020120009774A

    公开(公告)日:2012-02-02

    申请号:KR1020100070444

    申请日:2010-07-21

    CPC classification number: G01N33/4833 A61K8/68 C40B30/06 G01N33/15

    Abstract: PURPOSE: A method for evaluating skin moisturizing ability is provided to quickly and accurately distinguish CER(NS) in a horny substance and to screen a product for enhancing moisturizing ability. CONSTITUTION: A method for evaluating skin moisturizing ability comprises: a step of preparing a sample from a test person; a step of measuring TEWL(transepidermal water loss) of the sample; a step of measuring each content of 8 kinds of ceramides(C16Cer, C18Cer, C18:1Cer, C20Cer, C24Cer, C24:1Cer, C16SM and C18SM) by chromatography; a step of drawing correlation function of TEWL and each ceramide content; and a step of digitizing the skin moisturizing ability of the test person. The ceramide content is measured by UPLC-MS/MS-ESI.

    Abstract translation: 目的:提供一种评价皮肤保湿能力的方法,以快速,准确地区分角质物质中的CER(NS),并筛选产品以增强保湿能力。 构成:评价皮肤保湿能力的方法包括:从试验人员制备样品的步骤; 测量样品的TEWL(经皮水分流失)的步骤; 通过色谱法测定8种神经酰胺(C16Cer,C18Cer,C18:1Cer,C20Cer,C24Cer,C24:1Cer,C16SM和C18SM)的每种含量的步骤; 绘制TEWL的相关函数和每种神经酰胺含量的步骤; 以及测试者的皮肤保湿能力的数字化步骤。 神经酰胺含量通过UPLC-MS / MS-ESI测定。

    유색콩 추출물을 함유하는 조성물
    25.
    发明公开
    유색콩 추출물을 함유하는 조성물 无效
    包含色素提取物的组合物

    公开(公告)号:KR1020110138000A

    公开(公告)日:2011-12-26

    申请号:KR1020100058067

    申请日:2010-06-18

    CPC classification number: A61K36/48

    Abstract: PURPOSE: An antithrombotic composition containing colored bean extract and fraction thereof is provided to contain adenosine and to treat cardiovascular and cerebralvascular diseases and hypertension. CONSTITUTION: An antithrombotic composition contains colored bean extract isolated using water, C1-C5 alcohol, or mixture thereof and organic acid. The organic acid includes citric acid, acetic acid, butyric acid, palmitic acid, oxalic acid, tartaric acid, carboxylic acid, or sulfonic acid. The C1-C5 alcohol is methane, ethanol, isopropylalcohol, n-propyl alcohol, n-butanol, or isobutanol. A fraction of the extract is prepared by fractioning the alcohol extract of colored beans using a synthetic adsorption column containing polystylene and benzene polymers.

    Abstract translation: 目的:提供含有彩色豆提取物及其级分的抗血栓形成组合物,用于含有腺苷并治疗心血管和脑血管疾病和高血压。 构成:抗血栓组合物含有使用水,C1-C5醇或其混合物和有机酸分离的有色豆提取物。 有机酸包括柠檬酸,乙酸,丁酸,棕榈酸,草酸,酒石酸,羧酸或磺酸。 C1-C5醇是甲烷,乙醇,异丙醇,正丙醇,正丁醇或异丁醇。 通过使用含有聚苯乙烯和苯聚合物的合成吸附塔对有色豆的醇提取物进行分级来制备提取物的一部分。

    2-사이클로펜텐-1-온 옥심 유도체를 유효성분으로 포함하는 슬리밍 화장료 조성물
    27.
    发明公开
    2-사이클로펜텐-1-온 옥심 유도체를 유효성분으로 포함하는 슬리밍 화장료 조성물 有权
    含有2-环戊烯-1-酮氧化物衍生物的体内化合物的化妆品组合物

    公开(公告)号:KR1020100103670A

    公开(公告)日:2010-09-27

    申请号:KR1020107017553

    申请日:2008-12-03

    CPC classification number: A61K31/15

    Abstract: PURPOSE: A slimming cosmetic composition containing 2-cyclopentene-1-one oxime derivative is provided to promote lipid lysis in adipocytes(3T3-L1) and to reduce body fat. CONSTITUTION: A slimming cosmetic composition contains 2-cyclopentene-1-one oxime derivatives compound of chemical formula 1 or pharmaceutically acceptable salt as an active ingredient. The cosmetic composition induces decrease of neutral fat by promoting lipid lysis. The cosmetic composition is used in the form of emulsion, lotion, cream, gel, oil, spray, ointment, powder, compact, pack cleanser, shampoo, rinse, patch, or pad.

    Abstract translation: 目的:提供含有2-环戊烯-1-酮肟衍生物的减肥美容组合物,以促进脂肪细胞(3T3-L1)中的脂质溶解,并减少体脂肪。 构成:减肥化妆品组合物含有化学式1的2-环戊烯-1-酮肟衍生物化合物或其药学上可接受的盐作为活性成分。 化妆品组合物通过促进脂质溶解诱导中性脂肪的减少。 化妆品组合物以乳液,洗剂,霜剂,凝胶,油,喷雾剂,软膏剂,粉剂,紧凑型包装清洁剂,洗发剂,漂洗剂,补片或垫片的形式使用。

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