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公开(公告)号：KR1020120038662A
公开(公告)日：2012-04-24
申请号：KR1020100100227
申请日：2010-10-14
Applicant: (주)아모레퍼시픽
CPC classification number: A61K47/36 , A61K9/06 , A61K47/10 , A61K47/30 , A61K2121/00
Abstract: PURPOSE: A method for preparing lipid-coated hydrogel particles is provided to prevent reduction of sealing efficiency of a drug. CONSTITUTION: A method for preparing lipid-coated hydrogel particles comprises: a step of preparing hydrogel particles using water soluble polymers and water soluble crosslinking agent; a step of dissolving the lipid in organic solvent; a step of dispersing the hydrogel particles to the organic solvent; and a step of adding water to the dispersed liquid and performing reduced pressure distillation. The organic solvent is main organic solvent or alcohol of C1-C6.
Abstract translation: 目的：提供一种制备脂质包被水凝胶颗粒的方法，以防止药物密封效率降低。 构成：制备含脂质水凝胶颗粒的方法包括：使用水溶性聚合物和水溶性交联剂制备水凝胶颗粒的步骤; 将脂质溶解在有机溶剂中的步骤; 将水凝胶颗粒分散到有机溶剂中的步骤; 以及向分散液中添加水并进行减压蒸馏的工序。 有机溶剂是C1-C6的主要有机溶剂或醇。
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公开(公告)号：KR1020100097856A
公开(公告)日：2010-09-06
申请号：KR1020090016713
申请日：2009-02-27
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A cosmetic composition for skin whitening is provided to suppress melanogenesis and to prevent skin pigmentation. CONSTITUTION: A cosmetic composition for skin whitening contains pfaffia glomerata root juice and arginine PCA as active ingredients. The composition futher contains ascorbic glycoside, glycyrrhiza extract, arbutin, ascorbic acid, or kojic acid. The pfaffia glomerata root juice is contained in 0.00001-1.0 weight%. The arginine PCA is contained in 0.00001-1.0 weight%.
Abstract translation: 目的：提供一种用于皮肤美白的化妆品组合物以抑制黑素生成并防止皮肤色素沉着。 构成：用于皮肤美白的化妆品组合物含有作为活性成分的pfaffia glomerata根汁和精氨酸PCA。 该组合物还含有抗坏血酸苷，甘草提取物，熊果苷，抗坏血酸或曲酸。 番茄根汁含量为0.00001-1.0重量％。 精氨酸PCA含量为0.00001-1.0重量％。
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公开(公告)号：KR1020100060780A
公开(公告)日：2010-06-07
申请号：KR1020080119520
申请日：2008-11-28
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A cosmetic composition which enhances skin rebirth is provided to enhance cell activation and to improve anti-wrinkle and elasticity. CONSTITUTION: A skin cosmetic composition contains 0.1-10 weight% of octacosanol and 0.1-30 weight% of Lepidium meyenii extract as an active ingredient. The octacosanol and Lepidium meyenii extract is mixed in a weight ratio of 1-9:9-1. The Lepidium meyenii extract is isolated using ethanol. The cosmetic composition is used in the form of skin, lotion, massage cream, nutrition cream, pack, gel, or ointment, patch, or spray.
Abstract translation: 目的：提供增强皮肤重生的化妆品组合物，以增强细胞活化和改善抗皱和弹性。 构成：皮肤化妆品组合物含有0.1-10重量％的二十八烷醇和0.1-30重量％的梅毒提取物作为活性成分。 二十八烷醇和梅毒提取物以1-9：9-1的重量比混合。 使用乙醇分离梅毒提取物。 化妆品组合物以皮肤，洗剂，按摩霜，营养霜，包装，凝胶或软膏，贴剂或喷雾剂的形式使用。
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公开(公告)号：KR1020100060753A
公开(公告)日：2010-06-07
申请号：KR1020080119484
申请日：2008-11-28
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A cosmetic composition for anti-aging is provided to protect skin from metal stress, external stress, and toxic factor and to activate skin cell regeneration. CONSTITUTION: A cosmetic composition for anti-aging contains 0.00001-1.0 weight% of pfaffia glomerata root juice and 0.00001-1.0 weight% of arginine PCA. The composition further contains 0.00001-10 weight% of oleanolic acid, ursolic acid, betacarotene, or retinol.
Abstract translation: 目的：提供抗衰老的化妆品组合物，以保护皮肤免受金属压力，外部压力和毒性因素的影响，并激活皮肤细胞再生。 构成：用于抗衰老的化妆品组合物含有0.001-1-0重量％的巴菲特薄荷根汁和0.00001-1.0重量％的精氨酸PCA。 该组合物还含有0.00001-10重量％的齐墩果酸，熊果酸，β-胡萝卜素或视黄醇。
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25.发明公开하이드록시프로필-베타사이클로 덱스트린을 이용하여가용화된 유용성 생리활성성분을 담지하는 고분자-리포좀나노복합체 有权聚合物脂质体复合物与各种水解生物材料溶解的羟丙基-β; -CYCLODEXTRIN
公开(公告)号：KR1020070091443A
公开(公告)日：2007-09-11
申请号：KR1020060020942
申请日：2006-03-06
Applicant: (주)아모레퍼시픽
Abstract: A polymer-liposome complex with various hydrophobic physiological materials solubilized by hydroxypropyl-beta-cyclodextrin is provided to secure the skin absorption promoting effect and the titer decrease preventing effect of a hydrophobic physiological active ingredient by supporting the hydrophobic physiological active ingredient in an inner aqueous phase of the complex using hydroxypropyl-beta-cyclodextrin. A polymer-liposome complex is characterized in that it comprises a liposome structure including a poly(methacrylic acid-co-n-alkyl methacrylate) random copolymer represented by the formula(1)(wherein n is from 11 to 22, and the molar ratio of x:y is 85:15-70:30) and a lipid layer, and a hydrophobic physiological active ingredient solubilized by hydroxypropyl-beta-cyclodextrin is supported at the inner phase of the liposome structure. The method comprises the steps of: (a) mixing the copolymer of the formula(1) and lipid with water and dissolving it with heating at a temperature of 50-70 deg.C; (b) mixing hydroxypropyl-beta-cyclodextrin and a hydrophobic physiological active ingredient with water and heating it at a temperature of 60-70 deg.C with solubilizing the hydrophobic physiological active ingredient using an emulsifier; (c) adjusting the pH of the solution obtained from the step(b) with an acid or a base to more than 7; (d) mixing the mixture solution obtained from the step(a) with the aqueous solution of the step(c) heated at a temperature of 50-70 deg.C and firstly dispersing it using an emulsifier; (e) nano-granulating the mixture solution obtained from the step(d) using a high pressure emulsifier; and (f) removing organic solvent used from the mixture solution obtained from the step(e) using a rotary evaporator.
Abstract translation: 提供了通过羟丙基-β-环糊精溶解的各种疏水性生理材料的聚合物 - 脂质体复合物，以通过将疏水性生理活性成分支撑在内部水相中来确保疏水性生理活性成分的皮肤吸收促进作用和滴度降低防止效果 的复合物使用羟丙基-β-环糊精。 聚合物 - 脂质体复合物的特征在于其包含脂质体结构，其包括由式（1）表示的聚（甲基丙烯酸 - 共 - 正烷基甲基丙烯酸酯）无规共聚物（其中n为11至22，并且摩尔比 的x：y为85:15-70:30），脂质体层和由羟丙基-β-环糊精溶解的疏水性生理活性成分负载在脂质体结构的内相。 该方法包括以下步骤：（a）将式（1）的共聚物与脂质与水混合，并在50-70℃的温度下加热溶解; （b）将羟丙基-β-环糊精和疏水性生理活性成分与水混合并在60-70℃的温度下加热，使用乳化剂增溶疏水性生理活性成分; （c）用酸或碱调节由步骤（b）获得的溶液的pH至大于7; （d）将由步骤（a）获得的混合溶液与步骤（c）的水溶液在50-70℃的温度下混合，并首先用乳化剂分散; （e）使用高压乳化剂将由步骤（d）获得的混合溶液纳米制粒; 和（f）使用旋转蒸发器除去从步骤（e）获得的混合物溶液中使用的有机溶剂。
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Patent Agency Ranking26.发明授权
公开(公告)号：KR100716802B1
公开(公告)日：2007-05-14
申请号：KR1020050134707
申请日：2005-12-30
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 산성도 민감성 고분자를 이용한 고분자-리포좀 나노복합체의 제조와 이를 함유하는 피부 외용제 조성물에 관한 것으로, 구체적으로는 메타아크릴산과 n-알킬 메타아크릴레이트로 구성된 산성도 민감성 고분자, 지질 및 콜레스테롤을 사용하여 제조한 고분자-리포좀 나노복합체 또는 나노에멀젼으로서 산성도 변화에 대하여 민감한 감응성을 가지고 있어 내상에 함입되는 생리활성 성분을 생체 내에서 효과적으로 방출하여 전달체로서의 효과를 증진시킬 수 있을 뿐 아니라 종래의 지질 기반으로 제조된 리포좀보다 수용액상 및 각종 염(salt)이 함유된 수용액 그리고 피부외용제 조성물 및 화장품 제형 내에서도 안정하게 존재하도록 설계된 고분자-지질기반 약물전달체 및 피부외용제 조성물에 관한 것이다.
산성도 민감성 고분자, 고분자-리포좀 나노복합체, 리포좀, 나노에멀젼, 제형안정성Abstract translation: 与酸性敏感的聚合物的聚合物本发明涉及含有与该纳米复合材料的脂质体制剂，具体地，使用的酸性敏感聚合物，脂质和胆固醇组成的甲基丙烯酸和甲基丙烯酸烷基酯的皮肤外用组合物，正 制造聚合物 - 脂质体纳米复合材料或纳米乳剂相对于酸性的敏感灵敏度，在有效地将发射的生物活性成分的变化，以在体内的内伤被结合以及增强的效果在基于脂质的常规制造的输送系统 基于脂质的药物递送系统和用于皮肤的外用制剂，其被设计为即使在用于皮肤和化妆品制剂的外用组合物中也能够稳定存在。
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公开(公告)号：KR101800213B1
公开(公告)日：2017-11-24
申请号：KR1020100064031
申请日：2010-07-02
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/97 , A61K8/0212 , A61K36/60 , A61K36/605 , A61K36/83 , A61K2800/782 , A61Q19/00 , A61Q19/02
Abstract: 본발명은닥나무추출물을함유하는피부미백용조성물에관한것으로, 보다상세하게는청시닥나무, 개시닥나무, 산닥나무, 시닥나무, 삼지닥나무, 마주잎꾸지나무, 민뚜지나무, 두메닥나무또는참닥나무추출물을함유하여피부에부작용없이안전하게사용할수 있고멜라닌생성을억제하여색소침착을저해하는효과가뛰어난피부미백용조성물에관한것이다.
Abstract translation: 本发明涉及一种用于皮肤增白，包括纸桑树提取物，并且更具体地cheongsi桑树的组合物，公开了桑椹，酸楮，当纸桑树，违抗桑树，面对叶片kkuji木闵ttuji木材DUME桑树或确实桑树提取物 抑制变色的效果可以被安全地使用，而不在皮肤上的副作用和抑制黑色素产生涉及含有优异的皮肤增白组合物。
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公开(公告)号：KR101681683B1
公开(公告)日：2016-12-01
申请号：KR1020100063992
申请日：2010-07-02
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/97 , A61K36/60 , A61K2800/782 , A61Q19/02
Abstract: 본발명은닥나무의꽃과열매추출물을함유하는피부외용제조성물에관한것으로, 보다상세하게는닥나무의꽃과열매로부터얻은추출물을유효성분으로함유하여멜라닌생성을효과적으로억제함으로써우수한피부미백효과를나타내는피부외용제조성물에관한것이다.
Abstract translation: 本发明涉及一种皮肤外用组合物，其包含桑叶的花和果实的提取物，更具体地说，涉及含有桑叶花和果实提取物作为活性成分的皮肤外用组合物，其表现出极好的作用 通过有效抑制黑色素生成，增加皮肤美白效果。
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公开(公告)号：KR1020160116790A
公开(公告)日：2016-10-10
申请号：KR1020150045037
申请日：2015-03-31
Applicant: (주)아모레퍼시픽 , 한양대학교 에리카산학협력단
CPC classification number: A61K8/87 , A61K8/02 , A61K8/0241 , A61K8/044 , A61K8/72 , A61K8/8123 , A61K2800/412 , A61K2800/413 , A61K2800/624 , A61Q19/00
Abstract: 본발명은엘라스토머마이크로입자및 이를둘러싼압전층을포함하는자기이온영동(self-iontophoresis) 성능을가지는콜로이드, 이의제조방법및 이를함유한화장료조성물을제공한다. 본발명에따르면별도의기기의도움없이그 자체로서이온영동이발생하여화장료조성물내의수용성유효성분을효과적으로경피에전달및 흡수시킬수 있다.
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