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公开(公告)号：KR1020120083943A
公开(公告)日：2012-07-27
申请号：KR1020100078279
申请日：2010-08-13
Applicant: (주)아모레퍼시픽
Inventor： 백흥수
IPC: A61K31/047 , A61K31/05 , A61K8/33 , A61K8/34 , A61K8/97 , A61K36/60 , A61Q19/08 , A61Q19/00 , A61Q19/02 , A61Q17/04
CPC classification number: A61K31/047 , A61K8/33 , A61K8/345 , A61K8/347 , A61K8/97 , A61K31/05 , A61K36/60 , A61Q17/04 , A61Q19/005 , A61Q19/02 , A61Q19/08
Abstract: PURPOSE: An external use skin composition containing propanoid derivative is provided to enhance skin anti-aging, moisturizing and anti-inflammation and to treat acne and skin trouble. CONSTITUTION: An external use skin composition contains 0.001-50 wt% of propanoid derivatives substituted with prenyl groups of chemical formula 1 as an active ingredient.The derivatives include broxonin A, broxonin B, broxonin C, broxonin D, broxonin E, broxonin F, kasinol C, kasinol D, kasinol F, kasinol G, kasinol J, kasinol K, kasinol L, kasinol M or kasinol N. The derivatives are isolated from Broussonetia kazinokii.
Abstract translation: 目的：提供含有丙酸衍生物的外用皮肤组合物，以增强皮肤的抗衰老，保湿和抗炎，并治疗痤疮和皮肤问题。 构成：外用皮肤组合物含有0.001-50重量％的以化学式1的异戊烯基作为活性成分取代的类异构体衍生物。衍生物包括二羟色胺A，broxonin B，broxonin C，broxonin D，broxonin E，broxonin F， 卡西诺醇C，卡西诺醇D，卡西诺醇F，卡西诺醇G，卡西醇J，卡辛醇K，卡西醇L，卡西醇M或卡西诺醇N.衍生物从布鲁氏菌（Broussonetia kazinokii）中分离。
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公开(公告)号：KR1020120025903A
公开(公告)日：2012-03-16
申请号：KR1020100088083
申请日：2010-09-08
Applicant: (주)아모레퍼시픽
IPC: C07D241/44 , A61K9/00 , A61K47/06 , A61L31/16
CPC classification number: C07D241/44 , A61K9/0056 , A61K47/06 , A61L31/16
Abstract: PURPOSE: A novel quinoxaline compound, isomer thereof, precursor drug thereof, or pharmaceutically acceptable salt thereof is provided to absorb UVA and UVB. CONSTITUTION: A quinoxaline compound is denoted by chemical formula 1. An UV absorber or pharmaceutical or cosmetic composition for antiaging contains the quinoxaline compound, isomer thereof, precursor drug thereof, or pharmaceutically acceptable salt, hydrate, or solvate thereof as an active ingredient.
Abstract translation: 目的：提供一种新的喹喔啉化合物，其异构体，其前体药物或其药学上可接受的盐以吸收UVA和UVB。 构成：喹喔啉化合物由化学式1表示。用于抗衰老的紫外线吸收剂或药物或化妆品组合物含有喹喔啉化合物，其异构体，其前体药物或其药学上可接受的盐，水合物或溶剂化物作为活性成分。
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公开(公告)号：KR1020120021710A
公开(公告)日：2012-03-09
申请号：KR1020100078282
申请日：2010-08-13
Applicant: (주)아모레퍼시픽
Inventor： 백흥수
IPC: A61K31/352 , A61K31/355 , A61K8/49 , A61Q5/00 , A61Q19/00
CPC classification number: A61K31/352 , A61K8/498 , A61K31/355 , A61Q5/00 , A61Q19/00
Abstract: PURPOSE: A composition for preventing hair greying and treating vitiligo is provided to promote melanogenesis and to enhance MITF expression. CONSTITUTION: A composition for preventing hair greying or treating vitiligo contains 0.001-50 wt% of flavonoid derivative of chemical formula 1 as an active ingredient. In chemical formula 1, Y1 and Y2 is H, wherein Y1 and Y2 are different or same. The flavonoid derivative is kasinol A, B, E, or H. The flavonoid derivatives activate melanocytes and treat vitiligo.
Abstract translation: 目的：提供一种防止头发变灰和治疗白癜风的组合物，以促进黑素生成并增强MITF表达。 构成：用于防止头发变灰或治疗白癜风的组合物含有0.001-50重量％的化学式1的类黄酮衍生物作为活性成分。 在化学式1中，Y1和Y2是H，其中Y1和Y2是不同的或相同的。 类黄酮衍生物是卡西诺醇A，B，E或H.类黄酮衍生物活化黑素细胞并治疗白癜风。
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公开(公告)号：KR100864677B1
公开(公告)日：2008-10-23
申请号：KR1020070029255
申请日：2007-03-26
Applicant: (주)아모레퍼시픽
IPC: C07C233/07 , C07C233/10
Abstract: 본 발명은 항비만 효과를 나타내는 하기 화학식 1로 표시되는 3,5-디히드록시벤조산 유도체 화합물 및 이의 제조방법에 관한 것이다:
[화학식 1]
상기 식 중, R은 아다만틸, 시클로헥실 또는 헥실이다.
3,5-디히드록시벤조산 유도체, 항비만, 루시퍼라아제, IDH3α, CPT1, 혈당-
公开(公告)号：KR100851044B1
公开(公告)日：2008-08-12
申请号：KR1020070083905
申请日：2007-08-21
Applicant: (주)아모레퍼시픽
Abstract: 3,5-Dihydroxy benzamide derivatives are provided to whiten the skin due to a depigmenting activity and improve stability in aqueous solution and organic solvent in formulation by inhibiting structure change. A cosmetic composition for whitening the skin comprises 0.01-20 wt.% of 3,5-dihydroxy benzamide derivatives represented by a formula(1), wherein a hydroxyl group is located in the 2,3-, 2,4-, 2,5-, 3,4- or 3,5-site, and is used in forms of emulsion, cream, cosmetic lotion, essence, pack, gel, powder, makeup base, foundation, lotion, ointment, patch, beauty solution, cleansing foam, cleansing cream, cleansing water, body lotion, body cream, body oil, body essence, shampoo, rinse, body cleanser, soap, hair dye or spray.
Abstract translation: 提供3,5-二羟基苯甲酰胺衍生物，由于脱色活性而使皮肤变白，并通过抑制结构变化提高配方中水溶液和有机溶剂的稳定性。 用于使皮肤美白的化妆品组合物包含0.01-20重量％的由式（1）表示的3,5-二羟基苯甲酰胺衍生物，其中羟基位于2,3-，2,4-， 5-，3,4-或3,5-位，并以乳液，霜剂，化妆水，精华，包装，凝胶，粉末，化妆底，粉底，洗剂，软膏，贴片，美容液，清洁剂的形式使用 泡沫，清洁霜，清洁水，身体乳液，身体霜，身体油，身体精华，洗发水，漂洗，身体清洁剂，肥皂，染发剂或喷雾剂。
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Patent Agency Ranking
公开(公告)号：KR100643514B1
公开(公告)日：2006-11-23
申请号：KR1020050041060
申请日：2005-05-17
Applicant: (주)아모레퍼시픽
IPC: C07C233/64 , A61K8/368
Abstract: Provided are a hydroxybenzoic acid amide compound which suppresses the generation of melanin, its preparation method, and a whitening cosmetic composition containing the compound. The hydroxybenzoic acid amide compound is represented by the formula 1, wherein R1 and R2 are H or OH. The method comprises the steps of dissolving hydroxybenzoic acid in a solvent, adding a catalyst and a base drop by drop, and reacting it with acetic anhydride to prepare an acetylated compound represented by the formula II; dissolving the acetylated compound of the formula II in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare an amide compound represented by the formula III; and reacting the amine compound of the formula III with a base to hydrolyze it (See the reaction scheme 1), wherein R3 and R4 is H or an acetoxy group.
Abstract translation: 本发明提供抑制黑色素生成的羟基苯甲酸酰胺化合物及其制备方法和含有该化合物的美白化妆品组合物。 羟基苯甲酸酰胺化合物由式1表示，其中R 1和R 2是H或OH。 该方法包括以下步骤：将羟基苯甲酸溶解在溶剂中，逐滴加入催化剂和碱，并使其与乙酸酐反应以制备式II表示的乙酰化化合物; 将式II的乙酰化的化合物溶解在溶剂中并加入碱，氯甲酸乙酯和金刚烷胺以制备式III表示的酰胺化合物; 和使式III的胺化合物与碱反应以水解（参见反应方案1），其中R 3和R 4是H或乙酰氧基。
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公开(公告)号：KR100636737B1
公开(公告)日：2006-10-20
申请号：KR1020050032607
申请日：2005-04-20
Applicant: (주)아모레퍼시픽
IPC: C07C225/20
Abstract: Provided are a gallic acid adamantamine amide compound which inhibits the generation of melanin, a method for preparing the compound, and a cosmetic composition containing the compound. The gallic acid adamantamine amide compound is represented by the formula 1. The method comprises the steps of dissolving gallic acid in a solvent, adding a catalyst and a base to the solution drop by drop, and reacting it with acetic anhydride to prepare the acetylated compound represented by the formula II (See the reaction scheme 1); dissolving the acetylated compound in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare the amide compound represented by the formula III; and reacting the obtained amide compound with a base to hydrolyze it, thereby preparing the gallic acid adamantamine amide compound represented by the formula 1. Preferably the catalyst is dimethyl aminopyridine; and the base is triethylamine.
Abstract translation: 本发明提供抑制黑色素生成的没食子酸金刚胺酰胺化合物，其制备方法以及含有该化合物的化妆品组合物。 没食子酸金刚烷胺酰胺化合物由式1表示。该方法包括以下步骤：将没食子酸溶解在溶剂中，逐滴向溶液中加入催化剂和碱，并使其与乙酸酐反应以制备乙酰化的化合物 由式II表示（参见反应方案1）; 将乙酰化的化合物溶解在溶剂中，加入碱，氯甲酸乙酯和金刚烷胺制备式III所示的酰胺化合物; 并使所得酰胺化合物与碱反应以将其水解，从而制备式1代表的没食子酸金刚烷胺酰胺化合物。优选该催化剂是二甲基氨基吡啶; 碱是三乙胺。
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公开(公告)号：KR100629712B1
公开(公告)日：2006-09-29
申请号：KR1020040020401
申请日：2004-03-25
Applicant: (주)아모레퍼시픽
IPC: C07C239/14
Abstract: 본 발명은 하기 화학식 1로 표시되는 히드록삼산(Hydroxamic acid) 유도체 및 그 제조방법에 관한 것이다:
[화학식 1]
상기 식 중에서, R
1 및 R
2 는 수소, C
1-10 의 알킬 또는 C
3-6 의 알킬 고리이고;
R
3 는 CONH, NHCO, CONR
5 , 또는 NR
5 CO 이며, 이때, R
5 는 수소 또는 C
1-10 의 알킬이고; 및
R
4 는 -(CH)n- 이며, n = 0, 1이다.
또한 본 발명은 상기 화학식 1의 히드록삼산 유도체를 유효성분으로 함유하는 피부노화 방지용 피부 외용제 조성물에 관한 것이다.
레티노이드 * 레티노익산 수용체 * 히드록삼산 유도체 * 항노화 * 콜라겐 * 엘라스틴 * 콜라게나아제 발현억제 * 엘라스테이즈 발현억제 * 탄력 개선 * 피부 외용제-
公开(公告)号：KR101957843B1
公开(公告)日：2019-03-14
申请号：KR1020110101797
申请日：2011-10-06
Applicant: (주)아모레퍼시픽
IPC: C07C233/43 , A61K8/42 , A61K31/165 , A61Q7/00
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公开(公告)号：KR101887197B1
公开(公告)日：2018-09-06
申请号：KR1020110109656
申请日：2011-10-26
Applicant: (주)아모레퍼시픽
Abstract: 본발명은홀로그램과같은광학적특성을구현한메이크업화장료조성물에관한것으로서, 보다구체적으로는유용성색소를포함한콜레스테릭액정을사용함으로써피부나입술에도포시에도홀로그램과같은광학적특성이그대로구현이가능하며, 다량의염료를사용하는것이가능하여색상표현의범위가보다넓은메이크업화장료조성물에관한것이다.
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