Abstract:
PURPOSE: Carnosic acid, a derivative thereof, or a pharmaceutically acceptable salt thereof is provided to suppress c-kit activation and signal transduction in melanocytes, and to improve skin whitening. CONSTITUTION: A c-kit activity inhibitor contains carnosic acid of chemical formula 1, a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. The derivative is carnosic acid methyl ester or carnosic acid ethyl alcohol. The carnosic acid, a derivative thereof, or a pharmaceutically acceptable salt thereof is derived from rosemary and/or sage. The inhibitor contains 0.0001-10 wt% of the active ingredient. A composition for skin whitening contains the derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof. The composition further contains one or more selected from a group consisting of a Gycyrrhiza extract, arbutin, ascorbic acid, and kojic acid.
Abstract:
본발명은천연유래화장료조성물에관한것으로, 상세하게본 발명에따른천연유래화장료조성물은합성폴리머를사용하지않음에도불구하고, 수중유형의유화안정성을극대화할 수있음과동시에종래천연유래화장료조성물에서발생되는백탁현상, 발한현상등의발생없이우수한발림성과높은수분감을제공할수 있어, 친환경적인천연화장품을원하는소비자들의니즈를만족시킬수 있다.
Abstract:
The present invention provides a novel pseudo-ceramide compound represented by Chemical Formula 1, an isomer, a pharmaceutically allowable salt, a pro-drug, a hydroxide, or a solvated compound thereof. [Chemical Formula 1] (In Chemical Formula 1, R1 and R2 are independently non-substituted or hydroxyl group-substituted C 9 to 23 saturated or unsaturated aliphatic chains.) According to the present invention, the compound has excellent stability and dissolubility and is effective in moisturizing the skin so as to protect the skin from external stimuli without side effects and be used as an active ingredient for recovering damaged skin and preventing skin damage. Accordingly, the compound can be used as an external skin application composition for moisturizing the skin, as a cosmetic composition, or as a pharmaceutical composition.
Abstract:
The present invention relates to a novel phenylacetic acid amide derivative compound, isomers thereof, pharmaceutically acceptable salt thereof, prodrug thereof, a hydrate or a solvate thereof, and a composition for skin whitening comprising the same. The novel compound or the like has excellent skin whitening effect.