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公开(公告)号：WO2014084676A1
公开(公告)日：2014-06-05
申请号：PCT/KR2013/011026
申请日：2013-11-29
Applicant: (주)아모레퍼시픽
IPC: C07C233/09 , C07C233/02
CPC classification number: A61K8/42 , A61K8/68 , A61K2800/40 , A61Q19/007 , C07C233/18 , C07C235/08 , C07C235/28
Abstract: 본 발명은 신규한 유사 세라마이드 화합물, 이의 이성질체, 이의 약학적으로 허용 가능한 염, 이의 프로드럭, 이의 수화물 또는 이의 용매화물을 제공한다. 본 발명에 따르면, 안정성 및 용해도가 우수하고 피부 보습에 효과가 뛰어나 피부 보호 효과를 가지므로, 부작용 없이 외부자극으로부터 피부를 보호하고, 손상된 피부회복 및 예방용 유효물질로 사용 가능하다. 따라서, 피부 보습용 피부 외용제 조성물, 화장료 조성물 또는 약학 조성물로 사용될 수 있다.
Abstract translation: 本发明提供：新颖的假花生酰胺化合物，其异构体，其药学上可接受的盐，其前药，其水合物或其溶剂化物。 本发明具有皮肤保护作用，因为本发明在皮肤保湿中具有优异的效果，并且具有优异的稳定和可溶性，因此本发明可以保护皮肤免受外部刺激而没有副作用，并可用作活性物质 皮肤恢复和预防受损。 因此，本发明可以用作皮肤保湿皮肤病外用组合物，化妆品组合物或药物组合物。
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公开(公告)号：KR1020140070474A
公开(公告)日：2014-06-10
申请号：KR1020130147705
申请日：2013-11-29
Applicant: (주)아모레퍼시픽
IPC: C07C235/08 , A61K31/164 , A61P17/16
CPC classification number: A61K8/42 , A61K8/68 , A61K2800/40 , A61Q19/007 , C07C233/18 , C07C235/08 , C07C235/28
Abstract: The present invention provides a novel pseudo-ceramide compound represented by Chemical Formula 1, an isomer, a pharmaceutically allowable salt, a pro-drug, a hydroxide, or a solvated compound thereof. [Chemical Formula 1] (In Chemical Formula 1, R1 and R2 are independently non-substituted or hydroxyl group-substituted C 9 to 23 saturated or unsaturated aliphatic chains.) According to the present invention, the compound has excellent stability and dissolubility and is effective in moisturizing the skin so as to protect the skin from external stimuli without side effects and be used as an active ingredient for recovering damaged skin and preventing skin damage. Accordingly, the compound can be used as an external skin application composition for moisturizing the skin, as a cosmetic composition, or as a pharmaceutical composition.
Abstract translation: 本发明提供由化学式1表示的新型假神经酰胺化合物，异构体，药学上可允许的盐，前药，氢氧化物或溶剂化物。 [化学式1]
（在化学式1中，R1和R2分别为非 取代或羟基取代的C 9〜23饱和或不饱和脂肪链）根据本发明，该化合物具有优异的稳定性和溶解性，并且有效地保湿皮肤，从而保护皮肤免受外部刺激而没有副作用 并用作恢复受损皮肤并防止皮肤损伤的活性成分。 因此，该化合物可以用作皮肤保湿剂，化妆品组合物或作为药物组合物的外用皮肤施用组合物。
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Patent Agency Ranking3.发明公开지방산 연장 효소 발현 및 탄소사슬 발현 조절을 통한 아토피성 피부의 피부 장벽 기능 회복 효능 물질 스크리닝 방법 审中-实审通过控制脂肪酸快速表达和碳链表达来控制皮肤粘膜功能恢复原位真皮的候选材料筛选方法
公开(公告)号：KR1020130034169A
公开(公告)日：2013-04-05
申请号：KR1020110098052
申请日：2011-09-28
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A method for screening a material which recovers skin barrier function of atopic skin through controlling expression of fatty acid elongase and carbon chain is provided to detecting ceramide fatty acid and to accurately screen skin improving substances. CONSTITUTION: A method for screening a material for treating atopic dermatitis comprises: a step of identifying expression level of elongase in keratinocytes treated with candidate materials; and a step of determining a material which enhances the expression level of the elongase as a material which improves atopic dermatitis. [Reference numerals] (AA) Score; (BB) Control group;
Abstract translation: 目的：通过控制脂肪酸延伸酶和碳链的表达来筛选恢复特应性皮肤的皮肤屏障功能的材料，用于检测神经酰胺脂肪酸并准确筛选皮肤改善物质。 构成：筛选用于治疗特应性皮炎的材料的方法包括：鉴定用候选材料处理的角质形成细胞中延伸酶的表达水平的步骤; 以及确定提高延长酶的表达水平的材料作为改善特应性皮炎的材料的步骤。 （附图标记）（AA）得分; （BB）对照组;
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公开(公告)号：KR101932248B1
公开(公告)日：2018-12-21
申请号：KR1020110098052
申请日：2011-09-28
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 후보 물질을 처리한 피부 각질 세포에서 연장 효소(elongase)의 발현 정도를 확인하는 단계를 포함하는 아토피 피부염 개선용 물질 스크리닝 방법을 개시한다. 또한 본 발명은 피부의 연장 효소 발현 정도 분석부를 포함하는 아토피 피부염 진단 키트를 개시한다.
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公开(公告)号：KR1020140069931A
公开(公告)日：2014-06-10
申请号：KR1020120137822
申请日：2012-11-30
Applicant: (주)아모레퍼시픽
IPC: C07C233/09 , C07C233/02
Abstract: The present invention provides a novel pseudo-ceramide compound represented by Chemical Formula 1, an isomer thereof, a pharmaceutically acceptable salt thereof, a pro-drug thereof, a hydrate thereof, and a solvate thereof. [Chemical Formula 1] (In Chemical Formula 1, R is a C9 to 17 saturated or unsaturated aliphatic chain, and R′ is an amino group or an alkoxy group having a C10 to 18 saturated aliphatic chain.) According to the present invention, the novel pseudo-ceramide compound has a skin protecting effect by having excellent stability, dissolubility, and skin moisturization, so that the novel pseudo-ceramide compound can be used as an active ingredient for protecting the skin from external stimuli without side effects, preventing the skin from damage, and recovering damaged skin. Accordingly, the novel pseudo-ceramide compound can be used as a skin-moisturizing composition for external application on skin, a cosmetic composition, or a pharmaceutical composition.
Abstract translation: 本发明提供由化学式1表示的新型假神经酰胺化合物，其异构体，药学上可接受的盐，其前体药物，其水合物及其溶剂合物。 [化学式1]（化学式1中，R为C 9〜17饱和或不饱和脂肪族链，R'为氨基或碳原子数为10〜18的饱和脂肪族链的烷氧基。）根据本发明， 新型伪神经酰胺化合物通过具有优异的稳定性，溶解性和皮肤保湿性而具有皮肤保护效果，因此新颖的假神经酰胺化合物可以用作保护皮肤免受外部刺激的活性成分而没有副作用，从而防止 皮肤受损，并恢复受损皮肤。 因此，新颖的假神经酰胺化合物可以用作皮肤外用的皮肤保湿组合物，化妆品组合物或药物组合物。
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