公开(公告)号：KR1020140091968A

公开(公告)日：2014-07-23

申请号：KR1020130004063

申请日：2013-01-14

Applicant: 가톨릭대학교 산학협력단

Inventor： 최성욱 ,  김주환 ,  황석준 ,  이지선

IPC: A61K9/22 ,  A61L15/60 ,  A61L15/28

CPC classification number: A61K9/20 ,  A61K9/205 ,  A61K9/2063 ,  A61K9/5042

Abstract: The present invention relates to sustained release hydrogel with improved discharge amount adjustment and a method of producing the same. More specifically, the hydrogel is made negatively (-) charged and the internal material of the hydrogel is made positively (+) charged so that the internal material is slowly discharged by means of strong electrostatic gravitation. By the means of the present invention, the problem whereby the discharge amount of the existing materials is adjusted only by the means of the pores of the hydrogel is solved, so that an internal material discharge speed can be more effectively adjusted by the means of the electrostatic gravitation.

Abstract translation: 本发明涉及具有改进的排放量调节的缓释水凝胶及其制备方法。 更具体地说，水凝胶是带负电荷的（ - ），水凝胶的内部材料被正面（+）带电，使得内部材料通过强烈的静电引力缓慢排出。 通过本发明，解决了现有材料的排出量仅通过水凝胶的孔隙调节的问题，从而可以通过以下方式更有效地调节内部材料的排出速度 静电引力。

公开(公告)号：KR1020130047779A

公开(公告)日：2013-05-09

申请号：KR1020110109392

申请日：2011-10-25

Applicant: 가톨릭대학교 산학협력단

Inventor： 박용일 ,  이지선 ,  장성재 ,  김현복

IPC: A61K31/7008 ,  A61K36/605 ,  A61K31/70 ,  A61P37/00

CPC classification number: A61K31/715 ,  A23L29/30 ,  A23V2200/324 ,  A61K36/605 ,  Y10S514/885

Abstract: PURPOSE: A Korean mulberry-derived polysaccharide which enhances immunity, and a pharmacological composition containing the same are provided to enhance immunity without cytotoxicity, and to be used as a material for pharmaceutical products, functional foods, and functional cosmetic products. CONSTITUTION: A pharmaceutical composition for enhancing immunity contains polysaccharides including: a main chain including basic skeleton of methyl group-conjugated alpha-1,4-galacturonic acid and alpha-1,2-rhamnose; and a side chain including 5-linked alpha-arabinose, 4-linked beta-galactan, and arabinogalactan. The polysaccharide is derived from Morus spp. using ethanol. The pharmaceutical composition contains rhamnose, arabinose, galactose, and galacturonic acid as monosaccharides forming the polysaccharides. The polysaccharide enhances expression of IL-6 and TNF-alpha.

Abstract translation: 目的：提供增强免疫力的韩国桑树衍生的多糖，以及含有该多糖的药理组合物，以增强免疫力而不具有细胞毒性，并且用作药物产品，功能性食品和功能性化妆品的材料。 构成：用于增强免疫力的药物组合物含有多糖，包括：包括甲基偶联的α-1,4-半乳糖醛酸和α-1,2-鼠李糖的基本骨架的主链; 和包含5-连接的α-阿拉伯糖，4-连接的β-半乳聚糖和阿拉伯半乳聚糖的侧链。 多糖衍生自桑树。 使用乙醇。 作为形成多糖的单糖，药物组合物含有鼠李糖，阿拉伯糖，半乳糖和半乳糖醛酸。 多糖增强IL-6和TNF-α的表达。