公开(公告)号：KR1020110090443A

公开(公告)日：2011-08-10

申请号：KR1020100010215

申请日：2010-02-04

Applicant: 박시향 ,  경상대학교산학협력단

Inventor： 박시향 ,  최병대

IPC: A61K8/98 ,  A61Q19/00

CPC classification number: A61K8/987 ,  A61K8/735 ,  A61K35/655 ,  A61K2800/805 ,  A61Q19/00

Abstract: PURPOSE: A cosmetic composition containing a glycosaminoglycan composite is provided to ensure skin regeneration effect without skin irritation and to suppress skin aging by moisturizing. CONSTITUTION: A cosmetic composition 0.01-30 weight% of glycosaminoglycan isolated from Styela plicata. The glycosaminoglycan composite is prepared by heating Styela plicata in 1-10 times of water at 100-130°C for 2-5 hours, treating with 50-80% of ammonium persulfate to remove proteins, and treating with 3-7 times of alcohol to dry precipitate. The composition is manufactured in the form of lotion, nutrition cream, massage cream, massage pack, or foundation of emulsifying type.

Abstract translation: 目的：提供含有糖胺聚糖复合材料的化妆品组合物，以确保皮肤再生效果而不引起皮肤刺激，并通过保湿来抑制皮肤老化。 构成：从Styela plicata分离的化妆品组合物0.01-30重量％的糖胺聚糖。 糖胺聚糖复合物通过在100-130℃的1-10倍水中加热Styela plicata制备2-5小时，用50-80％的过硫酸铵处理以除去蛋白质，并用3-7倍的酒精处理 干燥沉淀。 该组合物以洗剂，营养霜，按摩膏，按摩包或乳化基础的形式制成。

公开(公告)号：KR1020080111787A

公开(公告)日：2008-12-24

申请号：KR1020070060162

申请日：2007-06-19

Applicant: 재단법인서울대학교산학협력재단 ,  경상대학교산학협력단

Inventor： 조명행 ,  최병대 ,  허성웅 ,  김화

IPC: A61K31/715 ,  A61K35/60 ,  A61P29/00

CPC classification number: A61K31/737 ,  A61K35/655 ,  Y10S514/886

Abstract: An expression inhibitor of VCAM and COX-2 in inflammation disease is provided to offer an anti-inflammation material including GAGs as an active ingredient and to reduce oncogenesis by providing the basic particle mechanism about anti-inflammation effect. An expression inhibitor of VCAM and COX-2 in inflammation disease comprises glycosaminoglycans extracted from the skin of styela clava or sea squirt as an active ingredient. The glycosaminoglycan is chondroitin sulfate and suppresses the activity of the NF- kappa B (nuclear factor kappaB).

Abstract translation: 提供炎症疾病中VCAM和COX-2的表达抑制剂，提供包括GAGs在内的抗炎物质作为活性成分，并通过提供抗炎作用的基本粒子机制来减少肿瘤形成。 VCAM和COX-2在炎症疾病中的表达抑制剂包括从石蕊或海绵的皮肤提取的糖胺聚糖作为活性成分。 糖胺聚糖是硫酸软骨素，抑制NF-κB（核因子κB）的活性。