公开(公告)号：KR1020080111787A

公开(公告)日：2008-12-24

申请号：KR1020070060162

申请日：2007-06-19

Applicant: 재단법인서울대학교산학협력재단 ,  경상대학교산학협력단

Inventor： 조명행 ,  최병대 ,  허성웅 ,  김화

IPC: A61K31/715 ,  A61K35/60 ,  A61P29/00

CPC classification number: A61K31/737 ,  A61K35/655 ,  Y10S514/886

Abstract: An expression inhibitor of VCAM and COX-2 in inflammation disease is provided to offer an anti-inflammation material including GAGs as an active ingredient and to reduce oncogenesis by providing the basic particle mechanism about anti-inflammation effect. An expression inhibitor of VCAM and COX-2 in inflammation disease comprises glycosaminoglycans extracted from the skin of styela clava or sea squirt as an active ingredient. The glycosaminoglycan is chondroitin sulfate and suppresses the activity of the NF- kappa B (nuclear factor kappaB).

Abstract translation: 提供炎症疾病中VCAM和COX-2的表达抑制剂，提供包括GAGs在内的抗炎物质作为活性成分，并通过提供抗炎作用的基本粒子机制来减少肿瘤形成。 VCAM和COX-2在炎症疾病中的表达抑制剂包括从石蕊或海绵的皮肤提取的糖胺聚糖作为活性成分。 糖胺聚糖是硫酸软骨素，抑制NF-κB（核因子κB）的活性。