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公开(公告)号：KR1020080111787A
公开(公告)日：2008-12-24
申请号：KR1020070060162
申请日：2007-06-19
Applicant: 재단법인서울대학교산학협력재단 , 경상대학교산학협력단
IPC: A61K31/715 , A61K35/60 , A61P29/00
CPC classification number: A61K31/737 , A61K35/655 , Y10S514/886
Abstract: An expression inhibitor of VCAM and COX-2 in inflammation disease is provided to offer an anti-inflammation material including GAGs as an active ingredient and to reduce oncogenesis by providing the basic particle mechanism about anti-inflammation effect. An expression inhibitor of VCAM and COX-2 in inflammation disease comprises glycosaminoglycans extracted from the skin of styela clava or sea squirt as an active ingredient. The glycosaminoglycan is chondroitin sulfate and suppresses the activity of the NF- kappa B (nuclear factor kappaB).
Abstract translation: 提供炎症疾病中VCAM和COX-2的表达抑制剂，提供包括GAGs在内的抗炎物质作为活性成分，并通过提供抗炎作用的基本粒子机制来减少肿瘤形成。 VCAM和COX-2在炎症疾病中的表达抑制剂包括从石蕊或海绵的皮肤提取的糖胺聚糖作为活性成分。 糖胺聚糖是硫酸软骨素，抑制NF-κB（核因子κB）的活性。
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2.发明授权공역 리놀레인산을 어류 지질 성분으로 전환시키면서 어류의 성장율을 동시에 개선시키기 위한 어류용 사료 및 그 용도 有权饲养用于将CLA转化成鱼类的脂肪组分和用于改进鱼类生长比例的鱼类及其用途
公开(公告)号：KR100861943B1
公开(公告)日：2008-10-09
申请号：KR1020070041685
申请日：2007-04-30
Applicant: 경상대학교산학협력단
CPC classification number: A23K50/80 , A23K20/116 , A23L17/70
Abstract: A use of fish feed containing carotenoid, highly unsaturated fatty acid and conjugated linoleic acid as an active ingredient is provided to ensure improvement in the growth of fish and oxidation stability of fish meat while converting conjugated linoleic acid to lipid components of fish when fed to fish. Fish feed containing fish meal, soybean meal, wheat flour, cuttlefish liver oil, vitamin, mineral and soybean oil is characterized in that it contains 0.5% by weight of carotenoid selected from natural carotenoid and synthetic carotenoid, 5 to 25% by weight of highly unsaturated fatty acid and 1 to 5% by weight of conjugated linoleic acid, based on the total weight of the fish feed. The fish feed overcomes the problems of inhibiting the growth of fish when a quantity of conjugated linoleic acid is fed to fish and improves meat quality by accumulation of carotenoid pigments when fed to fish.
Abstract translation: 提供含有类胡萝卜素，高度不饱和脂肪酸和共轭亚油酸作为活性成分的鱼饲料的使用，以确保鱼类生长的改善和鱼肉的氧化稳定性，同时将共轭亚油酸转化成鱼类的脂质成分 。 含有鱼粉，豆粕，小麦粉，墨鱼肝油，维生素，矿物油和大豆油的鱼饲料的特征在于，其含有0.5重量％的选自天然类胡萝卜素和合成类胡萝卜素的类胡萝卜素，5至25重量％ 不饱和脂肪酸和1至5重量％的共轭亚油酸，基于鱼饲料的总重量。 鱼饲料克服了当将一定量的共轭亚油酸喂入鱼类时抑制鱼类生长的问题，并且当饲喂鱼类时通过类胡萝卜素颜料的积累来改善肉质。
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公开(公告)号：KR101006700B1
公开(公告)日：2011-01-10
申请号：KR1020070060545
申请日：2007-06-20
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은 생체 분석 물질을 빠르게 추적(tracking), 표적(targeting) 및 형상(imaging) 하는데 이용할 수 있는 형광 표면증강 라만 산란 나노-표지 입자 및 이의 제조방법에 관한 것이다. 본 발명에 따른 형광 표면증강 라만 산란 나노-표지 입자는 형광 및 라만 산란에 매우 민감하기 때문에 생체 분석 물질을 보다 쉽고, 빠르게 분석할 수 있다. 따라서, 본 발명에 따른 형광 표면증강 라만 산란 나노-표지 입자는 세포와 조직에서 암 또는 다른 질병과 관련된 다양한 세포학적 및 분자학적 현상의 분석에 쉽게 이용될 수 있다.
라만, 형광, 나노-표지입자, 아포프토시스-
公开(公告)号：KR100874761B1
公开(公告)日：2008-12-19
申请号：KR1020070029334
申请日：2007-03-26
Applicant: 재단법인서울대학교산학협력재단
IPC: C07H3/00
CPC classification number: C07H3/00
Abstract: The present invention relates to a fluorescent dye-labeled glucose analog, and a synthesis method and usage of the same, and more particularly, to novel glucose α and &bgr; anomers in which a fluorescent dye is labeled by O-1-glycosylation, an asymmetric synthesis method of the anomers, a molecular bioimaging method of the anomers, and a screening method of curing or preventing drugs for diseases related to glucose metabolism.
Abstract translation: 荧光染料标记的葡萄糖类似物及其合成方法和用途技术领域本发明涉及荧光染料标记的葡萄糖类似物及其合成方法和用途，并且更具体地涉及新型葡萄糖＆amp; 和＆amp; bgr; 其中通过O-1-糖基化标记荧光染料的端基异构体，端基异构体的不对称合成方法，端基异构体的分子生物成像方法，以及用于治疗或预防与葡萄糖代谢有关的疾病的药物的筛选方法。
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公开(公告)号：KR1020080029946A
公开(公告)日：2008-04-03
申请号：KR1020070098863
申请日：2007-10-01
Applicant: 재단법인서울대학교산학협력재단
IPC: A61K48/00 , C12N15/866 , A61K47/48 , A61P35/00
CPC classification number: A61K48/00 , A23V2200/308 , C12N15/866
Abstract: A novel viral gene carrier is provided to deliver a gene specifically to tumor cells by controlling the gene delivery efficiency with low cytotoxicity and high stability and having higher transduction efficiency to a receptor positive KB cell. A viral gene carrier is characterized in that it is prepared by modifying the surface of a recombinant baculovirus vector including a green fluorescent protein, luciferase or a PDCD4 (programmed cell death 4) gene using a folate-polyethylene glcyol conjugate. A method for preparing the viral gene carrier comprises the steps of: (a) preparing the recombinant baculovirus vector; (b) preparing the folate-polyethylene glycol conjugate; and (c) modifying the recombinant baculovirus vector surface with the folate-polyethylene glycol conjugate.
Abstract translation: 提供了一种新的病毒基因载体，通过以低细胞毒性和高稳定性控制基因传递效率并且对受体阳性KB细胞具有较高的转导效率，特异性地向肿瘤细胞递送基因。 病毒基因载体的特征在于其通过使用叶酸 - 聚乙烯胶体缀合物修饰包含绿色荧光蛋白，荧光素酶或PDCD4（程序性细胞死亡4）基因的重组杆状病毒载体的表面来制备。 制备病毒基因载体的方法包括以下步骤：（a）制备重组杆状病毒载体; （b）制备叶酸 - 聚乙二醇缀合物; 和（c）用叶酸 - 聚乙二醇缀合物修饰重组杆状病毒载体表面。
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Patent Agency Ranking
公开(公告)号：KR100817854B1
公开(公告)日：2008-03-31
申请号：KR1020060090516
申请日：2006-09-19
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: G01J3/02 , G01J3/0227 , G01J3/0291 , G01J3/44 , G01N2015/0038 , G01N2015/0092 , G01N2015/1493
Abstract: 본 발명은 라만 산란과 광산란(Light Scattering) 검출 시스템에 관한 것으로, 특히 라만 산란과 동적 광산란(Dynamic Light Scattering)의 동시 검출 장치 및 방법에 관한 것이다.
본 발명은 라만 산란과 동적 광산란의 동시 검출 장치로서, 라만 산란과 광산란의 동시 검출는 입사광을 시료에 입사하고 라만 산란과 광산란을 동시에 수집하기 위한 180° 구조의 라만 산란 측정 및 90° 구조의 광산란 측정을 이용한 검출수단; 및 상기 산란광 검출 수단과 연결되어 자기상관함수를 연산하여 입자의 크기 및 분포를 측정하고, 분자 구조를 측정하기 위한 컴퓨터를 포함한다. 이 장치는 나노 크기 이상의 물질의 크기와 이를 이루는 분자적 정보를 동시에 관찰할 수 있고 물질의 변화에 따른 분자적 환경의 변화와 그 크기 및 분포의 변화를 동반하는 현상을 관찰할 수 있어 나노 물질 및 단백질 항원-항체 관련 연구에 매우 유용하다.
라만 산란, 동적 광산란, 분광계, 동시측정-
公开(公告)号：KR1020080025845A
公开(公告)日：2008-03-24
申请号：KR1020060090516
申请日：2006-09-19
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: G01J3/02 , G01J3/0227 , G01J3/0291 , G01J3/44 , G01N2015/0038 , G01N2015/0092 , G01N2015/1493
Abstract: A simultaneous detection apparatus of Raman and light scattering is provided to analyze information on nano material and its molecules by simultaneously detecting Raman scattering and light scattering of one sample. A simultaneous detection apparatus of Raman and light scattering includes a laser generator(110), a Raman scattering detector(120), a dynamic light scattering detector, a spectrometer(140), and a computer(150). The laser generator generates a laser beam of 514.5nm Ar-ion as incident light. The incident light passes through a light condensing lens(112) and is reflected from a plane mirror(111) to enter the Raman scattering detector. The Raman scattering detector has a notch filter(121), an objective lens(123), and a first collecting lens(125). When the light reflected from the plane mirror enters a sample, the light is scattered while some of the light is collected again by the objective lens. Raman scattering light is transmitted to the spectrometer by the first collecting lens. The spectrometer detects the spectrum of the Raman scattering light. The dynamic light scattering detector, arranged at an angle of 90 degrees with respect to the incident light, has a second collecting lens(131), an iris(132), and a PMT(Photomultiplier Tube) detector(133). The computer is connected to the dynamic light scattering detectors, performs an autocorrelation function to measure the size and distribution of particles, and measures molecular structure.
Abstract translation: 提供拉曼和光散射的同时检测装置，通过同时检测一个样品的拉曼散射和光散射来分析纳米材料及其分子的信息。 拉曼和光散射的同时检测装置包括激光发生器（110），拉曼散射检测器（120），动态光散射检测器，光谱仪（140）和计算机（150）。 激光发生器产生514.5nm Ar离子的激光束作为入射光。 入射光通过聚光透镜（112）并从平面镜（111）反射进入拉曼散射检测器。 拉曼散射检测器具有陷波滤波器（121），物镜（123）和第一收集透镜（125）。 当从平面镜反射的光进入样品时，光被散射，而一些光被物镜再次收集。 拉曼散射光通过第一收集透镜传输到光谱仪。 光谱仪检测拉曼散射光的光谱。 相对于入射光以90度的角度布置的动态光散射检测器具有第二收集透镜（131），光圈（132）和PMT（光电倍增管）检测器（133）。 计算机连接到动态光散射检测器，执行自相关函数测量粒子的大小和分布，并测量分子结构。
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公开(公告)号：KR1020100001563A
公开(公告)日：2010-01-06
申请号：KR1020080061519
申请日：2008-06-27
Applicant: 재단법인서울대학교산학협력재단
Abstract: PURPOSE: A poly(ester amine)/DNA complex for non-viral DNA carrier is provided to ensure poly(ester amine)-controlled resolution, low cytotoxin, and high transfection efficiency, to be useful as an effective polymer carrier, and to exhibit big potential in intercellular gene transfer. CONSTITUTION: A method for manufacturing a poly(ester amine) polymer comprises the steps of: respectively dissolving glyceroldimethylacrylate or glyceroltrimethylacrylate and low molecular polyethylenimine (molecular weight 200-3,000) in methanol anhydride and then adding a glycerol dimethylacrylate solution to a polyethylenimine solution and mixing them; stirring and heating the mixed solution at 50-70 °C for 12-36 hours; dialyzing the mixture for 2-5 hours to 12-36 hours; and then lyophilizing the obtained polymer.
Abstract translation: 目的：提供用于非病毒DNA载体的聚（酯胺）/ DNA复合物，以确保聚（酯胺）控制的分辨率，低细胞毒素和高转染效率，可用作有效的聚合物载体，并显示 细胞间基因转移的巨大潜力。 构成：制备聚（酯胺）聚合物的方法包括以下步骤：分别将丙烯酸甘油酯二甲基丙烯酸酯或甘油三甲基丙烯酸酯和低分子量聚乙烯亚胺（分子量200-3,000）溶解在甲醇酐中，然后将甘油二甲基丙烯酸酯溶液加入到聚乙烯亚胺溶液中并混合 他们; 在50-70℃下搅拌和加热混合溶液12-36小时; 将混合物透析2-5小时至12-36小时; 然后将所得聚合物冻干。
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公开(公告)号：KR100908871B1
公开(公告)日：2009-07-23
申请号：KR1020070088547
申请日：2007-08-31
Applicant: 재단법인서울대학교산학협력재단
IPC: A61K36/489 , A61K36/23 , A61P31/00
Abstract: 본 발명은 네오스포라 캐니늄 감염증 예방 및 치료용 조성물에 관한 것이다.
본 발명에 따른 고삼 또는 사상자 추출물 또는 이의 분획물을 포함하는 약학적 조성물은 N. 캐니늄 감염증을 예방 또는 치료하는데 매우 유용하다. 구체적으로 본 발명의 약학적 조성물은 마우스에서 N. 캐니늄 감염을 방어할 수 있으며 임신 염소에 있어서는 유산 발생율을 경감시킬 수 있다.
네오스포라 캐니늄, 고삼, 사상자Abstract translation: 本发明涉及用于预防和治疗犬新孢子虫感染的组合物。
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10.发明公开알파-일레오스테아르산을 포함하는 유방암 치료용 조성물및 이를 이용한 피피에이알γ 활성 조절에 의한 질환의치료방법 无效用于治疗包含ALPHA-ELEOSTEACIC酸的乳腺癌的组合物和通过使用其调节PPARγ活性来治疗疾病的方法
公开(公告)号：KR1020090012520A
公开(公告)日：2009-02-04
申请号：KR1020070076422
申请日：2007-07-30
Applicant: 재단법인서울대학교산학협력재단 , 주식회사 리포젠
Abstract: A composition for treatment of breast cancer is provided to investigate anti-cancer capability and mechanism in MCF-7 breast cancer cell using alpha-eleostearic acid. A composition for treatment of breast cancer includes alpha-eleostearic acid to active ingredient. A remedial method of disease at cancer cell line includes a step of processing the alpha-eleostearic acid of a therapeutically effective amount to the cancer cell line and prevents, suppresses or improves pathology or symptom of diseases by adjustment of PPAR gamma activity or phosphorylation of ERK1/2.
Abstract translation: 提供了一种用于治疗乳腺癌的组合物，用于研究使用α-蒿酸的MCF-7乳腺癌细胞的抗癌能力和机制。 用于治疗乳腺癌的组合物包括对活性成分的α-蒿酸。 在癌细胞系疾病的补救方法包括将治疗有效量的α-蒿酸处理至癌细胞系的步骤，通过调整PPARγ活性或ERK1磷酸化来预防，抑制或改善疾病的病理学或症状 / 2。
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