公开(公告)号：KR100792630B1

公开(公告)日：2008-01-09

申请号：KR1020060063108

申请日：2006-07-05

Applicant: 고려대학교 산학협력단

Inventor： 김현정 ,  김찬화 ,  김미령 ,  조은희

IPC: C07K14/00 ,  G01N33/53 ,  C12Q1/00

CPC classification number: G01N33/6893 ,  G01N2333/775 ,  G01N2800/042

Abstract: A bio marker for diagnosing diabetic nephropathy is provided to identify the attack of the diabetic nephropathy from a human blood and the initial diagnosis and the progress stage of the diabetic nephropathy in diabetes. A bio marker composition comprises a protein decreasing in a blood of a patient suffering from the diabetic nephropathy than in a blood of a diabetic individual and selected from the group consisting of: c-type lectin domain family 3, member B having an amino acid sequence of SEQ ID : NO. 1, a molecular weight of 22-24kD and pI of 5.0-6.0; apolipoprotein CIII having an amino acid sequence of SEQ ID : NO. 2, a molecular weight of 8-10kD and pI of 4.2-5.2; retinol binding protein 4 having an amino acid sequence of SEQ ID : NO. 3, a molecular weight of 22-24kD and pI of 4.9-5.9; proapo-A-I protein having an amino acid sequence of SEQ ID : NO. 4, a molecular weight of 28-30kD and pI of 4.9-5.9; ficolin 3 precursor having an amino acid sequence of SEQ ID : NO. 5, a molecular weight of 32-34kD and pI of 5.7-6.7; vitamin D binding protein precursor having an amino acid sequence of SEQ ID : NO. 6, a molecular weight of 54-56kD and pI of 5.0-6.0; histidine-rich glycoprotein having an amino acid sequence of SEQ ID : NO. 7, a molecular weight of 39-41kD and pI of 3.4-4.4; complement factor H-related 1 having an amino acid sequence of SEQ ID : NO. 8, a molecular weight of 38-40kD and pI of 7.3-8.3; haptoglobin-related protein precursor having an amino acid sequence of SEQ ID : NO. 9, a molecular weight of 38-40kD and pI of 6.2-7.2; hemopexin precursor having an amino acid sequence of SEQ ID : NO. 10, a molecular weight of 51-53kD and pI of 6.1-7.1; complement factor I light chain having an amino acid sequence of SEQ ID : NO. 11, a molecular weight of 22-24kD and pI of 4.7-5.7; sex hormone-binding globulin having an amino acid sequence of SEQ ID : NO. 12, a molecular weight of 43-45kD and pI of 5.7-6.7; apolipoprotein E having an amino acid sequence of SEQ ID : NO. 13, a molecular weight of 35-37kD and pI of 5.2-6.2; and plasma glutathione peroxidase precursor having an amino acid sequence of SEQ ID : NO. 14, a molecular weight of 25-27kD and pI of 7.7-8.7.

Abstract translation: 提供用于诊断糖尿病肾病的生物标志物，用于鉴定人血糖的糖尿病肾病的发作及糖尿病肾病的初步诊断和进展阶段。 生物标志物组合物包含在患有糖尿病肾病的患者的血液中比在糖尿病个体的血液中降低的蛋白质，并且选自：c型凝集素结构域家族3，具有氨基酸序列的成员B SEQ ID NO： 1，分子量22-24kD，pI为5.0-6.0; 具有SEQ ID NO：1的氨基酸序列的载脂蛋白CIII。 2，分子量为8-10kD，pI为4.2-5.2; 视黄醇结合蛋白4具有SEQ ID NO：1的氨基酸序列。 3，分子量22-24kD，pI为4.9-5.9; 具有SEQ ID NO：1的氨基酸序列的proapo-A-I蛋白。 4，分子量28-30kD，pI为4.9-5.9; 具有SEQ ID NO：1的氨基酸序列的ficolin 3前体。 5，分子量32-34kD，pI为5.7-6.7; 具有SEQ ID NO：1的氨基酸序列的维生素D结合蛋白前体。 6，分子量为54-56kD，pI为5.0-6.0; 富含组氨酸的糖蛋白，其氨基酸序列为SEQ ID NO： 7，分子量39-41kD，pI为3.4-4.4; 具有SEQ ID NO：1的氨基酸序列的补体因子H相关1。 8，分子量38-40kD，pI为7.3-8.3; 具有SEQ ID NO：1的氨基酸序列的触珠蛋白相关蛋白前体。 9，分子量38-40kD，pI为6.2-7.2; 具有SEQ ID NO：1的氨基酸序列的血红蛋白前体。 10，分子量为51-53kD，pI为6.1-7.1; 具有SEQ ID NO：1的氨基酸序列的补体因子I轻链。 11，分子量22-24kD，pI为4.7-5.7; 具有SEQ ID NO：1的氨基酸序列的性激素结合球蛋白。 12，分子量43-45kD，pI为5.7-6.7; 具有SEQ ID NO：1的氨基酸序列的载脂蛋白E。 13，分子量35-37kD，pI为5.2-6.2; 和具有SEQ ID NO：1的氨基酸序列的血浆谷胱甘肽过氧化物酶前体。 14，分子量25-27kD，pI为7.7-8.7。

公开(公告)号：KR101442315B1

公开(公告)日：2014-09-24

申请号：KR1020110017757

申请日：2011-02-28

Applicant: 고려대학교 산학협력단

Inventor： 김찬화 ,  김상훈 ,  장영우 ,  김현정

IPC: A61K31/35 ,  A61P3/10 ,  A61P3/00

Abstract: 본 발명은 화학식 1로 표시되는 워트마닌(wortmannin), 유사체 또는 그의 약학적으로 허용가능한 염을 유효성분으로 함유하는 당뇨병성 신증 개선 및 치료용 약학적 조성물을 제공한다. 상술한 본 발명에 의하면 PI3K 억제를 통한 신보호 효과에 의해, 알부민뇨 및 알부민-크레아티닌 비를 현저하게 감소시킬 수 있고, 당뇨병성 신증에서 나타나는 사구체의 조직병리학적 회복을 유도하여 당뇨병성 신증을 효율적으로 개선 및 치료할 수 있는 이점이 있다.

公开(公告)号：KR1020120136913A

公开(公告)日：2012-12-20

申请号：KR1020110056118

申请日：2011-06-10

Applicant: 고려대학교 산학협력단

Inventor： 김종승 ,  김현정 ,  정종화

IPC: G01N31/22 ,  C07D403/06 ,  G01N21/78 ,  G01N21/76

Abstract: PURPOSE: A chemical sensor for detecting cyanide ions is provided to effectively detect cyanide ions by UV/vis spectrum change and color change. CONSTITUTION: A bisindole derivative has selectivity to cyanide ions and has a structure represented by chemical formula 1. A chemical sensor for detecting cyanide ions includes a bisindole derivative which is anchored on a mesoporous silica nanoparticle represented by chemical formula 3. The chemical sensor is manufactured in the shape of a disk pellet. A method for detecting cyanide ions includes the UV/vis spectrum change or color change of the chemical sensor including the bisindole derivative.

Abstract translation: 目的：提供一种用于检测氰化物离子的化学传感器，以通过紫外/可见光谱变化和颜色变化来有效地检测氰离子。 构成：双吲哚衍生物对氰化物离子具有选择性，并且具有由化学式1表示的结构。用于检测氰化物离子的化学传感器包括锚定在由化学式3表示的介孔二氧化硅纳米颗粒上的双吲哚衍生物。化学传感器被制造 呈圆盘形状。 检测氰离子的方法包括包含双吲哚衍生物的化学传感器的UV / vis光谱变化或颜色变化。

公开(公告)号：KR1020110020454A

公开(公告)日：2011-03-03

申请号：KR1020090078071

申请日：2009-08-24

Applicant: 고려대학교 산학협력단

Inventor： 김종승 ,  김현정 ,  김자형

IPC: C07D311/06 ,  C07D407/04 ,  C07D407/02

Abstract: PURPOSE: A coumarin derivative with bivalent mercury ion selectivity is provided to ensure high solubility and high fluorescence intensity in low bivalent mercury ion concentration. CONSTITUTION: A coumarin derivative has a bivalent ion selectivity and is denoted by chemical formula 1. The coumarin derivative of chemical formula 1 is prepared by reacting a compound of chemical formula 2 with 1,2-ethandithiol according to reaction formula 1. The bivalent mercury ion is selectively detected using coumarin derivative of chemical formula 1. The detection of the bivalent mercury ion is performed by measuring UV ray absorbance of the coumarin derivative.

Abstract translation: 目的：提供具有二价汞离子选择性的香豆素衍生物，以确保低二价汞离子浓度下的高溶解度和高荧光强度。 香豆素衍生物具有二价离子选择性并由化学式1表示。化学式1的香豆素衍生物通过化学式2的化合物与1,2-乙二硫醇根据反应式1反应制备。二价汞 使用化学式1的香豆素衍生物选择性地检测离子。二价汞离子的检测通过测量香豆素衍生物的紫外线吸光度来进行。

公开(公告)号：KR1020100091695A

公开(公告)日：2010-08-19

申请号：KR1020090011008

申请日：2009-02-11

Applicant: 고려대학교 산학협력단

Inventor： 김종승 ,  김현정 ,  정효성

IPC: C07C235/68

Abstract: PURPOSE: Calix[4]arene derivatives are provided to obtain remarkable UV-vis absorbance change and fluorescence change when the calyx[4]arene derivatives form a complex with a fluorine ion(F^-) and to have excellent detection performance of the fluoride ion in an aqueous solution. CONSTITUTION: Calix[4]arene derivatives are marked by chemical formula 1 or chemical formula 2. The calix[4]arene derivatives have the selectivity for a fluoride ion(F^-). A method for detecting the fluorine ion detects the fluorine ion selectively using the calix[4]arene derivatives. The fluorine ion is detected through the measurement of color change of the combination of the calix[4]arene derivatives and the fluoride ion, UV-vis absorbance change, or fluorescence change.

Abstract translation: 目的：当花萼[4]芳烃衍生物与氟离子（F ^ - ）形成复合物时，提供Calix [4]芳族衍生物以获得显着的UV-vis吸光度变化和荧光变化，并具有优异的氟化物检测性能 离子在水溶液中。 组分：Calix [4]芳烃衍生物用化学式1或化学式2标记。杯[4]芳烃衍生物对氟离子（F ^ - ）具有选择性。 检测氟离子的方法使用杯[4]芳烃衍生物选择性地检测氟离子。 通过测量杯[4]芳烃衍生物和氟离子的组合，UV-vis吸光度变化或荧光变化的颜色变化来检测氟离子。

公开(公告)号：KR1020100049994A

公开(公告)日：2010-05-13

申请号：KR1020080109065

申请日：2008-11-04

Applicant: 고려대학교 산학협력단 ,  한국원자력연구원

Inventor： 김종승 ,  김현정 ,  김하석 ,  김양래 ,  이일희 ,  김광욱

IPC: C07D491/10 ,  C07D491/02

Abstract: PURPOSE: A rhodamine derivative with copper ion selectivity and a method for detecting copper ion using the same are provided to change UV/vis absorbance and fluorescence. CONSTITUTION: A rhodamine derivative has copper ion selectivity and is denoted by chemical formula 1. The rhodamine derivative is fixed on a platinum film for copper ion detection. The copper ion is detected using rhodamine derivative. The copper ion detection is performed by measuring UV/Vis absorbance or fluorescence change. The ion detection is performed in organic solvent or aqueous solution.

Abstract translation: 目的：提供具有铜离子选择性的罗丹明衍生物和使用其的铜离子检测方法以改变UV / vis吸光度和荧光。 构成：罗丹明衍生物具有铜离子选择性，并由化学式1表示。罗丹明衍生物固定在铂膜上用于铜离子检测。 使用罗丹明衍生物检测铜离子。 通过测量UV / Vis吸光度或荧光变化来进行铜离子检测。 离子检测在有机溶剂或水溶液中进行。

公开(公告)号：KR1020100044492A

公开(公告)日：2010-04-30

申请号：KR1020080103647

申请日：2008-10-22

Applicant: 고려대학교 산학협력단

Inventor： 김종승 ,  김현정 ,  이종해

IPC: C07D249/10

Abstract: PURPOSE: A coumarin derivative including a copper ion detecting property is provided to use the derivative as a high-sensitivity fluorescence crane sensor for detecting copper ion with an excellent fluorescence emission phenomenon. CONSTITUTION: A coumarin derivative marked as the chemical formula 1 includes a copper ion detecting property. The coumarin derivative is produced by reacting 7-diethylaminocourmarin-3-aldehyde and 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol. The detection of a copper ion is performed by measuring the change of fluorescence by the formation of a complex of the coumarin derivative and the copper ion. A selective detection method of the copper ion comprises the following steps: radiating a solution including a metal ion after adding a coumarin derivative solution to excite the solution; and measuring the fluorescence emitted from the solution.

Abstract translation: 目的：提供一种包含铜离子检测性质的香豆素衍生物，以使用该衍生物作为高灵敏度荧光起重机传感器，用于检测具有优异荧光发射现象的铜离子。 构成：标记为化学式1的香豆素衍生物包括铜离子检测性质。 香豆素衍生物通过7-二乙基氨基嘌呤-3-醛和4-氨基-5-苯基-4H-1,2,4-三唑-3-硫醇反应制备。 通过形成香豆素衍生物和铜离子的络合物来测量荧光的变化来进行铜离子的检测。 铜离子的选择性检测方法包括以下步骤：在加入香豆素衍生物溶液以激发溶液之后辐射包含金属离子的溶液; 并测量从溶液中发出的荧光。

公开(公告)号：KR1020090047637A

公开(公告)日：2009-05-13

申请号：KR1020070113574

申请日：2007-11-08

Applicant: 재단법인서울대학교산학협력재단 ,  고려대학교 산학협력단

Inventor： 오석배 ,  정승준 ,  김성아 ,  안동국 ,  김현정 ,  나흥식

IPC: A61K31/12 ,  A61P25/04 ,  A61P29/00

CPC classification number: A61K31/12

Abstract: 본 발명은 커큐민 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 통증 예방 및 치료용 조성물에 관한 것으로, 본 발명에 따른 통증 예방 및 치료용 조성물은 온도, 캡사이신 및 산을 포함하는 다양한 자극 물질들에 의한 치통 및 염증을 포함하는 모든 통증들을 유발하는 TRPV1의 활성을 유의적으로 저해시켜 이에 의해 유발되는 통증을 효과적으로 저해할 수 있으며 천연물로부터 생산되기 때문에 생물학적 안정성이 높으므로 진통제, 통증 예방 및 개선용 기능성 치약, 기능성 식품 및 식품첨가제 등 통증 치료 및 완화용 제품에 유용하게 사용될 수 있다.
커큐민, 캡사이신 수용체, TRPV1/VR1, 통증 치료 약품, 통증 조절 식품

公开(公告)号：KR101047129B1

公开(公告)日：2011-07-07

申请号：KR1020080103647

申请日：2008-10-22

Applicant: 고려대학교 산학협력단

Inventor： 김종승 ,  김현정 ,  이종해

IPC: C07D249/10

Abstract: 본 발명은 구리 이온 선택성을 갖는 하기 화학식 (1)의 쿠마린(coumarin) 유도체, 이를 제조하는 방법, 이를 이용한 구리 이온 검출 방법 및 형광화학센서에 관한 것으로서, 더욱 상세하게는 구리 이온 선택성을 갖는 이미노-쿠마린(imino-coumarin: IC)이 구리 이온과 착물을 형성할 때 나타나는 형광 방출 증가를 이용하여 구리 이온을 검출하는 방법에 관한 것이다.

(1)
쿠마린, 구리 이온, 화학센서