公开(公告)号：KR101129365B1

公开(公告)日：2012-03-26

申请号：KR1020090072793

申请日：2009-08-07

Applicant: 고려대학교 산학협력단

Inventor： 이상헌 ,  설동근 ,  태기융 ,  황선욱 ,  더비,리차드 ,  강석

IPC: A61K9/16 ,  A61K31/165 ,  A61P19/00

Abstract: 본 발명은 캡사이신이 포집된 생분해성 고분자 나노입자를 포함하는 것을 특징으로 하는 추간판 질환용 서방성 치료제 및 이의 제조방법에 관한 것이다.
캡사이신, 나노입자

公开(公告)号：KR1020110094265A

公开(公告)日：2011-08-23

申请号：KR1020110079278

申请日：2011-08-09

Applicant: 고려대학교 산학협력단

Inventor： 이상헌 ,  설동근 ,  태기융 ,  황선욱 ,  더비,리차드 ,  강석

IPC: A61K9/16 ,  A61K31/165 ,  A61P19/00

CPC classification number: A61K9/5192 ,  A61K9/5161 ,  A61K31/165

Abstract: PURPOSE: A sustained release therapeutic agent containing biodegradable polymer nanoparitcles for treating intervertebral disc diseases is provided. CONSTITUTION: A sustained release therapeutic agent for intervertebral disc diseases contains polylactic acid nanoparticles. The therapeutic agent further contains fibrin. A method for manufacturing the therapeutic agent comprises: a step of mixing a first solution containing polylactic acid, capsaicin, and organic solvent and a second solution containing PVA(polyvinyl alcohol) and soluble solvent; a step of treating by ultrasonic wave to form an oil-in-water emulsion; and a step of removing the organic solvent from the emulsion.

Abstract translation: 目的：提供含有用于治疗椎间盘疾病的可生物降解的聚合物纳米颗粒的缓释治疗剂。 构成：椎间盘疾病的缓释治疗剂含有聚乳酸纳米粒子。 治疗剂还含有纤维蛋白。 制备治疗剂的方法包括：将含有聚乳酸，辣椒素和有机溶剂的第一溶液和含有PVA（聚乙烯醇）和可溶性溶剂的第二溶液混合的步骤; 通过超声波处理以形成水包油乳液的步骤; 以及从乳液中除去有机溶剂的步骤。

公开(公告)号：KR1020110064996A

公开(公告)日：2011-06-15

申请号：KR1020090121809

申请日：2009-12-09

Applicant: 고려대학교 산학협력단

Inventor： 설동근

IPC: G01N33/68 ,  G01N33/58

Abstract: PURPOSE: A proteomics biomarker for detecting phthalate exposure is provided to prevent or treat diseases occurrence by phthalate exposure. CONSTITUTION: A biomarker for detecting phthalate exposure contains Cystatin C, Rho-GDIα, Retinol Binding Protein, Gelsolin, DEK, Raf Kinase Inhibitor Protein, Triose Phosphate Inhibitor, Cofilin-1, or Haptoglobi. The phthalate is a compound of chemical formula 1. In chemical formula 1, R1 and R2 is independently C6-12 aryl-substituted or non-substituted alkyl of 1-24 carbon atoms or aryl of 6-12 carbon atoms. A protein array for detecting phthalate exposure contains the proteomics biomarker. The proteomics biomarker is isotope, Cy3, Cy5, FITC(poly L-lysine-fluorescein isothiocyanate), RITC(rhodamine-B-isothiocyanate), or rhodamine.

Abstract translation: 目的：提供检测邻苯二甲酸酯暴露的蛋白质组学生物标志物，以预防或治疗邻苯二甲酸酯暴露引起的疾病。 构成：用于检测邻苯二甲酸酯暴露的生物标志物包含半胱氨酸蛋白酶抑制剂C，Rho-GDIα，视黄醇结合蛋白，凝溶胶蛋白，DEK，Raf激酶抑制蛋白，磷酸三糖抑制剂，Cofilin-1或Haptoglobi。 邻苯二甲酸酯是化学式1的化合物。在化学式1中，R 1和R 2独立地是具有1-24个碳原子的C 6-8芳基取代或未取代的烷基或6-12个碳原子的芳基。 用于检测邻苯二甲酸酯暴露的蛋白质阵列含有蛋白质组学生物标志物。 蛋白质组学生物标志物是同位素，Cy3，Cy5，FITC（聚L-赖氨酸 - 异硫氰酸荧光素），RITC（罗丹明-B-异硫氰酸酯）或罗丹明。

公开(公告)号：KR100788789B1

公开(公告)日：2007-12-27

申请号：KR1020060082163

申请日：2006-08-29

Applicant: 고려대학교 산학협력단

Inventor： 설동근

IPC: C07K14/47

CPC classification number: G01N33/6893 ,  G01N2333/47 ,  G01N2333/75 ,  G01N2800/42

Abstract: A bio-marker protein in plasma is provided to diagnose exposure to formaldehyde and the degree of the exposure effectively. And an agent for diagnosing exposure to formaldehyde comprising an antibody against the same is provided. A bio-marker for diagnosing exposure to formaldehyde comprises a protein of which expression is changed in accordance to the formaldehyde exposure and which is selected from the group consisting of SNAP-23 having an amino acid sequence of SEQ ID : NO. 1, the molecular weight of 22-24kD and the pI of 4.3-5.3; apolipoprotein A-1 having an amino acid sequence of SEQ ID : NO. 2, the molecular weight of 29-31kD and the pI of 5.0-6.0; apolipoprotein E having an amino acid sequence of SEQ ID : NO. 3, the molecular weight of 34-36kD and the pI of 4.7-5.7; clusterin having an amino acid sequence of SEQ ID : NO. 4, the molecular weight of 24-26kD and the pI of 4.4-5.4; Fibrinogen gamma having an amino acid sequence of SEQ ID : NO. 5, the molecular weight of 49-51kD and the pI of 4.9-5.9; and kinesin having an amino acid sequence of SEQ ID : NO. 6, the molecular weight of 29-31kD, and the pI of 4.4-5.4. An agent for diagnosing exposure to formaldehyde comprises an antibody specifically binding to the protein as an effective ingredient.

Abstract translation: 提供血浆中的生物标记蛋白以有效地诊断甲醛的暴露程度和暴露程度。 并且提供了用于诊断暴露于甲醛的试剂，其包含针对其的抗体。 用于诊断甲醛暴露的生物标志物包括其表达根据甲醛暴露而改变的蛋白质，其选自由具有SEQ ID NO：1的氨基酸序列的SNAP-23组成的组。 1，分子量22-24kD，pI为4.3-5.3; 具有SEQ ID NO：1的氨基酸序列的载脂蛋白A-1。 2，分子量29-31kD，pI为5.0-6.0; 具有SEQ ID NO：1的氨基酸序列的载脂蛋白E。 3，分子量34-36kD，pI为4.7-5.7; 具有SEQ ID NO： 4，分子量24-26kD，pI为4.4-5.4; 具有SEQ ID NO：1的氨基酸序列的纤维蛋白原γ。 5，分子量为49-51kD，pI为4.9-5.9; 和具有SEQ ID NO：1的氨基酸序列的驱动蛋白。 6，分子量29-31kD，pI为4.4-5.4。 用于诊断甲醛暴露的试剂包括与蛋白质特异性结合的抗体作为有效成分。