-
公开(公告)号:KR101129365B1
公开(公告)日:2012-03-26
申请号:KR1020090072793
申请日:2009-08-07
Applicant: 고려대학교 산학협력단
IPC: A61K9/16 , A61K31/165 , A61P19/00
Abstract: 본 발명은 캡사이신이 포집된 생분해성 고분자 나노입자를 포함하는 것을 특징으로 하는 추간판 질환용 서방성 치료제 및 이의 제조방법에 관한 것이다.
캡사이신, 나노입자-
公开(公告)号:KR1020110094265A
公开(公告)日:2011-08-23
申请号:KR1020110079278
申请日:2011-08-09
Applicant: 고려대학교 산학협력단
IPC: A61K9/16 , A61K31/165 , A61P19/00
CPC classification number: A61K9/5192 , A61K9/5161 , A61K31/165
Abstract: PURPOSE: A sustained release therapeutic agent containing biodegradable polymer nanoparitcles for treating intervertebral disc diseases is provided. CONSTITUTION: A sustained release therapeutic agent for intervertebral disc diseases contains polylactic acid nanoparticles. The therapeutic agent further contains fibrin. A method for manufacturing the therapeutic agent comprises: a step of mixing a first solution containing polylactic acid, capsaicin, and organic solvent and a second solution containing PVA(polyvinyl alcohol) and soluble solvent; a step of treating by ultrasonic wave to form an oil-in-water emulsion; and a step of removing the organic solvent from the emulsion.
Abstract translation: 目的:提供含有用于治疗椎间盘疾病的可生物降解的聚合物纳米颗粒的缓释治疗剂。 构成:椎间盘疾病的缓释治疗剂含有聚乳酸纳米粒子。 治疗剂还含有纤维蛋白。 制备治疗剂的方法包括:将含有聚乳酸,辣椒素和有机溶剂的第一溶液和含有PVA(聚乙烯醇)和可溶性溶剂的第二溶液混合的步骤; 通过超声波处理以形成水包油乳液的步骤; 以及从乳液中除去有机溶剂的步骤。
-
-
公开(公告)号:KR101138317B1
公开(公告)日:2012-04-25
申请号:KR1020110079278
申请日:2011-08-09
Applicant: 고려대학교 산학협력단
IPC: A61K9/16 , A61K31/165 , A61P19/00
Abstract: 본 발명은 캡사이신이 포집된 생분해성 고분자 나노입자를 포함하는 것을 특징으로 하는 추간판 질환용 서방성 치료제 및 이의 제조방법에 관한 것이다.
-
公开(公告)号:KR1020110015197A
公开(公告)日:2011-02-15
申请号:KR1020090072793
申请日:2009-08-07
Applicant: 고려대학교 산학협력단
IPC: A61K9/16 , A61K31/165 , A61P19/00
CPC classification number: A61K9/5192 , A61K9/5161 , A61K31/165
Abstract: PURPOSE: A sustained release therapeutic agent for treating disk diseases containing biodegradable polymer nanoparticles and a method for manufacturing the same are provided to selectively remove painful nerve of dorsal root ganglia. CONSTITUTION: A sustained release therapeutic agent for treating disk diseases contains biodegradable polymer nanoparticles. The biodegradable nanoparticles are polylactic acid(PLLA), polylactic-glycolic copolymer(PLGA) polycarpropactan(PCL), polyglycolic acid(PGA), polylactic-caprolactan copolymer(PLCL) or polyglycolic-caprolactan copolymer(PGCL). The therapeutic agent further contains fibrin. A method for manufacturing the therapeutic agent comprises: a step of mixing a first solution containing biodegradable polymers, capsaicin and organic solvent and a second solution containing PVA(polyvinyl alcohol) and soluble solvent; a step of treating by ultrasonication to form oil-in-water emulsion; and a step of removing the organic solvent from the emulsion.
Abstract translation: 目的:提供一种用于治疗包含可生物降解的聚合物纳米颗粒的盘状疾病的缓释治疗剂及其制造方法,以选择性地去除背根神经节的疼痛神经。 构成:用于治疗椎间盘疾病的缓释治疗剂包含可生物降解的聚合物纳米颗粒。 可生物降解的纳米颗粒是聚乳酸(PLLA),聚乳酸 - 乙交酯共聚物(PLGA)聚丙交酯(PCL),聚乙醇酸(PGA),聚乳酸 - 己内酰胺共聚物(PLCL)或聚乙醇酸 - 己内酰胺共聚物(PGCL)。 治疗剂还含有纤维蛋白。 制造治疗剂的方法包括:将含有可生物降解的聚合物的第一溶液,辣椒素和有机溶剂与含有PVA(聚乙烯醇)和可溶性溶剂的第二溶液混合的步骤; 通过超声波处理形成水包油乳液的步骤; 以及从乳液中除去有机溶剂的步骤。
-
-
-
-