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公开(公告)号：KR101129365B1
公开(公告)日：2012-03-26
申请号：KR1020090072793
申请日：2009-08-07
Applicant: 고려대학교 산학협력단
IPC: A61K9/16 , A61K31/165 , A61P19/00
Abstract: 본 발명은 캡사이신이 포집된 생분해성 고분자 나노입자를 포함하는 것을 특징으로 하는 추간판 질환용 서방성 치료제 및 이의 제조방법에 관한 것이다.
캡사이신, 나노입자-
公开(公告)号：KR1020110094265A
公开(公告)日：2011-08-23
申请号：KR1020110079278
申请日：2011-08-09
Applicant: 고려대학교 산학협력단
IPC: A61K9/16 , A61K31/165 , A61P19/00
CPC classification number: A61K9/5192 , A61K9/5161 , A61K31/165
Abstract: PURPOSE: A sustained release therapeutic agent containing biodegradable polymer nanoparitcles for treating intervertebral disc diseases is provided. CONSTITUTION: A sustained release therapeutic agent for intervertebral disc diseases contains polylactic acid nanoparticles. The therapeutic agent further contains fibrin. A method for manufacturing the therapeutic agent comprises: a step of mixing a first solution containing polylactic acid, capsaicin, and organic solvent and a second solution containing PVA(polyvinyl alcohol) and soluble solvent; a step of treating by ultrasonic wave to form an oil-in-water emulsion; and a step of removing the organic solvent from the emulsion.
Abstract translation: 目的：提供含有用于治疗椎间盘疾病的可生物降解的聚合物纳米颗粒的缓释治疗剂。 构成：椎间盘疾病的缓释治疗剂含有聚乳酸纳米粒子。 治疗剂还含有纤维蛋白。 制备治疗剂的方法包括：将含有聚乳酸，辣椒素和有机溶剂的第一溶液和含有PVA（聚乙烯醇）和可溶性溶剂的第二溶液混合的步骤; 通过超声波处理以形成水包油乳液的步骤; 以及从乳液中除去有机溶剂的步骤。
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公开(公告)号：KR1020070073008A
公开(公告)日：2007-07-10
申请号：KR1020060000463
申请日：2006-01-03
Applicant: 고려대학교 산학협력단
IPC: C08B37/08
CPC classification number: C08B37/0072 , A61L27/20
Abstract: Provided are an acrylated hyaluronic acid derivative or its salt, its preparation method, a crosslinked hydrogel using the derivative or salt which can be injected in vivo and regenerates tissue with minimum damage, and a composition for regenerating tissue or preventing re-adsorption containing the hydrogel. The acrylated hyaluronic acid derivative is represented by the formula(1), wherein R is -NH-CO-(CH2)n-CO-NH-; and n is 4-8. The acrylated hyaluronic acid derivative is prepared by reacting hyaluronic acid and a diamine represented by H2N-R-NH2 in the presence of a polymerizing agent; and reacting the obtained one with an acrylating agent. Preferably the acrylating agent is N-acryloxysuccinimide. The hydrogel is prepared by crosslinking the acrylated hyaluronic acid derivative of the formula(1) or its salt with a crosslinking agent having a thiol group.
Abstract translation: 提供了一种丙烯酸酯化透明质酸衍生物或其盐，其制备方法，使用可以在体内注射并且以最小损伤再生组织的衍生物或盐的交联水凝胶，以及用于再生组织或防止含有水凝胶的再吸附的组合物 。 丙烯酸酯化透明质酸衍生物由式（1）表示，其中R是-NH-CO-（CH 2）n -CO-NH-; n为4-8。 丙烯酸酯化的透明质酸衍生物通过使透明质酸和由H 2 N-R-NH 2表示的二胺在聚合剂的存在下反应制备; 并使所得到的与丙烯酸酯化剂反应。 优选地，丙烯酸酯化剂是N-丙烯酰氧基琥珀酰亚胺。 水凝胶的制备方法是将具有式（1）的丙烯酸酯化透明质酸衍生物或其盐与具有硫醇基的交联剂交联。
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Patent Agency Ranking
公开(公告)号：KR101138317B1
公开(公告)日：2012-04-25
申请号：KR1020110079278
申请日：2011-08-09
Applicant: 고려대학교 산학협력단
IPC: A61K9/16 , A61K31/165 , A61P19/00
Abstract: 본 발명은 캡사이신이 포집된 생분해성 고분자 나노입자를 포함하는 것을 특징으로 하는 추간판 질환용 서방성 치료제 및 이의 제조방법에 관한 것이다.
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公开(公告)号：KR1020110015197A
公开(公告)日：2011-02-15
申请号：KR1020090072793
申请日：2009-08-07
Applicant: 고려대학교 산학협력단
IPC: A61K9/16 , A61K31/165 , A61P19/00
CPC classification number: A61K9/5192 , A61K9/5161 , A61K31/165
Abstract: PURPOSE: A sustained release therapeutic agent for treating disk diseases containing biodegradable polymer nanoparticles and a method for manufacturing the same are provided to selectively remove painful nerve of dorsal root ganglia. CONSTITUTION: A sustained release therapeutic agent for treating disk diseases contains biodegradable polymer nanoparticles. The biodegradable nanoparticles are polylactic acid(PLLA), polylactic-glycolic copolymer(PLGA) polycarpropactan(PCL), polyglycolic acid(PGA), polylactic-caprolactan copolymer(PLCL) or polyglycolic-caprolactan copolymer(PGCL). The therapeutic agent further contains fibrin. A method for manufacturing the therapeutic agent comprises: a step of mixing a first solution containing biodegradable polymers, capsaicin and organic solvent and a second solution containing PVA(polyvinyl alcohol) and soluble solvent; a step of treating by ultrasonication to form oil-in-water emulsion; and a step of removing the organic solvent from the emulsion.
Abstract translation: 目的：提供一种用于治疗包含可生物降解的聚合物纳米颗粒的盘状疾病的缓释治疗剂及其制造方法，以选择性地去除背根神经节的疼痛神经。 构成：用于治疗椎间盘疾病的缓释治疗剂包含可生物降解的聚合物纳米颗粒。 可生物降解的纳米颗粒是聚乳酸（PLLA），聚乳酸 - 乙交酯共聚物（PLGA）聚丙交酯（PCL），聚乙醇酸（PGA），聚乳酸 - 己内酰胺共聚物（PLCL）或聚乙醇酸 - 己内酰胺共聚物（PGCL）。 治疗剂还含有纤维蛋白。 制造治疗剂的方法包括：将含有可生物降解的聚合物的第一溶液，辣椒素和有机溶剂与含有PVA（聚乙烯醇）和可溶性溶剂的第二溶液混合的步骤; 通过超声波处理形成水包油乳液的步骤; 以及从乳液中除去有机溶剂的步骤。
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公开(公告)号：KR101044599B1
公开(公告)日：2011-06-29
申请号：KR1020090072792
申请日：2009-08-07
Applicant: 고려대학교 산학협력단
Abstract: 본 발명은 말단에 광가교결합 가능한 작용기를 갖는 수용성의 생체적합성 중합체를 가교결합시켜 제조된 온도변화에 따라 직경이 변화하는 온도민감성 나노운반체 및 상기 나노운반체 내에 포함된 카이모파파인(chymopapain)을 포함하는 것을 특징으로 하는 추간판용 서방성 치료제 및 이의 제조방법에 관한 것이다.
카이모파파인, 나노운반체-
公开(公告)号：KR1020110015196A
公开(公告)日：2011-02-15
申请号：KR1020090072792
申请日：2009-08-07
Applicant: 고려대학교 산학협력단
CPC classification number: A61K38/4873 , A61K9/0002 , A61K9/1641 , A61K47/34 , B82Y5/00
Abstract: PURPOSE: A sustained release therapeutic agent for an intervertebral disc containing temperature-sensitive nano-carriers and chymopapain and a method for manufacturing the same are provided to preserve normal disc. CONSTITUTION: A sustained release therapeutic agent for an intervertebral disc contains: temperature-sensitive nano-carriers which is obtained by cross-linking soluble biocompatible polymers having a photo-crosslinkable functional group and chemopapain contained in the nano-carrier. The functional group is acrylate, diacrylate, oligoacrylate, methacrylate, dimethacylate, oligomethacrylate, coumarin, thyamine or cinnamate.
Abstract translation: 目的：提供用于含有温度敏感性纳米载体和木瓜凝乳蛋白酶的椎间盘的缓释治疗剂及其制造方法以保持正常的椎间盘。 构成：用于椎间盘的持续释放治疗剂包含：通过交联具有光可交联官能团的可溶性生物相容性聚合物和包含在纳米载体中的化学发光蛋白得到的温度敏感性纳米载体。 官能团为丙烯酸酯，二丙烯酸酯，低聚丙烯酸酯，甲基丙烯酸酯，二甲基丙烯酸酯，低聚甲基丙烯酸酯，香豆素，甲胺或肉桂酸酯。
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公开(公告)号：KR100737954B1
公开(公告)日：2007-07-13
申请号：KR1020060000463
申请日：2006-01-03
Applicant: 고려대학교 산학협력단
IPC: C08B37/08
Abstract: 본 발명은 아크릴화된 히알루론산 유도체 또는 이의 염, 이를 사용하여 제조된 하이드로겔, 이들의 제조 방법, 및 상기한 하이드로겔을 포함하는 조직 재생용 조성물에 관한 것이다. 본 발명의 하이드로겔은 생체 내 주사가 가능하여 결손 부위에 최소의 손상을 주면서 조직을 재생시키는데 이용할 수 있다.
히알루론산 유도체, 하이드로겔, 조직 재생
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