公开(公告)号：KR1020110132080A

公开(公告)日：2011-12-07

申请号：KR1020100051895

申请日：2010-06-01

Applicant: 대구가톨릭대학교산학협력단

Inventor： 우미희 ,  최재수

IPC: C07C59/76 ,  A61K36/04 ,  A61K31/201

CPC classification number: C07C59/76 ,  A61K31/201 ,  A61K36/04

Abstract: PURPOSE: A compound from gloiopeltis furcata is provided to use as a treatment of Alzheimer's disease due to the anticholinesterase-activity by moderate activity about acetylcholinesterase and butylcholinesterase. CONSTITUTION: A compound from gloiopeltis furcata, which is (5E, 7E)-9-oxodeca-5,7-dienoic acid or a pharmaceutical thereof, is in the chemical formula 11. A composition for preventing and curing of Alzheimer's disease comprises one or more compounds selected from 2-(3-hydroxy-5-oxotetrahydrofuran-3-yl) acetic acid, glutaric acid, succinic acid, nicotinic acid, (E)-4-hydroxyhex-2-enoicacid, cholesterol, 7-hydroxycholesterol, uridine, glycerol, 5-(hydroxymethyl)-2-methoxybenzene-1,3-diol, (5E,7E)-9-oxodeca-5,7-dienoic acid, (Z)-3-ethylidene-4-methylpyrrolidine-2,5-dione, dehydrovomifoliol, loliolide, cholesterylstearate, palmitic acid, cis-5,8,11,14,17-eicosapentaenoic acid, and α-linolenic acid.

Abstract translation: 目的：提供来自gloiopeltis furcata的化合物作为阿尔茨海默病的治疗，由于通过对乙酰胆碱酯酶和丁基胆碱酯酶的中等活性的抗胆碱酯酶活性。 构成：作为（5E，7E）-9-十二碳-5,7-二烯酸或其药物的来自丝状毛癣菌的化合物在化学式11中。用于预防和治愈阿尔茨海默氏病的组合物包括一种或 更多的选自2-（3-羟基-5-氧代四氢呋喃-3-基）乙酸，戊二酸，琥珀酸，烟酸，（E）-4-羟基己-2-烯酸，胆固醇，7-羟基胆固醇，尿苷 ，甘油，5-（羟甲基）-2-甲氧基苯-1,3-二醇，（5E，7E）-9-氧代癸-5,7-二烯酸，（Z）-3-亚乙基-4-甲基吡咯烷-2， 顺式-5,8,11,14,17-二十碳五烯酸，α-亚麻酸，顺式-5,8,11,14,17-二十碳五烯酸和α-亚麻酸。

公开(公告)号：KR101786999B1

公开(公告)日：2017-10-18

申请号：KR1020160127340

申请日：2016-10-04

Applicant: 대구가톨릭대학교산학협력단

Inventor： 우미희 ,  정수양 ,  최재수

IPC: A61K31/56 ,  A61K31/19 ,  A61K31/7048 ,  A61K36/37 ,  A23L33/10 ,  A23L33/105

Abstract: 본발명은귀전우로부터분리된화합물을포함하는대사성질환의예방또는치료용조성물에관한것이다. 상기귀전우로부터분리된화합물은단백질타이로신탈인산화효소 1B 또는알파-글루코시다아제의저해활성이우수하여당뇨병또는비만의예방또는치료용조성물로유용하게사용될수 있다.

公开(公告)号：KR101783309B1

公开(公告)日：2017-10-10

申请号：KR1020150065093

申请日：2015-05-11

Applicant: 대구가톨릭대학교산학협력단

Inventor： 우미희 ,  최재수

IPC: A61K36/88 ,  A61K31/365 ,  A61K31/70 ,  A61K31/7034 ,  A23L1/30

Abstract: 본발명은자주색만년초추출물또는이로부터분리된화합물을포함하는대사성질환의예방또는치료용조성물에관한것이다. 상기자주색만년초추출물또는이로부터분리된화합물은단백질타이로신탈인산화효소 1B의저해효과가우수하여대사성질환의예방또는치료용조성물로유용하게사용될수 있다.

公开(公告)号：KR101686537B1

公开(公告)日：2016-12-14

申请号：KR1020150045952

申请日：2015-04-01

Applicant: 대구가톨릭대학교산학협력단

Inventor： 우미희 ,  정수양 ,  최재수

IPC: A61K31/56 ,  A61K31/19 ,  A61K31/7048 ,  A61K36/37 ,  A23L1/30

Abstract: 본발명은귀전우로부터분리된화합물을포함하는대사성질환의예방또는치료용조성물에관한것이다. 상기귀전우로부터분리된화합물은단백질타이로신탈인산화효소 1B 또는알파-글루코시다아제의저해활성이우수하여당뇨병또는비만의예방또는치료용조성물로유용하게사용될수 있다.

公开(公告)号：KR1020160122928A

公开(公告)日：2016-10-25

申请号：KR1020150052664

申请日：2015-04-14

Applicant: 대구가톨릭대학교산학협력단

Inventor： 민병선 ,  최재수

IPC: A61K36/11 ,  A61K31/352 ,  A61K31/7034 ,  A23L1/30

CPC classification number: A61K31/352 ,  A61K31/7034 ,  A61K36/11

Abstract: 본발명은석송강추출물또는이로부터분리된화합물을포함하는알츠하이머병의예방또는치료용조성물에관한것이며, 상기석송강추출물또는이로부터분리된화합물은아세틸콜린에스테라아제, 부티릴콜린에스테라아제및 β-세크레타제 1의억제효과가우수하여알츠하이머병의예방또는치료용조성물로유용하게사용될수 있다.

Abstract translation: 本发明eunseok松江提取物或指向的组合物用于预防或治疗阿尔茨海默氏病，其包括从该分离的化合物中，石松提取，或从分离的化合物是乙酰胆碱酯酶，丁酰基胆碱酯酶和β-分泌酶 所述第一的抑制效果更优异，并且可以用作预防或治疗阿尔茨海默氏病的组合物是有用的。

公开(公告)号：KR1020150137253A

公开(公告)日：2015-12-09

申请号：KR1020140064786

申请日：2014-05-29

Applicant: 대구가톨릭대학교산학협력단

Inventor： 최재수 ,  우미희 ,  한유란

IPC: A23L33/00

CPC classification number: A23L33/00

Abstract: 본발명은톳() 추출물의디클로로메탄또는에틸아세테이트분획물을유효성분으로함유하는당뇨예방또는개선용건강식품조성물및 약학조성물과톳을에탄올로추출한추출물을디클로로메탄또는에틸아세테이트로분획하여제조하는것을특징으로하는항당뇨활성이증진된톳 분획물의제조방법에관한것이다.

Abstract translation: 本发明涉及一种健康功能食品组合物和用于预防或改善含有Hizikia fusiformis提取物的二氯甲烷馏分或乙酸乙酯部分作为活性成分的糖尿病的药物组合物，以及用于制备具有增强作用的Hizikia fusiformis级分的方法 抗糖尿病活性，其通过使用乙醇分离用二氯甲烷或乙酸乙酯萃取的Hizikia fusiformis提取物来制备Hizikia梭形梭菌馏分。

公开(公告)号：KR1020130140448A

公开(公告)日：2013-12-24

申请号：KR1020120063862

申请日：2012-06-14

Applicant: 부경대학교 산학협력단 ,  대구가톨릭대학교산학협력단

Inventor： 정현아 ,  우미희 ,  김형락 ,  우희철 ,  최재수

IPC: A61K36/05 ,  A61P3/10 ,  A61P3/00

Abstract: The present invention relates to novel uses of capsosiphon fulvescens extract or compounds isolated therefrom for preventing or treating diabetic complications and, more specifically, to a pharmaceutical composition and a health supplement for preventing or treating diabetic complications which include capsosiphon fulvescens extract, soluble extract of non-polar solvent, or compounds isolated therefrom (capsofulvesin A, capsofulvesin B, chalinasterol) as active ingredients. The capsosiphon fulvescens extracts or compounds isolated therefrom (capsofulvesin A, capsofulvesin B, chalinasterol) have excellent suppression activities on aldose reductase and excellent suppression activities on final glycation products. Therefore, the capsosiphon fulvescens extracts or compounds isolated therefrom can be utilized as medicines such as pharmaceutical compositions and health supplements for preventing or treating diabetic complications so that the value of the capsosiphon fulvescens extracts or compounds isolated therefrom can be extremely high when applying in food and medical industries. Specially, the capsosiphon fulvescens extracts or compounds isolated therefrom in the present invention are substances derived from natural substances and have stability without cytotoxicity so that the compositions of the present invention which includes the same as active ingredients can be safely used for long time.

Abstract translation: 本发明涉及一种用于预防或治疗糖尿病并发症的胆红素提取物或其分离的化合物的新用途，更具体地，涉及用于预防或治疗糖尿病并发症的药物组合物和健康补充剂，其包括辣椒皂苷提取物，非可溶性提取物， - 极性溶剂，或从其分离的化合物（海藻多柔比星A，棉铃藓素B，沙拉宁醇）作为活性成分。 辣椒油提取物或从其中分离的化合物（海藻多糖A，血浆壳多糖B，沙利度醇）对醛糖还原酶具有优异的抑制活性，对最终糖基化产物具有优异的抑制活性。 因此，辣椒油提取物或其分离的化合物可用作药物，例如用于预防或治疗糖尿病并发症的药物组合物和健康补充剂，从而当应用于食物中时，辣椒素提取物或从其分离的化合物的值可能非常高 医疗行业。 特别地，在本发明中，辣椒油提取物或从其分离的化合物是天然物质衍生的物质，具有稳定性而没有细胞毒性，因此本发明的包含与活性成分相同的组合物可以长时间安全使用。

公开(公告)号：KR101178500B1

公开(公告)日：2012-09-07

申请号：KR1020100051895

申请日：2010-06-01

Applicant: 대구가톨릭대학교산학협력단

Inventor： 우미희 ,  최재수

IPC: C07C59/76 ,  A61K36/04 ,  A61K31/201

Abstract: 본 발명은 불등가사리로부터 분리한 신규한 화학식 11의 화합물과 공지의 화합물 2 내지 18 및 이들을 유효성분으로 함유하여 항콜린에스테라아제 활성을 통한 알츠하이머 질환의 예방 또는 치료용 약제학적 조성물 및 알츠하이머 질환의 예방 또는 개선용 건강기능식품 조성물에 관한 것으로, 본 발명에 따른 상기 불등가사리 유래 화합물들은 적절한 아세틸콜린에스테라아제(AChE) 및 부틸콜린에스테라아제(BChE)에 대한 저해 활성을 통한 항콜린에스테라아제 활성을 나타냄으로써 알츠하이머 질환의 예방 및 치료를 잠재적 치료제로서 이용할 수 있는 효과가 있다.

公开(公告)号：KR100908038B1

公开(公告)日：2009-07-15

申请号：KR1020070091964

申请日：2007-09-11

Applicant: 대구가톨릭대학교산학협력단

Inventor： 최재수 ,  우미희

IPC: A61K36/03 ,  A61P3/10

Abstract: An Ecklonia stolonifera extract is provided to have aldose reductase and activity of inhibiting production of advanced glycation end product and diabetic complication and to be safe without toxicity and side effect. An Ecklonia stolonifera extract has aldose reductase and activation of inhibiting production of advanced glycation end product. The Ecklonia stolonifera extract is an Ecklonia stolonifera crude extract by extracting the Ecklonia stolonifera with lower alcohol of C1~C4. The Ecklonia stolonifera crude extract is Ecklonia stolonifera methanol extract.

Abstract translation: 提供了Ecklonia stolonifera提取物以具有醛糖还原酶和抑制晚期糖基化终产物产生和糖尿病并发症的活性，并且是安全的，没有毒性和副作用。 Ecklonia stolonifera提取物具有醛糖还原酶和抑制晚期糖基化终产物生成的活化。 Ecklonia stolonifera提取物是一种Ecklonia stolonifera粗提物，通过用C1〜C4的低级醇提取Ecklonia stolonifera。 Ecklonia stolonifera粗提物是Ecklonia stolonifera甲醇提取物。