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    암억제 단백질을 발현하는 알파바이러스계 발현 벡터,이의 제조 방법 및 용도
    21.
    发明公开
    암억제 단백질을 발현하는 알파바이러스계 발현 벡터,이의 제조 방법 및 용도 有权
    基于ALPHAVIRUS的表达载体表达肿瘤抑制蛋白，其制备方法及其用途同时显示各种肿瘤抑制蛋白和有效抑制肿瘤的作用

    公开(公告)号：KR1020040077600A

    公开(公告)日：2004-09-04

    申请号：KR1020040060593

    申请日：2004-07-30

    Applicant: 충남대학교산학협력단

    Inventor： 김철중 ,  이승훈 ,  홍석일 ,  부하령 ,  신광순 ,  이종수

    IPC: A61K48/00 ,  C12N15/86

    CPC classification number: A61K48/00 ,  A61K2039/585 ,  C12N15/85

    Abstract: PURPOSE: Alphavirus-based expression vectors expressing tumor suppressor proteins, a method for preparing the same and the use thereof are provided, thereby simultaneously expressing various tumor suppressor proteins, and consequently suppressing tumor effectively. CONSTITUTION: The alphavirus-based expression vector expressing tumor suppressor proteins comprises a first tumor suppressing gene or angiogenesis suppressing gene which is operably linked to a first subgenomic promoter; a second tumor suppressing gene or angiogenesis suppressing gene which is operably linked to a second subgenomic promoter; and a third tumor suppressing gene or angiogenesis suppressing gene which is operably linked to a third subgenomic promoter, wherein the first, second and third tumor suppressing genes or angiogenesis suppressing genes are the same or different; the tumor suppressing gene is p53 gene or PTEN gene; the antigiogenesis suppressing gene is angiostatin gene; and the alphavirus-based expression vector expresses tumor suppressor proteins Semliki forest virus(SFV) and Sindbis virus.

    Abstract translation: 目的：提供表达肿瘤抑制蛋白的基于甲病毒的表达载体，其制备方法及其用途，同时表达各种肿瘤抑制蛋白，从而有效抑制肿瘤。 构成：表达肿瘤抑制蛋白的基于甲病毒的表达载体包含与第一亚基因组启动子有效连接的第一肿瘤抑制基因或血管发生抑制基因; 与第二亚基因组启动子可操作地连接的第二肿瘤抑制基因或血管发生抑制基因; 和与第三亚基因组启动子可操作地连接的第三肿瘤抑制基因或血管发生抑制基因，其中第一，第二和第三肿瘤抑制基因或血管发生抑制基因相同或不同; 肿瘤抑制基因是p53基因或PTEN基因; 抗血管生成抑制基因是血管抑素基因; 并且基于甲病毒的表达载体表达肿瘤抑制蛋白Semliki森林病毒（SFV）和辛德毕斯病毒。

    의료용 접착제 조성물
    24.
    发明公开
    의료용 접착제 조성물 有权
    医用胶组合物

    公开(公告)号：KR1020120050354A

    公开(公告)日：2012-05-18

    申请号：KR1020100111804

    申请日：2010-11-10

    Applicant: 주식회사 바이오리더스 ,  국민대학교산학협력단 ,  충남대학교산학협력단 ,  한국생명공학연구원

    Inventor： 성문희 ,  우야마히로시 ,  미에이와모토 ,  최재철 ,  부하령 ,  김철중

    IPC: C09J177/04 ,  C09J11/06 ,  A61L15/58 ,  A61F13/02

    CPC classification number: A61L24/046 ,  A61L15/58 ,  C08K5/053 ,  C08K5/1545 ,  C09J177/04 ,  C08L77/04

    Abstract: PURPOSE: A medical adhesive composition is provided to use poly-gamma-glutamic acid, thereby having edible, water-soluble, anionic, biodegradable properties. CONSTITUTION: A medical adhesive composition comprises poly-gamma-glutamic acid or salt thereof, and sugar or sugar alcohol. The poly-gamma-glutamic acid salt is selected from sodium polyglutamate, polyglutamic acid potassium salt, polyglutamic acid calcium salt, and polyglutamic acid ammonium sat, and polyglutamic acid zinc salt. The molecular weight of the poly-gamma-glutamic acid and salt thereof is 1-15,000 kDa. The salt is selected fructose, glucose, mannose, sucrose, maltose, trehalose, oligosaccharide, starch and maltodextrin. The sugar alcohol is selected from xylitol, lactitol, isomalt, sorbitol, maltitol, and glycerol.

    Abstract translation: 目的：提供一种医用粘合剂组合物，以使用聚-γ-谷氨酸，从而具有食用，水溶性，阴离子，可生物降解的特性。 构成：医用粘合剂组合物包含聚-γ-谷氨酸或其盐，以及糖或糖醇。 聚-γ-谷氨酸盐选自聚谷氨酸钠，聚谷氨酸钾盐，聚谷氨酸钙盐和聚谷氨酸铵sat，以及聚谷氨酸锌盐。 聚-γ-谷氨酸及其盐的分子量为1-15,000kDa。 选择果糖，葡萄糖，甘露糖，蔗糖，麦芽糖，海藻糖，寡糖，淀粉和麦芽糖糊精。 糖醇选自木糖醇，乳糖醇，异麦芽酮糖醇，山梨糖醇，麦芽糖醇和甘油。

    김치유래 락토바실러스 플란타룸 ＢＬＳ４１ 및 그 용도
    30.
    发明公开
    김치유래 락토바실러스 플란타룸 ＢＬＳ４１ 및 그 용도 有权
    来自KIMCHI的LACTOBACILLUS PLANTARUM BLS41及其使用

    公开(公告)号：KR1020090086796A

    公开(公告)日：2009-08-14

    申请号：KR1020080012264

    申请日：2008-02-11

    Applicant: 주식회사 바이오리더스 ,  한국생명공학연구원 ,  충남대학교산학협력단

    Inventor： 성문희 ,  김철중 ,  성문석 ,  부하령 ,  강윤환

    IPC: C12N1/20 ,  C12N1/00

    CPC classification number: C12R1/25 ,  A01N63/00 ,  A23K10/18

    Abstract: A novel Lactobacillus plantarum BLS41 which is derived from Kimchi is provided to have antifungal and antibacterial activities and use as an ingredient of eco-friendly microorganism agent. A Lactobacillus plantarum BLS41(KCTC 11056BP) which is derived from Kimchi has antifungal or anti-pathogenic acitivies. The antifungal agent comprises Lactobacillus plantarum BLS41(KCTC 11056BP) or its culture product. The antifungal agent is produced in a form of liquid suspension, stabilized liquid suspension, emulsified concentrate, capsule, aqueous flowables, dry flowables, or granule. The fungus is Erwinia sp., Pseudomonas sp., or Fusarium sp.

    Abstract translation: 提供一种源自泡菜的植物乳杆菌BLS41，具有抗真菌和抗菌活性，作为环保微生物剂的成分。 源自泡菜的植物乳杆菌BLS41（KCTC 11056BP）具有抗真菌或抗病原体活性。 抗真菌剂包括植物乳杆菌BLS41（KCTC 11056BP）或其培养产物。 抗真菌剂以液体悬浮液，稳定化液体悬浮液，乳化浓缩物，胶囊，水性流动剂，干燥流动剂或颗粒的形式制备。 真菌是欧文氏菌属，假单胞菌属或镰刀菌属。

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