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公开(公告)号：KR1020140025914A
公开(公告)日：2014-03-05
申请号：KR1020120092486
申请日：2012-08-23
Applicant: 부경대학교 산학협력단
IPC: A61K31/336 , A61K36/03 , A61P3/10
Abstract: The present invention relates to novel uses of prevention or treatment of diabetic complications of fucoxanthin, specifically, to a pharmaceutical composition for preventing or treating (improving) diabetic complications which includes fucoxanthin derived from sea brown algae such as Eiseniabicyclis, Undariapinnatifida or Hijikiafusiformis as active ingredients, to health supplement, and to insulin sensitive enhancer. The fucoxanthin of the present invention has enhanced inhibition activities of aldose reductase and advanced glycation end-products, and improves insulin resistance by increasing insulin signal transduction through PTP1B suppression activities. Therefore, the fucoxanthin of the present invention can be utilized as a drug such as pharmaceutical composition and health supplement which can prevent or treat the diabetic complications so that the fucoxanthin has greatly high value if applied to food and medicine industries. Especially, the fucoxanthin of the present invention has safety without cytotoxicity as a material derived from natural material so that the composition including the same as the active ingredient can be safe for long term use.
Abstract translation: 本发明涉及预防或治疗岩藻黄素的糖尿病并发症的新用途，具体地，涉及用于预防或治疗（改善）糖尿病并发症的药物组合物，其包括衍生自海藻褐藻类的藻黄素，例如茜草属，，ida ida或Hijikia fusiformis作为活性成分 ，健康补充剂和胰岛素敏感增强剂。 本发明的岩藻黄质具有增强的醛糖还原酶和晚期糖基化终产物的抑制活性，并且通过PTP1B抑制活性增加胰岛素信号转导来改善胰岛素抵抗。 因此，本发明的岩藻黄质可以用作可以预防或治疗糖尿病并发症的药物，例如药物组合物和健康补充剂，如果应用于食品和药物工业，则岩藻黄质具有非常高的价值。 特别地，本发明的岩藻黄质具有安全性而没有细胞毒性作为源自天然材料的材料，因此含有活性成分的组合物对于长期使用来说是安全的。
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22.发明授权알콜성 간손상에 대한 간보호 활성을 지닌 곰피 또는 감태의 주정 추출물과 그로부터 분리한 플로로탄닌류를 함유하는 간보호용 조성물 有权从Ecklonia stolonifera或E.cava分离的乙醇级分，乙酸乙酯级分和氯光亮素用于肝脏保护酒精性肝损伤，并将其用作肝保护
公开(公告)号：KR101301190B1
公开(公告)日：2013-08-29
申请号：KR1020110039212
申请日：2011-04-26
Applicant: 부경대학교 산학협력단
Abstract: 본 발명은 곰피 또는 감태 주정 추출물로부터 분리된 플로로탄닌류를 함유하는 알콜성 간손상에 대한 간보호용 조성물에 관한 것으로, 보다 구체적으로는 곰피 또는 감태 주정 추출물에 함유된 플로로탄닌류가 알콜에 의한 HepG2 간세포 손상에 대하여 간세포 사멸 억제효과를 갖는 간 보호용 조성물에 관한 것이다.
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23.发明公开알콜성 간손상에 대한 간보호 활성을 지닌 곰피 또는 감태의 주정 추출물과 그로부터 분리한 플로로탄닌류를 함유하는 간보호용 조성물 有权从Ecklonia stolonifera或E.cava分离的乙醇级分，乙酸乙酯级分和氯光亮素用于肝脏保护酒精性肝损伤，并将其用作肝保护
公开(公告)号：KR1020120121308A
公开(公告)日：2012-11-05
申请号：KR1020110039212
申请日：2011-04-26
Applicant: 부경대학교 산학협력단
Abstract: PURPOSE: A hepatoprotection composition containing phlorotannins isolated from Ecklonia stolonifera or Ecklonia cava extract is provided to be used as a pharmaceutical composition for preventing and treating liver diseases. CONSTITUTION: A hepatoprotection composition which suppresses hepatocyte injury due to alcohol contains spirit extract of Ecklonia stolonifera or Ecklonia cava as an active ingredient. A health food composition for hepatoprotection contains the spirit extract of Ecklonia stolonifera or Ecklonia cava as an active ingredient. A pharmaceutical composition for hepatoprotection contains phlorotannin compounds as an active ingredient, isolated and purified from an ethyl acetate fraction of Ecklonia stolonifera or Ecklonia cava. The phlorotannin compounds are eckol, dieckol, dioxynodehydroeckol, phlorofucofuroeckol A, and phlorofucofuroeckol B. [Reference numerals] (AA) Ecklonia stolonifera and Ecklonia cava; (BB) Shade drying; (CC) Powder; (DD) Reflux extraction(repeat three times), using spirit; (EE) Extraction; (FF) Filtering at reduced pressure; (GG) Vacuum concentration, 40°C(removing organic solvent); (HH) Crude extract of Ecklonia stolonifera and Ecklonia cava; (II) Organic solvent soluble fraction(repeat 3-4 times); (JJ) N-hexane soluble extract; (KK) Water soluble fraction; (LL) Dichloromethane soluble extract; (MM) Water soluble fraction; (NN) Ethyl acetate soluble extract; (OO) Water soluble fraction
Abstract translation: 目的：提供一种含有从Ecklonia stolonifera或Ecklonia cava提取物中分离的嗜氯光亮素的肝保护组合物，用作预防和治疗肝脏疾病的药物组合物。 构成：抑制酒精肝细胞损伤的肝保护组合物含有Ecklonia stolonifera或Ecklonia cava的精神提取物作为活性成分。 用于肝保护的保健食品组合物含有Ecklonia stolonifera或Ecklonia cava的精神提取物作为活性成分。 用于肝保护的药物组合物含有作为活性成分的顺铂单宁化合物，从Ecklonia stolonifera或Ecklonia cava的乙酸乙酯部分分离和纯化。 顺铂单宁化合物是eckol，甲羟戊酸，二羟基脱氢羟克洛芬，间苯二酚，甲氧基甲醇和苯氧氟喹诺酮B.参考标号（AA）Ecklonia stolonifera和Ecklonia cava; （BB）树荫干燥; （CC）粉; （DD）回流提取（重复三次），使用精神; （EE）提取; （FF）减压过滤; （GG）真空浓度40℃（去除有机溶剂）; （HH）Ecklonia stolonifera和Ecklonia cava的粗提物; （二）有机溶剂可溶成分（重复3-4次）; （JJ）N-己烷可溶提取物; （KK）水溶性成分; （LL）二氯甲烷可溶提取物; （MM）水溶性成分; （NN）乙酸乙酯可溶提取物; （OO）水溶性成分
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24.发明公开다시마 추출물 또는 이로부터 분리한 폴피린계 화합물을 유효 성분으로 함유하는 당뇨성 합병증의 예방 및 치료용 약학 조성물 有权一种包含提取物的分离物的组合物，其分离其预防或治疗糖尿病并发症
公开(公告)号：KR1020120103236A
公开(公告)日：2012-09-19
申请号：KR1020110021388
申请日：2011-03-10
Applicant: 부경대학교 산학협력단
CPC classification number: A61K36/03 , A23V2200/328 , A61K2236/33 , Y10S514/866 , Y10S514/886 , Y10S514/914
Abstract: PURPOSE: A pharmaceutical composition or health food containing Laminaria japonica extract or polyphyrin compounds isolated from the same is provided to prevent or treat diabetic complication. CONSTITUTION: A pharmaceutical composition for preventing and treating diabetic complication contains Laminaria japonicaextract or polyphyrin compounds as an active ingredient. The polypyrincompounds are denoted by chemical formula 1 or 2. The Laminaria japonica extract includes crude extract, ethanol, and non-polar solvent soluble extract. A food composition for preventing and treating diabetes complication contains the extract as an active ingredient.
Abstract translation: 目的：提供含有从其分离的j ica提取物或多卟啉化合物的药物组合物或保健食品，以预防或治疗糖尿病并发症。 构成：用于预防和治疗糖尿病并发症的药物组合物含有椴树胶提取物或多卟啉化合物作为活性成分。 聚吡啶化合物由化学式1或化学式2表示。aria粳提取物包括粗提物，乙醇和非极性溶剂可溶提取物。 用于预防和治疗糖尿病并发症的食物组合物含有提取物作为活性成分。
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25.发明授权연수추출물 또는 그로부터 분리한캠프페롤-3-글루쿠로나이드를 함유하는 고지혈증의 예방 및치료용 조성물 有权用于预防和治疗高脂血症的组合物，其含有从其分离的软水提取物或坎帕醇-3-葡萄糖醛酸苷
公开(公告)号：KR100703596B1
公开(公告)日：2007-04-06
申请号：KR1020050105469
申请日：2005-11-04
Applicant: 부경대학교 산학협력단
IPC: A61K31/7048 , A61P3/06
Abstract: 본 발명은 연수 (
Nelumbo
nucifera stamen) 추출물 또는 그로부터 분리된 화합물인 캠프페롤-3-글루쿠로나이드 (Kaempferol 3-
O -β-D-glucuronide)를 유효성분으로 함유하는 고지혈증의 예방 및 치료용 조성물에 관한 것으로, 본 발명의 연수 추출물 또는 그로부터 분리된 화합물인 캠프페롤-3-글루쿠로나이드는 혈중 총콜레스테롤 및 중성지질 함량을 유의적으로 감소시킴으로서 항고지혈 효과를 나타내므로, 상기 조성물은 고지혈증의 예방 및 치료용 약학조성물로 유용하게 이용될 수 있다.
연수, 캠프페롤-3-글루쿠로나이드, 고지혈증, 총콜레스테롤, 중성지질, 약학 조성물.Abstract translation: 在本发明中，
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Patent Agency Ranking26.发明公开황금 추출물 또는 이로부터 분리한 바이칼린, 바이칼레인,우고닌 또는 5,7,2,5-테트라하이드록시-8,6-디메톡시플라본을 함유하는 노화 방지 및 억제용 약학조성물 无效包含已经具有过氧化物活性的，IA ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING ING
公开(公告)号：KR1020040107713A
公开(公告)日：2004-12-23
申请号：KR1020030037012
申请日：2003-06-10
Applicant: 부경대학교 산학협력단
IPC: A61K7/48
Abstract: PURPOSE: Provided is a pharmaceutical composition comprising the extract of Scutellaria baicalensis which has peroxynitrite scavenging activity, or baicalin, baicalein, wogonin or 5,7,2,5-tetrahydroxy-8,6-dimethoxyflavone isolated from the extract. The composition effectively scavenges peroxynitrite to inhibit the generation of reactive oxygen species(ROS) and the nitration of proteins. Therefore, it prevents and inhibits aging. CONSTITUTION: The pharmaceutical composition for prevention and inhibition of aging is characterized by containing, as an active ingredient, (i) the crude of Scutellaria baicalensis or the nonpolar solvent extract thereof, wherein the crude extract is obtained by using methanol and the nonpolar solvent extract is obtained by using ethylacetate; or (ii) baicalin, baicalein, wogonin or 5,7,2,5-tetrahydroxy-8,6-dimethoxyflavone isolated from the extract, in the amount of 0.01-50 wt.%, based on the total weight of the composition. Therefore, the composition prevent and inhibits aging, and prevents and treats diseases caused by peroxynitrite.
Abstract translation: 目的：提供一种药物组合物，其包含具有过氧亚硝酸盐清除活性的黄芩提取物，或从提取物中分离的黄芩苷，黄芩素，沃可素或5,7,2,5-四羟基-8,6-二甲氧基黄酮。 组合物有效地清除过氧亚硝酸盐以抑制活性氧（ROS）的产生和蛋白质的硝化。 因此，它可以防止和抑制老化。 构成：用于预防和抑制衰老的药物组合物的特征在于含有（i）黄芩原液或其非极性溶剂提取物作为活性成分，其中粗提物通过使用甲醇和非极性溶剂提取物 通过使用乙酸乙酯获得; 或（ii）从所述提取物中分离的黄芩苷，黄芩素，沃可素或5,7,2,5-四羟基-8,6-二甲氧基黄酮，其量为组合物总重量的0.01-50重量％。 因此，该组合物可预防和抑制老化，并预防和治疗由过氧亚硝酸盐引起的疾病。
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公开(公告)号：KR101469961B1
公开(公告)日：2014-12-08
申请号：KR1020140024156
申请日：2014-02-28
Applicant: 부경대학교 산학협력단
IPC: A61K31/409 , A61K36/02 , A61P3/10 , A61P27/02
Abstract: 본 발명은 다시마 추출물 또는 그로부터 분리한 폴피린계 화합물(porpyrin-related compounds)을 함유하는 당뇨성 합병증 억제에 활성을 갖는 약학 조성물 또는 건강 식품에 관한 것으로, 상기 추출물은 알도즈 환원 효소 및 최종당화산물 생성 억제 활성을 나타내고, 천연 약재로서 안전성이 확보되어 있으므로 당뇨성 합병증 예방 또는 치료용 약학조성물과 식품 조성물로로 유용하게 이용될 수 있다.
Abstract translation: 本发明涉及一种药物组合物或保健食品，其包含从其分离的j粳提取物或porpyrin相关化合物，其对糖尿病并发症具有抑制活性。 提取物显示醛糖还原酶和晚期糖基化终产物的抑制活性产生，并被确定为天然药物; 从而可以用作药物组合物和用于预防或治疗糖尿病并发症的食品组合物。
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28.发明公开
公开(公告)号：KR1020140048905A
公开(公告)日：2014-04-24
申请号：KR1020140024156
申请日：2014-02-28
Applicant: 부경대학교 산학협력단
IPC: A61K31/409 , A61K36/02 , A61P3/10 , A61P27/02
CPC classification number: A61K36/03 , A23V2200/328 , A23V2250/202 , A61K2236/33 , A61K2236/39 , Y10S514/866 , Y10S514/912 , Y10S514/914
Abstract: The present invention relates to a pharmaceutical composition or a health food comprising a Laminaria japonica extract or a porpyrin-related compound isolated therefrom which has inhibitory activity for diabetic complications. The extract shows inhibitory activity generation of aldose reductase and advanced glycation end-products and is ensured as a natural medicine; thereby can be used as a pharmaceutical composition and a food composition for preventing or treating the diabetic complications.
Abstract translation: 本发明涉及含有海带提取物或从中分离的卟啉相关化合物的药物组合物或健康食品，其对糖尿病并发症具有抑制活性。 该提取物显示出醛糖还原酶和晚期糖基化终产物的抑制活性，并确保其作为天然药物; 由此可以用作用于预防或治疗糖尿病并发症的药物组合物和食物组合物。
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29.发明公开엉겅퀴 추출물 또는 그로부터 분리한 루테오린５―Ｏ―β―Ｄ―글루코피라노시드의 화합물을 함유한 염증성 질환 예방 또는 치료용 약학조성물 및 건강기능식품 无效包含食品和健康食品的组合物5-O-β-D-吡喃葡萄糖苷或用于预防或治疗炎症疾病的环孢菌素的提取物
公开(公告)号：KR1020130087928A
公开(公告)日：2013-08-07
申请号：KR1020120009195
申请日：2012-01-30
Applicant: 부경대학교 산학협력단
IPC: A61K31/7048 , A61K31/7042 , A61K36/28 , A61K36/287
CPC classification number: A61K31/7048 , A23L29/035 , A61K36/28 , A61K2236/33 , Y10S514/866 , Y10S514/886
Abstract: PURPOSE: A pharmaceutical composition and a health food for preventing or treating inflammatory diseases are provided to suppress lipopolysaccharide-induced NO generation in RAW 264.7 macrophage and beef feet inflammation in a carrageenan-induced mouse, thereby strongly preventing inflammatory diseases and having stability as a natural medicinal material. CONSTITUTION: A pharmaceutical composition for preventing or treating inflammatory diseases contains a luteolin-5-O-beta-D-glucopyranoside compound as an active ingredient. The compound is derived from Cirsium maackii MAX. The pharmaceutical composition contains a crude extract or a non-solvent soluble extract of Cirsium maackii MAX as an active ingredient. The extract contains the luteolin-5-O-beta-D-glucopyranoside compound of chemical formula 1. A health food for preventing or treating inflammatory diseases contains the composition.
Abstract translation: 目的：提供用于预防或治疗炎性疾病的药物组合物和保健食品，以抑制角叉菜胶诱导的小鼠中RAW 264.7巨噬细胞和牛脚炎症中的脂多糖诱导的NO产生，从而强烈地预防炎性疾病并且具有作为天然的稳定性 药材。 构成：用于预防或治疗炎性疾病的药物组合物含有作为活性成分的木犀草素-5-O-β-D-吡喃葡萄糖苷化合物。 该化合物衍生自Cirsium maackii MAX。 该药物组合物含有作为活性成分的粗提取物或不溶于水溶性的粟米镰刀菌提取物。 提取物含有化学式1的木犀草素-5-O-β-D-吡喃葡萄糖苷化合物。用于预防或治疗炎性疾病的保健食品含有该组合物。
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30.发明公开곰피와 감태 추출물 유래의 플로로탄닌을 유효성분으로 하는 염증억제용 조성물 无效含有ECKLONIA STOLONIFERA和ECKLONIA CAVA提取物的有效成分的抗炎组合物作为有效成分
公开(公告)号：KR1020120054577A
公开(公告)日：2012-05-30
申请号：KR1020120038386
申请日：2012-04-13
Applicant: 부경대학교 산학협력단
IPC: C07D493/04 , A61K36/03 , A61K31/357 , A61P29/00
Abstract: PURPOSE: A composition containing phlorotannins derived from Ecklonia stolonifera and Ecklonia cava extract is provided to suppress iNOS and COX-2 expression and to prevent and treat inflammatory diseases. CONSTITUTION: A phlorofucofuroeckol A compound of chemical formula I is isolated from Ecklonia stolonifera and Ecklonia cava extract. A method for isolating and purifying the compound of chemical formula I comprises: a step of extracting ethanol extract of Ecklonia stolonifera and Ecklonia cava with n-hexane to prepare hexane water soluble extract; a step of extracting the hexane water soluble extract with ethyl acetate. The Ecklonia stolonifera and Ecklonia cava extract includes crude extract or non-polar solvent soluble extract. The crud extract is prepared using water, ethanol, methanol, butanol, or mixture thereof.
Abstract translation: 目的：提供一种含有源自Ecklonia stolonifera和Ecklonia cava提取物的光合色素的组合物，以抑制iNOS和COX-2的表达，并预防和治疗炎症性疾病。 化学式I化学式I化合物是从Ecklonia stolonifera和Ecklonia cava提取物中分离出来的。 用于分离和纯化化学式I化合物的方法包括：用正己烷萃取Ecklonia stolonifera和Ecklonia cava的乙醇提取物以制备己烷水溶性提取物的步骤; 用乙酸乙酯萃取己烷水溶性提取物的步骤。 Ecklonia stolonifera和Ecklonia cava提取物包括粗提物或非极性溶剂可溶性提取物。 粗提取物用水，乙醇，甲醇，丁醇或其混合物制备。
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