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    미세유동 장치의 제조방법 및 그에 의하여 제조되는미세유동 장치
    23.
    发明公开
    미세유동 장치의 제조방법 및 그에 의하여 제조되는미세유동 장치 失效
    一种制造微流体装置的方法及其制造的微流体装置

    公开(公告)号：KR1020070067988A

    公开(公告)日：2007-06-29

    申请号：KR1020050129584

    申请日：2005-12-26

    Applicant: 삼성전자주식회사

    Inventor： 황규연 ,  정성영 ,  김준호 ,  이헌주 ,  임희균

    IPC: B81C1/00 ,  G01N35/10 ,  B81B7/00 ,  B81B1/00

    CPC classification number: B01L3/502707 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0887 ,  Y10T156/1052

    Abstract: A method of fabricating a micro-fluidic device and a micro-fluidic device fabricated by the same are provided to fabricate the micro-fluidic device constructing two substrates with high efficiency in mass production. A method of fabricating a micro-fluidic device includes the steps of: stacking a support layer on a surface opposite to a surface coated with an adhesion material; coating a first substrate(10) on which a fluid port is formed with the adhesion material to form an adhesion layer; arranging a second substrate(20) on which a minute structure is formed on a surface of the adhesion layer of the first substrate coated with the adhesion layer so that the minute structure faces the fluid port; and heating the first substrate and the second substrate at a temperature ranging from 50 degrees to 180 degrees. The support layer is UV or blue tape. The adhesion material is negative photoresist material.

    Abstract translation: 提供了一种制造微流体装置的方法和由其制造的微流体装置，用于制造在大量生产中高效率地构造两个基板的微流体装置。 制造微流体装置的方法包括以下步骤：在与涂覆有粘合材料的表面相对的表面上堆叠支撑层; 用粘合材料涂覆其上形成有流体端口的第一基板（10）以形成粘合层; 在涂覆有粘合层的第一基板的粘合层的表面上布置有微结构的第二基板（20），使得微结构面向流体端口; 并在50度至180度的温度范围内加热第一衬底和第二衬底。 支撑层是UV或蓝色胶带。 粘合材料是负性光致抗蚀剂材料。

    유체의 ｐＨ를 전기화학적으로 조절하기 위한 미세유동장치및 그를 이용하여 ｐＨ를 조절하는 방법
    24.
    发明公开
    유체의 ｐＨ를 전기화학적으로 조절하기 위한 미세유동장치및 그를 이용하여 ｐＨ를 조절하는 방법 有权
    用于电化学调节其流体PH的微流体装置和使用该流体在微流体装置中调节流体PH的方法

    公开(公告)号：KR1020070066120A

    公开(公告)日：2007-06-27

    申请号：KR1020050126917

    申请日：2005-12-21

    Applicant: 삼성전자주식회사

    Inventor： 이헌주 ,  김준호 ,  정성영 ,  임희균

    IPC: C12Q1/68 ,  C12Q1/00

    CPC classification number: B01D61/44 ,  B01L3/502707 ,  B01L2200/0684 ,  B01L2300/10 ,  B01L2400/0487

    Abstract: A microfluidic device for electrochemically regulating the pH of a fluid is provided to rapidly and easily regulate the pH of the fluid in the device without generating gas during the electrolysis. And a method for regulating the pH of a fluid in the microfluidic device through electrolysis using the same device is provided. The microfluidic device comprises a chamber(105) including a metal(101) which is able to absorb hydrogen gas as a cathode electrode and a metal(103) which has higher standard oxidation potential than that of water and is non-reacting with water as an anode electrode; and is characterized in that gas is not generated in the chamber. In the device, the cathode electrode is Pd, the anode electrode is selected from the group consisting of Cu, Pb, Ag, Cr, Ti, Ni, Zn, and Sn, and the chamber further comprises an ion exchange material. The method for regulating the pH of a fluid comprises the steps of: (a) allowing a solution including ions having higher or lower standard oxidation potential than that of water to be flown in an anode chamber; (b) allowing a solution including ions having lower standard oxidation potential than that of water to be flown in a cathode chamber; and (c) applying electric current to the anode and cathode chambers through the anode and cathode electrodes to cause electrolysis at the anode and cathode chambers and regulate the pH of the solution flown in either the anode chamber or the cathode chamber.

    Abstract translation: 提供用于电化学调节流体pH的微流体装置，用于在电解期间快速且容易地调节装置中的流体的pH而不产生气体。 并且提供了通过使用相同的装置通过电解来调节微流体装置中的流体的pH的方法。 该微流体装置包括一个室（105），它包括能够吸收氢气作为阴极的金属（101）和具有比水高的标准氧化电位的金属（103），并且与水不反应 阳极电极; 其特征在于，在室中不产生气体。 在该器件中，阴极为Pd，阳极为选自Cu，Pb，Ag，Cr，Ti，Ni，Zn，Sn组成的组，该室还包含离子交换材料。 用于调节流体pH值的方法包括以下步骤：（a）允许包含具有比水的更高或更低的标准氧化电位的离子的溶液在阳极室中流动; （b）允许包含具有比水的更低的标准氧化电位的离子的溶液在阴极室中流动; 和（c）通过阳极和阴极电极向阳极室和阴极室施加电流，以在阳极室和阴极室处引起电解，并调节在阳极室或阴极室中流动的溶液的pH。

    상 분리를 이용한 세포 분리 방법 및 키트
    25.
    发明公开
    상 분리를 이용한 세포 분리 방법 및 키트 失效
    细胞分离方法和使用相分离的试剂盒

    公开(公告)号：KR1020060121519A

    公开(公告)日：2006-11-29

    申请号：KR1020050043749

    申请日：2005-05-24

    Applicant: 삼성전자주식회사

    Inventor： 황규연 ,  임희균 ,  김준호

    IPC: C12N15/00 ,  C12N7/02

    CPC classification number: C12N1/02 ,  C12N7/00 ,  C12N2795/00051

    Abstract: A cell separation method and kit by using phase separation are provided to separate high concentration of cells in fluidity control system, so that the high concentration of cells separated is applied to lab-on-a-chip. The cell separation method comprises the steps of: suspending a sample containing cells or viruses in kosmotropic salt solution of pH 3 to 6; flocculating the cells or viruses by adding a cationic polymer into the suspension; contacting the obtained solution with a solid substrate so as to adhere the cells or viruses to the substrate in the static or fluidic state; and separating the cell or virus-adhered solid substrate from the liquid phase, wherein the cationic polymer is polyamine selected from polyallylamine, polyamino acid, polyethyleneimine and polyethylimine; the kosmotropic salt is citrate or phosphate; and the solid substrate has plane, bead or pillar structure.

    Abstract translation: 提供了通过使用相分离的细胞分离方法和试剂盒来分离流动性控制系统中的高浓度细胞，从而将分离的高浓度的细胞应用于芯片上的实验室。 细胞分离方法包括以下步骤：将含有细胞或病毒的样品悬浮在pH3至6的差异性盐溶液中; 通过向悬浮液中加入阳离子聚合物来絮凝细胞或病毒; 使所得溶液与固体基质接触，以将细胞或病毒以静态或流体状态粘附至基质; 并将细胞或病毒粘附的固体基质与液相分离，其中阳离子聚合物是选自聚烯丙胺，聚氨基酸，聚乙烯亚胺和聚乙烯亚胺的多胺; 去离子盐是柠檬酸盐或磷酸盐; 固体基材具有平面，珠或柱结构。

    고정화된 금속-리간드 복합체에 의한 세포 용해 방법
    26.
    发明授权
    고정화된 금속-리간드 복합체에 의한 세포 용해 방법 失效
    固定化金属配体复合物的细胞裂解法

    公开(公告)号：KR100612869B1

    公开(公告)日：2006-08-14

    申请号：KR1020040090497

    申请日：2004-11-08

    Applicant: 삼성전자주식회사

    Inventor： 유창은 ,  김준호 ,  황규연 ,  임희균 ,  이헌주 ,  마수민 ,  허남 ,  이수석

    IPC: C12N15/00 ,  C12N15/09

    CPC classification number: C12Q1/6806 ,  Y10T436/25 ,  C12Q2523/308

    Abstract: 본 발명은 고체 지지체 상에 금속-리간드 복합체를 고정시키는 단계; 및 상기 지지체 상에 고정된 복합체와 세포 또는 바이러스 용액을 혼합하는 단계를 포함하는 세포 또는 바이러스의 용해 방법에 관한 것이다. 본 발명에 따르면, 고체 지지체에 화학 물질을 고정화시켜 세포 용해를 수행함으로써, 세포 용해 용액 첨가에 따른 희석 문제를 해소할 수 있으며, 또한 별도의 화학 물질의 제거 공정이 필요 없어 LOC 구현시 단계를 줄일 수 있다. 또한, 칩, 비드, 나노입자 등과 같은 다양한 종류의 고체 지지체를 사용할 수 있기 때문에 여러 가지 형태의 세포 용해 장치의 제작이 가능하다.

    핵산 어레이의 복제방법
    27.
    发明公开
    핵산 어레이의 복제방법 无效
    替代核酸阵列的方法

    公开(公告)号：KR1020040062847A

    公开(公告)日：2004-07-09

    申请号：KR1020030000381

    申请日：2003-01-03

    Applicant: 삼성전자주식회사

    Inventor： 김영아 ,  임희균 ,  이영환 ,  임근배

    IPC: C12Q1/68

    CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00364 ,  B01J2219/00387 ,  B01J2219/00432 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00677 ,  C12Q1/6837 ,  C40B50/14 ,  C40B60/14

    Abstract: PURPOSE: A method for replicating nucleic acid array is provided, thereby significantly reducing the costs and time for replicating nucleic acid array although the kinds or length of probes on the nucleic acid array are increased because the total of the second polynucleotides which is in-situ synthesized by using one nucleic acid array as a template are transferred into a new substrate. CONSTITUTION: The method for replicating nucleic acid array comprises the steps of: (i) fixing each first polynucleotide(2) having a nucleotide sequence complementary with a second polynucleotide and each first nucleic acid probe with a primer binding site(1) on a first substrate(10) to prepare a template nucleic acid array; (ii) binding a primer to the primer binding site(1) of each first nucleic acid probe fixed on the surface of the template nucleic acid array; (iii) in-situ synthesizing the second polynucleotide by using the primer from the first polynucleotide(2) as a template; and (iv) transferring the numerous synthesized second polynucleotides and seconds nucleic acid probes with the primer into a second substrate, wherein the first and second substrates are patterned with a metal membrane pattern or surface-treated with functional groups such as aldehyde, streptavidin or thiol; and the primer is universal primer.

    Abstract translation: 目的：提供了复制核酸阵列的方法，从而显着降低复制核酸阵列的成本和时间，尽管核酸阵列上的探针的种类或长度增加，因为原位的第二个多核苷酸的总数 通过使用一个核酸阵列作为模板合成转移到新的底物中。 构成：复制核酸阵列的方法包括以下步骤：（i）将具有与第二多核苷酸互补的核苷酸序列的每个第一多核苷酸（2）和每个第一核酸探针与引物结合位点（1）固定在第一个 底物（10）以制备模板核酸阵列; （ii）将引物与固定在模板核酸阵列表面上的每个第一核酸探针的引物结合位点（1）结合; （iii）通过使用来自第一多核苷酸（2）的引物作为模板原位合成第二多核苷酸; 和（iv）将许多合成的第二多核苷酸和秒核酸探针与引物转移到第二底物中，其中第一和第二底物用金属膜图案图案化或用官能团如醛，链霉亲和素或硫醇进行表面处理 ; 引物为通用引物。

    사스 코로나바이러스 검출용 프라이머, 그를 이용한 사스 코로나바이러스 검출 방법 및 키트
    30.
    发明公开
    사스 코로나바이러스 검출용 프라이머, 그를 이용한 사스 코로나바이러스 검출 방법 및 키트 有权
    用于检测SARS-CORONAVIRUS的PRIMER，用于检测SARS-CORONAVIRUS的方法和工具箱

    公开(公告)号：KR1020100094968A

    公开(公告)日：2010-08-27

    申请号：KR1020100078975

    申请日：2010-08-16

    Applicant: 삼성전자주식회사

    Inventor： 임희균 ,  김상효 ,  황정주 ,  이영선 ,  김영아

    IPC: C12Q1/68 ,  C12N15/11

    CPC classification number: Y02A50/451 ,  C12Q1/701 ,  C12Q1/6837 ,  C12Q1/6844

    Abstract: PURPOSE: A PCR primer for detecting SARS coronavirus is provided to easily detect SARS virus without cross reaction with other coronavirus. CONSTITUTION: A PCR primer set for detecting SARS(severe acute respiratory syndrome)-coronavirus comprises two base sequences of sequence numbers 1-46. A PCR primer set for detecting SARS-coronavirus comprises the PCR primer sets GS-SARS01-GS-SARS23. The detection of the SARS virus is performed by PCR using the PCR primer set.

    Abstract translation: 目的：提供用于检测SARS冠状病毒的PCR引物，以方便检测SARS病毒，而不与其他冠状病毒交叉反应。 构成：用于检测SARS（严重急性呼吸综合征） - 冠状病毒的PCR引物组包含序列号1-46的两个碱基序列。 用于检测SARS冠状病毒的PCR引物组包括PCR引物组GS-SARS01-GS-SARS23。 通过使用PCR引物组的PCR进行SARS病毒的检测。

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