Abstract:
Provided are anti-EGFR/anti-HER2 bispecific antibodies having anti-EGRF DARPin and anti-HER2 antibodies; a pharmaceutical composition comprising the same; a preparation method thereof; and a method for reducing side effects and/or enhancing positive effects of the anti-HER2 antibodies using anti-EGRF DARPin.
Abstract:
The present invention provides an anti-c-Met/anti-EGFR bispecific antibody, a pharmaceutical composition for preventing and/or treating cancer including the same, and an anti EGFR scFv fragment. The anti-c-Met/anti-EGFR bispecific antibody includes an anti-c-Met antibody or an antigen-binding fragment thereof, and anti-EGFR antibody or an antigen-binding fragment thereof. The anti-c-Met antibody is bound specifically to an epitope composed of five or more amino acids that are consecutive in a SEMA domain (SEQ ID NO. 79) of c-Met protein.
Abstract translation:本发明提供了抗c-Met /抗EGFR双特异性抗体,用于预防和/或治疗包括其的癌症的药物组合物和抗EGFR scFv片段。 抗c-Met /抗EGFR双特异性抗体包括抗c-Met抗体或其抗原结合片段和抗EGFR抗体或其抗原结合片段。 抗c-Met抗体与由c-Met蛋白质的SEMA结构域(SEQ ID NO:79)连续的五个或更多个氨基酸组成的表位特异性结合。
Abstract:
PURPOSE: An anti-c-Met antibody or an antigen binding fragment thereof and a pharmaceutical composition containing the same are provided to enhance cell migration, to enable wound healing or tissue regeneration, and to effectively promote cell proliferation. CONSTITUTION: An anti-c-Met antibody contains: a heavy chain variable region containing heavy chain CDR(complementarity determining region) amino acids of sequence numbers 1, 2, and 3; and a light chain variable region containing light chain CDR amino acids in sequence numbers 4, 5, and 6. c-Met is derived from the group consisting of human, monkey, mouse, and rat. The anti-c-Met antibody is a monoclonal antibody. A pharmaceutical composition for wound healing or tissue regeneration contains: pharmaceutically effective amount of the anti-c-Met antibody or an antigen binding fragment thereof; and pharmaceutically acceptable carrier, diluents, or excipient.
Abstract:
PURPOSE: An antibody which is specifically bonded to epitope within SEMA domain of c-Met is provided to efficiently prevent or treat cancer. CONSTITUTION: An antibody which is specifically bonded to epitope within SEMA domain of c-Met is indicated as amino acid sequence of sequence number 1. An epitope is a polypeptide having amino acid sequence of sequence number 2 or sequence number 3.
Abstract:
A sliding type portable electronic device having the convenience of manipulation and portability is provided to provide the convenience of a user by implementing an operation for opening a sliding device. A slide member combines first and second housings(101,102). The slide member guides the sliding movement of the second housing. The slide member includes a guide plate(211) and a guide member(213). An elastic member(241) provides driving force moving the second housing in a direction opening the first housing. A locking member maintains the first and the second housing in an overlapped state. The locking member includes a ball bearing within a locking hole(227b). A damping member relieves the movement speed change of the second housing moved by the driving force of the elastic member.
Abstract:
본 발명은 도전성 소재로 이루어지며, 상하방향으로 길게 배치되어 있으며, 생체분자 액적이 수용되는 수용부와, 상기 수용부와 연결되며 상기 생체분자 액적이 그 수용부의 외부로 토출되도록 그 수용부의 하단부에 형성된 토출구를 가지는 바늘 형상의 전계형성전극; 상기 전계형성전극의 하방에 배치되어 있고, 상기 전계형성전극의 토출구로부터 토출되는 생체분자 액적이 떨어져 부착되는 표적부를 가지며, 접지되어 있는, 기판의 상부표면에 물이 고체 성분 중에 분산되어 분포하여 수분 박막이 형성되어 있는 고체 기판; 및 상기 전계형성전극에 전하가 충전되도록 그 전계형성전극과 전기적으로 연결되어 있으며, 상기 전계형성전극에 충전된 전하와 그 전하에 의해 상기 기판에 유도된 전하 사이에 발생된 힘에 의해 상기 생체분자 액적이 상기 기판의 표적부로 떨어지도록 하는 개방형 전압인가장치를 포함하는 전기전하집중 현상을 이용하여 기판 상에 생체분자 액적을 프린팅하는 장치를 제공한다.
Abstract:
An apparatus for locking a case of a portable terminal is provided to detach the case from the portable terminal according as a user pushes a position on a side circumference of the terminal such that external cases can be easily exchanged. An apparatus for locking a case of a portable terminal comprises an attaching/detaching face(1a), an installing recess(1b), a pair of hooks, a spring support unit and a guide member(1f). The attaching/detaching face(1a) is formed on the portable terminal such that a case(2) can be attached to or detached from the portable terminal. A case locking unit(10) is installed at a certain position on a side circumference of the attaching/detaching dace(1a). The installing recess, formed at the attaching/detaching face(1a), offers a space for a sliding operation according as the case locking unit is pushed. The pair of hooks are formed on both sides in the installing recess(1b) such that the case locking unit(10) moves. The spring support unit moves a spring protrusion(13a), formed at the case locking unit(10) within the installing recess(1b), and also supports a coil spring(14) combined with the spring protrusion(13a). The guide member(1f) is formed in the installing recess such that it can guide combination of the case locking unit(10).
Abstract:
가. 청구범위에 기재된 발명이 속하는 기술분야. 안테나 하우징의 착탈장치에 관한 것이다. 나. 발명이 해결하려는 기술적 과제. 안테나 분실을 방지할 수 있는 안테나 하우징의 착탈장치를 제공함에 있다. 다. 발명의 해결방법의 요지. 전파의 송수신을 담당하는 안테나 장치와, 상기 안테나 장치를 보호하는 안테나 하우징을 포함하는 휴대용 단말기에 있어서, 독립적인 안테나 하우징; 상기 안테나 하우징을 지지하도록 본체에 형성된 중공형 서포트; 상기 안테나 하우징에서 연장된 단에 구비된 적어도 한 개 이상의 후크와, 상기 후크가 삽입되어 안테나 하우징이 본체에 고정되도록 적어도 한 개 이상 상기 서포트에 구비된 걸림 구멍으로 구성된 착탈수단으로 구성된다. 라. 발명의 중요한 용도. 안테나 장치를 포함하는 휴대용 단말기에 적용.