公开(公告)号：KR101528871B1

公开(公告)日：2015-06-16

申请号：KR1020120121991

申请日：2012-10-31

Applicant: 유한회사한풍제약

Inventor： 조형권 ,  박종군 ,  소윤조 ,  전기용 ,  이준경 ,  김대성 ,  변에리사 ,  유진주

IPC: A61K36/258 ,  A61K36/87 ,  A61K36/282 ,  A23L33/00

Abstract: 본발명은홍삼(Panax ginseng C.A.Meyer) 추출물; 포도(Vitis vinifera), 쑥(Artemisia), 복분자(Rubus coreanus Miquel)로이루어진군에서선택된 1 종이상의추출물;을유효성분으로함유하는세포활성화효능을갖는조성물에관한것이다. 구체적으로상기세포활성화효능은, 세포생존율, DNA 상해에대한회복, 세포고사의저해, 비주기성 DNA 합성, DNA 절단감소율, 저분자량의 DNA 함량감소, p53 단백질의발현량감소및 p53 의존성단백질의발현량감소를촉진하는기능을포함하는것을기술적특징으로하고있다.

公开(公告)号：KR101434163B1

公开(公告)日：2014-08-26

申请号：KR1020140008584

申请日：2014-01-23

Applicant: 유한회사한풍제약

Inventor： 조형권 ,  김성연 ,  한은별 ,  전기용 ,  전창현 ,  이준경 ,  김대성 ,  변에리사 ,  유진주

IPC: A61K36/488 ,  A61K8/97 ,  A61P29/00 ,  A61Q19/02 ,  A61Q19/00

CPC classification number: A61K8/97 ,  A61K36/488 ,  A61K2236/331 ,  A61Q17/00 ,  A61Q19/02 ,  A61Q19/08 ,  Y10S514/844

Abstract: The present invention relates to a composition having anti-oxidant, anti-inflammatory, and skin whitening effects and containing a kudzu aerial part extract as an active ingredient. More specifically, the present invention relates to a composition which can promote anti-oxidant, anti-inflammatory, and skin whitening effects without side effects using natural materials. The composition which can promote an anti-oxidant effect according to the present invention concentration-dependently exhibits an anti-oxidant effect as a result of a DPPH experiment. Moreover, the composition which can promote an anti-inflammatory effect according to the present invention can control the generation of NO and the expression of iNOS and COX-2. In addition, the composition which can promote a skin whitening effect according to the present invention can prevent melanin synthesis in cells, prevent melanin synthesis caused by α-MSH, inhibit melanin accumulation, control the expression of melanin synthesis enzymes and factors related to the synthesis, and improve skin whitening effect even at an in vivo level.

Abstract translation: 本发明涉及具有抗氧化剂，抗炎和皮肤美白效果的组合物，并且含有葛根部分提取物作为活性成分。 更具体地，本发明涉及一种可以使用天然材料促进抗氧化剂，抗炎和皮肤美白效果而没有副作用的组合物。 根据本发明可以促进抗氧化作用的组合物浓度依赖性地表现出作为DPPH实验的结果的抗氧化作用。 此外，根据本发明可以促进抗炎作用的组合物可以控制NO的产生和iNOS和COX-2的表达。 此外，根据本发明的能够促进皮肤美白效果的组合物可以防止细胞中的黑色素合成，防止由α-MSH引起的黑色素合成，抑制黑色素积聚，控制黑色素合成酶的表达和与合成有关的因子 ，即使在体内水平也能改善皮肤美白效果。

公开(公告)号：KR1020140056714A

公开(公告)日：2014-05-12

申请号：KR1020120121991

申请日：2012-10-31

Applicant: 유한회사한풍제약

Inventor： 조형권 ,  박종군 ,  소윤조 ,  전기용 ,  이준경 ,  김대성 ,  변에리사 ,  유진주

IPC: A61K36/258 ,  A61K36/87 ,  A61K36/282 ,  A23L33/00

CPC classification number: A61K36/258 ,  A61K36/282 ,  A61K36/87

Abstract: 본발명은홍삼(Panax ginseng C.A.Meyer) 추출물; 포도(Vitis vinifera), 쑥(Artemisia), 복분자(Rubus coreanus Miquel)로이루어진군에서선택된 1 종이상의추출물;을유효성분으로함유하는세포활성화효능을갖는조성물에관한것이다. 구체적으로상기세포활성화효능은, 세포생존율, DNA 상해에대한회복, 세포고사의저해, 비주기성 DNA 합성, DNA 절단감소율, 저분자량의 DNA 함량감소, p53 단백질의발현량감소및 p53 의존성단백질의발현량감소를촉진하는기능을포함하는것을기술적특징으로하고있다.

Abstract translation: 本发明涉及一种组合物，其包含一种或多种选自以下的提取物：人参（人参CAMeyer）提取物，葡萄（Vitis vinifera），艾蒿（艾蒿）和覆盆子（Rubus coreanus Miquel）作为活性成分， 并具有细胞活化作用。 特别地，本发明的细胞活化作用促进细胞活力; DNA损伤恢复; 抑制凋亡; 非定期DNA合成; DNA缺失率降低; 降低低分子量DNA含量; 并减少p53蛋白表达和p53依赖性蛋白表达。

公开(公告)号：KR101321754B1

公开(公告)日：2013-10-28

申请号：KR1020130034040

申请日：2013-03-29

Applicant: 유한회사한풍제약

Inventor： 조형권 ,  전기용 ,  이준경 ,  전창현 ,  김대성 ,  변에리사 ,  유진주 ,  권영배 ,  권중기 ,  김대기 ,  김세건 ,  정현주 ,  이은주

IPC: A61K36/488 ,  A61K36/732 ,  A61K36/284 ,  A61P19/02

CPC classification number: A61K36/732 ,  A61K36/185 ,  A61K36/25 ,  A61K36/284 ,  A61K36/31 ,  A61K36/714 ,  A61K2236/00 ,  A61K2300/00

Abstract: PURPOSE: A composition for prevention and treatment of rheumatoid arthritis and osteoarthritis is provided to suppress pain and inflammation of common symptoms in acute and chronic arthritis, and to improve exercise barrier which is a symptom of the chronic arthritis. CONSTITUTION: A composition for prevention and treatment of rheumatoid arthritis comprises an active ingredient mixed with: 350-450 wt% of Kalopanacis Cortex; 350-450 wt% of Chinese quince; 50-150 wt% of first extract which is extracted from Pulvis Aconiti Tuberis Purificatum; 150-250 wt% of Raphani Semen; and 50-150 wt% of second extract which is extracted from Atractylodis Rhizoma. The extract shows an effect which does not have chytotoxin to synoviocyte and chondrocyte. The extract shows effects of improving exercise barrier, and arthritic and analgesia. The extraction solvent for the first extract is 40-60 wt% of alcohol, and the extraction solvent for the second extract is water. [Reference numerals] (AA) Alleviating pain effect

Abstract translation: 目的：提供用于预防和治疗类风湿性关节炎和骨关节炎的组合物，以抑制急性和慢性关节炎中的常见症状的疼痛和炎症，并改善作为慢性关节炎症状的运动障碍。 构成：用于预防和治疗类风湿性关节炎的组合物包含与以下物质混合的活性成分：350-450重量％的卡拉帕拉西亚皮质; 中国柑橘350-450重量％ 50-150重量％的从Pulvis Aconiti Tuberis Purificatum提取的第一提取物; 150-250重量％的拉法尼精液; 和50-150重量％的从白术提取的第二提取物。 提取物显示对滑膜细胞和软骨细胞不具有chytotoxin的作用。 提取物显示改善运动障碍，关节炎和止痛的作用。 第一提取物的提取溶剂为40-60重量％的醇，第二提取物的提取溶剂为水。 （附图标记）（AA）缓解疼痛作用

公开(公告)号：KR1020020077715A

公开(公告)日：2002-10-14

申请号：KR1020010017455

申请日：2001-04-02

Applicant: 유한회사한풍제약

Inventor： 조형권 ,  전기용 ,  조인식

IPC: C07K1/12

CPC classification number: C07K1/12 ,  C07K14/43586 ,  C12Y304/22004

Abstract: PURPOSE: A method for producing silk-thread peptide is provided, thereby rapidly and cheaply producing the silk-thread peptide, which has a molecular weight of 500-10000 and 100% solubility at pH 4 to 9, in higher yield. CONSTITUTION: The method for producing silk-thread peptide comprises the steps of: inserting 1 part by weight of silk-thread protein into a solution containing 3 to 7 parts by weight of potassium chloride, 1.5 to 3.5 parts by volume(v/w) of ethanol, and 3 to 7 parts by volume(v/w) of water, and heating the solution at 85 to 95 deg. C for 1 to 3 hours to dissolve the silk-thread protein; dialyzing the silk-thread dissolved solution at 20 to 65 deg. C for 25 to 60 hours to remove salts; and adding 0.1 to 3.0%(w/v) of bromelain into 0.1 to 10.0%(w/v) of the silk-thread protein solution and reacting them at 25 to 30 deg. C for 1 to 5 hours.

Abstract translation: 目的：提供丝线肽的制造方法，从而以更高的收率迅速且廉价地生产分子量为500〜10000，溶解度为pH4〜9的丝线肽。 构成：丝线肽的制造方法包括：将1重量份丝线蛋白质插入含有3〜7重量份氯化钾，1.5〜3.5体积份（v / w）的溶液中， 的乙醇和3至7体积份（v / w）的水，并将溶液加热至85至95℃。 C 1〜3小时溶解丝线蛋白; 在20至65度透析丝线溶解溶液。 在25〜60小时内除去盐; 并将0.1〜3.0％（w / v）的菠萝蛋白酶加入0.1〜10.0％（w / v）丝素蛋白溶液中，并使其在25〜30℃反应。 C 1〜5小时。