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公开(公告)号：KR1020090002736A
公开(公告)日：2009-01-09
申请号：KR1020070066935
申请日：2007-07-04
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61L27/227 , A61K38/39 , A61L27/34 , A61L2430/02 , C07K14/78 , C07K2319/00 , C08L89/00
Abstract: A composition for promoting the osteogenesis, and a bone graft material coated with the composition are provided to improve the bone regeneration by increasing the differentiation of osteoblast. A composition for promoting the osteogenesis contains an oligopeptide comprising A-L-B as an active ingredient, wherein A is PHSRN, B is RGD, and L is a linker peptide comprising 15~25 amino acids. Preferably the oligopeptide contains a peptide linker between the amino acid represented by the sequence number 1 and the amino acid represented by the sequence number 2.
Abstract translation: 提供促进成骨的组合物和涂覆有组合物的骨移植材料，以通过增加成骨细胞的分化来改善骨再生。 用于促进成骨的组合物含有包含A-L-B作为活性成分的寡肽，其中A是PHSRN，B是RGD，L是包含15〜25个氨基酸的接头肽。 优选地，寡肽在由序列号1表示的氨基酸和由序列号2表示的氨基酸之间含有肽接头。
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公开(公告)号：KR1020050119489A
公开(公告)日：2005-12-21
申请号：KR1020040044596
申请日：2004-06-16
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: C07K7/08 , A61L27/22 , C07K5/1019 , C07K7/06
Abstract: 본 발명은 인공치아 특이 골유착용 부착 올리고 펩타이드에 관한 것으로서, 구체적으로 펩타이드 라이브러리를 이용한 스크리닝을 통하여 선별한 Ti 금속에 특이적으로 부착하는
서열번호 1 내지
서열번호 7 로 기재되는 올리고 펩타이드에 관한 것이다. 본 발명의 Ti 금속에 특이적 골유착용 부착하는 펩타이드는 Ti 금속과 생체분자간의 생체친화성을 높이는데 유용하게 사용될 수 있다.-
公开(公告)号：KR1020040020107A
公开(公告)日：2004-03-09
申请号：KR1020020051559
申请日：2002-08-29
Applicant: 재단법인서울대학교산학협력재단
IPC: C07K14/50
CPC classification number: C07K14/71 , C07K16/2863 , G01N33/57426 , G01N33/57484
Abstract: PURPOSE: A protein FGFR2 isomer specifically expressed from cancer cells is provided, thereby effectively diagnosing cancer using an antibody specific to the protein FGFR2 isomer. CONSTITUTION: A protein FGFR2 isomer specifically is expressed from cancer cells and has the amino acid sequence set forth in SEQ ID NO: 4 in which exons 7 to 10 are deleted. The protein specifically binds to FGF1, FGF2 or FGF7 and induces the activation of AKT or MAPK. A gene encoding the protein FGFR2 isomer has the nucleotide sequence set forth in SEQ ID NO: 3. An antibody specifically binding to the protein FGFR2 isomer is provided. A kit for diagnosis of cancer comprises the antibody to the protein FGFR2 isomer.
Abstract translation: 目的：提供从癌细胞特异性表达的蛋白FGFR2异构体，从而使用对蛋白FGFR2异构体特异的抗体有效地诊断癌症。 构成：蛋白质FGFR2异构体特异性地从癌细胞表达，并且具有SEQ ID NO：4所示的氨基酸序列，其中缺失外显子7至10。 蛋白质特异性结合FGF1，FGF2或FGF7，并诱导AKT或MAPK的活化。 编码蛋白FGFR2异构体的基因具有SEQ ID NO：3所示的核苷酸序列。提供了与蛋白质FGFR2异构体特异性结合的抗体。 用于诊断癌症的试剂盒包含对蛋白质FGFR2异构体的抗体。
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Patent Agency Ranking
公开(公告)号：KR1020040014006A
公开(公告)日：2004-02-14
申请号：KR1020020047170
申请日：2002-08-09
Applicant: 재단법인서울대학교산학협력재단
IPC: C07K7/08
CPC classification number: C07K7/08 , C07K5/0806 , C07K5/10 , C07K7/06
Abstract: PURPOSE: Oligosaccharides specifically binding to hydroxyapatite are provided, which oligosaccharides are useful as linkers between biomolecules for increasing the affinity of hydroxyapatite to human body materials. CONSTITUTION: Oligosaccharides specifically binding to hydroxyapatite are provided, wherein the oligosaccharides have the amino acid sequence selected from the SEQ ID NO: 1 to SEQ ID NO: 17; the oligosaccharides are selected by screening peptides specifically binding to hydroxyapatite using peptide library; and the hydroxyapatite has similar chemical components and structure to the human bone.
Abstract translation: 目的：提供与羟基磷灰石特异性结合的寡糖，这些寡糖可用作生物分子之间的接头，用于增加羟基磷灰石与人体材料的亲和力。 提供：提供与羟基磷灰石特异性结合的寡糖，其中寡糖具有选自SEQ ID NO：1至SEQ ID NO：17的氨基酸序列; 通过使用肽文库筛选特异性结合羟基磷灰石的肽来选择寡糖; 羟基磷灰石具有与人骨相似的化学成分和结构。
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公开(公告)号：KR1020030087278A
公开(公告)日：2003-11-14
申请号：KR1020020025274
申请日：2002-05-08
Applicant: 재단법인서울대학교산학협력재단
IPC: C07K7/06
CPC classification number: C07K7/06 , C12N15/1086
Abstract: PURPOSE: An oligopeptide specifically binding to chitosan is provided. The oligopeptide can be useful for selective separation of biocompatible chitosan and useful as a linker between chitosan and biomolecules. CONSTITUTION: An oligopeptide specifically binding to chitosan is provided, wherein the oligopeptide has the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3. The oligopeptide specifically binding to chitosan is isolated by inserting random amino acid sequences into a vector pFLITRIX containing the active portion of thioredoxin; transforming Escherichia coli with the vector pFLITRIX; culturing the transformed E. coli in an ampicillin containing IMC selection medium; adding tryptophane into the medium and culturing it to induce FLITRIX peptide; binding the transformed E. coli to chitosan fixed on a dish; selecting peptides specifically binding to PLGA; and sequencing the selected peptides.
Abstract translation: 目的：提供特异性结合壳聚糖的寡肽。 寡肽可用于生物相容性壳聚糖的选择性分离，可用作壳聚糖与生物分子之间的接头。 提供了与壳聚糖特异性结合的寡肽，其中寡肽具有SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3的氨基酸序列。通过插入随机氨基酸来分离与壳聚糖特异性结合的寡肽 酸序列转化成含有硫氧还蛋白活性部分的载体pFLITRIX; 用载体pFLITRIX转化大肠杆菌; 在含有氨苄青霉素的IMC选择培养基中培养转化的大肠杆菌; 将色氨酸加入到培养基中并培养以诱导FLITRIX肽; 将转化的大肠杆菌与固定在培养皿上的壳聚糖结合; 选择与PLGA特异性结合的肽; 并对所选择的肽进行测序。
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公开(公告)号：KR101824648B1
公开(公告)日：2018-03-14
申请号：KR1020150106774
申请日：2015-07-28
Applicant: 삼성전자주식회사 , 한양대학교 산학협력단
IPC: G10L19/008 , H04B13/00 , G10L21/00
Abstract: 데이터를송수신하는통신부; 진동을발생시켜신호를출력하는액추에이터(actuator); 음성신호의포먼트를증가시키는포먼트증강필터; 및상기통신부를통해상기음성신호를수신하도록제어하고, 선형예측부호화를기반으로상기음성신호로부터적어도하나이상의포먼트주파수를추정하며, 상기적어도하나이상의포먼트주파수의대역폭을추정하고, 상기음성신호가유성음인지무성음인지판별하며, 상기포먼트주파수, 상기포먼트주파수의대역폭, 상기판별한유성음또는무성음의특성및 인체의신호전달특성을기반으로상기포먼트증강필터를구성하고, 상기포먼트증강필터를상기음성신호에적용하며, 상기액추에이터를통해상기포먼트증강필터가적용된음성신호를상기인체를통해출력하도록제어하는제어부를포함하는음성신호처리장치가개시된다.
Abstract translation: 通信单元，用于发送和接收数据; 一种用于产生振动并输出信号的致动器; 共振峰增强滤波器，增加语音信号的形式; 并且基于所述线性预测编码从所述语音信号估计至少一个共振峰频率，估计所述至少一个共振峰频率的带宽， 共振峰增强滤波器基于共振峰频率，共振峰频率的带宽，有声或无声声音的特性以及人体的信号传输特性来配置， 以及控制单元，用于对语音信号应用滤波器并通过人体控制语音信号，以通过致动器输出应用了共振峰增强滤波器的语音信号。
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公开(公告)号：KR1020170106312A
公开(公告)日：2017-09-20
申请号：KR1020177018367
申请日：2015-09-23
Applicant: 삼성전자주식회사 , 한양대학교 산학협력단
IPC: G10L21/02 , G10L21/0216
CPC classification number: G10L21/0364 , G10L15/063 , G10L15/30 , G10L21/0205 , G10L21/0208 , G10L21/0232 , G10L25/84 , G10L21/02 , G10L2021/02163
Abstract: 적어도하나의음성신호를수신하는단계; 적어도하나의음성신호에대한 1차음성향상을수행하여제 1 음성신호를생성하는단계; 기학습된잡음제거이득정보로부터제 1 음성신호에대응되는잡음제거이득을선택하는단계; 및선택된잡음제거이득을기초로제 1 음성신호에대한 2차음성향상을수행하여, 제 2 음성신호를생성하는단계;를포함하는음성향상방법및 이를위한시스템을제공한다.
Abstract translation: 接收至少一个语音信号; 对至少一个语音信号执行第一语音增强以产生第一语音信号; 从学习噪声消除增益信息中选择与第一语音信号相对应的噪声消除增益; 并且通过基于所选择的噪声去除增益对第一语音信号执行第二语音增强来生成第二语音信号及其系统。
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公开(公告)号：KR1020160149961A
公开(公告)日：2016-12-28
申请号：KR1020150106774
申请日：2015-07-28
Applicant: 삼성전자주식회사 , 한양대학교 산학협력단
IPC: G10L19/008 , H04B13/00 , G10L21/00
Abstract: 데이터를송수신하는통신부; 진동을발생시켜신호를출력하는액추에이터(actuator); 음성신호의포먼트를증가시키는포먼트증강필터; 및상기통신부를통해상기음성신호를수신하도록제어하고, 선형예측부호화를기반으로상기음성신호로부터적어도하나이상의포먼트주파수를추정하며, 상기적어도하나이상의포먼트주파수의대역폭을추정하고, 상기음성신호가유성음인지무성음인지판별하며, 상기포먼트주파수, 상기포먼트주파수의대역폭, 상기판별한유성음또는무성음의특성및 인체의신호전달특성을기반으로상기포먼트증강필터를구성하고, 상기포먼트증강필터를상기음성신호에적용하며, 상기액추에이터를통해상기포먼트증강필터가적용된음성신호를상기인체를통해출력하도록제어하는제어부를포함하는음성신호처리장치가개시된다.
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