公开(公告)号：KR1020130138940A

公开(公告)日：2013-12-20

申请号：KR1020120062489

申请日：2012-06-12

Applicant: 조선대학교산학협력단 ,  주식회사 중앙백신연구소

Inventor： 오원근 ,  당타이중 ,  이승철 ,  유성식 ,  김은희

IPC: A61K31/045 ,  A61K31/05 ,  A61K36/12 ,  A61P31/12

Abstract: The present invention relates to a composition for preventing or treating corona virus related diseases, which contains a Dryopteris crassirhizoma extract or phloroglucinol derivatives isolated from the same. The composition has an excellent inhibitory effect on corona virus to be used as a treatment for viral cold or enteritis, cosmetics, health foods, disinfectants, animal feed, and animal medicines. [Reference numerals] (AA,BB) Compound 4 (μg/ml)

Abstract translation: 本发明涉及一种用于预防或治疗冠心病病毒相关疾病的组合物，其中含有从其中分离出的鳞翅类鳞翅目提取物或间苯三酚衍生物。 该组合物对用作病毒性感冒或肠炎，化妆品，保健食品，消毒剂，动物饲料和动物药物的治疗的电晕病毒具有优异的抑制作用。 （AA，BB）化合物4（μg/ ml）

公开(公告)号：KR101334143B1

公开(公告)日：2013-11-28

申请号：KR1020120062490

申请日：2012-06-12

Applicant: 조선대학교산학협력단 ,  주식회사 중앙백신연구소

Inventor： 오원근 ,  다오트롱투완 ,  누엔버치트 ,  최환원 ,  원호근 ,  윤인중

IPC: A61K31/352 ,  A61K31/35 ,  A61P31/16 ,  A61P31/12

Abstract: The present invention relates to a composition containing a Polygala karensium extract and xanthone-based compounds isolated from the same for preventing or treating flu, avian influenza, swine influenza, or novel swine-origin influenza. The Polygala karensium extract and xanthone-based compounds isolated from the same effectively and non-selectively suppress neuraminidase of flu virus, avian influenza virus, swine influenza virus, novel swine-origin influenza, and Tamiflu resistant novel swine-origin influenza virus, thereby being used as a therapeutic agent for treating flu, avian influenza, swine influenza, and swine-origin influenza and being applied in cosmetic products, health foods, animal feeds, and an animal medicinal industry. [Reference numerals] (AA) Swine influenza virus (H1N1);(BB,HH,NN,TT) Compound 1;(CC,II,OO,UU) Compound 2;(DD,JJ,PP,VV) Compound 3;(EE,KK,QQ,WW) Compound 4;(FF,LL,RR,XX) Compound 5;(GG) Avian influenza virus (H9N2);(MM) Novel swine-origin influenza virus (novel H1N1);(SS) Novel swine-origin influenza virus resistant to Tamiflu (H1N1[H274Y])

Abstract translation: 本发明涉及含有从其分离的Polygala karensium提取物和基于呫吨酮的化合物预防或治疗流感，禽流感，猪流感或新型猪源性流感的组合物。 从同样有效和非选择性地抑制流感病毒，禽流感病毒，猪流感病毒，新型猪源性流感病毒和Tamiflu抗性新型猪源性流感病毒的神经氨酸酶分离的Polygala karensium提取物和基于呫吨酮的化合物，从而被 用作治疗流感，禽流感，猪流感和猪源性流感的治疗剂，并用于化妆品，保健食品，动物饲料和动物医药行业。 化合物1;（CC，II，OO，UU）化合物2;（DD，JJ，PP，VV）化合物3;（AA）猪流感病毒（H1N1）;（BB，HH，NN，TT） （EE，KK，QQ，WW）化合物4;（FF，LL，RR，XX）化合物5;（GG）禽流感病毒（H9N2）;（MM）新型猪源性流感病毒（新型H1N1） ）抗Tamiflu（H1N1 [H274Y]）新型猪源性流感病毒

公开(公告)号：KR101132174B1

公开(公告)日：2012-04-05

申请号：KR1020100013217

申请日：2010-02-12

Applicant: 조선대학교산학협력단

Inventor： 오원근 ,  누엔피헝 ,  누엔티녹안 ,  강후원

IPC: A61K31/343 ,  A61K31/34 ,  A61K36/25 ,  A61P3/04

Abstract: PURPOSE: A compound which activates Erythrina abyssinica-derived AMPK is provided to prevent and treat diabetes, obesity, or metabolic syndrome with less cytotoxicity. CONSTITUTION: An Erythrina abyssinica extract for preventing or treating obesity or metabolic syndrome contains erythribyssin F, erythribyssin N, erythribyssin O, sigmoidin K, isosojagol, eryvarin, or erypoegin F. A health food or pharmaceutical composition for preventing or treating obesity or metabolic syndrome contains the Erythrina abyssinica extract as an active ingredient. The pharmaceutical composition also contains pharmaceutically acceptable carrier or excipient.

公开(公告)号：KR101062174B1

公开(公告)日：2011-09-05

申请号：KR1020080113655

申请日：2008-11-14

Applicant: 조선대학교산학협력단 ,  (주)아모레퍼시픽

Inventor： 오원근 ,  텅풍티엔 ,  누엔두이투완 ,  김정기 ,  김완기 ,  이상준

IPC: A23L1/30 ,  A23L33/00

Abstract: 본 발명은 감잎 유래의 AMP-활성 단백질키나제 효소(AMP-activated protein kinase; AMPK)를 활성화 시키는 화합물 및 이를 유효성분으로 포함하는 비만 예방과 치료용 조성물에 관한 것으로, 감잎을 에탄올 추출한 후 크로마토그래피를 이용하여 순수 분리 정제하여 얻은 AMPK 활성화 화합물과 이를 유효성분으로 함유하는 비만 또는 당뇨병의 예방과 치료 용도에 관한 것이다.
감잎, AMP-활성 단백질키나제 효소, 비만, 당뇨

公开(公告)号：KR1020110093279A

公开(公告)日：2011-08-18

申请号：KR1020100013217

申请日：2010-02-12

Applicant: 조선대학교산학협력단

Inventor： 오원근 ,  누엔피헝 ,  누엔티녹안 ,  강후원

IPC: A61K31/343 ,  A61K31/34 ,  A61K36/25 ,  A61P3/04

Abstract: PURPOSE: A compound which activates Erythrina abyssinica-derived AMPK is provided to prevent and treat diabetes, obesity, or metabolic syndrome with less cytotoxicity. CONSTITUTION: An Erythrina abyssinica extract for preventing or treating obesity or metabolic syndrome contains erythribyssin F, erythribyssin N, erythribyssin O, sigmoidin K, isosojagol, eryvarin, or erypoegin F. A health food or pharmaceutical composition for preventing or treating obesity or metabolic syndrome contains the Erythrina abyssinica extract as an active ingredient. The pharmaceutical composition also contains pharmaceutically acceptable carrier or excipient.

Abstract translation: 目的：提供一种激活源自艾氏黑质素的AMPK的化合物，以预防和治疗糖尿病，肥胖或代谢综合征，细胞毒性较小。 构成：用于预防或治疗肥胖症或代谢综合征的黑曜石提取物含有赤藓红F，红细菌素N，赤藓糖苷O，乙状结肠素K，异山梨醇，赤藓红或紫杉醇F.用于预防或治疗肥胖或代谢综合症的保健食品或药物组合物含有 白芷提取物作为活性成分。 药物组合物还含有药学上可接受的载体或赋形剂。

公开(公告)号：KR1020100129481A

公开(公告)日：2010-12-09

申请号：KR1020090048065

申请日：2009-06-01

Applicant: 조선대학교산학협력단 ,  (주)아모레퍼시픽

Inventor： 오원근 ,  누엔피헝 ,  레티반트 ,  강후원 ,  신의석 ,  최진규 ,  서대방 ,  이상준

IPC: A61K36/185 ,  A61P3/04 ,  A23L1/30 ,  A61K31/341

CPC classification number: A61K36/185 ,  A61K31/341 ,  A61K2236/333

Abstract: PURPOSE: A Myristica fragrans-derived 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan is provided to activates AMP-activated protein kinase(AMPK) and to prevent and treat metabolic syndrome-associated diseases. CONSTITUTION: A Myristica fragrans extract is obtained by isolating Myristica fragrans with 10-30% of ethanol solution and contains lignin compounds of nectandrin B, nectandrin A, fragransin C1, verrucosin, saucernetin or tetrahydrofuroguaiacin. A functional food for treating obesity or metabolic syndrome contains Myristica fragrans extract.

Abstract translation: 目的：提供肉豆蔻衍生的2,5-双 - 芳基-3,4-二甲基四氢呋喃木脂素以激活AMP-活化的蛋白激酶（AMPK）并预防和治疗代谢综合征相关疾病。 构成：通过用10-30％的乙醇溶液分离肉豆蔻，获得肉豆蔻提取物，并含有nectandrin B，nectandrin A，fragransin C1，verrucosin，saucernetin或四氢呋喃桂皮素的木质素化合物。 用于治疗肥胖症或代谢综合症的功能性食物包含肉豆蔻提取物。

公开(公告)号：KR100962334B1

公开(公告)日：2010-06-10

申请号：KR1020090099238

申请日：2009-10-19

Applicant: 주식회사 중앙백신연구소 ,  조선대학교산학협력단

Inventor： 김은희 ,  유성식 ,  원호근 ,  오원근 ,  박준수 ,  강후원 ,  누엔티녹안

IPC: A61K36/9066 ,  A61P31/16 ,  A23L1/30 ,  A61K31/12

CPC classification number: A61K31/12 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/9066 ,  A23V2250/21

Abstract: PURPOSE: A composition containing diaryheptanoid compounds for preventing and treating avian and swine influenza and novel swine-origin influenza A is provided to non-selectively suppress neuraminidase. CONSTITUTION: A pharmaceutical composition for preventing or treating oseltamivir phosphate-resistant novel swine-origin influenza A contains Curcuma longa extract as an active ingredient. The Curcuma longa extract contains bisdemethoxycurcumin, demethoxycurcumin, or curcumine. The Curcuma longa extract is obtained using ethanol, methanol, acetone, ethyl acetate, or chloroform. A health food for preventing or treating Tamiflu resistant novel swine-origin influenza A contains bisdemethoxycurcumin, demethoxycurcumin, or curcumine.

Abstract translation: 目的：提供一种含有用于预防和治疗禽流感和猪流感病毒的日化类固醇化合物和新型猪源甲型流感病毒的组合物，用于非选择性抑制神经氨酸酶。 构成：用于预防或治疗磷酸奥司他韦的新型猪源甲型流感A的药物组合物含有姜黄提取物作为活性成分。 姜黄提取物含有二去甲氧基姜黄素，去甲氧基姜黄素或姜黄素。 使用乙醇，甲醇，丙酮，乙酸乙酯或氯仿得到姜黄提取物。 用于预防或治疗Tamiflu抗性的猪源甲型流感A的保健食品含有双二甲氧基姜黄素，去甲氧基姜黄素或姜黄素。

公开(公告)号：KR1020100054638A

公开(公告)日：2010-05-25

申请号：KR1020080113632

申请日：2008-11-14

Applicant: 조선대학교산학협력단

Inventor： 오원근 ,  배기환 ,  텅풍티엔 ,  누엔두이투완

IPC: A23L1/30 ,  A23L33/00

CPC classification number: A23L33/105 ,  A23V2002/00 ,  A23V2200/02 ,  A23V2200/326 ,  A23V2250/2132 ,  A23V2250/214 ,  A61K31/216

Abstract: PURPOSE: Phenolic compounds having antioxidant activity from Ilex kudingcha extract and functional food containing the same are provided to prevent or treat diseases caused by active oxygen containing oxygen-resistant compounds as beneficial components. CONSTITUTION: The health food contains Ilex kudingcha methanol extract as active ingredients. The Ilex kudingcha methanol extract includes a compound 1[3-caffeoylquinic acid], a compound 2 [5-caffeoylquinicacid], a compound 3 [4-caffeoylquinic acid], a compound 4 [4-caffeoylquinic acid methyl ester, a compound 5[4,5-dicaffeoylquinic acid methyl ester], a compo0und 6 [3,5-dicaffeoylquinic acid methyl ester], a compound 7[caffeoic acid methyl ester], a compound 8 [3,4-dicaffeoylquinic acid methyl ester] and a compound 9 [3,5-di-O-caffeoyl-epi-quinic acid n-butyl ester].

Abstract translation: 目的：提供具有来自枸杞提取物和含有其的功能性食品的抗氧化活性的酚类化合物，以预防或治疗由含活性氧的耐氧化合物引起的疾病作为有益成分。 规定：保健食品含有枸杞子甲醇提取物作为活性成分。 枸杞醇甲醇提取物包括化合物1 [3-咖啡酰奎宁酸]，化合物2 [5-咖啡酰奎宁酸]，化合物3 [4-咖啡酰奎宁酸]，化合物4 [4-咖啡酰奎宁酸甲酯，化合物5 [ 4,5-二脱酰基奎尼酸甲酯]，化合物7 [椰子酸甲酯]，化合物8 [3,4-二脱酰奎尼酸甲酯]和化合物 9 [3,5-二-O-咖啡酰基 - 邻 - 奎尼酸正丁酯]。

公开(公告)号：KR100950445B1

公开(公告)日：2010-04-02

申请号：KR1020090101628

申请日：2009-10-26

Applicant: 주식회사 중앙백신연구소 ,  조선대학교산학협력단

Inventor： 윤인중 ,  이홍식 ,  김동원 ,  오원근 ,  박준수 ,  부이탄텅 ,  다오트롱투완

IPC: A61K36/484 ,  A61P31/16 ,  A23L1/30 ,  A61K31/12

CPC classification number: A61K31/12 ,  A23K20/111 ,  A23L2/52 ,  A23L29/035 ,  A61K36/484 ,  A61K2236/333 ,  Y10S514/888

Abstract: PURPOSE: A Glycyrrhiza uralensis extract and calcone based compounds suppressing neuraminidase are provided to treat novel swine-origin influenza. CONSTITUTION: A Glycyrrhiza uralensis extract for preventing or treating avian and swine ingluenza contains is extracted using ethanol or methanol and contains chalcone based compound. The chalcone based compound is Licochacone F, Echicnatin, Licochalcon D, Licochalcone A, Isoliquiritigenin, Licoagrochalcone A, 5-Prenylbutein and Kanzonol C. A functional health food for preventing or treating diseases relating to avian and swine influenza contains Glycyrrhiza uralensis extract. A pharmaceutical composition for preventing or treating diseases relating to avian and swine influenza contains Glycyrrhiza uralensis extract or chalcone compouns as active ingredient. The pharmaceutical composition also contains pharmaceutically acceptable carrier or excipient.

Abstract translation: 目的：提供甘草提取物和基于煅烧物的抑制神经氨酸酶的化合物，用于治疗新型猪源性流感。 构成：用乙醇或甲醇提取用于预防或治疗禽流感和猪流感病毒的甘草提取物，并含有查耳酮基化合物。 基于查耳酮的化合物是Licochacone F，Echicnatin，Licochalcon D，Licochalcone A，Isoliquiritigenin，Licoagrochalcone A，5-丙氨酸丁醇和Kanzonol C.用于预防或治疗与禽流感和猪流感有关的疾病的功能保健食品含有甘草提取物。 用于预防或治疗与禽流感和猪流感有关的疾病的药物组合物含有甘草提取物或查耳酮组合物作为活性成分。 药物组合物还含有药学上可接受的载体或赋形剂。