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21.发明授权
公开(公告)号：KR100543954B1
公开(公告)日：2007-04-12
申请号：KR1020030073575
申请日：2003-10-21
Applicant: 충남대학교산학협력단
Abstract: 본 발명은 하기 화학식 (1)로 표시된 신물질 1
N -벤질-4-메틸벤젠-1,2-디아민과 이의 제법 및 이 물질을 유효성분으로 과색소 침착 피부질환을 예방 및 치료할 수 있는 미백기능 화장품 조성물에 관한 것이다.
1N-벤질-4-메틸벤젠-1,2-디아민, 미백, 화장품, 기능성, 멜라닌, 티로신, 티로시나제-
公开(公告)号：KR100547643B1
公开(公告)日：2006-01-31
申请号：KR1020040000925
申请日：2004-01-07
Applicant: 충남대학교산학협력단
IPC: B29B17/00
Abstract: 본 발명은 폐플라스틱 필름을 이용한 고부가가치의 왁스 제조장치에 관한 것이다. 더 상세하게는, 본 발명은 용융조(10)에 폐플라스틱 필름을 투입한 후, 250℃ 내지 300℃ 로 용융시켜 폐플라스틱에 함유된 다양한 불순물을 분리하고, 용융된 폐플라스틱용융물은 열분해 반응조(12)로 이송시켜, 350~390℃로 열분해함으로써 평균분자량이 1000~5000이고 점도(140℃)가 300~400 cP 인 고열량의 왁스를 제조하는 장치를 제공하는 것이다. 본발명에 의해, 환경오염의 주원인인 폐플라스틱 필름등에서 흙 등의 이물질 제거를 위한 수세 및 건조과정과 같은 복잡한 공정없이, 단순히 용융조에서 용융함으로써 비중이 큰 흙 등의 불순물을 비중차에 의해 하부로 분리하고, 플라스틱 용융물은 열분해 반응조(12)로 이송하여 분해시켜, 분산제, 접착제 및 첨가조제 등 다양한 분야에 사용할 수 있는 고부가가치의 왁스를 제조할 수 있으며, 폐수가 전혀 발생하지 않는 무폐수 방류시스템의 개발을 통한 2차 환경오염방지, 폐기물 처리에 의한 환경오염 방지, 매립 및 소각에 따른 비용절감 및 사회 간접수입 증대와 같은 효과를 가져올 수 있다.
폐플라스틱 필름, 열분해, 열분해 반응조, 고부가 왁스Abstract translation: 本发明涉及使用废塑料膜的高附加价值的蜡制造设备。 更具体地，本发明装入封闭的塑料薄膜为熔浴（10），熔点为250℃到300℃除去包含在废塑料的各种杂质，和熔融废塑料熔化热分解反应器（ 转移至12），1000-5000的平均分子量，通过热分解至350〜390℃是用于与粘度产生的蜡提供的装置（140℃）为300〜400厘泊的卡路里。 根据本发明，底部由废塑料洗涤的主要原因与水用于去除外来物质如灰尘等薄膜和没有复杂的处理，例如污染的杂质，诸如干燥处理，只需大比重和熔体在熔融浴土壤如比重差 即通过分解分离，并且将塑料熔体可与高蜡来制备，并转移到热解反应器（12），可以在各种领域中，如分散剂，粘合剂和另外制备值一起使用，没有废水排放废水不发生在所有在 其次，通过系统开发可以防止环境污染，通过废物处理防止环境污染，降低垃圾填埋和焚烧造成的成本，增加社会间接收入。
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公开(公告)号：KR1020040093962A
公开(公告)日：2004-11-09
申请号：KR1020030027850
申请日：2003-04-30
Applicant: 충남대학교산학협력단
IPC: C07C65/40
Abstract: PURPOSE: A novel chalcone-based derivative is provided, which has an interleukin-5 inhibiting effect and a chronic allergic inflammation curing effect and is a low molecule and a non-peptide material. CONSTITUTION: The novel chalcone-based derivative represented by the formula(1) is produced by condensing a compound represented by the formula(2) and a compound represented by the formula(3) in an alcohol solvent in the presence of a base, wherein the alcohol solvent is a C1-C5 alcohol and the base is sodium hydroxide or potassium hydroxide. In the formulas, R1 and R2 are benzyloxy, cyclohexyl methoxy, hydrogen, or hydroxy and R3 is hydroxy or -COOH.
Abstract translation: 目的：提供一种新型的查耳酮衍生物，其具有白细胞介素-5抑制作用和慢性过敏性炎症治疗效果，是低分子和非肽材料。 构成：由式（1）表示的新型查耳酮系衍生物通过在醇溶剂中在碱存在下将式（2）表示的化合物与式（3）表示的化合物缩合而制备，其中 醇溶剂是C1-C5醇，碱是氢氧化钠或氢氧化钾。 式中R1和R2是苄氧基，环己基甲氧基，氢或羟基，R3是羟基或-COOH。
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Patent Agency Ranking
公开(公告)号：KR1020040093500A
公开(公告)日：2004-11-06
申请号：KR1020030027369
申请日：2003-04-30
Applicant: 충남대학교산학협력단
IPC: C07D311/36
Abstract: PURPOSE: Isoflavonone derivative which inhibits IL-5 activity are provided. The derivative inhibits the introduction of eosinophil which is an inflammatory cell causing asthma into the airway, and improves the airway sensitivity to alleviate asthma symptom. CONSTITUTION: The isoflavonone derivatives of the formula (1) inhibiting IL-5 activity is provided, wherein R1 is benzyloxy, hydrogen or hydroxy; R2 is benzyloxy, hydrogen or hydroxy; R3 is hydroxy, -OCH2COOCH3, -OCH2COOH or compound groups of formula (2). The method for preparing the isoflavonone derivative of the formula (1) comprises the steps of: reacting a compound of the formula (3) to prepare an isoflavonone derivative of formula (1-1); reacting the compound of the formula (1-1) with benzyl triammonium chloride and glucopyranosyl bromoacetate in the presence of base to prepare a compound of the formula (1-2); reacting the compound of the formula (1-1) with epichlorohydrin in the presence of base to prepare an epoxymethyl derivative of the formula (1-4); and reacting the compound of formula (1-4) with anhydrous sodium acetate and titanium tetraisopropoxide in acetic acid to prepare a compound of the formula (1-5), deprotecting the compound of the formula (1-4) to prepare a compound of the formula (1-6), and reacting the compound of the formula (1-4) with sodium acetate and titanium tetraisopropoxide in methanol to prepare compounds of the formulas (1-7) and (1-8).
Abstract translation: 目的：提供抑制IL-5活性的异黄酮衍生物。 该衍生物抑制嗜酸性粒细胞的引入，嗜酸粒细胞是导致哮喘进入气道的炎症细胞，并且改善气道敏感性以减轻哮喘症状。 构成：提供抑制IL-5活性的式（1）的异黄酮衍生物，其中R1是苄氧基，氢或羟基; R2是苄氧基，氢或羟基; R3是羟基，-OCH2COOCH3，-OCH2COOH或式（2）的化合物基团。 制备式（1）的异黄酮衍生物的方法包括以下步骤：使式（3）的化合物与式（1-1）的异黄酮衍生物反应; 在碱的存在下使式（1-1）的化合物与苄基三氯化铵和溴代吡喃葡萄糖基吡喃酮反应，以制备式（1-2）的化合物; 在碱的存在下使式（1-1）的化合物与表氯醇反应以制备式（1-4）的环氧甲基衍生物; 并使式（1-4）化合物与无水乙酸钠和四异丙醇钛在乙酸中反应，制得式（Ⅰ-1）化合物，使式（1-4）化合物脱保护，制备 式（1-6）表示，并使式（1-4）化合物与乙酸钠和四异丙氧基钛在甲醇中反应，制备式（1-7）和（1-8）的化合物。
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公开(公告)号：KR1020040077106A
公开(公告)日：2004-09-04
申请号：KR1020030012533
申请日：2003-02-28
Applicant: 충남대학교산학협력단
IPC: B01D53/00
CPC classification number: Y02A50/235 , B01D46/0036 , B01D46/0065 , B01D53/02
Abstract: PURPOSE: Provided are a complex filter for a gas scrubber, which is able to simultaneously remove volatile organic compounds, ionic gas and heavy metals, and a gas scrubber, which is able to continuously regenerate the complex filter during the system operation. CONSTITUTION: The complex filter comprises a cation exchange filter part (A) adsorbing and removing cationic contaminants in gas to be treated, an anion exchange filter part (B) adsorbing and removing anionic contaminants in gas to be treated, an inorganic adsorbing part (C) filtering non-ionic contaminants including heavy metals and volatile organic components and a case(3) having at least one of the cation exchange filter part, anion exchange filter part and inorganic adsorbing part within at regular intervals. The gas scrubber where the complex filter for the gas scrubber is installed comprises a regenerating solution storing means regenerating the complex filter for the gas scrubber, a pumping means pumping the regenerating solution stored in the regenerating solution storing means to the top part of the complex filter and a regenerating solution spraying means periodically or intermittently.
Abstract translation: 目的：提供一种用于气体洗涤器的复杂过滤器，其能够同时除去挥发性有机化合物，离子气体和重金属，以及气体洗涤器，其能够在系统操作期间连续地再生复杂过滤器。 构成：复合过滤器包括吸附和去除要处理的气体中的阳离子污染物的阳离子交换过滤器部分（A），吸附和去除待处理气体中的阴离子污染物的阴离子交换过滤器部分（B），无机吸附部分（C ）过滤非离子污染物，包括重金属和挥发性有机成分，以及具有至少一个阳离子交换过滤器部分，阴离子交换过滤器部分和无机吸附部分的情况（3）。 安装气体洗涤器的复合过滤器的气体洗涤器包括再生溶液存储装置，用于再生用于气体洗涤器的复合过滤器，泵送装置将存储在再生溶液存储装置中的再生溶液泵送到复合过滤器的顶部 和再生溶液喷雾装置周期地或间歇地。
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公开(公告)号：KR1020100022429A
公开(公告)日：2010-03-02
申请号：KR1020090053199
申请日：2009-06-16
Applicant: 충남대학교산학협력단 , 충북대학교 산학협력단
IPC: C07D239/10 , A61K31/17
Abstract: PURPOSE: A derivatives of cyclic thio-urea and a composition containing the same are provided to prevent and relieve pigmentation of melanocytes and to treat hypepigmentation. CONSTITUTION: A derivative of cyclic thio-urea is denoted by chemical formula 1. A method for preparing the derivative comprises: a step of reacting diaminopropane(2) with ditertialybutyl dicarbonate to prepare a compound(3); a step of condensing aldehyde(4) with the compound and reducing to obtain an amine compound(5); a step of reacting the amine compound under the basic condition to obtain cyclized cyclic urea derivative(6); and a step of reacting the cyclic urea derivative with Lawesson's reagent to obtain the derivative of thio-urea derivative(1).
Abstract translation: 目的：提供环硫脲的衍生物和含有它们的组合物，以预防和缓解黑素细胞的色素沉着和治疗色素沉着。 组成：环硫脲的衍生物由化学式1表示。制备衍生物的方法包括：使二氨基丙烷（2）与二碳酸二叔丁酯反应制备化合物（3）的步骤; 将醛（4）与化合物缩合并还原以获得胺化合物（5）的步骤; 在碱性条件下使胺化合物反应得到环化的环状脲衍生物（6）的步骤; 和环脲衍生物与Lawesson试剂反应得到硫脲衍生物（1）的衍生物的步骤。
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27.发明公开신물질 1,3-디하이드로벤즈이미다졸-2-싸이온 유도체, 그의제법 및 이를 유효성분으로 하는 미백용 화장료 조성물 有权1,3-二氢苯并咪唑-2-酮的新衍生物，它们的制备和化妆品组合物，作为有效成分的这些化合物
公开(公告)号：KR1020090105640A
公开(公告)日：2009-10-07
申请号：KR1020080031219
申请日：2008-04-03
Applicant: 충남대학교산학협력단
IPC: C07D235/28 , A61K31/415
Abstract: PURPOSE: A novel 1,3-dihydrobanzimidazol-2-thion derivative is provided to prevent pigmentation, attenuate the color of melanin and ensure skin whitening effect. CONSTITUTION: A 1,3-dihydrobenzimidazol-2-thion derivative is denoted by the chemical formula 1. In chemical formula 1, R1 is alkyl(C1-C5) or chloro, n is 1, 2, or 3. A method for producing 1,3-dihydrobenzimidazol-2-thion derivative comprises: a step of converting 2-nitroaniline derivative (chemical formula 2) to 1N-benzyl-2-nitroaniline derivative (chemical formula 3); a step of converting the 1N-benzyl-2-nitroaniline derivative to a 1N-benzyl-2-aminoanyline derivative (chemical formula 4); a step of converting the 1N-benzyl-2-aminoanyline derivative to 1,3-dihydrobenzimidazol-2-one derivative (chemical formula 7); and a step of converting the 1,3-dihydrobenzimidazol-2-one derivative to 1,3-dihydrobenzamidazol-2-thion derivative.
Abstract translation: 目的：提供新的1,3-二氢苯并咪唑-2-衍生物，以防止色素沉着，减弱黑色素的颜色，并确保皮肤美白效果。 构成：化学式1表示1,3-二氢苯并咪唑-2-基衍生物。在化学式1中，R 1为烷基（C 1 -C 5）或氯，n为1,2或3。 1,3-二氢苯并咪唑-2-基衍生物包括：将2-硝基苯胺衍生物（化学式2）转化为1N-苄基-2-硝基苯胺衍生物（化学式3）的步骤; 将1N苄基-2-硝基苯胺衍生物转化为1N苄基-2-氨基苯胺衍生物（化学式4）的步骤。 将1N苄基-2-氨基苯胺衍生物转化为1,3-二氢苯并咪唑-2-酮衍生物（化学式7）的步骤。 以及将1,3-二氢苯并咪唑-2-酮衍生物转化为1,3-二氢苯并咪唑-2-基衍生物的步骤。
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公开(公告)号：KR1020050072578A
公开(公告)日：2005-07-12
申请号：KR1020040000925
申请日：2004-01-07
Applicant: 충남대학교산학협력단
IPC: B29B17/00
CPC classification number: Y02P70/26 , Y02W30/62 , B29B17/02 , B29B2017/0496
Abstract: 본 발명은 폐플라스틱 필름을 이용한 고부가가치의 왁스 제조장치에 관한 것이다. 더 상세하게는, 본 발명은 용융조(10)에 폐플라스틱 필름을 투입한 후, 250℃ 내지 300℃ 로 용융시켜 폐플라스틱에 함유된 다양한 불순물을 분리하고, 용융된 폐플라스틱용융물은 열분해 반응조(12)로 이송시켜, 350~390℃로 열분해함으로써 평균분자량이 1000~5000이고 점도(140℃)가 300~400 cP 인 고열량의 왁스를 제조하는 장치를 제공하는 것이다. 본발명에 의해, 환경오염의 주원인인 폐플라스틱 필름등에서 흙 등의 이물질 제거를 위한 수세 및 건조과정과 같은 복잡한 공정없이, 단순히 용융조에서 용융함으로써 비중이 큰 흙 등의 불순물을 비중차에 의해 하부로 분리하고, 플라스틱 용융물은 열분해 반응조(12)로 이송하여 분해시켜, 분산제, 접착제 및 첨가조제 등 다양한 분야에 사용할 수 있는 고부가가치의 왁스를 제조할 수 있으며, 폐수가 전혀 발생하지 않는 무폐수 방류시스템의 개발을 통한 2차 환경오염방지, 폐기물 처리에 의한 환경오염 방지, 매립 및 소각에 따른 비용절감 및 사회 간접수입 증대와 같은 효과를 가져올 수 있다.
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