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公开(公告)号：KR1020110029850A
公开(公告)日：2011-03-23
申请号：KR1020090087697
申请日：2009-09-16
Applicant: 포항공과대학교 산학협력단
Abstract: PURPOSE: A chemodosimeter approach to sensing organic and inorganic mercury species through fluorescence is provided to detect organic and inorganic mercury using a fluorescent fluorescein derivative compound. CONSTITUTION: A fluorescein derivative compound or salts thereof are represented by chemical formula (1). In chemical formula (1), R1, R2, R3 and R4 are hydrogen, halogen, or cyclic substituted C1-C30 substituted or unsubstituted alkyl, as a substituted or unsubstituted aryl group, linear or branched alkyl, aryl, and ester.
Abstract translation: 目的：提供通过荧光检测有机和无机汞物种的化学计量法，以使用荧光荧光素衍生物化合物检测有机和无机汞。 构成：荧光素衍生物化合物或其盐由化学式（1）表示。 在化学式（1）中，R 1，R 2，R 3和R 4是氢，卤素或环状取代的C 1 -C 30取代或未取代的烷基，作为取代或未取代的芳基，直链或支链烷基，芳基和酯。
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公开(公告)号：KR1020110008970A
公开(公告)日：2011-01-27
申请号：KR1020090066548
申请日：2009-07-21
Applicant: 포항공과대학교 산학협력단
IPC: C07D491/10 , C07D491/02
Abstract: PURPOSE: A novel rhodamine B derivative compound for detecting silver ion and silver nanoparticles is provided to selectively quantitate silver nanoparticles and to ensure high substrate selectivity. CONSTITUTION: A rhodamin B derivative compound is denoted by chemical formula 1. In chemical formula 1, R1 and R2 are independently hydrogen, halogen, substituted or non-substituted alkyl, substituted or non-substituted aryl group; and R3 is independently -Net_2, -NHR, or -NH_2. The compound has "turn-on" fluorescent and chromogenic characteristic by coordinating a silver ion on iodine by intramolecular electron transfer. The silver ion is produced after oxidation of ion-binding silver ion and silver nanoparticles. A chemical sensor for detecting silver contains the rhodamin B derivative compound of chemical formula 1.
Abstract translation: 目的：提供一种用于检测银离子和银纳米颗粒的新型罗丹明B衍生化合物，以选择性定量银纳米颗粒并确保高基材选择性。 组成：罗丹明B衍生化合物由化学式1表示。在化学式1中，R 1和R 2独立地为氢，卤素，取代或未取代的烷基，取代或未取代的芳基; 并且R 3独立地是-Net 2，-NHR或-NH 2。 该化合物通过配位在碘上的银离子通过分子内电子转移而具有“开启”荧光和显色特征。 银离子在离子结合银离子和银纳米颗粒氧化后产生。 用于检测银的化学传感器含有化学式1的罗丹明B衍生化合物。
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公开(公告)号：KR1020080032934A
公开(公告)日：2008-04-16
申请号：KR1020060099085
申请日：2006-10-11
Applicant: 포항공과대학교 산학협력단
IPC: C07F15/00
CPC classification number: C07F15/006
Abstract: Palladium pincer complexes with a hexagonal metal ring are provided to improve catalyst activity as compared with conventional pincer complexes when they are applied to Heck reaction, and maintain stability under stringent conditions including high temperature. The palladium pincer complexes represented by the formula(2) are provided in order to catalyze organic reactions including Heck reaction, wherein R1 is hydrogen or optionally substituted C1-5 alkyl group, nitro group, halogen atom or alkoxy group; X is O, S or CH2; and L is a ligand selected from halogen atom, or acetate of SO3CF3. The palladium pincer complexes represented by the formula(2) are prepared by reacting 1,3-bis(2-pyridyloxy) benzene or its derivatives with compounds represented by the formula(4) of K2PdX4 in which X is halogen atom.
Abstract translation: 提供具有六方金属环的钯钳形复合物，以便当它们应用于Heck反应时与常规钳形复合物相比提高催化剂活性，并在包括高温在内的严格条件下保持稳定性。 提供由式（2）表示的钯钳形络合物，以便催化包括Heck反应的有机反应，其中R 1是氢或任选取代的C 1-5烷基，硝基，卤素原子或烷氧基; X是O，S或CH 2; L是选自卤原子或SO 3 CF 3的乙酸酯的配体。 由式（2）表示的钯钳形络合物是通过使1,3-双（2-吡啶氧基）苯或其衍生物与其中X为卤素原子的K2PdX4的式（4）表示的化合物反应制备的。
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公开(公告)号：KR101809828B1
公开(公告)日：2017-12-18
申请号：KR1020160044727
申请日：2016-04-12
Applicant: 포항공과대학교 산학협력단
IPC: G01N33/58 , G01N33/574 , G01N21/64 , A61K49/00
Abstract: 본발명은화학식 5의화합물또는이의유사체(analogues)를포함하는, 타이로신인산화효소(tyrosine kinase) 감지용형광프로브조성물, 및이의용도에관한것으로서, 더욱구체적으로는종래화합물 1(KP1)의구조적변화를통하여보다향상된특성을가진형광프로브, 이를이용한세포와조직영상화방법, 살아있는동물을대상으로한 암진단및 영상화방법에관한것이다. 본발명에의하면, 향상된민감도와선택성을나타내는진보된감지특성으로인하여, 암조직의선택적영상화에효과적으로활용될수 있다.
Abstract translation: 本发明涉及用于检测酪氨酸激酶的荧光探针组合物，其包含式（V）的化合物或其类似物，并且涉及其用途，并且更具体地涉及用于检测酪氨酸激酶 通过改变具有改进特性的荧光探针，使用其的细胞和组织成像方法，以及用于活体动物的癌症诊断和成像方法。 由于其先进的感测特性，本发明可以有效地用于癌症组织的选择性成像，其表现出改进的灵敏度和选择性。
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Patent Agency Ranking
公开(公告)号：KR101662444B1
公开(公告)日：2016-10-04
申请号：KR1020150061828
申请日：2015-04-30
Applicant: 포항공과대학교 산학협력단
IPC: C07D225/02 , A61K49/10 , A61K49/06
CPC classification number: C07D487/08 , A61K49/0021 , C07C221/00 , C07C225/22 , C07C231/08 , C07C233/33 , C07C303/38 , C07C311/20 , C07C2601/14 , C07D207/08 , C07D221/14 , C07D295/116
Abstract: 본발명은새로운일광자또는이광자흡수형광체화합물, 이를제조하는방법, 및이를이용한세포영상화방법등에관한것으로서, 더욱구체적으로는종래의이광자흡수형광체인아세단에비해더 큰형광양자수율과큰 흡수단면값을가져생체영상화에우수하게적용가능한새로운이광자흡수형광체화합물에관한것이다. 본발명에따른화합물은새로운 D-π-A 형태의형광체개발에유용하게이용할수 있다.
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公开(公告)号：KR101524915B1
公开(公告)日：2015-06-02
申请号：KR1020130053252
申请日：2013-05-10
Applicant: 포항공과대학교 산학협력단
CPC classification number: G01N33/5023 , C07C223/06 , C09K11/06 , C12Q1/485 , G01N33/574 , G01N33/582 , G01N2333/91205 , G01N2333/9121 , G01N2500/10
Abstract: 본발명은오쏘(ortho)-히드록시(hydroxy)-벤즈알데하이드(benzaldehyde) 구조를포함하는화합물을이용한타이로신인산화효소(tyrosin kinase) 감지를위한형광프로브및 이의용도에관한것으로, 구체적으로, 하기화학식 1 또는이의유사체를포함하는타이로신인산화효소감지를위한형광프로브, 및이를이용한용도에관한것이다. 본발명에의한형광프로브는간편하게합성할수 있고, 이광자여기가가능하며, 생체내에서안정성및 낮은세포독성을갖는작은분자(small molecule) 프로브로서, 타이로신인산화효소와결합하여형광변화를나타낼수 있어, 타이로신인산화효소를과발현하는세포또는조직을영상화할수 있으므로, 이러한조직의영상화용조성물및 영상화방법에유용하게이용될수 있다. 뿐만아니라, 타이로신인산화효소를과발현하는암 세포또는조직에결합하여형광을나타낼수 있어, 암세포또는조직의영상화에도유용하게이용될수 있다: [화학식 1].
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公开(公告)号：KR1020130130254A
公开(公告)日：2013-12-02
申请号：KR1020120052711
申请日：2012-05-17
Applicant: 포항공과대학교 산학협력단
IPC: C07D311/58 , C07C215/86 , G01N33/52 , G01N33/573
CPC classification number: C12Q1/26 , C07C221/00 , C07C223/06 , C07C253/30 , C07C255/42 , C07C255/43 , C07D311/58 , C07D311/92 , C07F7/1852 , C12Q1/42 , G01N2333/90638 , G01N2800/2835 , G01N2800/304
Abstract: The present invention relates to a compound which is a novel two photon phosphor, a method for preparing the compound, fluorescent sensors and molecular probes which are capable of detecting each substrate or enzyme activity using the same and a method for detecting enzyme activities and the likes using the same and, more specifically, to the two-photon phosphor which has high phostability of acedan which is the two-photon absorbed phosphor and has large cross-section values for two photon absorption and high fluorescent efficiency of coumarin which is one-photon absorbed phosphor and has advantages in imaging in vivo by absorbing and emitting longer wavelength than that of the existing acedan or coumarin. The compound according to the present invention can be utilized as a fluorescent sensor having high sensitivity and selectivity for each substrate and specially used for searching activities and inhibitors of MAO enzymes in order to be used for researching and treating diseases related to the MAO enzyme such as mood disorder and the likes.
Abstract translation: 本发明涉及一种新颖的双光子荧光体化合物，一种制备化合物的方法，能够检测每种底物或酶活性的荧光传感器和分子探针，以及检测酶活性的方法等 更具体地说，涉及双光子吸收的磷光体具有高的可见光性的双光子荧光体，并且具有两个光子吸收的高横截面值和作为单光子的香豆素的高荧光效率 吸收的荧光体，并且通过吸收和发射比现有的acedan或香豆素更长的波长在体内成像具有优点。 根据本发明的化合物可用作对每种底物具有高灵敏度和选择性的荧光传感器，特别用于搜索MAO酶的活性和抑制剂，以用于研究和治疗与MAO酶相关的疾病，例如 情绪障碍等。
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公开(公告)号：KR101130128B1
公开(公告)日：2012-07-06
申请号：KR1020080075033
申请日：2008-07-31
Applicant: 포항공과대학교 산학협력단
IPC: C07C233/15 , C07C231/02 , G01N33/50
Abstract: 본 발명은 α-아미노산을 감지할 수 있는 신규한 트리플로로아세토페논 유도체에 관한 것으로서, 보다 상세하게는 α-아미노산 음이온을 감지할 때 형광 세기가 현저히 증가되는 트리플로로아세토페논 유도체에 관한 것이다.
본 발명에 따른 트리플로로아세토페논 유도체는 하기 화학식(I)으로 표현되며,
(I)
여기서, 상기 R
1
, R
2
및 R
3 는 H 또는 고리의 치환 C
1 -C
30 의 치환 또는 비치환된 알킬, 치환 또는 비치환된 아릴기로서, 선형 또는 가지달린 알킬, 아릴, 및 에스테르로 이루어진 그룹에서 독립적으로 선택되며, 상기 R
4 는 -COCF
3 를 나타낸다.
본 발명에 따른 상기 화합물은 α-아미노산과 결합시 현저히 증가된 형광특성이 나타난다.-
公开(公告)号：KR1020100013494A
公开(公告)日：2010-02-10
申请号：KR1020080075033
申请日：2008-07-31
Applicant: 포항공과대학교 산학협력단
IPC: C07C233/15 , C07C231/02 , G01N33/50
Abstract: PURPOSE: A fluorescent trifluoroacetophenone-based derivative compound is provided to ensure high substrate selectivity to α-amino acid negative ions and excellent sensitivity, and to obtain a chemical sensor for detecting α-amino acid negative ions. CONSTITUTION: A fluorescent trifluoroacetophenone-based derivative compound and salts thereof are represented by chemical formula (I). In chemical formula (I), R1, R2 and R3 are H or C1-C30 substituted or unsubstituted alkyl and substituted or unsubstituted aryl group, and selected from the group consisting of linear or branched alkyl, aryl and ester, wherein R4 shows -COCF3.
Abstract translation: 目的：提供荧光三氟乙酰苯衍生化合物，以确保对α-氨基酸负离子的高底物选择性和极好的灵敏度，并获得用于检测α-氨基酸负离子的化学传感器。 构成：荧光三氟乙酰苯类衍生化合物及其盐由化学式（I）表示。 在化学式（I）中，R 1，R 2和R 3为H或C 1 -C 30取代或未取代的烷基和取代或未取代的芳基，选自直链或支链烷基，芳基和酯，其中R4表示-COCF3 。
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