-
公开(公告)号：KR101127163B1
公开(公告)日：2012-03-20
申请号：KR1020090006515
申请日：2009-01-28
Applicant: 한국과학기술연구원
Abstract: 본 발명은 신규 박테리아 균주 KME-002 및 이의 용도에 관한 것으로, 더욱 상세하게는 멍게로부터 분리한 해양 박테리아 균주 KME-002의 유전자 형태 및 생화학적 성상을 분석하여 신규 박테리아 균주임이 밝혀졌으며, 상기 균주가 담즙의 주성분인 콜린산(cholic acid) 유도체 중 7-케토데옥시콜린산(7-ketodexoycholic acid) 및 3-옥소데옥시콜린산(3-Oxodeoxycholic acid)를 생산하고, 양식 멍게에게 일명 조그랑증 및 물렁증 등의 질병을 유발하는 원인균임이 밝혀짐으로써 신규 균주 KME-002, 이의 유전체 및 성분은 콜린산 유도체의 대량생산, 및 멍게 질병 예방 및 치료에 유용하게 이용될 수 있다.
박테리아 균주 KME-002, 콜린산 유도체, 7-케토데옥시콜린산, 3-옥소데옥시콜린산, 멍제 질병.-
22.发明公开
公开(公告)号：KR1020110140015A
公开(公告)日：2011-12-30
申请号：KR1020100060181
申请日：2010-06-24
Applicant: 한국과학기술연구원
CPC classification number: A61K36/77 , A61K36/31 , A61K36/488 , A61K36/539 , A61K2300/00
Abstract: PURPOSE: A composition containing Longan arillus extract or mixture extract thereof is provided to protect dopaminergic neuron and to effectively prevent or treat neurodegenerative diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating neurodegenerative diseases contains Longan arillus extract as an active ingredient. The pharmaceutical composition additionally contains Angelicae tenuissimae radix or Polygalaceae extract. The pharmaceutical composition also contains Pueraria lobata (Willd.) Ohwi, Scutellariae Radix, Platycodi Radix, Angelica dahurica Bentham et Hooker, Cimicifugae Rhizoma, Raphanus sativus L. or Acori Gramineri Rhizoma. The extract is isolated using water, low alcohol of C1-C4, hexane, methylene chloride, acetonitrile or acetone organic solvent, or mixture thereof. A food composition for preventing or treating neurodegenerative diseases contains Longan arillus extract as an active ingredient.
Abstract translation: 目的：提供含有龙眼肠杆菌提取物或其混合物提取物的组合物以保护多巴胺能神经元并有效预防或治疗神经变性疾病。 构成：用于预防或治疗神经变性疾病的药物组合物含有龙眼花粉提取物作为活性成分。 该药物组合物另外含有天竺葵（Angelicae tenuissimae radix）或Polygalaceae提取物。 该药物组合物还含有葛根（Willd。）Ohwi，Scutellariae Radix，Platycodi Radix，Angelica dahurica Bentham et Hooker，Cimicifugae Rhizoma，Raphanus sativus L.或Acori Gramineri Rhizoma。 使用水，C1-C4的低级醇，己烷，二氯甲烷，乙腈或丙酮有机溶剂或其混合物分离提取物。 用于预防或治疗神经退行性疾病的食物组合物含有龙眼肠杆菌提取物作为活性成分。
-
公开(公告)号：KR101093778B1
公开(公告)日：2011-12-19
申请号：KR1020090022209
申请日：2009-03-16
IPC: A61K36/896 , A61P25/28 , A61K31/4741 , A61K31/473
Abstract: 개상사화 (
Lycoris aurea ) 추출물, 및/또는 이의 분획물, 및/또는 상기 추출물 또는 분획물로부터 분리된 화합물 라이코리시딘 및 라이코리시디놀의 치매의 예방 및/또는 치료 용도가 제공된다.
개상사화, Lycoris aurea, 치매, 알츠하이머 병, 베타-아밀로이드, 베타-세크리테아제, 라이코리시딘 (lycoricidine), 라이코리시디놀 (lycoricidinol)-
公开(公告)号：KR1020110112258A
公开(公告)日：2011-10-12
申请号：KR1020110086690
申请日：2011-08-29
Applicant: 한국과학기술연구원
IPC: A61K31/4741 , A61K31/55 , A61K36/896 , A61P25/28
CPC classification number: A61K36/896 , A61K31/4741
Abstract: 제주상사화(
Lycoris
chejuensis ) 추출물, 및/또는 이로부터 분리된 디하이드로라이코리시딘, 2-메톡시판크라신, 라이코리시딘 및/또는 라이코리시디놀을 유효성분으로 함유하는 퇴행성 신경 질환의 예방, 개선, 및/또는 치료용 조성물 및 건강기능성 식품, 및 이들의 제조방법이 제공된다.-
25.发明公开아스퍼질러스 ＫＭＤ 901 균주, 이로부터 분리된 다이케토피페라진 화합물, 및 이를 함유하는 암 예방 또는 치료용 조성물 有权曲霉菌 KMD901菌株，从其分离的二酮哌嗪类，以及用于预防癌症治疗的组合物
公开(公告)号：KR1020110045763A
公开(公告)日：2011-05-04
申请号：KR1020090102461
申请日：2009-10-27
Applicant: 한국과학기술연구원
IPC: C12N1/14 , C07D513/04 , A61K31/542 , A61K35/74 , C12R1/66
CPC classification number: C12N1/14 , A61K31/542 , A61K35/74 , C07D513/04 , C12R1/66
Abstract: PURPOSE: A novel compound isolated from Aspergillus sp. KMD901 is provided to be used as a anticancer agent. CONSTITUTION: An Aspergillus sp. strain(deposit number KCCM 11047P) is derived from marine deposit soil. A composition for preventing or treating cancer contains Aspergillus sp. strain, culture material of the strain, dried material or concentrate of the culture material, organic solvent extract which is obtained from the culture using ethyl acetate, alcohol of C1-C4, methylene chloride, ether, or chloroform, or fraction. A composition for preventing or treating cancer contains acetylaranotin of chemical formula 1, acetylapoaranotin of chemical formula 2, dehydro-deoxyapoaranotin of chemical formula 3 or pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 目的：从曲霉菌中分离出一种新型化合物。 KMD901被用作抗癌剂。 构成：曲霉菌 菌株（保藏号KCCM 11047P）来自海洋沉积物土壤。 用于预防或治疗癌症的组合物含有曲霉属（Aspergillus sp。 菌株，培养物质的培养物，培养物的干燥物质或浓缩物，使用乙酸乙酯，C1-C4，二氯甲烷，乙醚，氯仿，或者馏分的培养物得到的有机溶剂提取物。 用于预防或治疗癌症的组合物含有化学式1的乙酰氨基酰胺，化学式2的乙酰氨基酰胺，化学式3的脱氢脱氧阿片酰胺或其药学上可接受的盐作为活性成分。
-
Patent Agency Ranking
公开(公告)号：KR1020100104064A
公开(公告)日：2010-09-29
申请号：KR1020090022209
申请日：2009-03-16
IPC: A61K36/896 , A61P25/28 , A61K31/4741 , A61K31/473
CPC classification number: A61K31/4741 , A61K36/896 , A61K2236/333 , A61K2236/55
Abstract: PURPOSE: A composition containing Lycoris aurea extract, fraction thereof, or compound isolated from the same for preventing or treating dementia is provided to apply in a single method and in a cocktail method with conventional therapeutic agent such as tacrine, donepezil, and rivastigmine. CONSTITUTION: A composition for preventing or treating dementia contains Lycoris aurea extract as an active ingredient. The Lycoris aurea extract is isolated using water or low alcohol of C1-C4. The Lycoris aurea extract is also an acetic acid ethyl fraction, butanol fraction, or mixture thereof. The composition for preventing or treating dementia contains lycoricidine of chemical formula 1, lycoricidinol of chemical formula 2, or pharmaceutically acceptable salt as an active ingredient. The dementia is Alzheimer's disease. A health food for preventing or treating dementia contains the composition.
Abstract translation: 目的：提供含有Lycoris aurea提取物，其级分或从其分离的用于预防或治疗痴呆的化合物的组合物以单一方法和鸡尾酒法与常规治疗剂如他克林，多奈哌齐和利伐斯的明一起应用。 构成：用于预防或治疗痴呆的组合物含有Lycoris aurea提取物作为活性成分。 使用C1-C4的水或低级醇分离Lycoris aurea提取物。 Lycoris aurea提取物也是乙酸乙酯，丁醇馏分或其混合物。 用于预防或治疗痴呆的组合物含有化学式1的抗可乐定，化学式2的抗坏血酸醇，或其药学上可接受的盐作为活性成分。 痴呆症是阿尔茨海默病。 用于预防或治疗痴呆症的保健食品含有该组合物。
-
公开(公告)号：KR1020100087495A
公开(公告)日：2010-08-05
申请号：KR1020090006514
申请日：2009-01-28
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A novel bacteria strain Aeromicrobium halocynthiae KME-001 is provided to produce taurocholic acid amoun cholic acid derivatives and to cause disease of sea squirt. CONSTITUTION: A novel bacteria strain Aeromicrobium halocynthiae KME-001(deposit number KFCC11430P) contains 16S rDNA of sequence number 1. The novel strain is aerobic gram-positive nonsporeforming Bacillus. The strain produces taurocholic acid of chemical formula 1. A method for producing taurocholic acid comprises: a step of inoculating Aeromicrobium halocynthiae KME-001 KME-001 to liquid medium and culturing; a step of adding adsorbent resin and organic solvent or directly adding organic solvent to the culture medium; a step of performing column chromatography to obtain a fraction; a step of performing column chromatography from the fraction to obtain taurocholic acid of chemical formula 1; and a step of purifying tauroholic acid.
Abstract translation: 目的：提供一种新型细菌菌株，气溶胶氧氟尿嘧啶KME-001，用于生产牛磺胆酸氨基酸衍生物并引起海吐病。 构成：一种新型细菌菌株蓝藻毒素KME-001（保藏号KFCC11430P）含有序列1的16S rDNA。新菌株为需氧革兰氏阳性非成芽芽孢杆菌。 该菌株产生化学式1的牛磺胆酸。一种制造牛磺胆酸的方法，其特征在于，包括：向液体培养基中接种卤代氯氰尿苷KME-001 KME-001并培养的步骤; 添加吸附树脂和有机溶剂或直接向培养基中加入有机溶剂的步骤; 进行柱色谱以获得级分的步骤; 从级分进行柱色谱以获得化学式1的牛磺胆酸的步骤; 和纯化牛磺罗维酸的步骤。
-
公开(公告)号：KR102262465B1
公开(公告)日：2021-06-09
申请号：KR1020190062802
申请日：2019-05-28
Applicant: 경희대학교 산학협력단 , 한국과학기술연구원 , 서울대학교산학협력단 , 한국과학기술원 , 재단법인 전통천연물기반 유전자동의보감 사업단
IPC: A61K36/268 , A61K36/346 , A61K36/54 , A61P11/00 , A61P37/08 , A23L33/105 , A23K10/30
-
-
30.发明授权
-
-
-
-
-
-
-
-
-
Search Results
99
records
(took 0.025 seconds)
