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    이고들빼기 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 간 기능 개선용 약학적 조성물 및 간 기능 개선용 건강기능 식품조성물
    21.
    发明公开
    이고들빼기 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 간 기능 개선용 약학적 조성물 및 간 기능 개선용 건강기능 식품조성물 有权
    药物组合物和健康功能食品组合物，用于改善含有青蒿素提取物的肝脏功能，其分离或其分离的化合物作为活性成分

    公开(公告)号：KR1020100091131A

    公开(公告)日：2010-08-18

    申请号：KR1020100011969

    申请日：2010-02-09

    Applicant: 한국과학기술연구원

    Inventor： 노주원 ,  이샛별 ,  윤지호 ,  정상훈 ,  이희주 ,  강경수 ,  유지혜 ,  김명수 ,  안수용 ,  김종환

    IPC: A61K36/28 ,  A61K31/222 ,  A61K31/7028 ,  A61P35/00

    CPC classification number: A61K36/28 ,  A61K31/222 ,  A61K31/7028

    Abstract: PURPOSE: A composition containing Youngia denticulate extract or compound isolated from the same are provided to induce activation of quinone reductase(QR) and to improve liver function. CONSTITUTION: A pharmaceutical composition for preventing cancer contains Youngia denticulate extract as an active ingredient, which is isolated using water, organic solvent or mixture solvent thereof. An organic solvent is alcohol of C1-C4, acetic acid ethyl, methylene chloride, or chloroform. The Youngia denticulate extract detoxifies carcinogen by enhancing quinone reductase activation. A pharmaceutical composition for preventing cancer contains Youngia denticulate fraction as an active ingredient. The Youngia denticulate fraction is obtained by frequently fractioning Youngia denticulate extract using n-hexane, ethyl acetate, and n-butanol. The pharmaceutical composition for preventing cancer contains a compound of chemical formula 1, 2, 3, 4, or 5 as an active ingredient.

    Abstract translation: 目的：提供含有Youngia牙质提取物或从其分离的化合物的组合物以诱导醌还原酶（QR）的活化并改善肝功能。 构成：用于预防癌症的药物组合物含有作为活性成分的青ia牙提取物，其使用水，有机溶剂或其混合溶剂分离。 有机溶剂是C1-C4，乙酸乙酯，二氯甲烷或氯仿的醇。 青霉素小齿提取物通过增强醌还原酶活化来解毒致癌物质。 用于预防癌症的药物组合物含有作为活性成分的青霉素小齿状部分。 通过使用正己烷，乙酸乙酯和正丁醇频繁分选杨氏小齿提取物获得青霉素小齿级分。 用于预防癌症的药物组合物含有作为活性成分的化学式1,2,3,4或5的化合物。

    고삼 추출물 또는 이로부터 분리한 5-메틸소포라플라바논Ｂ를 유효성분으로 함유하는 당뇨병 합병증 또는 비만의예방 및 치료용 약학적 조성물
    22.
    发明公开
    고삼 추출물 또는 이로부터 분리한 5-메틸소포라플라바논Ｂ를 유효성분으로 함유하는 당뇨병 합병증 또는 비만의예방 및 치료용 약학적 조성물 失效
    用于预防和治疗糖尿病合并症或含有SOPHORA FLAVASCENS提取物的药物的药物组合物或其作为活性成分的分离的5-甲基磺酰丙酮B

    公开(公告)号：KR1020080090710A

    公开(公告)日：2008-10-09

    申请号：KR1020070033872

    申请日：2007-04-05

    Applicant: 한국과학기술연구원

    Inventor： 노주원 ,  김철영 ,  정상훈 ,  강경수 ,  이희주 ,  이샛별

    IPC: A61K31/352 ,  A61K36/48 ,  A61P3/10

    Abstract: A 5-methylsophoraflavanone B isolated from an extract of Sophora flavascens is provided to show inhibitory effect on the activity of aldose reductase causing diabetic complications and prevent obesity by inhibiting differentiation of fat cells, thereby being usefully used for preventing or treating the diabetic complications or the obesity. A pharmaceutical composition for preventing and treating diabetic complications or obesity comprises an extract of Sophora flavascens or 5-methylsophoraflavanone B isolated therefrom and represented by a formula(1) as an effective ingredient, wherein the extract of Sophora flavascens or the 5-methylsophoraflavanone B is prepared by extracting dried materials of Sophora flavascens roots with C1-4 alcohol to obtain the extract of Sophora flavascens, subjecting the extract to high speed liquid chromatography to isolate the 5-methylsophoraflavanone B and purifying the isolated 5-methylsophoraflavanone B. Further, the C1-4 alcohol is ethanol.

    Abstract translation: 提供从苦参中提取物中分离出的5-甲基异佛唑酮B，以显示对糖尿病并发症的醛糖还原酶的活性的抑制作用，并通过抑制脂肪细胞的分化来预防肥胖，从而有效地用于预防或治疗糖尿病并发症或 肥胖。 用于预防和治疗糖尿病并发症或肥胖症的药物组合物包含由其分离并由式（1）代表的作为有效成分的苦参皂甙或5-甲基异佛唑酮乙酸酯B的提取物，其中苦参中的苦参提取物或5-甲基异佛唑酮B为 通过用C 1-4醇提取苦参皂甙干燥物质，得到苦参皂甙提取物，高效液相色谱法分离5-甲基异佛唑酮B，纯化分离出的5-甲基异佛唑酮B.制备C1， -4酒精是乙醇。

    텍토리딘 또는 그 비배당체를 포함하는 항암용 조성물
    23.
    发明授权
    텍토리딘 또는 그 비배당체를 포함하는 항암용 조성물 失效
    텍토리딘또는그비배당체를포함하는항암용조성물물

    公开(公告)号：KR100740184B1

    公开(公告)日：2007-07-18

    申请号：KR1020060019940

    申请日：2006-03-02

    Applicant: 한국과학기술연구원

    Inventor： 정상훈 ,  노주원 ,  이샛별 ,  차광현

    IPC: A61K31/352 ,  A61P35/00

    Abstract: An anti-cancer composition containing tectoridin or aglycone thereof is provided to increase metabolism of carcinogens in cancer cells, inhibit growth of cancer cells, induce no colony formation of cancer cells and reduce expressions of genes associated with cancer cell generation and metastasis, so that the composition is useful for treatment of female cancers. The composition for treating female cancer or disease associated with female hormone contains tectoridin or aglycone thereof which is obtained by (a) extracting Belamcanda chinensis DC. rhizome with an organic solvent, and (b) fractionating the organic solvent extract of Belamcanda chinensis DC. rhizome by subjecting it to silica gel chromatography, wherein the female cancer includes breast cancer, endometrical carcinoma and ovarian cancer, and the disease associated with female hormone includes telangiectasia, osteoporosis and vein thrombosis.

    Abstract translation: 提供含有鸢尾黄素或其苷配基的抗癌组合物，用于增加癌细胞中致癌物质的代谢，抑制癌细胞的生长，诱导癌细胞的集落形成，减少与癌细胞生成和转移有关的基因的表达， 组合物对于治疗女性癌症是有用的。 用于治疗女性癌症或与雌激素有关的疾病的组合物含有通过（a）提取Belamcanda chinensis DC获得的鸢尾苷或其苷元。 （b）分馏Belamcanda chinensis DC的有机溶剂提取物。 通过对其进行硅胶层析，其中女性癌症包括乳腺癌，内分泌癌和卵巢癌，并且与女性激素有关的疾病包括毛细血管扩张症，骨质疏松症和静脉血栓形成。

    개미취속 식물의 추출물을 유효성분으로 포함하는 항노화용 조성물
    28.
    发明公开
    개미취속 식물의 추출물을 유효성분으로 포함하는 항노화용 조성물 审中-实审
    包含属于埃希氏菌属植物提取物作为活性成分的抗衰老组合物

    公开(公告)号：KR1020170124494A

    公开(公告)日：2017-11-10

    申请号：KR1020170142154

    申请日：2017-10-30

    Applicant: 한국과학기술연구원

    Inventor： 노주원 ,  김명석 ,  남의정 ,  정상훈 ,  오상록

    IPC: A61K8/97 ,  A61K8/49 ,  A23L33/105 ,  A61K8/06 ,  A61Q19/08

    CPC classification number: A61K8/97 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/318 ,  A61K8/06 ,  A61K8/4973 ,  A61Q19/08

    Abstract: 본명세서에는개미취속(L.) 식물의추출물, 이의분획물또는이들로부터분리한화합물을유효성분으로포함하는항노화용조성물이개시된다. 상기항노화용조성물은노화에따른피부변화를예방, 지연또는개선하는효과가있다. 또한, 상기항노화용조성물은콜라겐분해효소의발현또는활성을억제하거나, 또는콜라겐의발현또는활성을촉진시킴으로써, 피부주름을예방또는개선하고피부탄력을증진시켜주는효과가있다.

    Abstract translation: 这里，包括：从在（L.）植物的米迦勒菊花分离的化合物的术语nohwayong组合物中提取，或其它们作为活性成分的本发明公开的级分。 抗衰老组合物具有预防，延缓或改善由衰老引起的皮肤变化的作用。 另外，其特征在于，所述组合物具有这样的效果的nohwayong通过抑制胶原降解酶的表达或活性或者促进或胶原表达或活性，预防或通过促进皮肤弹性改善皮肤皱纹。

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