公开(公告)号：KR1020130070172A

公开(公告)日：2013-06-27

申请号：KR1020110137368

申请日：2011-12-19

Applicant: 한국전자통신연구원

Inventor： 정상돈 ,  김용희 ,  백남섭

IPC: A61B5/0478 ,  A61B5/0482

CPC classification number: A61B5/04001 ,  A61B2562/046

Abstract: PURPOSE: A device for recording a neural signal and a method for recording the neural signal using the same are provided to minimize the overlapping of the signals among neurons, thereby stably recording the signal. CONSTITUTION: A device for recording a neural signal includes a substrate, multiple stimulation electrodes (112s), and a recording electrode (112r). The substrate has an electrode region. The stimulation electrodes are regularly arranged at the electrode region. The body of a neuron is attached to the stimulation electrodes. The recording electrode is placed between the stimulation electrodes. The axon (A) of the neuron is attached to the recording electrode.

Abstract translation: 目的：提供用于记录神经信号的装置和用于记录神经信号的方法，以使神经元之间的信号的重叠最小化，从而稳定地记录信号。 构成：用于记录神经信号的装置包括基板，多个刺激电极（112s）和记录电极（112r）。 基板具有电极区域。 刺激电极规则地布置在电极区域。 神经元的身体附着在刺激电极上。 记录电极位于刺激电极之间。 神经元的轴突（A）附着在记录电极上。

公开(公告)号：KR1020130063776A

公开(公告)日：2013-06-17

申请号：KR1020110130323

申请日：2011-12-07

Applicant: 한국전자통신연구원

Inventor： 김용희 ,  백남섭 ,  한영환 ,  정명애 ,  정상돈

IPC: G03F7/26 ,  G03F7/00

Abstract: PURPOSE: A micro-patterning method using a poly-D-lysine bond is provided to induce the growth of cells for a long period of time using the covalent bond of poly-D-lysine. CONSTITUTION: A micro-patterning method using a poly-D-lysine bond includes: a step of preparing a substrate(10) on which a hydroxyl functional group(11) is formed; a step of chemically bonding the surface of the substrate with APTES(3-aminopropyltriethoxysilane, 12); a step of applying photoresist on the substrate and patterning the photoresist; a step of forming glutaraldehyde and poly-D-lysine(19) on the patterned photoresist; and a step of removing the patterned photoresist.

Abstract translation: 目的：提供使用聚-D-赖氨酸键的微图案化方法，以使用聚-D-赖氨酸的共价键长时间诱导细胞的生长。 构成：使用聚-D-赖氨酸键的微图案化方法包括：制备其上形成羟基官能团（11）的基材（10）的步骤; 用APTES（3-氨基丙基三乙氧基硅烷，12）化学键合基材表面的步骤; 在衬底上施加光致抗蚀剂并图案化光致抗蚀剂的步骤; 在图案化的光致抗蚀剂上形成戊二醛和聚-D-赖氨酸（19）的步骤; 以及去除图案化光致抗蚀剂的步骤。

公开(公告)号：KR1020120061387A

公开(公告)日：2012-06-13

申请号：KR1020100122693

申请日：2010-12-03

Applicant: 한국전자통신연구원

Inventor： 김용희 ,  정상돈 ,  이봉준 ,  백남섭 ,  이지현 ,  김국화 ,  정명애

IPC: A61B5/0408

Abstract: PURPOSE: An electrode for neural signal measurement and neural impulse is provided to obtain an increased surface area by employing nanostructures like nanowires. CONSTITUTION: An electrode for neural signal measurement and neural impulse comprises a plurality of nanostructures. Each end of the plurality of nanostructures are fixed to one side of a substrate and extended in a vertical direction. The nanostructures include conductive polymer formed on the exterior surface thereof to maintain the shape. The surface are of the electrode is increased by processing the conductive polymer on the surface of the nanostructure. Therefore, the charge capacitance and affinity to a nerve cell are improved at the same time, and the improved electrode can easily induce the growth of a nerve cell.

Abstract translation: 目的：提供神经信号测量和神经脉冲电极，通过采用纳米线等纳米结构获得增加的表面积。 构成：用于神经信号测量和神经脉冲的电极包括多个纳米结构。 多个纳米结构的每个端部固定在基板的一侧并沿垂直方向延伸。 纳米结构包括形成在其外表面上的导电聚合物以保持形状。 通过处理纳米结构表面上的导电聚合物来增加电极的表面。 因此，电荷电容和对神经细胞的亲和性同时提高，改善的电极容易诱导神经细胞的生长。

公开(公告)号：KR1020120048138A

公开(公告)日：2012-05-15

申请号：KR1020100109608

申请日：2010-11-05

Applicant: 한국전자통신연구원

Inventor： 백남섭 ,  김용희 ,  이지현 ,  정상돈 ,  정명애

IPC: C12Q1/24 ,  C12Q1/02 ,  C12M3/00 ,  B81C1/00

CPC classification number: C12N5/0068 ,  C07F7/0818 ,  C12N2535/00

Abstract: PURPOSE: A micropatterned substrate for cell adhesion or culture is provided to selectively adhere cells especially nerve cells and to form a patterned cell layer. CONSTITUTION: A micropatterned substrate for cell adhesion or culture contains micropattern layer formed on a substrate and the upper portion of the substrate. The micropattern layer is formed by covalent bond of a modified polyethylene imine with repetitive unit of chemical formula I with the surface of the substrate. In chemical formula I, R1 is -CnH2n-(n is integer selected amount 1-10).

Abstract translation: 目的：提供用于细胞粘附或培养的微图案化底物以选择性地粘附细胞，特别是神经细胞并形成图案化细胞层。 构成：用于细胞粘附或培养的微图案化底物包含在基底上形成的微图案层和基底的上部。 微图案层由改性聚乙烯亚胺与化学式I的重复单元与基材表面的共价键形成。 在化学式I中，R 1为-C n H 2n - （n为整数选择量1-10）。