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公开(公告)号：KR101373809B1
公开(公告)日：2014-03-11
申请号：KR1020090115915
申请日：2009-11-27
Applicant: 한국전자통신연구원
Abstract: 본 발명은 광 안정성을 갖는 형광 중합체 나노입자의 제조방법에 관한 것으로, 본 발명에 따른 형광 중합체 나노입자의 제조방법은 단량체 및 형광 유기분자를 용매중에 용해하여 에멀젼 중합을 통해 형광 유기분자가 포함된 형광 중합체 나노입자를 제조하는 단계; 상기 형광 중합체 나노입자 표면을 계면활성제로 처리하는 단계; 및 상기 계면활성제 처리된 형광 중합체 나노입자 표면을 실리카 코팅하는 단계를 포함한다. 이와 같은 방법으로 제조된 형광 중합체 나노입자는 광 탈색이 거의 없고, 소수성 형광 유기분자를 포함할 수 있고, 형광 유기분자의 농도가 높아져도 형광 세기가 줄어들지 않아 바이오 분석에 응용될 수 있다.
형광, 중합체, 실리카-
公开(公告)号：KR1020130070172A
公开(公告)日：2013-06-27
申请号：KR1020110137368
申请日：2011-12-19
Applicant: 한국전자통신연구원
IPC: A61B5/0478 , A61B5/0482
CPC classification number: A61B5/04001 , A61B2562/046
Abstract: PURPOSE: A device for recording a neural signal and a method for recording the neural signal using the same are provided to minimize the overlapping of the signals among neurons, thereby stably recording the signal. CONSTITUTION: A device for recording a neural signal includes a substrate, multiple stimulation electrodes (112s), and a recording electrode (112r). The substrate has an electrode region. The stimulation electrodes are regularly arranged at the electrode region. The body of a neuron is attached to the stimulation electrodes. The recording electrode is placed between the stimulation electrodes. The axon (A) of the neuron is attached to the recording electrode.
Abstract translation: 目的：提供用于记录神经信号的装置和用于记录神经信号的方法，以使神经元之间的信号的重叠最小化，从而稳定地记录信号。 构成：用于记录神经信号的装置包括基板，多个刺激电极（112s）和记录电极（112r）。 基板具有电极区域。 刺激电极规则地布置在电极区域。 神经元的身体附着在刺激电极上。 记录电极位于刺激电极之间。 神经元的轴突（A）附着在记录电极上。
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公开(公告)号：KR1020130063776A
公开(公告)日：2013-06-17
申请号：KR1020110130323
申请日：2011-12-07
Applicant: 한국전자통신연구원
Abstract: PURPOSE: A micro-patterning method using a poly-D-lysine bond is provided to induce the growth of cells for a long period of time using the covalent bond of poly-D-lysine. CONSTITUTION: A micro-patterning method using a poly-D-lysine bond includes: a step of preparing a substrate(10) on which a hydroxyl functional group(11) is formed; a step of chemically bonding the surface of the substrate with APTES(3-aminopropyltriethoxysilane, 12); a step of applying photoresist on the substrate and patterning the photoresist; a step of forming glutaraldehyde and poly-D-lysine(19) on the patterned photoresist; and a step of removing the patterned photoresist.
Abstract translation: 目的：提供使用聚-D-赖氨酸键的微图案化方法，以使用聚-D-赖氨酸的共价键长时间诱导细胞的生长。 构成：使用聚-D-赖氨酸键的微图案化方法包括：制备其上形成羟基官能团（11）的基材（10）的步骤; 用APTES（3-氨基丙基三乙氧基硅烷，12）化学键合基材表面的步骤; 在衬底上施加光致抗蚀剂并图案化光致抗蚀剂的步骤; 在图案化的光致抗蚀剂上形成戊二醛和聚-D-赖氨酸（19）的步骤; 以及去除图案化光致抗蚀剂的步骤。
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公开(公告)号：KR1020120061387A
公开(公告)日：2012-06-13
申请号：KR1020100122693
申请日：2010-12-03
Applicant: 한국전자통신연구원
IPC: A61B5/0408
Abstract: PURPOSE: An electrode for neural signal measurement and neural impulse is provided to obtain an increased surface area by employing nanostructures like nanowires. CONSTITUTION: An electrode for neural signal measurement and neural impulse comprises a plurality of nanostructures. Each end of the plurality of nanostructures are fixed to one side of a substrate and extended in a vertical direction. The nanostructures include conductive polymer formed on the exterior surface thereof to maintain the shape. The surface are of the electrode is increased by processing the conductive polymer on the surface of the nanostructure. Therefore, the charge capacitance and affinity to a nerve cell are improved at the same time, and the improved electrode can easily induce the growth of a nerve cell.
Abstract translation: 目的：提供神经信号测量和神经脉冲电极，通过采用纳米线等纳米结构获得增加的表面积。 构成：用于神经信号测量和神经脉冲的电极包括多个纳米结构。 多个纳米结构的每个端部固定在基板的一侧并沿垂直方向延伸。 纳米结构包括形成在其外表面上的导电聚合物以保持形状。 通过处理纳米结构表面上的导电聚合物来增加电极的表面。 因此，电荷电容和对神经细胞的亲和性同时提高，改善的电极容易诱导神经细胞的生长。
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公开(公告)号：KR1020120048138A
公开(公告)日：2012-05-15
申请号：KR1020100109608
申请日：2010-11-05
Applicant: 한국전자통신연구원
CPC classification number: C12N5/0068 , C07F7/0818 , C12N2535/00
Abstract: PURPOSE: A micropatterned substrate for cell adhesion or culture is provided to selectively adhere cells especially nerve cells and to form a patterned cell layer. CONSTITUTION: A micropatterned substrate for cell adhesion or culture contains micropattern layer formed on a substrate and the upper portion of the substrate. The micropattern layer is formed by covalent bond of a modified polyethylene imine with repetitive unit of chemical formula I with the surface of the substrate. In chemical formula I, R1 is -CnH2n-(n is integer selected amount 1-10).
Abstract translation: 目的：提供用于细胞粘附或培养的微图案化底物以选择性地粘附细胞，特别是神经细胞并形成图案化细胞层。 构成：用于细胞粘附或培养的微图案化底物包含在基底上形成的微图案层和基底的上部。 微图案层由改性聚乙烯亚胺与化学式I的重复单元与基材表面的共价键形成。 在化学式I中，R 1为-C n H 2n - （n为整数选择量1-10）。
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Patent Agency Ranking
公开(公告)号：KR1020100065678A
公开(公告)日：2010-06-17
申请号：KR1020080124133
申请日：2008-12-08
Applicant: 한국전자통신연구원
CPC classification number: A61N1/0534
Abstract: PURPOSE: A brain stimulation electrode of the RF base selective functional transplantation type is provided, which can overcome the brain dysfunction by generating the metergasis of brain nerves about the innate disorders and acquired disorders from various reasons. CONSTITUTION: A brain stimulation electrode of the RF base selective functional transplantation type includes: a step(S10) of forming a supporting part with the wire; a step(S20) of forming an electrode tip by raising the nanostructures from the supporting part; a step(S30) of coating the electrode tip and supporting part with the transparent conductive film; a step(S40) of forming the insulating protection layer on the supporting part; and a step(S50) of interlinking the power supply unit and the supporting part transmitting and receiving each frequency using the wireless telecommunication.
Abstract translation: 目的：提供RF基因选择性功能移植类型的脑刺激电极，可以通过从各种原因产生关于先天性疾病和获得性疾病的脑神经的metergasis来克服脑功能障碍。 构成：RF基极选择性功能移植型的脑刺激电极包括：利用线形成支撑部的步骤（S10） 通过从支撑部分升高纳米结构来形成电极头的步骤（S20）; 使用透明导电膜涂布电极头和支撑部的工序（S30） 在所述支撑部上形成所述绝缘保护层的工序（S40） 以及使用无线电信将电源单元和支持部件互连到发送和接收每个频率的步骤（S50）。
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公开(公告)号：KR101704729B1
公开(公告)日：2017-02-09
申请号：KR1020110130323
申请日：2011-12-07
Applicant: 한국전자통신연구원
Abstract: 본발명은폴리디라이신(Poly-D-lysine)의결합을이용한미세패턴형성방법에관한것으로더욱상세하게는뉴런세포의특정영역에서의성장을유도하기위한폴리디라이신의결합을이용한미세패턴형성방법에관한것이다. 신경세포접착물질인폴리디라이신의공유결합을이용하여장시간세포성장을유도할수 있는미세패턴형성방법을제공하는데있다.
Abstract translation: 目的：提供使用聚-D-赖氨酸键的微图案化方法，以使用聚-D-赖氨酸的共价键长时间诱导细胞的生长。 构成：使用聚-D-赖氨酸键的微图案化方法包括：制备其上形成羟基官能团（11）的基材（10）的步骤; 用APTES（3-氨基丙基三乙氧基硅烷，12）化学键合基材表面的步骤; 在衬底上施加光致抗蚀剂并图案化光致抗蚀剂的步骤; 在图案化的光致抗蚀剂上形成戊二醛和聚-D-赖氨酸（19）的步骤; 以及去除图案化光致抗蚀剂的步骤。
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公开(公告)号：KR1020160107527A
公开(公告)日：2016-09-19
申请号：KR1020150030383
申请日：2015-03-04
Applicant: 한국전자통신연구원
CPC classification number: C23F1/44 , A61B5/04001 , A61B2562/0215 , A61B2562/0217 , A61B2562/125 , B82Y5/00 , B82Y40/00 , C23F1/02 , C23F1/14 , C23F1/30 , C25D3/46 , C25D3/48 , C25D5/10 , C25D5/48 , C25D7/00 , A61B2562/0209 , A61N1/04
Abstract: 본발명의실시예에따른신경전극의표면개질방법은신경전극어레이를형성하는단계; 상기신경전극어레이의표면에식각용액에대한용해도가서로다른제1 금속나노입자와제2 금속나노입자를동시에전기전착하는단계; 및상기제2 금속나노입자를상기식각용액을이용하여선택적으로식각하여상기신경전극어레이표면에상기제1 금속나노입자로구성된다공성구조를형성하는단계를포함할수 있다.
Abstract translation: 根据本发明的实施例，神经电极的表面改性方法包括：形成神经电极阵列的步骤; 在神经电极阵列的表面上同时电沉积第一金属纳米颗粒和第二金属纳米颗粒的步骤，其中第一金属纳米颗粒和第二金属纳米颗粒相对于蚀刻溶液具有不同的溶解度; 以及通过蚀刻溶液选择性地蚀刻第二金属纳米颗粒以在神经电极阵列的表面上形成由第一金属纳米颗粒制成的多孔结构的步骤。 因此，该方法降低了阻抗以降低热噪声。
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公开(公告)号：KR1020150095964A
公开(公告)日：2015-08-24
申请号：KR1020140016016
申请日：2014-02-12
Applicant: 한국전자통신연구원
Abstract: 플렉시블 전극은 기판, 상기 기판의 표면에 형성된 전극, 상기 전극의 하부에 위치되고 상기 기판 내에 형성된 제1 다공성 구조체, 상기 기판 상에 형성되고 상기 전극을 노출시키는 개구부를 포함하는 전극 보호막 및 상기 개구부를 통해 노출된 상기 전극 상에 형성된 제2 다공성 구조체를 포함한다. 이와 같은 방법으로 제작된 플렉시블 전극은 유연한 기판과 금 나노입자에 의한 접착 표면적 증가에 의해 전극과 기판과의 접착력이 향상되어 장기간 전극 안정성을 갖는다. 따라서, 이러한 장기간 전극 안정성 요구되는 인체삽입용 전극으로 사용가능하며, 다양한 분야에 신경전극에 의한 전기자극 및 신경신호 측정용 전극으로 사용될 수 있다.
Abstract translation: 柔性电极包括：基底; 形成在基板的表面上的电极; 第一多孔结构，其被放置在电极的下部并形成在基板中; 电极保护膜，其具有形成在所述基板上并露出所述电极的开口部; 以及在所述电极上形成的第二多孔结构，所述第二多孔结构被所述开口部暴露。 通过上述方法制造的柔性电极具有长期的电极稳定性，因为由于柔性基底和金纳米颗粒而导致的粘附表面积的增加，电极和基底之间的粘合强度得到提高。 因此，柔性电极可以用作插入人体的电极，这需要长期的电极稳定性，并且也可以用作用于测量由各种领域的神经电极引起的电刺激和神经信号的电极。
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公开(公告)号：KR1020140043236A
公开(公告)日：2014-04-08
申请号：KR1020120108117
申请日：2012-09-27
Applicant: 한국전자통신연구원
IPC: A61N1/05 , A61B5/04 , A61B5/0478
Abstract: Provided is a manufacturing method of neural electrodes, which includes provision of electrodes, simultaneous electrical deposition of gold nanoparticles and platinum nanoparticles, and selective combination of molecules containing a thiol functional group on surfaces of the gold nanoparticles. [Reference numerals] (S10) Provision of electrode; (S20) Simultaneous deposition of gold and platinum nanoparticles on the surface of an electrode; (S30) Combining molecules containing a thiol functional group on surfaces of the golf nanoparticles
Abstract translation: 提供了一种神经电极的制造方法，其包括提供电极，金纳米颗粒和铂纳米颗粒的同时电沉积以及在金纳米颗粒的表面上含有硫醇官能团的分子的选择性组合。 （附图标记）（S10）电极的设置; （S20）在电极表面上同时沉积金和铂纳米颗粒; （S30）在高尔夫球纳米粒子的表面上组合含有硫醇官能团的分子
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