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公开(公告)号：KR100402055B1
公开(公告)日：2003-10-17
申请号：KR1020010022944
申请日：2001-04-27
Applicant: 한국화학연구원
IPC: C07C317/32
Abstract: PURPOSE: Provided is a method for economically synthesizing glibenclamide, with powder shape, which is used as an intermediate for synthesis of medicine useful for treatment of diabetes. CONSTITUTION: The method comprises the steps of (i) reacting N-phenethyl-5-chloro-2-methoxybenzamide with chlorosulfonic acid(ClSO3H) represented by formula 2 in the presence of thionyl chloride(SOCl2) to form p-(N-phenethyl-5-chloro-2-methoxybenzamide)sulfonylchloride represented by formula 3; (ii) reacting sulfonylchloride compound represented by formula 3 with ammonia to form p-(N-phenethyl-5-chloro-2-methoxybenzamide)sulfoneamide represented by formula 4; (iii) reacting sulfoneamide compound represented by formula with alkali metal hydroxide in the presence of alcohol solvent to form p-(N-phenethyl-5-chloro-2-methoxybenzamide)sulfone amide-metal salt represented by formula 5; and (iv) reacting the metal represented by formula 5 with cyclohexyl isocyanate or phenylcyclohexyl carbamate to form glibenclamide represented by formula 1.
Abstract translation: 目的：提供一种经济地合成格列本脲粉末状的方法，其用作合成用于治疗糖尿病的药物的中间体。 构成：该方法包括以下步骤：（i）使N-苯乙基-5-氯-2-甲氧基苯甲酰胺与式2代表的氯磺酸（ClSO 3 H）在亚硫酰氯（SOCl 2）存在下反应形成对 - （N-苯乙基 -5-氯-2-甲氧基苯甲酰胺）磺酰氯，由式3表示; （ii）使由式3表示的磺酰氯化合物与氨反应以形成由式4表示的对 - （N-苯乙基-5-氯-2-甲氧基苯甲酰胺）磺酰胺; （ⅲ）在醇溶剂存在下使下式表示的磺酰胺化合物与碱金属氢氧化物反应，生成式5表示的对 - （N-苯乙基-5-氯-2-甲氧基苯甲酰胺）磺酰胺 - 金属盐; （iv）使由式5表示的金属与环己基异氰酸酯或苯基环己基氨基甲酸酯反应以形成由式1表示的格列本脲。
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公开(公告)号：KR1020010106604A
公开(公告)日：2001-12-07
申请号：KR1020000027433
申请日：2000-05-22
Applicant: 한국화학연구원
IPC: C07D213/00
Abstract: 본 발명은 다음 화학식 1로 표시되는 할옥시폽 아미드 화합물과 그의 제조방법, 벼농사에서 발생하는 피를 방제하는 용도, 이들 화합물을 포함하는 제초제 조성물에 관한 것이다.
상기 화학식 1에서 :
R은 메틸기, 또는 에틸기를 나타내고; X는 수소원자, 할로겐원자, 시아노기, C
1 ∼C
6 의 알킬기, C
1 ∼C
6 의 알콕시기, 1∼3개의 할로겐원자가 치환된 C
1 ∼C
3 의 할로알킬기, 1∼3개의 할로겐원자가 치환된 C
1 ∼C
3 의 할로알콕시기, C
2 ∼C
4 의 알콕시알콕시기, C
2 ∼C
6 의 알케닐기, 또는 C
2 ∼C
6 의 알케닐옥시기를 나타내고; Y는 수소원자, 또는 플루오로원자를 나타내고; n은 1, 또는 2의 정수를 나타내며, n이 2일 경우 X는 각기 다른 치환체들의 조합이 되어도 좋다.-
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公开(公告)号：KR1020160107387A
公开(公告)日：2016-09-19
申请号：KR1020150029718
申请日：2015-03-03
Applicant: 한양대학교 산학협력단 , 한국화학연구원
IPC: A61K31/519 , A61K31/18 , A61K31/136
Abstract: 본발명은결핵균 AHAS(acetohydroxyacid synthase) 저해기반의다제내성결핵(Multi drug resistance(MDR)-TB)균억제용조성물에관한것이다. 본발명의조성물을사용함으로써종래의결핵치료제에내성을갖는다제내성결핵균을효과적으로억제할수 있다.
Abstract translation: 本发明涉及一种基于结核分枝杆菌乙酰羟酸合成酶（AHAS）抑制多药耐药性结核分枝杆菌（MDR-TB）的组合物。 通过使用本发明的组合物，可以有效地抑制具有抗常规药物治疗结核分枝杆菌的耐多药耐药结核分枝杆菌。
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公开(公告)号：KR1020150015310A
公开(公告)日：2015-02-10
申请号：KR1020130091223
申请日：2013-07-31
CPC classification number: C12N1/20 , C12N1/38 , C12N2500/76 , C12R1/465 , Y10S435/886
Abstract: The present invention relates to a culture medium composition for mass-producing Streptomyces scopuliridis strains. In particular, the culture medium composition for mass-producing Streptomyces scopuliridis KR-001 strains produced by mixing a carbon source and a nitrogen source under an optimal condition has excellent microorganism growing and herbicidal activities and exhibits an effect in reducing production costs. Accordingly, the culture medium composition can be usefully used in mass-culturing Streptomyces scopuliridis strains so as to produce a weed pest controlling agent.
Abstract translation: 本发明涉及用于批量生产链霉菌链霉菌菌株的培养基组合物。 特别地，通过在最佳条件下混合碳源和氮源而生产的用于批量生产链霉菌（Streptomyces scopuliridis）KR-001菌株的培养基组合物具有优异的微生物生长和除草活性，并且具有降低生产成本的效果。 因此，培养基组合物可以有效地用于大规模培养链霉菌链霉菌菌株中以产生杂草害虫控制剂。
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Patent Agency Ranking
公开(公告)号：KR101340463B1
公开(公告)日：2013-12-11
申请号：KR1020110130230
申请日：2011-12-07
Abstract: 본 발명은 DHNQ(5,8-dihydroxy-1,4-naphthoquinone) 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 가시박(
Sciyos
angulatus
L.) 방제용 조성물에 관한 것으로, 구체적으로 본 발명의 따른 DHNQ(5,8-dihydroxy-1,4-naphthoquinone)은 미생물 및 식물의 비오틴 생합성 경로에 관여하여 식물생장에 주요한 역할을 하는 KAPAS(7-keto-8-aminopelargonic acid synthase) 작용을 억제하고, 국내 전 지역 심각한 피해를 야기하고 있는 가시박에 대한 유의적인 제초활성을 나타내므로, 인체의 안전한 천연 제초제의 유효성분으로 유용하게 사용될 수 있다.-
公开(公告)号：KR1020130063714A
公开(公告)日：2013-06-17
申请号：KR1020110130230
申请日：2011-12-07
Abstract: PURPOSE: DHNQ(5,8-dihydroxy-1,4-naphthoquinone) is provided to suppress KAPAS(7-keto-8-aminopelargonic acid synthase) which is related to a biotin biosynthesis pathway of microbes and plants, and to significantly remove Sicyos angulatus L. with safety to human body. CONSTITUTION: An herbicidal composition for preventing Sicyos angulatus L. contains DHNQ of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient. DHNQ is derived from black walnut and suppresses KAPAS activity. A method for controlling Sicyos angulatus L. comprises a step of treating Sicyos angulatus L., a seed thereof, or a habitat thereof with the herbicidal composition.
Abstract translation: 目的：提供DHNQ（5,8-二羟基-1,4-萘醌）以抑制与微生物和植物的生物素生物合成途径相关的KAPAS（7-酮-8-氨基壬酸合成酶），并显着除去Sicyos angulatus L.具有安全的人体。 构成：用于防治水atus atus的除草组合物含有化学式1的DHNQ或其药学上可接受的盐作为活性成分。 DHNQ来自黑胡桃，抑制KAPAS活性。 用于控制ang鱼的方法包括用除草组合物处理芸苔的种子或其栖息地的步骤。
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公开(公告)号：KR101201203B1
公开(公告)日：2012-11-15
申请号：KR1020120033835
申请日：2012-04-02
IPC: C07D413/04
CPC classification number: C07D413/04 , B01J31/0271
Abstract: PURPOSE: An industrial method for preparing [5-{(2,6-difluorobenzyloxy)methyl}-4,5-dihydro-5-methyl-3-(3-methylthiophene-2-yl)-isoxazole](methiozolin) is provided to obtain a large amount of the methiozolin of high purity and to cultivate agricultural crops. CONSTITUTION: A method for preparing thiozolin(chemical formula 1) comprises: a step of reacting 4,5-dihydro-5-methyl-3-{(3-methylthiophene-2-yl)-isoxazole-5-yl}methanol of chemical formula 2 with 2,6-difluorobenzyl(chloride or bromide) of chemical formula 3 using an alkali metal base and a phase converting catalyst in a mixture of water and organic solvent at 50-100 Deg. C. to prepare the concentrate of an organic layer; and a step of crystallizing the concentrate in a mixture solvent of water/ethanol, water/isopropanol, or C1-C3 alcohol/n-heptane. The organic solvent is benzene, toluene, xylene, chlorobenzene, or 1,2-dichloroethane. The alkali metal base is sodium hydroxide, potassium hydroxide, or lithium hydroxide.
Abstract translation: 目的：提供制备[5 - {（2,6-二氟苄氧基）甲基} -4,5-二氢-5-甲基-3-（3-甲基噻吩-2-基） - 异恶唑]（甲氧基）唑的工业方法） 获得大量高纯度的甲氧唑啉并培育农作物。 构成：制备噻唑啉（化学式1）的方法包括：将化合物的4,5-二氢-5-甲基-3 - {（3-甲基噻吩-2-基） - 异恶唑-5-基}甲醇 式2与化学式3的2,6-二氟苄基（氯化物或溴化物）使用碱金属碱和相转化催化剂在水和有机溶剂的混合物中在50-100℃下反应。 C.制备有机层的浓缩物; 以及将浓缩物在水/乙醇，水/异丙醇或C 1 -C 3醇/正庚烷的混合溶剂中结晶的步骤。 有机溶剂为苯，甲苯，二甲苯，氯苯或1,2-二氯乙烷。 碱金属碱是氢氧化钠，氢氧化钾或氢氧化锂。
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公开(公告)号：KR101103840B1
公开(公告)日：2012-01-06
申请号：KR1020090090692
申请日：2009-09-24
IPC: C07D239/54 , A01N43/54 , A01N41/06
CPC classification number: C07D239/54 , A01N43/54
Abstract: 본 발명은 하기 화학식 1로 표시되는 우라실계 화합물과 이 화합물의 제조방법, 및 이 화합물을 활성성분으로 포함하는 제초제에 관한 것이다.
상기 화학식 1에서, R
1 , R
2 , R
3 , R
4 , R
5 , X, Y, Z, 및 W는 각각 발명의 상세한 설명에서 정의한 바와 같다.
우라실, 제초제, 피리미딘다이온-
公开(公告)号：KR1020110110420A
公开(公告)日：2011-10-07
申请号：KR1020100029716
申请日：2010-04-01
IPC: A01N43/54 , A01N41/00 , C07D239/10 , A01P13/02
CPC classification number: A01N43/54 , A01N25/02 , A01N25/04 , A01N25/08 , A01N25/12 , A01N25/14 , A01N25/30 , C07D239/14
Abstract: 본 발명은 제초성 우라실계 화합물과 상기 화합물의 제조방법, 그리고 상기 화합물을 포함하는 제초제에 관한 것이다.
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