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1.发明公开
公开(公告)号：KR1020130049125A
公开(公告)日：2013-05-13
申请号：KR1020110114193
申请日：2011-11-03
Abstract: PURPOSE: A composition containing Plumbagin as an active ingredient for preventing Sicyos angulatus is provided to suppress KAPAS(7-keto-8-aminopelargonic acid synthase) which is important for plant growth. CONSTITUTION: A herbicidal composition for preventing Sicyos angulatus contains Plumbagin as an active ingredient. Plumbagin is derived from Plumbago auriculata and is denoted by chemical formula 1. Plumbagin suppresses KAPAS activity by being treated in a concentration of 500-2,500 ug/ml. A method for eliminating Sicyos angulatus comprises a step of treating Sicyos angulatus, seeds thereof, or a habitat thereof with the herbicidal composition.
Abstract translation: 目的：提供含有Plumbagin作为预防水preventing鱼的活性成分的组合物，以抑制对植物生长重要的KAPAS（7-酮-8-氨基壬酸合成酶）。 构成：用于预防水ul鱼的除草组合物含有Plumbagin作为活性成分。 Plumbagin衍生自Plumbago auriculata，由化学式1表示。Plumbagin通过以500-2,500ug / ml的浓度处理抑制KAPAS活性。 消除水eliminating鱼的方法包括用除草组合物处理ang鱼，其种子或其栖息地的步骤。
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公开(公告)号：KR101340463B1
公开(公告)日：2013-12-11
申请号：KR1020110130230
申请日：2011-12-07
Abstract: 본 발명은 DHNQ(5,8-dihydroxy-1,4-naphthoquinone) 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 가시박(
Sciyos
angulatus
L.) 방제용 조성물에 관한 것으로, 구체적으로 본 발명의 따른 DHNQ(5,8-dihydroxy-1,4-naphthoquinone)은 미생물 및 식물의 비오틴 생합성 경로에 관여하여 식물생장에 주요한 역할을 하는 KAPAS(7-keto-8-aminopelargonic acid synthase) 작용을 억제하고, 국내 전 지역 심각한 피해를 야기하고 있는 가시박에 대한 유의적인 제초활성을 나타내므로, 인체의 안전한 천연 제초제의 유효성분으로 유용하게 사용될 수 있다.-
公开(公告)号：KR1020130063714A
公开(公告)日：2013-06-17
申请号：KR1020110130230
申请日：2011-12-07
Abstract: PURPOSE: DHNQ(5,8-dihydroxy-1,4-naphthoquinone) is provided to suppress KAPAS(7-keto-8-aminopelargonic acid synthase) which is related to a biotin biosynthesis pathway of microbes and plants, and to significantly remove Sicyos angulatus L. with safety to human body. CONSTITUTION: An herbicidal composition for preventing Sicyos angulatus L. contains DHNQ of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient. DHNQ is derived from black walnut and suppresses KAPAS activity. A method for controlling Sicyos angulatus L. comprises a step of treating Sicyos angulatus L., a seed thereof, or a habitat thereof with the herbicidal composition.
Abstract translation: 目的：提供DHNQ（5,8-二羟基-1,4-萘醌）以抑制与微生物和植物的生物素生物合成途径相关的KAPAS（7-酮-8-氨基壬酸合成酶），并显着除去Sicyos angulatus L.具有安全的人体。 构成：用于防治水atus atus的除草组合物含有化学式1的DHNQ或其药学上可接受的盐作为活性成分。 DHNQ来自黑胡桃，抑制KAPAS活性。 用于控制ang鱼的方法包括用除草组合物处理芸苔的种子或其栖息地的步骤。
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4.发明授权
公开(公告)号：KR101294783B1
公开(公告)日：2013-08-08
申请号：KR1020110114193
申请日：2011-11-03
Abstract: 본 발명은 플럼바고 아우리쿨라타(
Plumbago
auriculata ) 유래 플럼바긴(plumbagin)을 유효성분으로 함유하는 제초제 조성물에 관한 것으로, 구체적으로, 천연물 유래 나프토퀴논 화합물이 제초제 효능이 있는지 확인하였으며, 본 발명의 갯지렁이과 식물 플럼바고 아우리쿨라타로부터 유래하는 천연 나프토퀴논 화합물 플럼바긴이 KAPAS 저해 활성이 있고, 식물생장에 중요한 KAPAS를 저해함으로써, 가시박(
Sciyos
angulatus L.)에 대해 탁월한 방제효과를 보여주고 있으므로, 상기 플럼바긴을 가시박 제초제로 이용할 수 있다.-
5.发明授权도라지 막분리 추출물 또는 플라티코시드 Ｅ를 유효성분으로 함유하는 아토피 피부염의 예방 또는 치료용 조성물 有权用于预防或治疗特应性皮炎的药物组合物，所述特应性皮炎含有桔梗或槟榔醇E的膜分离提取物作为活性成分
公开(公告)号：KR101131108B1
公开(公告)日：2012-04-03
申请号：KR1020100024191
申请日：2010-03-18
Applicant: 한국화학연구원
Abstract: 본 발명은 도라지 막분리 추출물 또는 플라티코시드 Ｅ를 유효성분으로 함유하는 아토피 피부염의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 도라지 막분리 추출물 또는 플라티코시드 E는 아토피 증상을 완화시킬 뿐만 아니라, 염증세포 침윤, 괴사 딱지의 발생, 조직의 두께 및 비만세포 수를 감소시키고, 혈중 IgE 함량 및 IL-4 함량을 용량의존적으로 감소시킴으로써 아토피 피부염을 예방 또는 치료하는데 유용하게 사용할 수 있다.
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Patent Agency Ranking6.发明公开작약 종자 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 약학적 조성물 有权包含提取物的活性成分的药物组合物，其分离物或其分离的化合物作为活性成分
公开(公告)号：KR1020120016861A
公开(公告)日：2012-02-27
申请号：KR1020100079356
申请日：2010-08-17
Applicant: 한국화학연구원
IPC: A61K36/65 , A61K31/343 , A61P25/28 , A61P25/00
CPC classification number: A61K36/65 , A23L29/035 , A23V2200/322 , A61K31/216 , A61K31/343 , A61K2236/33
Abstract: PURPOSE: A pharmaceutical composition containing Paeonia lactiflora seed extract, fraction thereof, or compound isolated from the same is provided to suppress BACE-1 activity and to treat and prevent neurodegenerative diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating neurodegenerative diseases contains Paeonia lactiflora seed extract as an active ingredient. The neurodegenerative diseases include Alzheimer's dieses, Parkinsons's disease, progressive supranuclear palsy. The extract is prepared using water, alcohol of C1-C4, or mixture solvent thereof. The pharmaceutical composition contains Paeonia lactiflora seed fraction as an active ingredient. The pharmaceutical composition also contains compounds as an active ingredient. The method for preparing the compounds comprises: a step of adding water, C1-C3 alcohol, or mixture thereof to the Paeonia lactiflora seeds to prepare Paeonia lactiflora seed extract; a step of fractioning the extract with water, dichloromethane, and ethyl acetate to prepare a fraction; a step of performing silicagel column chromatography of the fraction.
Abstract translation: 目的：提供含有芍药提取物，其部分或从其分离的化合物的药物组合物以抑制BACE-1活性并治疗和预防神经变性疾病。 构成：用于预防或治疗神经变性疾病的药物组合物含有芍药种子提取物作为活性成分。 神经变性疾病包括阿尔茨海默氏病，帕金森氏病，进行性核上性麻痹。 萃取液用水，C1-C4的醇或其混合溶剂制备。 该药物组合物含有作为活性成分的芍药芍药种子。 药物组合物还含有作为活性成分的化合物。 制备化合物的方法包括：将水，C1-C3醇或其混合物加入到芍药种子中以制备芍药提取物的步骤; 用水，二氯甲烷和乙酸乙酯分级提取物以制备级分的步骤; 进行该级分的硅胶柱色谱的步骤。
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公开(公告)号：KR1020120116115A
公开(公告)日：2012-10-22
申请号：KR1020110033674
申请日：2011-04-12
Applicant: 한국화학연구원 , 국민대학교산학협력단
IPC: A61K31/045 , A61K31/05 , A61K36/87 , A23L33/10 , A23L33/105 , A23L2/52
CPC classification number: A61K31/045 , A23L2/52 , A23L33/10 , A23L33/105 , A61K31/05 , A61K36/87 , A61K2300/00
Abstract: PURPOSE: An anticancer drug composition including resveratrol derivative compound separated from grape stem shell is provided to prevent and treat all kinds of cancers including lung cancer, ovarian cancer, melanoma, central nervous system tumor, colon carcinoma, and leukemia. CONSTITUTION: An anticancer drug composition includes vitisinol C, vitisinol E, cis-vitisin A, vitisin B, vitisin C, a pharmaceutically acceptable salt and isomer or a mixture thererof, and grape stem shell extract including thereof as an active ingredient. The grape stem shell extract is obtained by extracting methanol, methanol aqueous solution, ethanol, ethanol aqueous solution, butanol, dichloromethane, ethyl acetate or a mixture thereof. The cancer is lung cancer, ovarian cancer, melanoma or colon carcinoma. A health enhancement food having cancer cell growth inhibition efficacy contains vitisinol C, vitisinol E, cis-viticin A, viticin B, viticin C, pharmaceutically acceptable salt, isomer or a mixture thereof, and grapes stem shell extract including the same. The food is in beverage form. The grape stem shell extract is obtained by the following steps: extracting the grape stem shell by methanol and suspending the obtained extract in distilled water; partitioning thereof by dichloromethane; and extracting the obtained water layer by ethyl acetate.
Abstract translation: 目的：提供包括从葡萄茎壳分离的白藜芦醇衍生物化合物的抗癌药物组合物，用于预防和治疗各种癌症，包括肺癌，卵巢癌，黑素瘤，中枢神经系统肿瘤，结肠癌和白血病。 构成：抗癌药物组合物包括维生素C，维生素E，顺式维生素A，维生素B，维生素C，其药学上可接受的盐和异构体或其混合物，以及包含它们的葡萄茎壳提取物作为活性成分。 葡萄茎壳提取物是通过提取甲醇，甲醇水溶液，乙醇，乙醇水溶液，丁醇，二氯甲烷，乙酸乙酯或其混合物得到的。 癌症是肺癌，卵巢癌，黑素瘤或结肠癌。 具有癌细胞生长抑制作用的健康增强食品包含维生素C，维生素E，顺式维生素A，维生素B，维生素C，其药学上可接受的盐，异构体或其混合物，以及包含其的葡萄茎壳提取物。 食物是饮料形式。 通过以下步骤获得葡萄茎壳提取物：用甲醇萃取葡萄茎壳，将得到的提取物悬浮于蒸馏水中; 用二氯甲烷分配; 并用乙酸乙酯萃取得到的水层。
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8.发明公开
公开(公告)号：KR1020110012431A
公开(公告)日：2011-02-09
申请号：KR1020090070151
申请日：2009-07-30
Applicant: 한국화학연구원
IPC: A61K31/70 , A61K36/346
CPC classification number: A61K31/704 , A61K36/346 , A61K2236/33 , A61K2236/333 , A61K2236/55
Abstract: PURPOSE: A method for preparing crude saponin composition with improved purity and enhanced effective saponin content is provided. CONSTITUTION: A method for preparing crude saponin composition with improved purity and enhanced effective saponin content from platycodon grandiflorum or extract thereof comprises: a step of extracting platycodon grandiflorum using distilled water, low alcohol of C1-C3, ethyl acetate, hexane, dichloromethane or mixture solvent thereof; a step of dissolving the extract in a distilled water and adsorbing saponin ingredient; a step of eluting the adsorbed saponin with ethanol or methanol solution to obtain saponin; and a step of purifying saponin using an organic solvent.
Abstract translation: 目的：提供一种改善纯度和提高有效皂苷含量的粗皂苷组合物的方法。 制备方法：提供纯化度高，皂甙含量提高的粗皂苷组合物的方法包括：使用蒸馏水，C1-C3，乙酸乙酯，己烷，二氯甲烷或混合物的低级醇提取桔梗的步骤 溶剂; 将提取物溶解在蒸馏水中并吸附皂苷成分的步骤; 用乙醇或甲醇溶液洗脱吸附的皂角苷以获得皂苷的步骤; 和使用有机溶剂提纯皂苷的步骤。
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9.发明授权작약 종자 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 약학적 조성물 有权药物组合物，其包含提取物芍药，其馏分或其分离的化合物作为活性成分
公开(公告)号：KR101338172B1
公开(公告)日：2013-12-09
申请号：KR1020100079356
申请日：2010-08-17
Applicant: 한국화학연구원
IPC: A61K36/65 , A61K31/343 , A61P25/28 , A61P25/00
Abstract: 본 발명에 따른 작약 종자의 추출물, 이의 분획물 또는 이로부터 분리한 화합물은 BACE-1 활성을 저해시켜 알츠하이머형 치매, 파킨슨 병, 진행성 핵상마비 등 퇴행성 뇌질환의 예방 또는 치료에 유용하게 사용될 수 있다.
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10.发明公开작약 종자 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 약학적 조성물 有权包含提取物的活性成分的药物组合物，其分离物或其分离的化合物作为活性成分
公开(公告)号：KR1020130083428A
公开(公告)日：2013-07-22
申请号：KR1020130081165
申请日：2013-07-10
Applicant: 한국화학연구원
IPC: A61K31/343 , A61K31/045 , A61K31/05 , A61K36/65
Abstract: PURPOSE: A Paeonia lactiflora seed extract, a fraction thereof, or a compound isolated therefrom, and a pharmaceutical composition containing the same are provided to suppress the activation of beta-secretase (BECE-1) and to prevent or treat neurodegenerative diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating neurodegenerative diseases contains one or more kinds of compounds selected among compounds of chemical formulas 1-8, as active ingredients. A method for preparing the compounds of chemical formulas 1-8 comprises the steps of: adding water, C1-C4 alcohols, or a mixture thereof to Paeonia lactiflora seeds and obtaining a Paeonia lactiflora seed extract; fractioning the extract with water, dichloromethane, and ethyl acetate and obtaining a fraction; and isolating compounds by performing silicagel column chromatography of the fraction and purifying the compounds.
Abstract translation: 目的：提供芍药芍药提取物，其一部分或从其分离的化合物和含有它们的药物组合物以抑制β-分泌酶（BECE-1）的活化并预防或治疗神经变性疾病。 构成：用于预防或治疗神经变性疾病的药物组合物含有选自化学式1-8化合物的一种或多种化合物作为活性成分。 制备化学式1-8的化合物的方法包括以下步骤：将水，C 1 -C 4醇或其混合物加入到芍药芍药种子中并获得芍药提取物; 用水，二氯甲烷和乙酸乙酯分级提取物，得到一部分; 并通过对级分进行硅胶柱色谱法分离化合物并纯化化合物。
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