公开(公告)号：AT273988T

公开(公告)日：2004-09-15

申请号：AT98959481

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： KU YI-YIN ,  RILEY DAVID A ,  LEE ELAINE C ,  TIEN JIEN-HEH J

IPC: C07H17/08

Abstract: The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4''-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A.

公开(公告)号：CA2615701A1

公开(公告)日：1999-06-24

申请号：CA2615701

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： RILEY DAVID A ,  LEE ELAINE C ,  KU YI-YIN ,  TIEN JIEN-HEH J

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04

Abstract: The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4''-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A.

公开(公告)号：CA2315209A1

公开(公告)日：1999-06-24

申请号：CA2315209

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： TIEN JIEN-HEH J ,  KU YI-YIN ,  LEE ELAINE C ,  RILEY DAVID A

IPC: C07H17/08

Abstract: The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4"-hydroxyl groups of erythromycin A, selectively methylating the 6position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A.