公开(公告)号：EP1165567A2

公开(公告)日：2002-01-02

申请号：EP00921426.3

申请日：2000-03-23

Applicant: ABBOTT LABORATORIES

Inventor： KAWAI, Megumi ,  GUNAWARDANA, Indrani, W.

IPC: C07D498/18 ,  A61P37/00 ,  A61K31/4353 ,  A61K31/407

CPC classification number: C07D498/18

Abstract: The present invention relates to novel compounds of formula (I), which are useful as immunomodulators, in particular, macrolide immunosuppressants. The invention also relates to the preparation of compounds of formula (I), compositions containing such compounds, and methods of using such compounds.

公开(公告)号：EP0564588B1

公开(公告)日：1997-02-12

申请号：EP92903749.7

申请日：1991-12-10

Applicant: ABBOTT LABORATORIES

Inventor： WIEDEMAN, Paul E. ,  KAWAI, Megumi ,  LULY, Jay, R. ,  OR, Yat, Sun ,  WAGNER, Rolf

IPC: C07K14/47 ,  C07K7/06 ,  A61K38/17

CPC classification number: C07K14/472 ,  A61K38/00

Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states. Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.

公开(公告)号：EP0564533A1

公开(公告)日：1993-10-13

申请号：EP92902123.0

申请日：1991-12-10

Applicant: ABBOTT LABORATORIES

Inventor： KAWAI, Megumi ,  WIEDEMAN, Paul, E. ,  LULY, Jay, R. ,  OR, Yat, Sun

IPC: C07K5 ,  C07K7 ,  C07K14 ,  A61K38

CPC classification number: C07K7/02 ,  A61K38/00 ,  C07K14/472

Abstract: Composés d'oligopeptides ou composés d'analogues d'oligopeptide répondant à la formule ABDEGLMQ servant de ligands pour le récepteur d'anaphylatoxine, qui sont utiles dans le traitement des états pathologiques inflammatoires. Cette invention concerne également des compositions de ligand de récepteur d'anaphylatoxine et un procédé permettant de moduler l'activité de l'anaphylatoxine.

Abstract translation: 寡肽化合物或具有用于该受体的过敏毒素式A-B-d-E-G-L-M-Q配体，其是在炎性疾病状态的治疗中有用的寡肽的类似物。 本发明还涉及过敏毒素受体配体组合物和用于调节过敏毒素活性的方法。

公开(公告)号：EP1973917A2

公开(公告)日：2008-10-01

申请号：EP06846085.6

申请日：2006-12-28

Applicant: ABBOTT LABORATORIES

Inventor： SHEPPARD, George ,  WANG, Gary ,  PALAZZO, Fabio ,  BELL, Randy ,  MANTEI, Robert ,  WANG, Jieyi ,  HUBBARD, Robert ,  KAWAI, Megumi ,  ERICKSON, Scott ,  BAMAUNG, Nwe ,  FIDANZE, Steve

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Compounds of formula (I) that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

Abstract translation: 公开了抑制蛋白激酶的式（I）化合物，含有该化合物的组合物和使用该化合物治疗疾病的方法。

公开(公告)号：EP1080070B1

公开(公告)日：2006-11-22

申请号：EP99924434.6

申请日：1999-05-21

Applicant: ABBOTT LABORATORIES

Inventor： KAWAI, Megumi ,  HENKIN, Jack ,  SHEPPARD, George, S. ,  CRAIG, Richard, A.

IPC: C07C237/42 ,  C07C237/22 ,  A61K31/195 ,  C07C311/46

CPC classification number: C07C237/22 ,  C07C311/46

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：EP0642516B1

公开(公告)日：2002-06-05

申请号：EP92920494.9

申请日：1992-09-08

Applicant: ABBOTT LABORATORIES

Inventor： LULY, Jay R. ,  KAWAI, Megumi ,  OR, Yat Sun ,  WIEDEMAN, Paul ,  WAGNER, Rolf

IPC: C07D498/18 ,  C07D498/04 ,  C07H19/01 ,  A61K31/395 ,  A61K31/33 ,  A61K31/70

CPC classification number: C07D487/14 ,  C07D513/14 ,  C07F7/1856 ,  C07F9/6561 ,  C07H19/01

Abstract: Immunomodulatory macrocylic compounds having the formula (VII) and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is selected from one of the formulae (Ia), (Ib) and (Ic), as well as pharmaceutical compositions containing the same.

公开(公告)号：EP1080070A2

公开(公告)日：2001-03-07

申请号：EP99924434.6

申请日：1999-05-21

Applicant: ABBOTT LABORATORIES

Inventor： KAWAI, Megumi ,  HENKIN, Jack ,  SHEPPARD, George, S. ,  CRAIG, Richard, A.

IPC: C07C237/42 ,  C07C237/22 ,  A61K31/195 ,  C07C311/46

CPC classification number: C07C237/22 ,  C07C311/46

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：EP1077995A1

公开(公告)日：2001-02-28

申请号：EP99925742.1

申请日：1999-05-21

Applicant: ABBOTT LABORATORIES

Inventor： KAWAI, Megumi ,  HENKIN, Jack ,  SHEPPARD, George, S. ,  CRAIG, Richard, A.

IPC: C07K5/11 ,  C07K5/065

CPC classification number: C07K5/1019 ,  A61K38/00 ,  C07K5/06078

Abstract: Compounds having Formula (I), or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：EP1073633A2

公开(公告)日：2001-02-07

申请号：EP99921611.2

申请日：1999-04-30

Applicant: ABBOTT LABORATORIES

Inventor： CRAIG, Richard, A. ,  HENKIN, Jack ,  KAWAI, Megumi ,  LYNCH, Linda, Lijewski ,  PATEL, Jyoti ,  SHEPPARD, George, S. ,  WANG, Jieyi

IPC: C07C323/60 ,  A61K31/16 ,  C07C237/14 ,  C07C237/12 ,  C07C311/19 ,  C07C235/16 ,  C07D295/185

CPC classification number: Y02P20/55

Abstract: A class of substituted β-amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.

公开(公告)号：EP0688217A1

公开(公告)日：1995-12-27

申请号：EP94910937.0

申请日：1994-03-14

Applicant: ABBOTT LABORATORIES

Inventor： KAWAI, Megumi ,  OR, Yat, Sun ,  LULY, Jay, R.

IPC: A61K31 ,  A61P37 ,  C07D498

CPC classification number: C07D498/18

Abstract: Immunomodulatory macrocyclic compounds having formula (I), and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R?107, R108, R109 and R110¿ is a radical having formula (II), (III) or (IV), as well as pharmaceutically compositions containing such compounds and methods of immunomodulatory therapy utilizing the same.