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1.发明申请TERMINALLY MODIFIED TRI-, TETRA- AND PENTAPEPTIDE ANAPHYLATOXIN RECEPTOR LIGANDS 审中-公开终末性修饰的三硝基苯并噻唑并吡啶并咪唑啉酮受体配体
公开(公告)号：WO1992021361A1
公开(公告)日：1992-12-10
申请号：PCT/US1992004331
申请日：1992-05-22
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , LULY, Jay, R. , KAWAI, Megumi , WIEDMAN, Paul, E.
IPC: A61K37/00
CPC classification number: C07K14/472 , A61K38/00 , C07K5/1016
Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states. Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.
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2.发明申请IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION 审中-公开咪达唑啶作为多发性激酶抑制剂的新型SCAFF
公开(公告)号：WO2011053476A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/053047
申请日：2010-10-18
Applicant: ABBOTT LABORATORIES , BA-MAUNG, Nwe Y. , CLARK, Richard F. , ERICKSON, Scott A. , FIDANZE, Steve D. , KAWAI, Megumi , MANTEI, Robert A. , SHEPPARD, George S. , SORENSON, Bryan K. , WANG, Gary T.
Inventor： BA-MAUNG, Nwe Y. , CLARK, Richard F. , ERICKSON, Scott A. , FIDANZE, Steve D. , KAWAI, Megumi , MANTEI, Robert A. , SHEPPARD, George S. , SORENSON, Bryan K. , WANG, Gary T.
IPC: C07D471/04 , A61K31/437 , A61P35/00
CPC classification number: C07D471/04
Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula (I).
Abstract translation: 公开了抑制蛋白激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。 式（I）。
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公开(公告)号：WO1994021253A1
公开(公告)日：1994-09-29
申请号：PCT/US1994002623
申请日：1994-03-11
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , KAWAI, Megumi , LULY, Jay, R.
IPC: A61K31/395
CPC classification number: C07D498/18
Abstract: Compounds having formula (I) and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R and R is hydrogen, and the other of R and R is a radical having formula (II), as well as pharmaceutically compositions containing such compounds and methods of immunomodulative therapy utilizing the same.
Abstract translation: 具有式（I）的化合物及其药学上可接受的盐，酯，酰胺和前药，其中R 104和R 105中的一个是氢，R 104和R 105中的另一个是基团 具有式（II）的化合物，以及含有这些化合物的药物组合物和利用其的免疫调节治疗方法。
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公开(公告)号：WO2007079164A3
公开(公告)日：2007-07-12
申请号：PCT/US2006/049461
申请日：2006-12-28
Applicant: ABBOTT LABORATORIES , SHEPPARD, George , WANG, Gary , PALAZZO, Fabio , BELL, Randy , MANTEI, Robert , WANG, Jieyi , HUBBARD, Robert , KAWAI, Megumi , ERICKSON, Scott , BAMAUNG, Nwe , FIDANZE, Steve
Inventor： SHEPPARD, George , WANG, Gary , PALAZZO, Fabio , BELL, Randy , MANTEI, Robert , WANG, Jieyi , HUBBARD, Robert , KAWAI, Megumi , ERICKSON, Scott , BAMAUNG, Nwe , FIDANZE, Steve
IPC: C07D487/04 , A61K31/4985 , A61K31/519 , A61P35/00
Abstract: Compounds of formula (I) that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
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5.发明申请3-AMINO-2-HRYDROXYALKANOIC ACIDS AND THEIR PRODRUGS 审中-公开3-AMINO-2-HRYDROXYALKANOIC ACIDS AND THE PRODRUGS
公开(公告)号：WO2004013085A1
公开(公告)日：2004-02-12
申请号：PCT/US2003/024396
申请日：2003-08-05
Applicant: ABBOTT LABORATORIES
Inventor： BAMAUNG, Nwe, Y. , CRAIG, Richard, A. , HENKIN, Jack , KAWAI, Megumi , SEARLE, Xenia, B. , SHEPPARD, George, S. , WANG, Jieyi
IPC: C07C229/36
CPC classification number: C07D263/04 , C07C229/22 , C07C229/28 , C07C229/34 , C07C323/58 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07D263/20 , C07D309/10
Abstract: Compounds having the formula are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
Abstract translation: 具有该式的化合物可用于治疗由血管生成引起或加重的病症。 还公开了包含该化合物的药物组合物，使用该化合物的治疗方法，抑制血管生成的方法和治疗癌症的方法。
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Patent Agency Ranking6.发明申请SUBSTITUTED ALICYCLIC-ALIPHATIC AMINE-CONTAINING MACROCYCLIC IMMUNOMODULATORS 审中-公开取代的ALICYCLIC-ALIPHATIC AMIN含大肠杆菌免疫调节剂
公开(公告)号：WO1994021634A1
公开(公告)日：1994-09-29
申请号：PCT/US1994002683
申请日：1994-03-11
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , LULY, Jay, R. , KAWAI, Megumi
IPC: C07D471/16
CPC classification number: C07D498/18
Abstract: Compounds having formula (I), and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R and R is hydrogen, and the other of R and R is a radical having formula (II), as well as pharmaceutically compositions containing such compounds and methods of immunomodulative therapy utilizing the same.
Abstract translation: 具有式（I）的化合物及其药学上可接受的盐，酯，酰胺和前药，其中R 104和R 105中的一个为氢，R 104和R 105中的另一个为 具有式（II）的基团，以及含有这些化合物的药物组合物和利用其的免疫调节治疗方法。
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公开(公告)号：WO1994021258A1
公开(公告)日：1994-09-29
申请号：PCT/US1994002741
申请日：1994-03-14
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , KAWAI, Megumi , OR, Yat, Sun , LULY, Jay, R.
IPC: A61K31/445
CPC classification number: C07D498/18
Abstract: Immunomodulatory macrocyclic compounds having formula (I), and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R , R , R and R is a radical having formula (II), (III) or (IV), as well as pharmaceutically compositions containing such compounds and methods of immunomodulatory therapy utilizing the same.
Abstract translation: 具有式（I）的免疫调节大环化合物及其药学上可接受的盐，酯，酰胺和前药，其中R 107，R 108，R 109和R 110之一是具有式（II）的基团 ），（III）或（IV），以及含有这些化合物的药物组合物和利用其的免疫调节治疗方法。
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8.发明申请HEXA- AND HEPTAPEPTIDE ANAPHYLATOXIN-RECEPTOR LIGANDS 审中-公开HEXA和HEPTAPEPAPDEANAPHYLATOXIN-RECEPTOR LIGANDS
公开(公告)号：WO1992011858A1
公开(公告)日：1992-07-23
申请号：PCT/US1991009319
申请日：1991-12-10
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , WIEDEMAN, Paul, E. , KAWAI, Megumi , LULY, Jay, R. , OR, Yat, Sun , WAGNER, Rolf
IPC: A61K37/00
CPC classification number: C07K14/472 , A61K38/00
Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states. Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.
Abstract translation: 式A-B-D-E-G-J-L-M-Q的寡肽化合物或寡肽类似物化合物是过敏毒素受体的配体，可用于治疗炎性疾病状态。 还公开了过敏毒素受体配体组合物和调节过敏毒素活性的方法。
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公开(公告)号：WO2004033419A1
公开(公告)日：2004-04-22
申请号：PCT/US2003/031671
申请日：2003-10-06
Applicant: ABBOTT LABORATORIES
Inventor： COMESS, Kenneth, M. , ERICKSON, Scott, A. , HENKIN, Jack , KALVIN, Douglas, M. , KAWAI, Megumi , KIM, Ki, H. , BAMAUNG, Nwe, Y. , PARK, Chan, Hoon , SHEPPARD, George, S. , VASUDEVAN, Anil , WANG, Jieyi , BARNES, David, M. , FIDANZE, Steve, D. , KOLACZKOWSI, Lawrence , MANTEI, Robert, A. , PARK, David, C. , SANDERS, William, J. , TEDROW, Jason, S. , WANG, Gary, T.
IPC: C07C311/08
CPC classification number: C07C323/25 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/37 , C07C311/44 , C07C311/46 , C07C317/28 , C07C323/49 , C07C323/63 , C07C323/67 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D209/08 , C07D209/42 , C07D213/70 , C07D213/71 , C07D215/36 , C07D215/48 , C07D231/18 , C07D233/54 , C07D233/84 , C07D261/10 , C07D285/06 , C07D285/14 , C07D333/34 , C07D333/38 , C07D413/04
Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
Abstract translation: 描述了具有甲硫氨酸氨基肽酶-2抑制剂（MetAP2）的化合物。 还描述了包含该化合物的药物组合物，使用该化合物的治疗方法，抑制血管生成的方法和治疗癌症的方法。
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公开(公告)号：WO1994021635A1
公开(公告)日：1994-09-29
申请号：PCT/US1994002711
申请日：1994-03-14
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , LULY, Jay, R. , KAWAI, Megumi , OR, Yat, Su , WIEDEMAN, Paul, E. , WAGNER, Rolf
IPC: C07D471/16
CPC classification number: C07D498/18 , C07D487/14 , C07D513/14 , C07F7/1804 , C07F9/6561 , C07H19/01
Abstract: Immunomodulatory macrocyclic compounds having formula (I), and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein Y is selected from one of formulae (Ia) and (Ib), as well as pharmaceutical compositions containing the same and methods of their use.
Abstract translation: 具有式（I）的免疫调节大环化合物及其药学上可接受的盐，酯，酰胺和前药，其中Y选自式（Ia）和（Ib）之一，以及含有它们的药物组合物及其制备方法 使用。
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