公开(公告)号：EP0870025B1

公开(公告)日：2009-11-18

申请号：EP97938467.4

申请日：1997-08-19

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C12N15/12 ,  C07K14/47 ,  C07K14/82 ,  C07K16/30 ,  C12N5/10 ,  C12Q1/68 ,  G01N33/53

CPC classification number: C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

公开(公告)号：EP1042506A1

公开(公告)日：2000-10-11

申请号：EP98964067.7

申请日：1998-12-16

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  C12N15/12 ,  C12N5/10 ,  C07K16/18 ,  C07K14/47 ,  G01N33/574

CPC classification number: C07K16/18 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS135 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS135-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS135 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：EP1027444A1

公开(公告)日：2000-08-16

申请号：EP98951079.7

申请日：1998-10-19

Applicant: Abbott Laboratories

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C12N15/63 ,  C12N5/10 ,  C12Q1/68 ,  C07K14/47 ,  C07K16/30 ,  G01N33/53 ,  G01N33/574 ,  G01N33/577 ,  A61K38/17

CPC classification number: C07K14/47 ,  C07K16/3015 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

Abstract translation: 描述了一组连续和部分重叠的RNA序列和由其编码的多肽，命名为BS106并从乳房组织转录。 这些序列可用于检测，诊断，分期，监测，预测，预防或治疗或确定个体对乳房疾病和病症如乳腺癌的倾向性。 还提供了特异性结合BS106编码的多肽或蛋白质的抗体，以及阻止组织特异性BS106多肽作用的激动剂或抑制剂，所述分子可用于治疗性治疗乳腺疾病，肿瘤或转移瘤。

公开(公告)号：EP0986652A1

公开(公告)日：2000-03-22

申请号：EP98925283.8

申请日：1998-06-05

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D. ,  YU, Hong

IPC: C12Q1/68 ,  C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  G01N33/574 ,  C12N5/12

CPC classification number: C07K14/47 ,  C07K16/18 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57438 ,  G01N33/57484

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BL172 and transcribed from urinary tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary tract cancer. Also provided are antibodies which specifically bind to BL172-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BL172 polypeptide, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.

公开(公告)号：EP0939824A1

公开(公告)日：1999-09-08

申请号：EP97913936.0

申请日：1997-10-31

Applicant: Abbott Laboratories

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: G01N33 ,  A61K38 ,  A61K39 ,  A61P35 ,  C07K14 ,  C07K16 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1

CPC classification number: C07K16/3015 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.