公开(公告)号：EP1711463A2

公开(公告)日：2006-10-18

申请号：EP05712865.4

申请日：2005-02-04

Applicant: ABBOTT LABORATORIES

Inventor： SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  JI, Jianguo ,  LI, Tao ,  PACE, Jennifer, M. ,  BRIGGS, Clark, A. ,  BUNELLE, William, H.

IPC: C07D207/08

CPC classification number: C07D207/08 ,  C07C211/31 ,  C07C217/24 ,  C07C2603/18 ,  C07C2603/26 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D209/88 ,  C07D211/22 ,  C07D211/46 ,  C07D243/08 ,  C07D295/104 ,  C07D307/91 ,  C07D311/86 ,  C07D333/76 ,  C07D451/06 ,  C07D453/02 ,  C07D487/04 ,  C07D487/08

Abstract: Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.

Abstract translation: 其中A和B是胺取代侧链的式（I）化合物，各种三环核心中的Y 1和Y 2，R x是任选的取代基。 考虑式（I）的化合物和组合物以及用于治疗由包含式（I）化合物和其它三环衍生物的±7nAChR配体防止或改善的病症或病症的方法。 使用氨基取代的衍生物的方法也在本文中描述。

公开(公告)号：EP2443122A1

公开(公告)日：2012-04-25

申请号：EP10788604.6

申请日：2010-06-18

Applicant: Abbott Laboratories

Inventor： SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B.

IPC: C07D471/18 ,  A61K31/439 ,  A61P25/00 ,  A61P29/00

CPC classification number: C07D471/18

Abstract: The invention relates to compounds that are diazahomoadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.

Abstract translation: 本发明涉及二氮杂高金刚烷衍生物的化合物，包含这些化合物的组合物，以及使用这些化合物和组合物的方法。

公开(公告)号：EP2069346B1

公开(公告)日：2011-12-21

申请号：EP08732554.4

申请日：2008-03-20

Applicant: ABBOTT LABORATORIES

Inventor： SCANIO, Marc J., C. ,  SHI, Lei ,  BUNNELLE, William, H. ,  SCHRIMPF, Michael, R.

IPC: C07D471/18 ,  A61K31/439 ,  A61P25/00

CPC classification number: C07D471/18

Abstract: TThe invention relates to compounds that are acetamide and carboxamide derivatives of azaadamantane, compositions comprising such compounds, and methods of using such compounds and compositions.

公开(公告)号：EP2069346A1

公开(公告)日：2009-06-17

申请号：EP08732554.4

申请日：2008-03-20

Applicant: ABBOTT LABORATORIES

Inventor： SCANIO, Marc J., C. ,  SHI, Lei ,  BUNNELLE, William, H. ,  SCHRIMPF, Michael, R.

IPC: C07D471/18

CPC classification number: C07D471/18

Abstract: TThe invention relates to compounds that are acetamide and carboxamide derivatives of azaadamantane, compositions comprising such compounds, and methods of using such compounds and compositions.

公开(公告)号：EP1656375A1

公开(公告)日：2006-05-17

申请号：EP04741916.3

申请日：2004-06-29

Applicant: NEUROSEARCH A/S ,  ABBOTT LABORATORIES

Inventor： PETERS, Dan ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet Ostergaard ,  AHRING, Philip K. ,  JORGENSEN, Tino Dyhring ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B.

IPC: C07D453/02 ,  A61K31/439 ,  A61P25/00

CPC classification number: C07D453/02

Abstract: This invention relates to novel quinuclidine derivatives represented by Formula (II) wherein represents an optional double bond; n is 1, 2 or 3; X represents a linker selected from -O-, -O-CH2-, -O-CH2-CH2-, -S-, -SO-, -SO2-, -CH2-, -S-CH2-CH2-,-CH2-, -C(=CH2)-, -NH-, -N(alkyl)-, -C(=O)-, -C(=S)-, oo, and ss; and Y represents O, S, SO2, or NR’ wherein R’ represents hydrogen or alkyl and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

公开(公告)号：EP1178982B1

公开(公告)日：2004-06-30

申请号：EP00932445.0

申请日：2000-05-15

Applicant: ABBOTT LABORATORIES

Inventor： SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  DAANEN, Jerome, F. ,  RYTHER, Keith, B. ,  JI, Jianguo

IPC: C07D401/04 ,  A61K31/4545 ,  A61K31/4439 ,  A61P25/00

CPC classification number: C07D401/04

公开(公告)号：EP1147112A1

公开(公告)日：2001-10-24

申请号：EP00906998.0

申请日：2000-01-25

Applicant: ABBOTT LABORATORIES

Inventor： BUNNELLE, William, H. ,  CRISTINA, Daniela, Barlocco ,  DAANEN, Jerome, F. ,  DART, Michael, J. ,  MEYER, Michael, D. ,  RYTHER, Keith, B. ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  TOUPENCE, Richard, B.

IPC: C07D487/08 ,  A61K31/395 ,  A61P25/00 ,  C07D471/08 ,  C07D519/00

CPC classification number: C07D471/08 ,  C07D401/08 ,  C07D487/08

Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2, and CH2CH2; Z is selected from the group consisting of CH2, CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.