-
1.发明申请
公开(公告)号：WO2006069196A1
公开(公告)日：2006-06-29
申请号：PCT/US2005/046480
申请日：2005-12-21
Applicant: ABBOTT LABORATORIES , PACE, Jennifer, M. , TIETJE, Karin , DART, Michael, J. , MEYER, Michael, D.
Inventor： PACE, Jennifer, M. , TIETJE, Karin , DART, Michael, J. , MEYER, Michael, D.
IPC: C07D417/06 , C07D413/06 , C07D409/06 , C07D405/06 , C07D401/06 , A61K31/404 , A61K31/55 , A61K31/496 , A61K31/454 , A61K31/435 , A61K31/428 , A61K31/422
CPC classification number: C07D403/06 , C07D209/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
Abstract: The present invention provides novel compounds of Formula (I), which are CB 2 selective ligands useful for the treatment of pain.
Abstract translation: 本发明提供了新的式（I）化合物，其为可用于治疗疼痛的CB 2/2选择性配体。
-
公开(公告)号：WO2005077899A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/003578
申请日：2005-02-04
Applicant: ABBOTT LABORATORIES , SCHRIMPF, Michael, R. , SIPPY, Kevin, B. , JI, Jianguo , LI, Tao , PACE, Jennifer, M. , BRIGGS, Clark, A. , BUNELLE, William, H.
Inventor： SCHRIMPF, Michael, R. , SIPPY, Kevin, B. , JI, Jianguo , LI, Tao , PACE, Jennifer, M. , BRIGGS, Clark, A. , BUNELLE, William, H.
IPC: C07D207/08
CPC classification number: C07D207/08 , C07C211/31 , C07C217/24 , C07C2603/18 , C07C2603/26 , C07D205/04 , C07D207/12 , C07D207/14 , C07D209/88 , C07D211/22 , C07D211/46 , C07D243/08 , C07D295/104 , C07D307/91 , C07D311/86 , C07D333/76 , C07D451/06 , C07D453/02 , C07D487/04 , C07D487/08
Abstract: Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y 1 and Y 2 form various tricyclic cores, X a and X b are C, CH, or N, as defined herein, and R x is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.
Abstract translation: 其中A和B是胺取代的侧链，Y 1和Y 2形成各种三环核心的式（I）化合物， 如本文所定义，X和X是C，CH或N，并且R X是任选的取代基。 考虑式（I）化合物和组合物以及用于治疗由包含式（I）化合物和其他三环衍生物的α7nAChR配体阻止或改善的病症或障碍的方法。 本文还描述了使用氨基取代的三环衍生物的方法。
-
Patent Agency Ranking3.发明申请SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES AS LIGANDS AT ALPHA 7 NICOTINIC ACETY LCHOLINE RECEPTORS 审中-公开取代的双唑胆碱衍生物作为ALPHA的配体7 NICOTINIC乙酰胆碱受体
公开(公告)号：WO2005028477A1
公开(公告)日：2005-03-31
申请号：PCT/US2004/030735
申请日：2004-09-17
Applicant: ABBOTT LABORATORIES , LI, Tao , BASHA, Anwer , BUNNELLE, William, H. , DART, Michael, J. , GALLAGHER, Megan, E. , JI, Jianguo , PACE, Jennifer, M. , RYTHER, Keith, B. , TIETJE, Karin, R. , MORTELL, Kathleen, H. , NERSESIAN, Diana, L. , SCHRIMPF, Michael, R.
Inventor： BASHA, Anwer , BUNNELLE, William, H. , DART, Michael, J. , GALLAGHER, Megan, E. , JI, Jianguo , PACE, Jennifer, M. , RYTHER, Keith, B. , TIETJE, Karin, R. , MORTELL, Kathleen, H. , NERSESIAN, Diana, L. , SCHRIMPF, Michael, R.
IPC: C07D471/04
CPC classification number: C07D487/08 , C07D471/04 , C07D471/08 , C07D487/04
Abstract: Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
Abstract translation: 式（I）化合物Z-Ar 1 -Ar 2其中Z是二氮杂双环胺，Ar 1是5-或6-元芳环，Ar 2选自未取代或取代的5-或 6元杂芳基环; 未取代或取代的双环杂芳基环; 3,4-（亚甲二氧基）苯基; 咔唑; tetrahydrocarbazolyl; 萘; 和苯基; 其中苯基在间位或对位被0,1,2或3个取代基取代。 该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。 还公开了包含式（I）化合物和使用这些化合物和组合物的方法的药物组合物。
-
公开(公告)号：EP1833824A1
公开(公告)日：2007-09-19
申请号：EP05855099.7
申请日：2005-12-21
Applicant: ABBOTT LABORATORIES
Inventor： PACE, Jennifer, M. , TIETJE, Karin , DART, Michael, J. , MEYER, Michael, D.
IPC: C07D417/06 , C07D413/06 , C07D409/06 , C07D405/06 , C07D401/06 , A61K31/404 , A61K31/55 , A61K31/496 , A61K31/454 , A61K31/435 , A61K31/428 , A61K31/422
CPC classification number: C07D403/06 , C07D209/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
Abstract: The present invention provides novel compounds of Formula (I), which are CB2 selective ligands useful for the treatment of pain.
Abstract translation: 本发明提供了式（I）的新型化合物，它们是用于治疗疼痛的CB 2选择性配体。
-
5.发明公开AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE 审中-公开AMINOSUTITUIERTE TRICYCLISCHE DERIVATE UND ANWENDUNGSVERFAHREN
公开(公告)号：EP1711463A2
公开(公告)日：2006-10-18
申请号：EP05712865.4
申请日：2005-02-04
Applicant: ABBOTT LABORATORIES
Inventor： SCHRIMPF, Michael, R. , SIPPY, Kevin, B. , JI, Jianguo , LI, Tao , PACE, Jennifer, M. , BRIGGS, Clark, A. , BUNELLE, William, H.
IPC: C07D207/08
CPC classification number: C07D207/08 , C07C211/31 , C07C217/24 , C07C2603/18 , C07C2603/26 , C07D205/04 , C07D207/12 , C07D207/14 , C07D209/88 , C07D211/22 , C07D211/46 , C07D243/08 , C07D295/104 , C07D307/91 , C07D311/86 , C07D333/76 , C07D451/06 , C07D453/02 , C07D487/04 , C07D487/08
Abstract: Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.
Abstract translation: 其中A和B是胺取代侧链的式（I）化合物，各种三环核心中的Y 1和Y 2，R x是任选的取代基。 考虑式（I）的化合物和组合物以及用于治疗由包含式（I）化合物和其它三环衍生物的±7nAChR配体防止或改善的病症或病症的方法。 使用氨基取代的衍生物的方法也在本文中描述。
-
公开(公告)号：EP1284976A2
公开(公告)日：2003-02-26
申请号：EP01944118.7
申请日：2001-04-27
Applicant: Abbott Laboratories
Inventor： SCHRIMPF, Michael, R. , TIETJE, Karin, R. , TOUPENCE, Richard, B. , JI, Jianguo , BASHA, Anwer , BUNNELLE, William, H. , DAANEN, Jerome, F. , PACE, Jennifer, M. , SIPPY, Kevin, B.
IPC: C07D487/00
CPC classification number: C07D471/04 , C07D487/04
Abstract: Compounds of formula (I), pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals (nicotinic acetylcholine receptor ligands).
-
7.发明公开SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES AS LIGANDS AT ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTORS 审中-公开取代二氮杂如α-7烟碱型乙酰胆碱受体的配体
公开(公告)号：EP1664045A1
公开(公告)日：2006-06-07
申请号：EP04784568.0
申请日：2004-09-17
Applicant: ABBOTT LABORATORIES
Inventor： BASHA, Anwer , BUNNELLE, William, H. , DART, Michael, J. , GALLAGHER, Megan, E. , JI, Jianguo , PACE, Jennifer, M. , RYTHER, Keith, B. , TIETJE, Karin, R. , MORTELL, Kathleen, H. , NERSESIAN, Diana, L. , SCHRIMPF, Michael, R. , LI, Tao
IPC: C07D471/04 , C07D487/04 , C07D487/08 , C07D471/08 , A61K31/435 , A61P25/00
CPC classification number: C07D487/08 , C07D471/04 , C07D471/08 , C07D487/04
Abstract: Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
-
-
-
-
-
-
Search Results
7
records
(took 0.022 seconds)
