公开(公告)号：DE3309158A1

公开(公告)日：1984-09-20

申请号：DE3309158

申请日：1983-03-15

Applicant: BASF AG

Inventor： ERNST HANSGEORG DR ,  GEHRKEN HENNING-PETER DR ,  PAUST JOACHIM DR

IPC: C07D317/60 ,  B01J31/16 ,  C07B61/00 ,  C07D311/72

Abstract: A process for the preparation of alpha -tocopherol of the formula I (I) by reacting a chroman derivative with a C14-Grignard reagent using a di-alkali metal tetrahalocuprate catalyst in a Schlosser-Fouquet reaction, wherein a chroman derivative of the general formula II (II) where Y is a leaving group, especially Br, is used and is reacted, at from -70 DEG to 0 DEG C., first with a solution of about 1 equivalent of a Grignard compound of the general formula III X-Mg-R (III) where X is Cl, Br or I and R is straight-chain or branched alkyl of 1 to 14 carbon atoms, preferably methyl, ethyl or and then with a solution of a Grignard reagent of the formula IIIa (IIIa) in an ether solvent and a solution of a di-alkali metal tetrahalocuprate in an ether solvent. The novel process simplifies the preparation of 2RS,4'RS,8'RS-, 2R,4'RS,8'RS- or 2R,4'R,8'R- alpha -tocopherol by reacting a chroman structural unit, containing a C2 side-chain in the 2-position, with the corresponding C14-Grignard compound.

公开(公告)号：DE3302497A1

公开(公告)日：1984-07-26

申请号：DE3302497

申请日：1983-01-26

Applicant: BASF AG

Inventor： ERNST HANSGEORG DR ,  SCHMIDT WOLFRAM DR ,  PAUST JOACHIM DR

IPC: C07D475/14 ,  C07D475/02 ,  C07D487/04

公开(公告)号：DE3244273A1

公开(公告)日：1984-05-30

申请号：DE3244273

申请日：1982-11-30

Applicant: BASF AG

Inventor： ERNST HANSGEORG DR ,  PAUST JOACHIM DR

IPC: C07C67/22 ,  C07C67/307 ,  C07C67/317 ,  C07C69/533 ,  C07C69/63 ,  C07C69/65

公开(公告)号：ES2238371T3

公开(公告)日：2005-09-01

申请号：ES01122344

申请日：2001-09-19

Applicant: BASF AG

Inventor： GRIMMER JOHANNES ,  MULLER THOMAS DR ,  ERNST HANSGEORG DR

IPC: C07D317/46 ,  A61K31/045 ,  A61K31/12 ,  C07C45/00 ,  C07C45/62 ,  C07C49/743 ,  C07C49/753 ,  C07C403/08 ,  C07D317/00 ,  C07D317/12 ,  C07D317/48 ,  C07F7/18

Abstract: Procedimiento para la obtención de derivados de ciclohexeno de las fórmulas generales I o II, en las que los substituyentes R1 y R2, independientemente entre sí, tienen el siguiente significado: R2 OH o un grupo protector transformable en un grupo hidroxi mediante hidrólisis, R3 y R4 hidrógeno, alquilo con 1 a 4 átomos de carbono; R5 hidrógeno, acilo con 1 a 4 átomos de carbono; mediante reducción de compuestos de alquina de las fórmulas generales III o IV, en las que los substituyentes R1 y R2 tienen el significado citado anteriormente, caracterizado porque se emplea como agente reductor una mezcla de cinc y al menos un compuesto B, seleccionado a partir del grupo constituido por sales amónicas, sales de cobre, sales alcalinas y alcalinotérreas.

公开(公告)号：ES2209735T3

公开(公告)日：2004-07-01

申请号：ES00118466

申请日：2000-08-25

Applicant: BASF AG

Inventor： WEGNER CHRISTOPH DR ,  PAUST JOACHIM DR ,  ERNST HANSGEORG DR

IPC: C07C41/28 ,  C07B61/00 ,  C07C41/50 ,  C07C43/15

公开(公告)号：AT229495T

公开(公告)日：2002-12-15

申请号：AT00115618

申请日：2000-07-20

Applicant: BASF AG

Inventor： PAUST JOACHIM DR ,  ERNST HANSGEORG DR ,  KACZMAREK REINHARD DR ,  JAEDICKE HAGEN DR

IPC: C07B61/00 ,  C07C231/08 ,  C07C233/18 ,  C07C233/47 ,  C07C233/69 ,  C07C233/83

Abstract: Preparation of N-acyl derivatives (I) using readily available starting materials. N-acyl derivatives of formula R -C(O)N(H)C(R )X (I) are prepared by reacting, in the presence of a compound of formula R -COOH (II), a carbonic acid amide of formula R -CONH2 (III) and a glyoxalmonoacetal derivative of formula R C(O)C(OR )OR (IV). R , R = H or optionally substituted alkyl or aryl; R ,R = 1 - 12C alkyl; and X = CH(OR ) or COOR . An Independent claim is also included for a compound of formula R -C(O)N(H)C(R )C(OR )OR (V).

公开(公告)号：DE4435421A1

公开(公告)日：1996-04-11

申请号：DE4435421

申请日：1994-10-04

Applicant: BASF AG

Inventor： KRAUSE WOLFGANG DR ,  ERNST HANSGEORG DR ,  PAUST JOACHIM DR ,  RHEUDE UDO DR ,  DOBLER WALTER DR

IPC: C07C67/307 ,  C07C69/65 ,  C07F9/40

Abstract: Prodn. of trialkyl 4-phosphono-2-methyl-2-butenoate esters of formula (I) with a high E-isomer content comprises (a) reacting an alkyl 2-hydroxy-2-methyl-3-butenoate of formula (II) with PBr3 or PCl3 at 0-80 degrees C in the absence of pyridine to form a mixt. of an alkyl 4-halo-2- methyl-2-butenoate of formula (III) and an alkyl 2-halo-2-methyl-3-butenoate of formula (IV), and (b) reacting the mixt. with a trialkyl phosphite of formula (V) at 70-140 degrees C. R1, R2 = Me or Et; X = Cl or Br. Also claimed is the prodn. of (III) as in step (a) above at a temp. of 20-80 degrees C.

公开(公告)号：FR2709490A1

公开(公告)日：1995-03-10

申请号：FR9410366

申请日：1994-08-29

Applicant: BASF AG

Inventor： ERNST HANSGEORG DR ,  PAUST JOACHIM DR ,  DOBLER WALTER DR ,  RHEUDE UDO DR

IPC: C07C403/16 ,  C07C47/21 ,  C07C69/66 ,  C07C403/00 ,  C07C403/24 ,  C07F9/50 ,  C07F9/54 ,  C07C49/325

Abstract: Process for the preparation of astaxanthin by reaction of the tertiary alcohol of formula II or of the diacetate of formula III in an inert solvent with aqueous hydrochloric acid or hydrobromic acid, which gives a halide which is converted, by reaction with triphenylphosphine, to a triphenylphosphonium salt which is reacted, according to a Wittig reaction, with 2,7-dimethyl-2,4,6-octatriene-1,8-dial. By carrying out the reaction of the halide with triphenylphosphine in an acyclic lower dialkyl ether, the triphenylphosphonium salt is obtained in a highly crystalline form which makes isolation easier and which improves the yields.

公开(公告)号：DE4014203A1

公开(公告)日：1991-11-07

申请号：DE4014203

申请日：1990-05-03

Applicant: BASF AG

Inventor： ERNST HANSGEORG DR ,  PAUST JOACHIM DR ,  HOFFMANN WERNER DR

IPC: C07C45/75 ,  C07C49/653 ,  C07C49/743 ,  C07C69/63 ,  C07C403/12 ,  C07C403/24 ,  C07F9/54

Abstract: Process for the preparation of canthaxanthine (Ia) and astaxanthine (Ib) of the general formula I … … in which R represents H (a) or OH (b), which process is characterised in that a tertiary alcohol of the general formula II … … in which R represents H (a) or OH (b), is reacted with trifluoroacetic acid, the novel trifluoroacetate obtained of the general formula III … … is reacted with triphenylphosphine, the novel triphenylphosphonium trifluoroacetate obtained of the general formula IV … … is reacted with 2,7-dimethyl-2,4,6-octatriene-1,8-dial under the conditions of a Wittig synthesis. In addition, the invention relates to the novel trifluoroacetates of the formula III and the corresponding triphenylphosphonium trifluoroacetates of the formula IV.

公开(公告)号：DE3578179D1

公开(公告)日：1990-07-19

申请号：DE3578179

申请日：1985-04-23

Applicant: BASF AG

Inventor： ERNST HANSGEORG DR ,  ECKHARDT HEINZ DR ,  PAUST JOACHIM DR

IPC: C07C67/00 ,  C07C241/00 ,  C07C245/08 ,  C07D475/14

Abstract: An improved process for the preparation of riboflavin by condensation of a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline derivative with barbituric acid in the presence of an acidic condensing agent in an organic solvent, wherein a 4,5-dimethyl-N-(D)-ribityl-2-(o-alkoxyphenylazo)-aniline of the formula IIa where R is alkyl of 1 to 4 carbon atoms, in particular methyl, is reacted with barbituric acid, as well as the novel intermediates of the formula IIa.